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| 1 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 2 | 5-HT_(3) receptor antagonists protect against pressure overload-induced cardiac hypertrophy in murine显示文摘Activation of cardiac sympathetic afferent reflex results in the increase of sympathetic activity.Serotonin(5-HT)activates cardiac sympathetic afferent through stimulating 5-HT_(3) receptors,the aim of present study is to test whether 5-HT_(3) receptor antagonists protect against cardiac hypertrophy.Cardiac hypertrophy induced by TAC for 4 weeks in mice was significantly inhibited by administration of 5-HT_(3) receptor antagonists,ondansetron(2.5 mg/kg,ip.)or tropisetron(2.5 mg/kg,ip.).Histological analysis revealed that the increased cardiac fibrosis in hypertrophic heart was relieved by ondansetron or tropisetron treatment.Ondansetron or tropisetron reduced the elevated plasma level of noradrenalin in mice with cardiac hypertrophy.Ondansetron and tropisetron had no effect on cardiomyocte hypertrophy induced by phenylephrine treatment in vitro.Finally,we took tropisetron as the representative drug and examined the effects of tropisetron on the desensitization of cardiac b-adrenergic receptor in rat treated with abdominal aortic banding(AB).Results showed that tropisetron restored the desensitization of cardiac b-adrenergic receptor in AB-treated rats.In conclusion,5-HT_(3) receptor antagonists protected against cardiac hypertrophy and restored the desensitization of cardiac adrenergic responsiveness,the mechanism in which may be through reducing the sympathetic activity. | Rong Huo Chang Chen Yan Chen Zhe Li Yunlong Hou Deli Dong | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 1 |
| 3 | Mechanical properties, degradation performance and cytotoxicity of Mg-Zn-Gd biomedical alloys with different compositions 显示文摘 | Zhang Baoping Hou Yunlong Wang Xiaodan | 2011 | Materials Scienceand EngineeringC2011，31，： | 1 |
| 4 | Status of the IHEP 1.3 GHz superconducting RF program显示文摘The 1.3 GHz superconducting radio-frequency (SRF) technology is one of the key technologies for the ILC and future XFEL and ERL projects in China. With the aim to develop 1.3 GHz SRF technology, IHEP has started a program to build an SRF Accelerating Unit. This unit contains a 9-cell 1.3 GHz superconducting cavity, a short cryomodule, a high power input coupler, a tuner and a low level RF system. This program also includes the SRF laboratory upgrade, which will permit the unit to be built and tested at IHEP. The unit will be used for the 1.3 GHz SRF system integration study, high power horizontal test and possible beam test in the future. In this paper, we report the recent R&D status of this program. The first large grain low-loss shape 9-cell superconducting RF cavity made by IHEP reached 20 MV/m in the first vertical test in July, 2010. The prototype tuner and low level RF (LLRF) system are under test. The high power input coupler and cryomodule are under fabrication. Several key SRF facilities for 9-cell cavity surface treatment and pre-tuning were successfully commissioned and are in operation. | GAO Jie ZHAI JiYuan PAN WeiMing LI ShaoPeng SUN Yi DAI JianPing CHI YunLong LI ZhongQuan ZHAO TongXian HUANG TongMing MA Qiang GE Rui LI ChunHua GUO HaiSheng WANG GuangWei QIU Feng LIN HaiYing HOU Mi WANG QunYao | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 1 |
| 5 | Stability of loess high-fill slope based on monitored soil moisture changes显示文摘This paper aims to assess the influence of moisture content changes during rainfall on the stability of loess high-fill slopes by taking a loess high-fill slope in Lanzhou City as an example.First,according to the moisture content monitoring data collected from a slope online monitoring system,direct shear tests were performed on soil samples of different moisture content to determine the relationship between the shear strength parameters and moisture content.Next,a coupled hydro-mechanical model with soil shear strength related to moisture content was established and used to analyze 16 working conditions with various rainfall intensities and durations for two cases:shear strength parameters from the site exploration report and those from this study.Finally,the results from the two cases were compared regarding the changes in stresses and displacements after rainfall infiltration to analyze the influence of moisture content on the stability of loess high-fill slopes.The conclusions are as follows:(1)Segmental relationship equations of cohesion and angle of internal friction were established for loess with various moisture content.(2)Under the conditions of different rainfall intensities,significant differences were observed in the trends of slope stress and displacement changes.(3)The slope displacement occurred in the shallow soil layer within about 12.5 m from the slope top,and the plastic strain concentrated in the soil layer within about 6 m from the slope top.(4)The results of slope stability analyses based on moisture content monitoring data are more in line with the observed. | XueLing Yong Yu Zhang YunLong Hou BingBing Han Ning An Hui Zhang Ying Ma | 2023 | Research in Cold and Arid Regions2023，15，4： | 0 |
| 6 | A novel ferroelectric based on quinuclidine derivatives显示文摘The compound[(CH3)2 CH-C3 H17 N][CoBr4](1)based on quinuclidine derivatives was achieved by the solution synthetic method and characterized by elemental analysis,infrared spectroscopy,single-crystal X-ray structural analysis and dielectric measurement,respectively.Variable-temperature single-crystal X-ray diffraction suggested that the compound unde rwent the phase transition from the space group C2/c to Cc.The polarization curve was measured using the Sawyer-Tower circuit.The structural phase transitions of 1 was ascribed to the distortion of a[(CH3)2 CH-C3 H17N]2+cation from this inorganicorganic hybrid material[(CH3)2 CH-C3 H17N][CoBr4].The strong change in dielectric anomalies makes compound 1 a suitable candidate for promising switchable dielectric materials.This work represents a feasible strategy thought for the targeted harvesting of low temperature ferroelectrics. | Siyu Deng Junyi Li Xiang Chen Yunlong Hou Lizhuang Chen | 2020 | Chinese Chemical Letters2020，31，6： | 0 |
| 7 | Dynamics of triboelectric nanogenerators: A review显示文摘Triboelectric nanogenerators(TENGs)represent a promising next‐generation renewable energy technology.TENGs have become increasingly popular for harvesting vibration energy in the environment due to their advantages of lightweight,broad range of material choices,low cost,and no pollution.However,issues such as input force irregularity,working bandwidth,efficiency calculation,and dynamic modeling hinder the use of TENGs in industrial or practical applications.In this paper,the modeling process of the dynamical system of a TENG is reviewed from the perspective of energy flow.In addition,this paper reviews the main contributions made in recent years to achieve optimized output based on springs,magnetic forces,and pendulums,and introduces different ways to increase the bandwidth of TENGs.Finally,the main problems of TENGs in the process of harvesting vibration energy are discussed.This review may serve as a practical reference for methods to convert irregular mechanical input sources into optimized output performance toward the commercialization of TENGs. | Guoqiang Xu Chuanyang Li Chaojie Chen Jingjing Fu Tingting Hou Yunlong Zi | 2022 | International Journal of Mechanical System Dynamics2022，2，4： | 0 |
| 8 | Integrated'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome显示文摘OBJECTIVE:To observe the efficacy of moxibustion in the treatment of chronic fatigue syndrome(CFS)and explore the effects on gut microbiota and metabolic profiles.METHODS:Forty-eight male Sprague-Dawley rats were randomly assigned to control group(Con),CFS model group(Mod,established by multiple chronic stress for 35 d),MoxA group(CFS model with moxibustion Shenque(CV8)and Guanyuan(CV4),10 min/d,28 d)and MoxB group(CFS model with moxibustion Zusanli(ST36),10 min/d,28 d).Open-field test(OFT)and Morris-water-maze test(MWMT)were determined for assessment the CFS model and the therapeutic effects of moxibustion.16S rRNA gene sequencing analysis based gut microbiota integrated untargeted liquid chromatograph-mass spectrometer(LC-MS)based fecal metabolomics were executed,as well as Spearman correlation analysis,was utilized to uncover the functional relevance between the potential metabolites and gut microbiota.RESULTS:The results of our behavioral tests showed that moxibustion improved the performance of CFS rats in the OFT and the MWMT.Microbiome profiling analysis revealed that the gut microbiomes of CFS rats were less diverse with altered composition,including increases in pro-inflammatory species(such as Proteobacteria)and decreases in anti-inflammatory species(such as Bacteroides,Lactobacillus,Ruminococcus,and Prevotella).Moxibustion partially normalized these changes in the gut microbiota.Furthermore,CFS was associated with metabolic disorders,which were effectively ameliorated by moxibustion.This was demonstrated by the normalization of 33 microbiota-related metabolites,including mannose(P=0.001),aspartic acid(P=0.009),alanine(P=0.007),serine(P=0.000),threonine(P=0.027),methionine(P=0.023),5-hydroxytryptamine(P=0.008),alpha-linolenic acid(P=0.003),eicosapentaenoic acid(P=0.006),hypoxanthine(P=0.000),vitamin B6(P=0.000),cholic acid(P=0.013),and taurocholate(P=0.002).Correlation analysis showed a significant association between the perturbed fecal microbiota and metabolite levels,with a notable negative relationship between LCA and Bacteroides.CONCLUSIONS:In this study,we demonstrated that moxibustion has an antifatigue-like effect.The results from the 16S rRNA gene sequencing and metabolomics analysis suggest that the therapeutic effects of moxibustion on CFS are related to the regulation of gut microorganisms and their metabolites.The increase in Bacteroides and decrease in LCA may be key targets for the moxibustion treatment of CFS. | LI Chaoran YANG Yan FENG Chuwen LI Heng QU Yuanyuan WANG Yulin WANG Delong WANG Qingyong GUO Jing SHI Tianyu SUN Xiaowei WANG Xue HOU Yunlong SUN Zhongren YANG Tiansong | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
| 9 | Single-cell technologies:From research to application显示文摘In recent years,more and more single-cell technologies have been developed.A vast amount of single-cell omics data has been generated by large projects,such as the Human Cell Atlas,the Mouse Cell Atlas,the Mouse RNA Atlas,the Mouse ATAC Atlas,and the Plant Cell Atlas.Based on these single-cell big data,thousands of bioinformatics algorithms for quality control,clustering,cell-type annotation,developmental inference,cell-cell transition,cell-cell interaction,and spatial analysis are developed.With powerful experimental single-cell technology and state-of-the-art big data analysis methods based on artificial intelligence,the molecular landscape at the single-cell level can be revealed. | Lu Wen Guoqiang Li Tao Huang Wei Geng Hao Pei Jialiang Yang Miao Zhu Pengfei Zhang Rui Hou Geng Tian Wentao Su Jian Chen Dake Zhang Pingan Zhu Wei Zhang Xiuxin Zhang Ning Zhang Yunlong Zhao Xin Cao Guangdun Peng Xianwen Ren Nan Jiang Caihuan Tian Zi-Jiang Chen | 2022 | The Innovation2022，3，6： | 0 |
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