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| 1 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 2 | Multi-scale object detection by top-down and bottom-up feature pyramid network显示文摘While moving ahead with the object detection technology, especially deep neural networks, many related tasks, such as medical application and industrial automation, have achieved great success. However, the detection of objects with multiple aspect ratios and scales is still a key problem. This paper proposes a top-down and bottom-up feature pyramid network(TDBU-FPN),which combines multi-scale feature representation and anchor generation at multiple aspect ratios. First, in order to build the multi-scale feature map, this paper puts a number of fully convolutional layers after the backbone. Second, to link neighboring feature maps, top-down and bottom-up flows are adopted to introduce context information via top-down flow and supplement suboriginal information via bottom-up flow. The top-down flow refers to the deconvolution procedure, and the bottom-up flow refers to the pooling procedure. Third, the problem of adapting different object aspect ratios is tackled via many anchor shapes with different aspect ratios on each multi-scale feature map. The proposed method is evaluated on the pattern analysis, statistical modeling and computational learning visual object classes(PASCAL VOC)dataset and reaches an accuracy of 79%, which exhibits a 1.8% improvement with a detection speed of 23 fps. | ZHAO Baojun ZHAO Boya TANG Linbo WANG Wenzheng WU Chen | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 11 |
| 3 | The crosstalk between autophagy and ferroptosis:what can we learn to target drug resistance in cancer?显示文摘Autophagy is a conserved intracellular degradation system that plays a dual role in cell death;thus,therapies targeting autophagy in cancer are somewhat controversial.Ferroptosis is a new form of regulated cell death featured with the iron-dependent accumulation of lethal lipid ROS.This pathway is morphologically,biochemically and genetically distinct from other forms of cell death.Accumulating studies have revealed crosstalk between autophagy and ferroptosis at the molecular level.In this review,we summarize the mechanisms of ferroptosis and autophagy,and more importantly,their roles in the drug resistance of cancer.Numerous connections between ferroptosis and autophagy have been revealed,and a strong causal relationship exists wherein one process controls the other and can be utilized as potential therapeutic targets for cancer.The elucidation of when and how to modulate their crosstalk using therapeutic strategies depends on an understanding of the fine-tuned switch between ferroptosis and autophagy,and approaches designed to manipulate the intensity of autophagy might be the key. | Yulu Zhou Yong Shen Cong Chen Xinbing Sui Jingjing Yang Linbo Wang Jichun Zhou | 2019 | Cancer Biology & Medicine2019，16，4： | 9 |
| 4 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 5 | Teracluster LSSC-II--Its designing principles and applications in large scale numerical simulations显示文摘The teracluster LSSC-II installed at the State Key Laboratory of Scientific and Engineering Computing, Chinese Academy of Sciences is one of the most powerful PC clusters in China. It has a peek performance of 2Tflops. With a Linpack performance of 1.04Tflops, it is ranked at the 43rd place in the 20th TOP500 List (November 2002), 51st place in the 21st TOP500 List (June 2003), and the 82nd place in the 22nd TOP500 List (November 2003) with a new Linpack performance of 1.3Tflops. In this paper, we present some design principles of this cluster, as well as its applications in some large-scale numerical simulations. | ZHANG Linbo, CHEN Shiyi, LI Xinliang, CAO Jianwen, ZHANG Wensheng & GONG XingaoState Key Laboratory of Scientific and Engineering Computing, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Department of Mechanical Engineering, The Johns Hopkins University and Center for Computational Science and Engineering, Peking University, Beijing 100875, China Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China Parallel Computing Laboratory, Institute of Software, Chinese Academy of Sciences, Beijing 100080, China Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Surface Physics Laboratory (National Key Laboratory), Fudan University, Shanghai 200433 Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China | 2004 | Science China Mathematics2004，47，z1： | 8 |
| 6 | An experimental study of tin partition between melt and aqueous fluid in F/Cl-coexisting magma显示文摘为了调查听矿石的形成机制,与忍受 F 花岗石联系了,在忍受 F 之间的听分区的试验性的研究花岗石融化,共存的忍受 HCl 水的液体与接近 NNO 的 fo 2 在 850 ° C 和 100MPa 被进行。锡的 Geochemical 行为被变化在以不同氧化铝浸透索引 ASI 开始稳固的材料跟踪,在 F 内容并且在开始各种各样的 HCl 集中的液体。结果显示出那 D 有 ASI 的 Sn 增加融化并且每铝土融化为进在 F/Cl-coexisting 系统的水的液体的听分区是有利的。更高的 HCl 集中的水的液体为锡的丰富是有益的。而且,在玻璃跑产品的氯内容在岩浆与 F 和 Cl 内容断然相关。在 F/Cl-coexisting 系统,花岗石在能为听矿石的形成用作一座水库的 melt 与内容(>∼1 wt%) 能提取并且充实的高 F 融化锡。然而,当在 melt 的 F 内容在 1 wt% 下面时,锡的分配系数将显著地增加。因此, F 内容的减少对进有高 HCl 内容的水的液体的锡的分区有利,因此支持热水的听矿石的免职。 | HU XiaoYan BI XianWu SHANG LinBo HU RuiZhong CAI GuoSheng CHEN YouWei | 2009 | Chinese Science Bulletin2009，54，6： | 4 |
| 7 | Enhanced oxidation of benzo[a]pyrene by crude enzyme extracts produced during interspecific fungal interaction of Trametes versicolor and Phanerochaete chrysosporium显示文摘The effects of interspecific fungal interactions between Trametes versicolor and Phanerochaete chrysosporium on laccase activity and enzymatic oxidation of polycyclic aromatic hydrocarbons(PAHs) were investigated.A deadlock between the two mycelia rather than replacement of one fungus by another was observed on an agar medium.The laccase activity in crude enzyme extracts from interaction zones reached a maximum after a 5-day incubation,which was significantly higher than that from regions of T.versicolor or P.chrysosporium alone.The enhanced induction of laccase activity lasted longer in half nutrition than in normal nutrition.A higher potential to oxidize benzo[a]pyrene by a crude enzyme preparation extracted from the interaction zones was demonstrated.After a 48 hr incubation period,the oxidation of benzo[a]pyrene by crude enzyme extracts from interaction zones reached 26.2%,while only 9.5% of benzo[a]pyrene was oxidized by crude extracts from T.versicolor.The oxidation was promoted by the co-oxidant 2,2'-azinobis-3ethylbenzthiazoline-6-sulphonate diammonium salt(ABTS).These findings indicate that the application of co-culturing of white-rot fungi in bioremediation is a potential ameliorating technique for the restoration of PAH-contaminated soil. | Linbo Qian | 2012 | Journal of Environmental Sciences2012，24，9： | 4 |
| 8 | Penumbral imaging and numerical evaluation of large area source neutron imaging system显示文摘The fusion neutron penumbral imaging system Monte Carlo model was established. The transfer functions of the two discrete units in the neutron source were obtained in two situations:Imaging in geometrical near-optical and real situation. The spatial resolutions of the imaging system in two situations were evaluated and compared. The penumbral images of four units in the source were obtained by means of 2-dimensional (2D) convolution and Monte Carlo simulation. The penumbral images were reconstructed with the same method of filter. The same results were confirmed. The encoding essence of penumbral imaging was revealed. With MCNP(Monte Carlo N-particle) simulation,the neutron penumbral images of the large area source (200 μm×200 μm) on scintillation fiber array were obtained. The improved Wiener filter method was used to reconstruct the penumbral image and the source image was obtained. The results agree with the preset neutron source image. The feasibility of the neutron imaging system was verified. | YueLei Wu HuaSi Hu BoPing Zhang LinBo Li Da Chen Qing Shan Jie Zhu | 2009 | Science China(Technological Sciences)2009，52，9： | 3 |
| 9 | Degradation of benzene derivatives in the CuMgFe-LDO/persulfate system:The role of the interaction between the catalyst and target pollutants显示文摘A novel insight on the role of interactions between target pollutants and the catalyst in the copper-containing layered double oxide(LDO)-catalyzed persulfate(PS)system was elucidated in the present study.4-Chlorophenol(4-CP),as a representative benzene derivative with a hydroxyl group,was completely removed within 5 min,which was much faster than the reaction of monochlorobenzene(MCB)without a hydroxyl group,with the degradation efficiency of 31.7%in 240 min.Through the use of radical quenching and surface inhibition experiments,it could be concluded that the interaction between 4-CP and CuMgFe-LDO,rather than free radicals,played a key role in the decomposition of 4-CP,while only the free radicals participated in the MCB degradation process.According to electron paramagnetic resonance and Xray photoelectron spectroscopy data,the formation of a Cu(II)-complex between phenolic hydroxyl groups and surface Cu(II)was primarily responsible for the degradation of phenolic compounds,in which PS accepted one electron from the complex and generated sulfate radicals and chelated radical cations.The chelated radical cations transferred one electron to Cu(Ⅱ)followed by Cu(I)generation and pollutant degradation successively. | Yun Chen Da Ouyang Wenying Zhang Jingchun Yan Linbo Qian Lu Han Mengfang Chen | 2020 | Journal of Environmental Sciences2020，32，4： | 2 |
| 10 | Regulation of mATG9 trafficking by Src- and ULK1mediated phosphorylation in basal and starvation-induced autophagy显示文摘Autophagy 要求多样的膜来源并且包含 mATG9 的膜 trafficking,在 ATG 家庭的唯一的膜蛋白质。然而,为 autophagy 开始的 mATG9 trafficking 的分子的规定仍然保持不清楚。这里,我们识别了在 mATG9 的 cytosolic N 终点以内排序信号的二保存经典适配器蛋白质,它调停从经由和 AP1/2 建筑群的相互作用的血浆膜和 trans-Golgi 网络(TGN ) 的 mATG9 的 trafficking。在 Tyr8 到的 Src phosphorylates mATG9 处于不着重的条件维持它的 endocytic 和组成的 trafficking。响应饥饿,在由 Src 的 Tyr8 并且在由 ULK1 的 Ser14 的 mATG9 的 phosphorylation 机能上地合作支持在 mATG9 和 AP1/2 建筑群之间的相互作用,为 autophagy 从血浆膜和 juxta 原子的区域导致 mATG9 的再分配到外部水池开始。我们的调查结果揭开 mATG9 trafficking 的新奇机制并且建议基础、导致压力的 autophagy 的协作。 | Changqian Zhou Kaili Ma Ruize Gao Chenglong Mu Linbo Chen Qiangqiang Liu Qian Luo Du Feng Yushan Zhu Quan Chen | 2017 | Cell Research2017，27，2： | 2 |
| 11 | High-performance modified uni-traveling carrier photodiode integrated on a thin-film lithium niobate platform显示文摘Lithium niobate on insulator(LNOI)has become an intriguing platform for integrated photonics for applications in communications,microwave photonics,and computing.Whereas,integrated devices including modulators,resonators,and lasers with high performance have been recently realized on the LNOI platform,high-speed photodetectors,an essential building block in photonic integrated circuits,have not been demonstrated on LNOI yet.Here,we demonstrate for the first time,heterogeneously integrated modified uni-traveling carrier photodiodes on LNOI with a record-high bandwidth of 80 GHz and a responsivity of 0.6 A/W at a 1550-nm wavelength.The photodiodes are based on an n-down In GaAs/InP epitaxial layer structure that was optimized for high carrier transit time-limited bandwidth.Photodiode integration was achieved using a scalable wafer die bonding approach that is fully compatible with the LNOI platform. | XIANGWEN GUO LINBO SHAO LINGYAN HE KEVIN LUKE JESSE MORGAN KEYE SUN JUNYI GAO TA-CHING TZU YANG SHEN DEKANG CHEN BINGTIAN GUO FENGXIN YU QIANHUAN YU MASOUD JAFARI MARKO LONčAR MIAN ZHANG ANDREAS BELING | 2022 | Photonics Research2022，10，6： | 2 |
| 12 | Involucre fossils of Carpinus,a northern temperate element,from the Miocene of China and the evolution of its species diversity in East Asia显示文摘East Asia has long been recognized as a major center for temperate woody plants diversity.Although several theories have been proposed to explain how the diversity of these temperate elements accumulated in the region,the specific process remains unclear.Here we describe six species of Carpinus,a typical northern hemisphere temperate woody plant,from the early Miocene of the Maguan Basin,southwestern China,southern East Asia.This constitutes the southernmost,and the earliest occurrence that shows a high species diversity of the genus.Together with other Carpinus fossil records from East Asia,we show that the genus had achieved a high diversity in East Asia at least by the middle Miocene.Of the six species here described,three have become extinct,indicating that the genus has experienced apparent species loss during its evolutionary history in East Asia.In contrast,the remaining three species closely resemble extant species,raising the possibility that these species may have persisted in East Asia at least since the early Miocene.These findings indicate that the accumulation of species diversity of Carpinus in East Asia is a complex process involving extinction,persistence,and possible subsequent speciation. | Li Xue Linbo Jia Gi-soo Nam Yongjiang Huang Shitao Zhang Yuqing Wang Zhuo Zhou Yongsheng Chen | 2020 | Plant Diversity2020，42，3： | 2 |
| 13 | Construction and identification of an RNA interference lentivirus vector targeting the Ras homology C gene of melanoma cells显示文摘 | Wang Qiying Wang Ximei Zhai Xiaomei Zhang Jianwen Chen Minjing Liu Linbo | 2014 | Chinese Medical Journal2014，，7： | 2 |
| 14 | Lin28 promotes Her2 expression and Lin28/Her2 predicts poorer survival in gastric cancer显示文摘 | Qinchuan Wang Jichun Zhou Jufeng Guo Rongyue Teng Jianguo Shen Yasheng Huang Shuduo Xie Qun Wei Wenhe Zhao Wenjun Chen Xiaoming Yuan Yongxia Chen Linbo Wang | 2014 | Tumor Biology2014，，11： | 1 |
| 15 | Experimental investigation of Z-pinch radiation source for indirect drive inertial confinement fusion显示文摘Z-pinch dynamic hohlraums(ZPDHs)could potentially be used to drive inertial confinement fusion targets.Double-or multishell capsules using the technique of volume ignition could exploit the advantages of ZPDHs while tolerating their radiation asymmetry,which would be unacceptable for a central ignition target.In this paper,we review research on Z-pinch implosions and ZPDHs for indirect drive targets at the Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics.The characteristics of double-shell targets and the associated technical requirements are analyzed through a one-dimensional computer code developed from MULTI-IFE.Some key issues regarding the establishment of suitable sources for dynamic hohlraums are introduced,such as soft X-ray power optimization,novel methods for plasma profile modulation,and the use of thin-shell liner implosions to inhibit the generation of prior-stagnated plasma.Finally,shock propagation and radiation characteristics in a ZPDH are presented and discussed,together with some plans for future work. | Zhenghong Li Zhen Wang Rongkun Xu Jianlun Yang Fan Ye Yanyun Chu Zeping Xu Faxin Chen Shijian Meng Jianmin Qi Qinyuan Hu Yi Qin Jiaming Ning Zhanchang Huang Linbo Li Shuqing Jiang | 2019 | Matter and Radiation at Extremes2019，4，4： | 1 |
| 16 | In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells显示文摘 | Jinwu Chen Changyong Wang Shuanghong Lü Junzheng Wu Ximin Guo Cuimi Duan Lingzhi Dong Ying Song Junchuan Zhang Dianying Jing Linbo Wu Jiandong Ding Dexue Li | 2005 | Cell and Tissue Research2005，，3： | 1 |
| 17 | Exploring a particle-size-reduction strategy of YAG:Ce phosphor via a chemical breakdown method显示文摘Particle size reduction of Y_(3)Al_(5)O_(12):Ce(YAG:Ce) phosphor is highly needed for micro-LED display applications.In this work,size control of YAG:Ce phosphor particles is achieved via carbon coating and further heat treatment.A thin layer of carbon is deposited on the surface of YAG:Ce by chemical vapor deposition.During the heat treatment,carbon reacts with oxygen element in the phosphor and escapes from phosphor particles.The reaction results in the phosphor breaking into smaller particles.The phosphors were characterized by laser light scattering for particle size distribution,scanning electron microscopy(SEM),transmission electron microscopy for morphologies,X-ray diffraction refinements for crystal structure and electron energy-loss spectroscopy for elemental analysis.It is demonstrated that the median diameter(D_(50)) of the phosphor particle size is significantly reduced from 19.1 to 0.96 μm yet the photoluminescent properties have little changes.The carbon coating and further heat treatment method show potential application in size control of phosphors. | Hongren Chen Licheng Ju Li Zhang Xin Wang Linbo Zhang Xin Xu Lin Gao Kehui Qiu Liangjun Yin | 2021 | Journal of Rare Earths2021，39，8： | 1 |
| 18 | Lymphatic mapping and sentinel node biopsy in gastric cancer显示文摘 | Xiangyang Song Linbo Wang Wenjun Chen | 2004 | Am J Surg2004，187，2： | 1 |
| 19 | Adsorption of cations onto the surfaces of silver nanoparticles显示文摘 | Yun Liu Chunyan Liu Linbo Chen | 2003 | Interface Science2003，，257： | 1 |
| 20 | CDP-GAN:Near-Infrared and Visible Image Fusion Via Color Distribution Preserved GAN显示文摘Dear Editor,This letter is concerned with dealing with the great discrepancy between near-infrared(NIR)and visible(VS)image fusion via color distribution preserved generative adversarial network(CDP-GAN).Different from the global discriminator in prior GAN,conflict of preserving NIR details and VS color is resolved by introducing an attention guidance mechanism into the discriminator.Moreover。 | Jun Chen Kangle Wu Yang Yu Linbo Luo | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，9： | 1 |
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