|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antisense telomerase RNA induced human gastric cancer cell apoptosis显示文摘INTRODUCTION Human tissue homeostasis is precisely regulated bycellular division,differentiation and death.Normalhuman somatic cells progressively lose telomererestriction fragment(TRF)length with eachsuccessive cell division,eventually leading tocellular quiescence,chromosomal end-degradationand apoptosis.On the contrary,stabilization oftelomere lengths by expressing telomerase,an RNA-dependent DNA polymerase,may be involved incellular immortality and carcinogenesis. | Fang Xin Zhang Xue Yong Zhang Dai Ming Fan Zi Yun Deng Yan Yan Han Ping Wu Jun Jie Fan | 2000 | World Journal of Gastroenterology2000，6，3： | 24 |
| 2 | Palaeogene fossil Populus leaves from Lanzhou Basin and their palaeoclimatic significance显示文摘An angiosperm compression flora is found in Palaeogene from Lanzhou Basin and the cuticular analysis of Populus davidiana Dode in the flora is carefully made. Fur-thermore, the fossil cuticles are compared with the epidermal structures of extant Populus leaves growing in different en-vironments, i.e. moist, semimoist, and semiarid to arid cli-matic regions. The present experiments indicate that mature leaves of P. davidiana show leaf size from big to small, leaf cuticles from thick to thin and anticlinal walls of epidermal cells from faintness to clarity along with the increase of lati-tudes of the plant distributions, the climatic variation from moist to arid, the annual precipitation from more to less and the annual mean temperature from high to low. The fossil P. davidiana differs from the specimens collected from Shandan in semiarid to arid climatic regions but closely resembles the Wushan leaves in a semi-moist climatic area in a lot of fea-tures. In a word, the new research may reflect that the flora lives in a semi-moist climatic environment. The present dis-covery of compression of Paleogene Populus davidiana is of great significance to studying vegetation types, climatic and environmental changes during the primal uplifting of the Qinghai-Tibet Plateau. | SUN Bainian1,2, YAN Defei1, XIE Sanping1, CONG Peiyun1, XIN Cunlin1 & YUN Fei1 1. Key Laboratory of Western China抯 Environmental Systems of the Ministry of Education, Lanzhou University, Lanzhou 730000, China 2. State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sci-ences, Nanjing 210008, China | 2004 | Chinese Science Bulletin2004，49，14： | 20 |
| 3 | Mesenchymal stem cells transduced by PLEGFP-N1 retroviral vector maintain their biological features and differentiation显示文摘Background Enhanced green fluorescent protein(EGFP) has been an important reporter gene for gene therapy. Human mesenchymal stem cells (hMSCs) are ideal target cells in cell transplantation and tissue engineering. We investigated their biological characteristics and differentiation mediated b y PLEGFP-N1 retroviral transduction. Methods hMSCs were isolated from human bone marrow by density g radient fractionation and adherence to plastic flasks. Individual colonies were selected and cultured in tissue dishes. Packaging cells PT67 were transfected by PLEGFP-N1 retroviral vector , and hMSCs were transduced by viral supernatant infection. Meanwhile, hMSCs-EGFP were identified by immune phenotypes and whe ther it could differentiate into osteoblasts or adipocytes under conditioned med ia was investigated. Results The rate of stably transduced hMSCs-EGFP was up to 96% after being screened by G418. hMSCs-EGFP exhibited fibroblast-like morpholog ical features. Flow cytometric analyses showed that hMSCs-EGFP were positive f or CD 73, CD 105, CD 166, CD 90 and CD 44, but negative for CD 34 and CD 45. In addition, it could functionally be induced i nto osteocytes or adipocytes under conditioned media. These biological features of hMSCs-EGFP were consistent with those of hMSCs. Conclusions hMSCs transduced by PLEGFP-N1 retroviral vector ca n be used in vivo securely because they can maintain their biological charac teristics and differentiation. It is a simple and reliable way to trace the ch anges of hMSCs in vivo by EGFP during cell transplantation and gene therapy . | HE Xu LI Yu-lin WANG Xin-rui GUO Xin NIU Yun | 2005 | Chinese Medical Journal2005，，20： | 20 |
| 4 | Overexpression of p27^(KIP1)induced cell cycle arrest in G_1 phase and subsequent apoptosis in HCC-9204 cell line显示文摘AIM We have previously reported that inducibleover-expression of Bak may prolong cell cycle inG1 phase and lead to apoptosis in HCC-9204 cells.This study is to investigate whether p27KIP1playsan important role in this process.METHODS In order to elucidate the exactfunction of p27KIP1in this process,a zinc induciblep27KIP1stable transfectant and transient p27KIP1-GFP fusion transfectant were constructed.Theeffects of inducible,p27KIP1on cell growth,cellcycle arrest and apoptosis were examined in themock,control pMD vector,and pMD-KIP1transfected HCC-9204 cells.RESULTS This p27KIP1-GFP transfectant maytransiently express the fusion gene.The cellgrowth was reduced by 35% at 48 h of p27KIP1induction with zinc treatment as determined bytrypan blue exclusion assay.These differencesremained the same after 72 h of p27KIP1expression,p27KIP1caused cell cycle arrest after24 h of induction,with 40% increase in G1population.Prolonged p27KIP1expression in thiscell line induced apoptotic cell death reflected byTUNEL assay.Fourty-eight h and 72 h of p27KIP1expression showed a characteristic DNA ladder onagarose gel electrophoresis. CONCLUSION Bak may induce cell cycle arrest inG1 phase through upregulating expression ofp27KIP1and subsequently lead to apoptosis inHCC-9204 cells.The p27KIP1-GFP fusion proteincan be transiently expressed in HCC-9204 cells.The inducible p27KIP1-expressing cell line providesa model to assess p27KIP1function. | Jiang Li Xin Ke Yang Xin Xin Yu Meng Liang Ge Wen Liang Wang Jie Zhang Yun De Hou Department of Pathology,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China State Key Laboratory for Molecular Virology and Genetic Engineering,Beijing 100052,China Department of Dermatology,Beijing Hospital,Beijing 100016,China Institute of Radiation Medicine,Beijing 100085,China | 2000 | World Journal of Gastroenterology2000，6，4： | 20 |
| 5 | Efects of a bioartificial liver support system on a cetaminophen-induced acute liver failure canines显示文摘Seeinvitedcommentaryonpage286Subjectheadingsliversupportsystem;acuteliverfailure;canines;porcinehepatocytes;bioartificiallive... | XUE Yi Long 1, ZHAO Shi Feng 2, ZHANG Zuo Yun 1, WANG Yue Feng 1, LI Xin Jian 1, HUANG Xiao Qiang 3, LUO Yun 1, HUANG Ying Cai 4 and LIU Cheng Gui 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 19 |
| 6 | Congenital vascular rings:a rare cause of respiratory distress in infants and children显示文摘背景先天的脉管的戒指可以经常在婴儿和小孩子引起 unexplained 呼吸症状。他们的诊断和治疗经常被推迟。脉管的戒指的很少研究在学习是与先天的脉管的 rings.Methods 描述临床的演讲,诊断和婴儿和孩子的外科的管理的这的 China.The 目的被报导了临床的历史,物理考试,调查,图象研究和外科的干预回顾地在 7 个孩子被评估(年龄范围:2 个月 -- 4 年,平均数 7 月) 与先天的脉管的 rings.Chest, X 光线照相术在所有病人被执行。有 3-dimensional (3D ) 的 Echocardiography 和计算断层摄影术(CT ) 重建在 6 个病人被执行。Esophagography,心脏的 catheterization 和 angiography,和 bronchoscopy 在 1, 1 和 4 个孩子,被执行 7 个病人中的六个有的 respectively.Results 呼吸症状包括周期性的咳嗽, stridor 和喘息。在症状的发作的年龄从 1 个月到 11 个月。胸 X 光检查没显示出在脉管的戒指上重要的任何东西,除支气管炎和肺病以外。提高对比的 CT 在 6 个病人诊断了脉管的戒指。有的四个病人加倍大动脉的拱门,二平衡拱门,二是正确的拱门主导。一个病人与左系带有一个恰好大动脉的拱门, 1 个病人有一个肺的动脉弹弓。Echocardiography 没能在 2 个病人诊断脉管的戒指。1 个病人的 esophagogram 显示出食道的压缩。4 个病人的 Bronchoscopy 显示出远侧的气管的压缩。7 个病人中的五个经历了脉管的戒指的外科的分割。外科的观察在每个 patient.Conclusions 病人,特别婴儿或幼仔证实了 CT 调查结果与象长期的咳嗽, stridor 和喘息那样的周期性的呼吸症状,孩子们应该被检查因为先天的脉管的提高 rings.Contrast 的 CT 的可能的存在能清楚地显示出脉管的戒指的解剖。作为一种 noninvasive 技术, echocardiography 对诊断有用。在征兆的病人的早外科的管理是有效的。 | MA Gui-qin LI Zhong-zhi LI Xiao-feng PENG Yun DU Zhong-dong JIN Lan-zhong WANG Fang-yun WEI Hai-yan ZHENG Lin ZHANG Xin | 2007 | Chinese Medical Journal2007，，16： | 19 |
| 7 | Microwave Exposure Impairs Synaptic Plasticity in the Rat Hippocampus and PC12 Cells through Over-activation of the NMDA Receptor Signaling Pathway显示文摘Objective The aim of this study is to investigate whether microwave exposure would affect the N-methyl-D-aspartate receptor(NMDAR) signaling pathway to establish whether this plays a role in synaptic plasticity impairment. Methods 48 male Wistar rats were exposed to 30 m W/cm2 microwave for 10 min every other day for three times. Hippocampal structure was observed through H&E staining and transmission electron microscope. PC12 cells were exposed to 30 m W/cm2 microwave for 5 min and the synapse morphology was visualized with scanning electron microscope and atomic force microscope. The release of amino acid neurotransmitters and calcium influx were detected. The expressions of several key NMDAR signaling molecules were evaluated. Results Microwave exposure caused injury in rat hippocampal structure and PC12 cells, especially the structure and quantity of synapses. The ratio of glutamic acid and gamma-aminobutyric acid neurotransmitters was increased and the intracellular calcium level was elevated in PC12 cells. A significant change in NMDAR subunits(NR1, NR2 A, and NR2B) and related signaling molecules(Ca2+/calmodulin-dependent kinase II gamma and phosphorylated c AMP-response element binding protein) were examined. Conclusion 30 m W/cm2 microwave exposure resulted in alterations of synaptic structure, amino acid neurotransmitter release and calcium influx. NMDAR signaling molecules were closely associated with impaired synaptic plasticity. | XIONG Lu SUN Cheng Feng ZHANG Jing GAO Ya Bing WANG Li Feng ZUO Hong Yan WANG Shui Ming ZHOU Hong Mei XU Xin Ping DONG Ji YAO Bin Wei ZHAO Li PENG Rui Yun | 2015 | Biomedical and Environmental Sciences2015，28，1： | 16 |
| 8 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 9 | Precise Asymptotics in the Law of the Iterated Logarithm of Moving-Average Processes显示文摘在这份报纸,我们讨论动人一般水准的过程,在的地方{伪 i ;-鈭?< i <鈭瀩 是一个二倍地无限的序列混合的相等分布式的蠁-或有平均数零的否定地联系的随机的变量和有限变化,{伪 i ;-鈭?< i <鈭瀩 是一绝对实数的 summable 顺序。设定。建议那。我们为任何东西证明那, | Yun Xia LI Li Xin ZHANG | 2006 | Acta Mathematica Sinica,English Series2006，22，1： | 15 |
| 10 | Changes of p53 and Waf1p21 and cell proliferation in esophageal carcinogenesis显示文摘Changesofp53andWaf1p21andcelproliferationinesophagealcarcinogenesisWANGLiDong1,YANGWanCai1,ZHOUQi1,XINGYing1,JIAYunYing2a... | WANG Li Dong 1, YANG Wan Cai 1, ZHOU Qi 1, XING Ying 1,JIA Yun Ying 2 and ZHAO Xin 1 | 1997 | World Journal of Gastroenterology1997，3，2： | 15 |
| 11 | Metabolic engineering and flux analysis of Corynebacterium glutamicum for L-serine production显示文摘L-Serine plays a critical role as a building block for cell growth, and thus it is difficult to achieve the direct fermentation of L-serine from glucose. In this study, Corynebacterium glutamicum ATCC 13032 was engineered de novo by blocking and attenuating the conversion of L-serine to pyruvate and glycine, releasing the feedback inhibition by L-serine to 3-phosphoglycerate dehydrogenase (PGDH), in combination with the co-expression of 3-phosphoglycerate kinase (PGK) and feedback-resistant PGDH (PGDHr). The resulting strain, SER-8, exhibited a lower specific growth rate and significant differences in L-serine levels from Phase I to Phase V as determined for fed-batch fermentation. The intracellular L-serine pool reached (14.22±1.41) μmol gCDM 1, which was higher than glycine pool, contrary to fermentation with the wild-type strain. Furthermore, metabolic flux analysis demonstrated that the over-expression of PGK directed the flux of the pentose phosphate pathway (PPP) towards the glycolysis pathway (EMP), and the expression of PGDHr improved the L-serine biosynthesis pathway. In addition, the flux from L-serine to glycine dropped by 24%, indicating that the deletion of the activator GlyR resulted in down-regulation of serine hydroxymethyltransferase (SHMT) expression. Taken together, our findings imply that L-serine pool management is fundamental for sustaining the viability of C. glutamicum, and improvement of C1 units generation by introducing the glycine cleavage system (GCV) to degrade the excessive glycine is a promising target for L-serine production in C. glutamicum. | LAI ShuJuan ZHANG Yun LIU ShuWen LIANG Yong SHANG XiuLing CHAI Xin WEN TingYi | 2012 | Science China(Life Sciences)2012，55，4： | 15 |
| 12 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 13 | Removal of heavy metals from a contaminated soilusing tartaric acid显示文摘This study reports the feasibility of remediation of a heavy metal (HM ) contaminated soil using tartaric acid, an environmentally-friendly extractant. Batch experiments were performed to test the factors influencing remediation of the HM contaminated soil. An empirical model was employed to describe the kinet ics of HM dissolution/desorption and to predict equilibrium concentrations of HM s in soil leachate. The changes of HMs in different fractions before and after t artaric acid treatment were also investigated. Tartaric acid solution containing HMs was regenerated by chestnut shells. Results show that utilization of tartar ic acid was effective for removal of HMs from the contaminated soil, attaining 5 0%—60% of Cd, 40%—50% of Pb, 40%—50% of Cu and 20%—30% of Zn in the pH ra nge of 3.5—4.0 within 24 h. Mass transfer coefficients for cadmium (Cd) and lead (Pb) were much higher than those for copper (Cu) and zinc (Zn). Sequ ential fractionations of treated and untreated soil samples showed that tartari c acid was effective in removing the exchangeable, carbonate fractions of Cd, Zn and Cu from the contaminated soil. The contents of Pb and Cu in Fe-Mn oxide fra citon were also significantly decreased by tartaric acid treatment. One hundred milliliters of tartaric acid solution containing HMs could be regenerated by 10 g chestnut shells in a batch reactor. Such a remediation procedure indicated tha t tartaric acid is a promising agent for remediation of HM contaminated soils. H owever, further research is needed before the method can be practically used for in situ remediation of contaminated sites. | KE Xin LI Pei-jun ZHOU Qi-xing ZHANG Yun SUN Tie-heng | 2006 | Journal of Environmental Sciences2006，18，4： | 13 |
| 14 | Rapid Detection and Identification of Infectious Pathogens Based on High-throughput Sequencing显示文摘 | Pei-Xiang Ni Xin Ding Yin-Xin Zhang Xue Yao Rui-Xue Sun Peng Wang Yan-Ping Gong Jia-Li Zhou Dong-Fang Li Hong-Long WO Xin Yi Ling Yang Yun Long | 2015 | Chinese Medical Journal2015，，7： | 13 |
| 15 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 16 | Expression and alterations of different molecular form γ-glutamyl transferase and total RNA concentration during the carcinogenesis of rat hepatoma显示文摘INTRODUCTIONCarcinogenesisiscloselyrelatedwithDNAsynthesisandhypermetabolismofnucleicacid.γglutamyltransferase(GGT,EC2.3.2.2... | TANG Qi Yun, YAO Deng Fu, LU Jian Xin, WU Xin Hua and MENG Xian Yong | 1999 | World Journal of Gastroenterology1999，5，4： | 12 |
| 17 | A review on 2D MoS_(2) cocatalysts in photocatalytic H_(2) production显示文摘Owing to their unique physicochemical,optical and electrical properties,two-dimensional(2D)MoS_(2) cocatalysts have been widely applied in designing and developing highly efficient composite photocatalysts for hydrogen generation under suitable light irradiation.In this review,we first elaborated on the fundamental aspects of 2D MoS_(2) cocatalysts to include the structural design principles,synthesis strategies,strengths and challenges.Subsequently,we thoroughly highlighted and discussed the modification strategies of 2D MoS_(2) H2-evolution cocatalysts,including doping heteroatoms(e.g.metals,non-metals,and co-doping),designing interfacial coupling morphologies,controlling the physical properties(e.g.thickness,size,structural defects or pores),exposing the reactive facets or edge sites,constructing cocatalyst heterojunctions,engineering the interfacial bonds and confinement effects.In the future,the forefront challenges in understanding and in precise controlling of the active sites at molecular level or atomic level should be carefully studied,while various potential mechanisms of photogenerated-electrons interactions should be proposed.The applications of MoS_(2) cocatalyst in the overall water splitting are also expected.This review may offer new inspiration for designing and constructing novel and efficient MoS_(2)-based composite photocatalysts for highly efficient photocatalytic hydrogen evolution. | Zizhan Liang Rongchen Shen Yun Hau Ng Peng Zhang Quanjun Xiang Xin Li | 2020 | Journal of Materials Science & Technology2020，56，21： | 12 |
| 18 | Four new constituents from Taraxacum mongolicum显示文摘二新黄酮 glycosides ,isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- l-arabinopyranoside ( 1 )和isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- d-glucopyranoside ( 2 ),新 lignan , mongolicumin A ( 3 ),和新 guaianolide , mongolicumin B ( 4 )从薄公英属 mongolicum 的天线部分被孤立。他们的结构被主要阐明光谱分析。 | Shu Yun Shi Qi Zhou Hua Peng Chang Xin Zhou Ming Hui Hu Qiao Feng Tao Xiao Jiang Hao Joachim Stoeckigt Yu Zhao | 2007 | Chinese Chemical Letters2007，18，11： | 11 |
| 19 | n-Butyl Pyridinium Nitrate as a Reusable Ionic Liquid Medium for Knoevenagel Condensation显示文摘The Knoevenagel condensation of carbonyl substrates with active methylene compounds proceeds smoothly with ammonium acetate as catalyst in n-butyl pyridinium nitrate to afford the desired products of good purity in moderate yields. | Yi Qun LI*, Xin Ming XU, Mei Yun ZHOU Department of Chemistry, Jinan University, Guangzhou 510632 | 2003 | Chinese Chemical Letters2003，14，5： | 10 |
| 20 | uPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K/Akt signaling pathway in patients with rheumatoid arthritis显示文摘Urokinase-type plasminogen activator receptor(uPAR),is a multifunctional receptor on cell surface,widely present in endothelial cells,fibroblasts,and a variety of malignant cells.Current studies have suggested that uPAR overexpressed on synovial tissues or in synovial fluid or plasma in patients with rheumatoid arthritis(RA).However,there are limited researches regarding the role of uPAR on fibroblast-like synoviocytes of rheumatoid arthritis(RA-FLSs)and its underlying mechanisms.Here,our studies show that the expression of uPAR protein was significantly higher in fibroblast-like synoviocytes(FLSs)from RA than those from osteoarthritis or traumatic injury patients.uPAR gene silencing significantly inhibited RA-FLSs cell proliferation,restrained cell transformation from the G0/G1 phase to S phase,aggravated cell apoptosis,interfered with RA-FLSs cell migration and invasion,and reduced activation of the PI3K/Akt signaling pathway,which may be associated withβ1-integrin.Cell supernatants from uPAR gene-silenced RA-FLSs markedly inhibited the migration and tubule formation ability of the HUVECs(a human endothelial cell line).Therefore,we demonstrate that uPAR changes the biological characteristics of RA-FLSs,and affects neoangiogenesis of synovial tissues in patients with RA.All of these may be associated with theβ1-integrin/PI3K/Akt signaling pathway.These results imply that targeting uPAR and its downstream signal pathway may provide therapeutic effects in RA. | Yan Liu Yun Feng Pan You-qiu Xue Lin-kai Fang Xing-hua Guo Xin Guo Meng Liu Bi-yao Mo Meng-ru Yang Fang Liu Yun-ting Wu Nancy Olsen Song Guo Zheng | 2018 | Cellular & Molecular Immunology2018，15，2： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员