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| 1 | Notch signaling pathway:architecture,disease,and therapeutics显示文摘The NOTCH gene was identified approximately 110 years ago.Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway.NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes.NOTCH signaling deeply participates in the development and homeostasis of multiple tissues and organs,the aberration of which results in cancerous and noncancerous diseases.However,recent studies indicate that the outcomes of NOTCH signaling are changeable and highly dependent on context.In terms of cancers,NOTCH signaling can both promote and inhibit tumor development in various types of cancer.The overall performance of NOTCH-targeted therapies in clinical trials has failed to meet expectations.Additionally,NOTCH mutation has been proposed as a predictive biomarker for immune checkpoint blockade therapy in many cancers.Collectively,the NOTCH pathway needs to be integrally assessed with new perspectives to inspire discoveries and applications.In this review,we focus on both classical and the latest findings related to NOTCH signaling to illustrate the history,architecture,regulatory mechanisms,contributions to physiological development,related diseases,and therapeutic applications of the NOTCH pathway.The contributions of NOTCH signaling to the tumor immune microenvironment and cancer immunotherapy are also highlighted.We hope this review will help not only beginners but also experts to systematically and thoroughly understand the NOTCH signaling pathway. | Binghan Zhou Wanling Lin Yaling Long Yunkai Yang Huan Zhang Kongming Wu Qian Chu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 14 |
| 2 | Hydrographic field investigations in the Northern South China Sea by open cruises during 2004-2013显示文摘 | Lili Zeng Qiang Wang Qiang Xie Ping Shi Lei Yang Yeqiang Shu Ju Chen Dandan Sui Yunkai He Rongyu Chen Dongxiao Wang | 2015 | Science Bulletin2015，60，6： | 10 |
| 3 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 4 | Trophic Ecology of Sharks in the Mid-East Pacific Ocean Inferred from Stable Isotopes显示文摘As apex predators, sharks are of ecological and conservation importance in marine ecosystems. In this study, trophic positions of sharks were estimated using stable isotope ratios of carbon and nitrogen for five representative species caught by the Chinese longline fleet in the mid-east Pacific, i.e., the blue shark(Prionace glauca), the bigeye thresher shark(Alopias superciliosus), the silky shark(Carcharhinus falciformis), the scalloped hammerhead(Sphyrna lewini), and the oceanic whitetip shark(Carcharhinus longimanus). Of these species, oceanic whitetip shark has the lowest trophic level and mean δ15N value(3.9 and 14.93‰± 0.84‰), whereas bigeye thresher shark has the highest level/values(4.5 and 17.02‰± 1.21‰, respectively). The bigeye thresher shark has significantly higher δ15N value than other shark species, indicating its higher trophic position. The blue shark and oceanic whitetip shark has significantly higher δ13C values than bigeye thresher shark, silky shark and scalloped hammerhead, possibly due to different diets and/or living habitats. The stable isotope data and stomach content data are highly consistent, suggesting that stable isotope analysis supplements traditional feeding ecology study of sharks, and thus contributes to understanding their trophic linkage. | LI Yunkai GONG Yi CHEN Xinjun DAI Xiaojie ZHU Jiangfeng | 2014 | Journal of Ocean University of China2014，13，2： | 6 |
| 5 | Quantitative response of oil sunflower yield to evapotranspiration and soil salinity with saline water irrigation显示文摘Appropriate application of water-salt-crop function model can optimize agricultural water management in regions with declining water supply,such as the Hetao district.Appropriate use of saline water is also based on the effects of irrigation water demand and water quality on crop growth quantitatively.Therefore,oil sunflower growth testing under both water and salt stress was completed from 2013 to 2014.Water salinity levels at 1.7 ds/m,4 ds/m,6 ds/m and 8 ds/m were used in the experiments.Two water deficit levels were reported,60%and 80%of the irrigation quota,which were considered moderate and mild deficit levels,respectively.All treatments were applied in planting the oil sunflower in critical growing periods,namely,floral initiation,anthesis and maturity.Linear,Cobb-Douglas,quadratic and transcendental function models were used to simulate the relative yield,evapotranspiration(ET)and electrical conductivity(EC).The predictive ability and sensitivity of each model were then evaluated.Compared with salt stress,water stress exerted a more significant effect on the oil sunflower yield;the water parameters(a1 and a3)were most sensitive in the water-salt-crop function model.Oil sunflower was most sensitive to water and salt stress during anthesis.The transcendental function generally showed a relatively high sensitivity coefficient and a relatively small statistical error.Therefore,the transcendental function is the most appropriate model for simulating and predicting the yield of oil sunflower irrigated with saline water.Applying the water-salt-crop function model in planting of oil sunflower can help in the development and utilization of saline water in the Hetao district. | He Xin Yang Peiling Ren Shumei Li Yunkai Jiang Guangyu Li Lianhao | 2016 | International Journal of Agricultural and Biological Engineering2016，9，2： | 4 |
| 6 | Gladius growth pattern and increment of jumbo squid(Dosidicus gigas)in the tropical Pacific Ocean显示文摘Gladius is an accepted hard tissue for determining the age,size-specific growth,and trophic dynamics of pelagic squid.However,little is known about the inter-and intra-stock variability of gladius growth pattern and increment deposition.In this study,the gladius growth patterns with somatic growth and gonad development were evaluated for two geographic stocks of the jumbo squid(Dosidicus gigas)in the tropical Pacific Ocean.The microstructure and periodicity of the gladius growth increments were also investigated.Results showed varied correlations between four gladius morphometric characteristics with dorsal mantle length,while growth in body weight almost followed a power model.Sexual gladius growth patterns occurred with gonad development,possibly due to different biological functions of these gladius parts and sex-specific energetic allocations.Gladius increments were observed formation in the stem and lateral plate and could be consistently enumerated.The daily periodicity of increment deposition,at least over 144 days old,was validated by comparing gladius increments with the ages obtained from the statoliths.The different oceanographic conditions between two areas likely influence the gladius growth and increment deposition and promote higher increment counts in squid from equatorial waters.Above all,these results provided new information on gladius microstructures and growth increment in different stocks of D.gigas and confirmed the use of this tissue for size-specific growth and age determination. | Yi Gong Yunkai Li Xinjun Chen Xiaodi Gao Ling Chen | 2018 | Aquaculture and Fisheries2018，3，4： | 4 |
| 7 | Involvement of long non-coding RNAs in the progression of esophageal cancer显示文摘Esophageal cancer(EC)is one of the most common malignant tumors of the digestive system with high incidence and mortality rate worldwide.Therefore,exploring the pathogenesis of ECand searching for new targeted therapies are the current research hotspot for EC treatment.Long non-coding RNAs(lncRNAs)are endogenous RNAs with more than 200 nucleotides,but without proteincoding function.In recent years,lncRNAs have gradually become the focuses in the field of non-coding RNA.Some lncRNAs have been proved to be closely related to the pathogenesis of EC.Many lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation,apoptosis,and metastasis by inhibiting or promoting target gene expression.LncRNAs can also regulate the progression of EC through epithelial-mesenchymal transformation(EMT),which is closely related to the occurrence,development,and prognosis of EC.In this article,we review and discuss the involvement of lncRNAs in the progression of EC. | Wenhua Xue Yuanyuan Zheng Zhibo Shen Lifeng Li Zhirui Fan Wenbin Wang Zijia Zhu Yunkai Zhai Jie Zhao Quancheng Kan | 2021 | Cancer Communications2021，41，5： | 4 |
| 8 | Early assessment of the safety and immunogenicity of a third dose(booster)of COVID-19 immunization in Chinese adults显示文摘Inducing durable and effective immunity against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)via vaccination is essential to combat the current pandemic of coronavirus disease 2019(COVID-19).It has been noticed that the strength of anti-COVID-19 vaccination-induced immunity fades over time,which calls for an additional vaccination regime,as known as booster immunization,to restore immunity among previously vaccinated populations.Here we report a pilot open-label trial of a third dose of BBIBP-CorV,an inactivated SARS-CoV-2 vaccine(Vero cell),on 136 participants aged between 18 to 63 years.Safety and immunogenicity in terms of neutralizing antibody titers and cytokine/chemokine responses were analyzed as the main endpoint until day 28.While systemic reactogenicity was either absent or mild,SARS-CoV-2-specific neutralizing antibody titers rapidly arose in all participants within 4 weeks,surpassing the peak antibody titers elicited by the initial two-dose immunization regime.Broad increases of cellular immunity-associated cytokines and chemokines were also detected in the majority of participants after the third vaccination.Furthermore,in an exploratory study,a newly developed recombinant protein vaccine,NVSI-06-08(CHO Cells),was found to be safe and even more effective than BBIBP-CorV in eliciting humoral immune responses in BBIBP-CorV-primed individuals.Together,these results indicate that a third immunization schedule with either homologous or heterologous vaccine showed favorable safety profiles and restored potent SARS-CoV-2-specific immunity,providing support for further trials of booster vaccination in larger populations. | Yuntao Zhang Yunkai Yang Niu Qiao Xuewei Wang Ling Ding Xiujuan Zhu Yu Liang Zibo Han Feng Liu Xinxin Zhang Xiaoming Yang | 2022 | Frontiers of Medicine2022，16，1： | 3 |
| 9 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 10 | The electrolyte comprising more robust water and superhalides transforms Zn-metal anode reversibly and dendrite-free显示文摘A great challenge for all aqueous batteries,including Zn-metal batteries,is the parasitic hydrogen evolution reaction on the low-potential anode.Herein,we report the formula of a highly concentrated aqueous electrolyte that mitigates hydrogen evolution by transforming water molecules more inert.The electrolyte comprises primarily ZnCl_(2) and LiCl as an additive,both of which are inexpensive salts.The O-H covalent bonds in water get strengthened in a chemical environment that has fewer hydrogen bonding interactions and a greater number of Zn-Cl superhalides,as suggested by integrated characterization and simulation.As a result,the average Coulombic efficiency of zincmetal anode is raised to an unprecedented>99.7%at 1mA cm^(−2).In the new electrolyte,the plating/stripping processes leave the zinc-metal anode dendrite-free,and the zinc-metal anode delivers stable plating/stripping cycles for 4000 hours with an areal capacity of 4 mAh cm^(−2) at 2mA cm^(−2).Furthermore,the high Coulombic efficiency of zinc-metal anode in the ZnCl_(2)-LiCl mixture electrolyte is demonstrated in full cells with a limited anode.The V_(2)O_(5)·H_(2)O||Zn full cell with an N/P mass ratio of 1.2 delivers a stable life of more than 2500 cycles,and the LiMn_(2)O_(4)||Zn hybrid cell with an N/P mass ratio of 0.6 exhibits 1500 cycles in its stable life. | Chong Zhang Woochul Shin Liangdong Zhu Cheng Chen Joerg C.Neuefeind Yunkai Xu Sarah I.Allec Cong Liu Zhixuan Wei Aigerim Daniyar Jia‐Xing Jiang Chong Fang P.Alex Greaney Xiulei Ji | 2021 | Carbon Energy2021，3，2： | 3 |
| 11 | The Heat Transfer Coefficients of the Heating Surface of 300 MWe CFB Boiler显示文摘A study of the heat transfer about the heating surface of three commercial 300 MWe CFB boilers was conducted in this work. The heat transfer coefficients of the platen heating surface, the external heat exchanger (EHE) and cyclone separator were calculated according to the relative operation data at different boiler loads. Moreover, the heat transfer coefficient of the waterwall was calculated by heat balance of the hot circuit of the CFB boiler. With the boiler capacity increasing, the heat transfer coefficients of these heating surface increases, and the heat transfer coefficient of the water wall is higher than that of the platen heating surface. The heat transfer coefficient of the EHE is the highest in high boiler load, the heat transfer coefficient of the cyclone separator is the lowest. Because the fired coal is different from the design coal in No.1 boiler, the ash content of the fired coal is much lower than that of the design coal. The heat transfer coefficients which calculated with the operation data are lower than the previous design value and that is the reason why the bed temperature is rather high during the boiler operation in No.1 boiler. | WU Haibo ZHANG Man LU Qinggang SUN Yunkai | 2012 | Journal of Thermal Science2012，21，4： | 3 |
| 12 | Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-β production by mediating H3K79me2/3 methylation in macrophages显示文摘Epigenetic modification,including histone modification,precisely controls target gene expression.The posttranscriptional regulation of the innate signaling-triggered production of inflammatory cytokines and type I interferons has been fully elucidated,whereas the roles of histone modification alteration and epigenetic modifiers in regulating inflammatory responses need to be further explored.Di/tri-methylation modifications of histone 3 lysine 79(H3K79me2/3)have been shown to be associated with gene transcriptional activation.Disruptor of telomeric silencing-1-like(Dot1l)is the only known exclusive H3K79 methyltransferase and regulates the proliferation and differentiation of tumor cells.However,the roles of Dot1l and Dot1l-mediated H3K79 methylation in innate immunity and inflammatory responses remain unclear.Here,we found that H3K79me2/3 modification levels at the Il6 and Ifnb1 promoters,as well as H3K79me2 modification at the Tnfαpromoter,were increased in macrophages activated by Toll-like receptor(TLR)ligands or virus infection.The innate signals upregulated Dot1l expression in macrophages and THP1 cells.Dot1l silencing or a Dot1l inhibitor preferentially suppressed the production of IL-6 and interferon(IFN)-βbut not of TNFαin macrophages and THP1 cells triggered by TLR ligands or virus infection.Dot1l was recruited to the proximal promoter of the Il6 and Ifnb1 but not Tnfαgene and then mediated H3K79me2/3 modification at the Il6 and Ifnb1 promoters,consequently facilitating the transcription and expression of Il6 and Ifnb1.Thus,Dot1l-mediated selective H3K79me2/3 modifications at the Il6 and Ifnb1 promoters are required for the full activation of innate immune responses.This finding adds new insights into the epigenetic regulation of inflammatory responses and pathogenesis of autoimmune diseases. | Xiang Chen Xingguang Liu Yunkai Zhang Wanwan Huai Qingqing Zhou Sheng Xu Xi Chen Nan Li Xuetao Cao | 2020 | Cellular & Molecular Immunology2020，17，1： | 3 |
| 13 | Multistatic ground-based differential interferometric MIMO radar for 3D deformation measurement显示文摘Deformation measurement is crucial for forecasting landslide hazards of natural and engineered slopes. Ground-based differential interferometric radar(GB-DInRad) uses phase differential interferometric technology for surface deformation measurements and offers the advantages of all-day, allweather, and noncontact measurements. | Cheng HU Yunkai DENG Weiniing TIAN | 2021 | Science China(Information Sciences)2021，64，12： | 3 |
| 14 | Uniformly dispersed FeOx atomic clusters by pulsed arc plasma deposition: An efficient electrocatalyst for improving the performance of Li-O2 battery显示文摘现在的学习探索了一个新方法改进非宝贵的金属的催化活动,特别在电气化学的反应。弧分泌物生产的高度电离的 Fe 血浆一致地在多孔的碳底层上被扔并且在碳表面上形成了原子簇。同样准备的 FeO x /C 材料在不同的当前的率下面在一节可充电的 Li-O 2 电池作为阴极材料被测试。结果以周期生活和反应率在电池性能显示出重要改进。而且, X 光检查衍射(XRD ) 和扫描电子显微镜学(SEM ) 结果证明同样准备的阴极材料稳定了阴极并且减少了方面反应并且当前的率是在分泌物产品的成核的一个关键因素。 | Xiangyi Luo Jun Lu Evan Sohm Lu Ma Tianpin Wu Jianguo Wen Dantong Qiu YunKai Xu Yang Ren Dean J. Miller Khalil Amine | 2016 | Nano Research2016，9，7： | 3 |
| 15 | A Low-Overhead Energy-Efficient ARQ Protocol for Wireless Sensor Networks显示文摘Wireless sensor network(WSN) is a typical kind of low-power and lossy network,in where ARQ(Automatic Repeat reQuest)schemes are often used to improve packets reliability.However,the ARQ related packets may incur significant load and consume more energy.This paper proposes a novel energy efficient ARQ protocol called ARQ+,which uses the nearest-first scheme and NAK aggregation scheme to reduce the amount and transmission hops of the ARQ related packets.Consequently,the energy consumption is significantly decreased.Theoretical analyses of ARQ+ on energy consumption,packet arrive ratio and latency are provided.Performance improvement of ARQ+ is validated by extensive simulations.They both show that ARQ+ has satisfactory energy efficiency,good packets arriving ratio and reasonable average packet delay comparing to traditional ARQ schemes. | WEI Yunkai MAO Yuming LENG Supeng HUANG Wentao | 2014 | China Communications2014，11，10： | 2 |
| 16 | Partition of GB-InSAR deformation map based on dynamic time warping and k-means显示文摘Ground-based interferometric synthetic aperture radar(GB-InSAR)can take deformation measurement with a high accuracy.Partition of the GB-InSAR deformation map benefits analyzing the deformation state of the monitoring scene better.Existing partition methods rely on labelled datasets or single deformation feature,and they cannot be effectively utilized in GBInSAR applications.This paper proposes an improved partition method of the GB-InSAR deformation map based on dynamic time warping(DTW)and k-means.The DTW similarities between a reference point and all the measurement points are calculated based on their time-series deformations.Then the DTW similarity and cumulative deformation are taken as two partition features.With the k-means algorithm and the score based on multi evaluation indexes,a deformation map can be partitioned into an appropriate number of classes.Experimental datasets of West Copper Mine are processed to validate the effectiveness of the proposed method,whose measurement points are divided into seven classes with a score of 0.3151. | TIAN Weiming DU Lin DENG Yunkai DONG Xichao | 2022 | Journal of Systems Engineering and Electronics2022，33，4： | 2 |
| 17 | Regulation of the order-disorder phase transition in a Cs_(2)NaFeCl_(6) double perovskite towards reversible thermochromic application显示文摘Multifunctional lead-free double perovskites demonstrate remarkable potential towards applications in various fields.Herein,an environmentally-friendly,low-cost,high-throughput Cs_(2)NaFeCl_(6) single crystal with exceedingly high thermal stability is designed and grown.It obtains a cubic lattice system in the temperature range of 80-500 K,accompanied by a completely reversible chromatic variation ranging from yellow to black.Importantly,the intriguing thermochromism is proved to own extremely high reproducibility(over 1000 cycles)without a hysteretic effect,originating from its structural flexibility that including(i)the noteworthy distortion/deformation of[NaCl_(6)]5−and[FeCl_(6)]3−octahedra;(ii)order-disorder arrangement transition of[NaCl_(6)]5−and[FeCl6]3−octahedra as the function of temperature.This study paves the way towards a new class of smart windows and camouflage coatings with an unprecedented colour range based on a Cs_(2)NaFeCl_(6) perovskite. | Wenzhe Li Naveed Ur Rahman Yeming Xian Hang Yin Yunkai Bao Yi Long Songyang Yuan Yangyi Zhang Yaxuan Yuan Jiandong Fan | 2021 | Journal of Semiconductors2021，42，7： | 2 |
| 18 | Prussian Blue Analogues as Electrodes for Aqueous Monovalent Ion Batteries显示文摘Aqueous batteries have engendered increasing attention as promising solutions for stationary energy storage due to their potentially low cost and innate safety.In various aqueous battery systems,Prussian blue analogues(PBAs)represent a class of promising electrode materials with fascinating electrochemical performance,owing to their large open frameworks,abundant ion insertion sites,and facile preparation.To date,PBAs have shown substantial progress towards storage of alkali metal ions(Li^(+),Na^(+),and K^(+)),H^(+),and NH4^(+) in aqueous electrolytes,which,however,has yet not been specifically summarized.This review selects some representative research to introduce the progress of PBAs in these battery systems and aims to discuss the crucial role of ionic charge carrier in affecting the overall electrode performance.Besides,some critical knowledge gaps and challenges of PBA materials have been pointed out for future development. | Shen Qiu Yunkai Xu Xianyong Wu Xiulei Ji | 2022 | Electrochemical Energy Reviews2022，5，2： | 2 |
| 19 | KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling显示文摘IL-6 plays important and pleiotropic roles in infection and inflammatory diseases,and its production needs to be tightly regulated.However,the epigenetic mechanism underlying Il6 gene transcription remains to be fully elucidated.Here,we report that lysine-specific demethylase 2b(KDM2B),which demethylates H3K4me3 and H3K36me2,is required in macrophages and dendritic cells for the induction of IL-6 but not TNF-α,IL-1,and IFN-β.Compared to wild-type mice,KDM2B-deficient mice were more resistant to endotoxin shock and colitis,with a less severe inflammatory pathogenesis phenotype and decreased IL-6 production in sera.KDM2B selectively bound the Il6 promoter but did not alter histone demethylation;instead,KDM2B interacted with Brahma-related gene 1(Brg1),the core ATPase subunit of SWI/SNF chromatin remodeling complexes,to facilitate chromatin accessibility of the Il6 promoter.Furthermore,KDM2B directly recruited RNA Polymerase II to further initiate and promote Il6 transcription.Thus,our finding identifies a novel nonclassical function of KDM2B in gene-specific transcription initiation and enhancement of Il6 independent of its demethylase activity and adds new insight into the specific epigenetic modification mechanism of inflammatory immune responses. | Qingqing Zhou Yunkai Zhang Bo Wang Wenhui Zhou Yong Bi Wanwan Huai Xi Chen Yihan Chen Zhongmin Liu Xingguang Liu Zhenzhen Zhan | 2020 | Cellular & Molecular Immunology2020，17，8： | 2 |
| 20 | CFD and digital particle tracking to assess flow characteristics in the labyrinth flow path of a drip irrigation emitter显示文摘 | Yunkai Li Peiling Yang Tingwu Xu Shumei Ren Xiongcai Lin Runjie Wei Hongbing Xu | 2008 | Irrigation Science2008，，5： | 2 |
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