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| 1 | Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy显示文摘The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destroying cancer cells. In recent decades, studies have mainly focused on adoptive immunotherapy using engineered T cells for the treatment of malignant diseases. Through gene engraftment of the patient's own T cells with chimeric antigen receptor(CAR),they can recognize tumor specific antigens effectively and eradicate selectively targeted cells in an MHC-independent fashion.To date, CAR-T cell therapy has shown great clinical utility in patients with B-cell leukemias. Owing to different CAR designs and tumor complex microenvironments, genetically redirected T cells may generate diverse biological properties and thereby impact their long-term clinical performance and outcome. Meanwhile some unexpected toxicities that result from CAR-T cell application have been examined and limited the curative effects. Diverse important parameters are closely related with adoptively transferred cell behaviors, including CAR-T cells homing, CAR constitutive signaling, T cell differentiation and exhaustion. Thus, understanding CARs molecular design to improve infused cell efficacy and safety is crucial to clinicians and patients who are considering this novel cancer therapeutics. In this review, the developments in CAR-T cell therapy and the limitations and perspectives in optimizing this technology towards clinical application are discussed. | Dongdong Ti Yunfei Niu Zhiqiang Wu Xiaobing Fu Weidong Han | 2018 | Science China(Life Sciences)2018，61，11： | 10 |
| 2 | Demonstration of epitaxial growth of strain-relaxed GaN films on graphene/SiC substrates for long wavelength light-emitting diodes显示文摘Strain modulation is crucial for heteroepitaxy such as GaN on foreign substrates.Here,the epitaxy of strain-relaxed GaN films on graphene/SiC substrates by metal-organic chemical vapor deposition is demonstrated.Graphene was directly prepared on SiC substrates by thermal decomposition.Its pre-treatment with nitrogen-plasma can introduce C–N dangling bonds,which provides nucleation sites for subsequent epitaxial growth.The scanning transmission electron microscopy measurements confirm that part of graphene surface was etched by nitrogen-plasma.We study the growth behavior on different areas of graphene surface after pre-treatment,and propose a growth model to explain the epitaxial growth mechanism of GaN films on graphene.Significantly,graphene is found to be effective to reduce the biaxial stress in GaN films and the strain relaxation improves indium-atom incorporation in InGaN/GaN multiple quantum wells(MQWs)active region,which results in the obvious red-shift of light-emitting wavelength of InGaN/GaN MQWs.This work opens up a new way for the fabrication of GaN-based long wavelength light-emitting diodes. | Ye Yu Tao Wang Xiufang Chen Lidong Zhang Yang Wang Yunfei Niu Jiaqi Yu Haotian Ma Xiaomeng Li Fang Liu Gaoqiang Deng Zhifeng Shi Baolin Zhang Xinqiang Wang Yuantao Zhang | 2021 | Light(Science & Applications)2021，10，7： | 2 |
| 3 | Investigation of melt-growth alumina/aluminum titanate composite ceramics prepared by directed energy deposition显示文摘Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics with low thermal expansion properties are promising for the rapid preparation of large-scale and complex components by directed energy deposition-laser based(DED-LB)technology.However,the wider application of DED-LB technology is limited due to the inadequate understanding of process conditions.The shaping quality,microstructure,and mechanical properties of Al_(2)O_(3)/Al_(6)Ti_(2)O_(13)(6 mol%TiO_(2))composite ceramics were systematically investigated as a function of energy input in an extensive process window.On this basis,the formation mechanism of solidification defects and the evolution process of microstructure were revealed,and the optimized process parameters were determined.Results show that high energy input improves the fluidity of the molten pool and promotes the uniform distribution and full growth of constituent phases,thus,facilitating the elimination of solidification defects,such as pores and strip gaps.In addition,the microstructure size is strongly dependent on the energy input,increasing when the energy input increases.Moreover,the morphology of theα-Al_(2)O_(3) phase gradually transforms from cellular into cellular dendrite with increasing energy input due to changing solidification conditions.Under the comprehensive influence of solidification defects and microstructure size,the fracture toughness and flexural strength of Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics present a parabolic law behavior as the energy input increases.Optimal shaping quality and excellent mechanical properties are achieved at an energy input range of 0.36-0.54 W*min^(2) g^(-1) mm^(-1).Within this process window,the average microhardness,fracture toughness,and flexural strength of Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics are up to 1640 Hv,3.87 MPa m^(1/2),and 227 MPa,respectively.This study provides practical guidance for determining the process parameters of DED-LB of melt growth Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics. | Yunfei Huang Dongjiang Wu Dake Zhao Fangyong Niu Guangyi Ma | 2021 | International Journal of Extreme Manufacturing2021，3，3： | 2 |
| 4 | Treatment of bone nonunion and bone defects associated with unsnccessful humeral condylar fracture repair with autogenous iliac bone reconstruction显示文摘 | Yunfei Niu Yushu Bai Shuogui Xu etal | 2012 | J Shoulder Elbow Surg2012，21，： | 1 |
| 5 | Investigation on the Cracking Mechanism of Melt Growth Alumina/Aluminum Titanate Ceramics Prepared by Laser Directed Energy Deposition显示文摘Oxide melt growth ceramics(OMGCs)exhibit excellent performance and microstructure stability near their melt-ing point and are expected to become a new structural material for long-term stable service in extremely high-temperature water-oxygen environments.Owing to its unique advantages of high efficiency,flexible manufac-turing,and near-net shaping,laser directed energy deposition(LDED)has become a promising technology for the rapid preparation of high-performance OMGCs.However,owing to the limited understanding of the crack-ing mechanism,the severe cracking problem that hinders OMGCs-LDED towards engineering applications has not been resolved.Alumina/aluminum titanate(Al_(2)O_(3)/Al_(x)Ti_(y)O_(z),A/AT)ceramics are prepared using an LDED system and their cracking characteristics are investigated.Subsequently,numerical simulations are conducted to reveal the dominant factors and influencing mechanisms of the cracking behavior.The results demonstrate that the cracking nucleation process is mainly controlled by solidification defects,whereas the cracking propagation process is determined primarily by both the microstructure and stress level.This study provides a theoretical basis for the development of appropriate cracking suppression methods for OMGCs-LDED. | Yunfei Huang Dongjiang Wu Chengxin Li Weijie Lv Guangyi Ma Cong Zhou Fangyong Niu | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，4： | 0 |
| 6 | EARLY RECOGNITION OF INTERNET TRAFFIC BASED ON SIGNATURE INSPECTION显示文摘The accurate and efficient classification of Internet traffic is the first and key step to ac-curate traffic management,network security and traffic analysis. The classic ways to identify flows is either inaccurate or inefficient,which are not suitable to be applied to real-time online classification. In this paper,we originally presented an early recognition method named Early Recognition Based on Deep Packet Inspection (ERBDPI) based on deep packet inspection,after analyzing the distribution of payload signature between packets of a flow in detail. The basic concept of ERBDPI is classifying flows based on the payload signature of their first some packets,so that we can identify traffic at the be-ginning of a flow connection. We compared the performance of ERBDPI with that of traditional sampling methods both synthetically and using real-world traffic traces. The result shows that ERBDPI can get a higher classification accuracy with a lower packet sampling rate,which makes it suitable to be applied to accurate real-time classification in high-speed links. | Niu Xiaona Guo Yunfei Zhang Jin Wang Chao | 2010 | Journal of Electronics(China)2010，27，2： | 0 |
| 7 | Black tantalic oxide submicro-particles coating on PEEK fibers woven into fabrics as artificial ligaments with photothermal antibacterial effect and osteogenic activity for promoting ligament-bone healing显示文摘Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)reconstruction remains a significant challenge.In this study,black tantalic oxide(BTO)submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide(WTO)through magnesium thermal reduction(MTR)method,and BTO was coated on polyetheretherketone(PEEK)fibers(PKF),which were woven into fabrics(PBT)as artificial ligaments.PBT with BTO coating exhibited excellent photothermal performance,which possessed not only antibac-terial effects in vitro but also anti-infective ability in vivo.PBT with optimized surface properties(e.g.,submicro-topography and hydrophilicity)not only significantly facilitated rat bone mesenchymal stem cells(BMSC)responses(e.g.,proliferation and osteogenic differentiation)in vitro but also stimulated new bone formation for ligament-bone healing in vivo.The presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial effect.In summary,BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection,thereby promoting ligament-bone healing.Therefore,PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction. | Fan Wang Mengyao Wang Qingsong He Xuehong Wang Ping Sun Yinjun Ji Yunfei Niu Fengqian Li Jie Wei | 2023 | Journal of Materials Science & Technology2023，，2： | 0 |
| 8 | Liquid-phase hydrodechlorination of trichloroethylene driven by nascent H_(2)under an open system:Hydrogenation activity,solvent effect and sulfur poisoning显示文摘Hydrodechlorination is a promising technology for the remediation of water body contaminated with trichloroethylene(TCE).In this work,the liquid-phase hydrogenation of TCE by Raney Ni(R-Ni)and Pd/C under an open system have been studied,in which nascent H_(2)(Nas-H_(2))generated in situ from the cathode acted as a hydrogen source.Experimental results showed that TCE was completely eliminate from the solution through the synergistic effects of hydrodechlorination and air flotation due to the formation of continuous micro/nano-sized Nas-H_(2)bubbles from the cathode.Furthermore,the effects of inorganic anions and organic solvents on R-Ni and Pd/C hydrogenation activity were investigated,respectively.The results showed that NO_(3)^(-) and acetonitrile can form a competitive reaction with TCE;Sulfur with lone-pair electrons will cause irreversible poisoning to these two catalysts,and have a stronger inhibitory effect on Pd/C.This work helps to realize the separation of volatile halogenated compounds from water environment and provides certain data support for the choice of catalyst in the actual liquid-phase hydrogenation system. | Weilai Wang Fan Zhang Yunfei Zhang Lei Xu Yuansheng Pei Junfeng Niu | 2021 | Journal of Environmental Sciences2021，33，10： | 0 |
| 9 | Mouse model for pangolin-origin coronavirus GX/P2V/2017 infection and cross-protection from COVID-19 ZF2001 subunit vaccine显示文摘Many severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–related coronaviruses have been discovered,constituting potential threats to human health.However,it remains unclear whether the currently available vaccines are effective against these coronaviruses.Here,we constructed a wild-type mouse model to evaluate pathogenicity of the SARS-CoV-2-related pangolin coronavirus GX/P2V/2017 and neutralization efficacy of the approved tandemrepeat SARS-CoV-2 spike receptor-binding domain(RBD)vaccine ZF2001.We found that ZF2001-induced cross-reactive and cross-neutralizing antibodies against GX/P2V/2017,and the vaccination alleviated the pathological lung damage caused by GX/P2V/2017 in mice.These results indicate that RBD may work as a promising candidate for pan-coronavirus vaccine development. | Xiao Qu Yunfei Jia Na Jia Huahao Fan Anqi Zheng Luoyuan Xia Zhenfei Wang Di Tian Sheng Niu Yu Hu Wenxia Tian Zhihai Chen Yigang Tong Yuwei Gao Wuchun Cao Qihui Wang George Fu Gao | 2023 | hLife2023，1，1： | 0 |
| 10 | Effect of annealing on the electrical performance of N-polarity GaN Schottky barrier diodes显示文摘A nitrogen-polarity(N-polarity)GaN-based high electron mobility transistor(HEMT)shows great potential for high-fre-quency solid-state power amplifier applications because its two-dimensional electron gas(2DEG)density and mobility are mini-mally affected by device scaling.However,the Schottky barrier height(SBH)of N-polarity GaN is low.This leads to a large gate leakage in N-polarity GaN-based HEMTs.In this work,we investigate the effect of annealing on the electrical characteristics of N-polarity GaN-based Schottky barrier diodes(SBDs)with Ni/Au electrodes.Our results show that the annealing time and tem-perature have a large influence on the electrical properties of N-polarity GaN SBDs.Compared to the N-polarity SBD without annealing,the SBH and rectification ratio at±5 V of the SBD are increased from 0.51 eV and 30 to 0.77 eV and 7700,respec-tively,and the ideal factor of the SBD is decreased from 1.66 to 1.54 after an optimized annealing process.Our analysis results suggest that the improvement of the electrical properties of SBDs after annealing is mainly due to the reduction of the inter-face state density between Schottky contact metals and N-polarity GaN and the increase of barrier height for the electron emis-sion from the trap state at low reverse bias. | Nuo Xu Gaoqiang Deng Haotian Ma Shixu Yang Yunfei Niu Jiaqi Yu Yusen Wang Jingkai Zhao Yuantao Zhang | 2024 | Journal of Semiconductors2024，45，4： | 0 |
| 11 | Dysregulation of PLOD2 Promotes Tumor Metastasis and Invasion in Hepatocellular Carcinoma显示文摘Background and Aims:Metastasis is a major factor associated with high recurrence and mortality in hepatocellular carcinoma(HCC)patients while the underlying mechanism of metastasis remains elusive.In our study,procollagen-lysine,2-oxoglutarate 5-dioxygenase 2(PLOD2)was shown to be involved in the process of metastasis in HCC.Methods:The Cancer Genome Atlas(TCGA)database and HCC tissue microarrays were used to evaluate the expression of genes.In vitro migration,invasion,in vivo subcutaneous tumor model and in vivo lung metastasis assays were used to determine the role of PLOD2 in tumor growth and metastasis in HCC.RNA sequencing and gene set enrichment analysis were performed to uncover the downstream factor of PLOD2 in HCC cells.A luciferase reporter assay was performed to evaluate the interaction between PLOD2 and interferon regulatory factor 5(IRF5).Results:The expression of PLOD2 in HCC tissues was higher than that in adjacent tissues,and increased PLOD2 expression was often found in advanced tumors and was correlated with poor prognosis in HCC patients.In vitro experiments,knockdown of PLOD2 reduced the migration and invasion of human HCC cells.Loss of PLOD2 suppressed human HCC growth and metastasis in a subcutaneous tumor model and a lung metastasis model.Baculoviral IAP repeat containing 3(BIRC3)was proven to be the downstream factor of PLOD2 in human HCC cells.In addition,PLOD2 was transcriptionally regulated by IRF5 in HCC cells.Conclusions:High expression of PLOD2 was regulated by IRF5,which was correlated with the poor survival of HCC patients.PLOD2 enhanced HCC metastasis via BIRC3,suggesting that PLOD2 might be a valuable prognostic biomarker for HCC treatment. | Keren Li Yi Niu Kai Li Chengrui Zhong Zhiyu Qiu Yichuan Yuan Yunxing Shi Zhu Lin Zhenkun Huang Dinglan Zuo Yunfei Yuan Binkui Li | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 0 |
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