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| 1 | Trophic Ecology of Sharks in the Mid-East Pacific Ocean Inferred from Stable Isotopes显示文摘As apex predators, sharks are of ecological and conservation importance in marine ecosystems. In this study, trophic positions of sharks were estimated using stable isotope ratios of carbon and nitrogen for five representative species caught by the Chinese longline fleet in the mid-east Pacific, i.e., the blue shark(Prionace glauca), the bigeye thresher shark(Alopias superciliosus), the silky shark(Carcharhinus falciformis), the scalloped hammerhead(Sphyrna lewini), and the oceanic whitetip shark(Carcharhinus longimanus). Of these species, oceanic whitetip shark has the lowest trophic level and mean δ15N value(3.9 and 14.93‰± 0.84‰), whereas bigeye thresher shark has the highest level/values(4.5 and 17.02‰± 1.21‰, respectively). The bigeye thresher shark has significantly higher δ15N value than other shark species, indicating its higher trophic position. The blue shark and oceanic whitetip shark has significantly higher δ13C values than bigeye thresher shark, silky shark and scalloped hammerhead, possibly due to different diets and/or living habitats. The stable isotope data and stomach content data are highly consistent, suggesting that stable isotope analysis supplements traditional feeding ecology study of sharks, and thus contributes to understanding their trophic linkage. | LI Yunkai GONG Yi CHEN Xinjun DAI Xiaojie ZHU Jiangfeng | 2014 | Journal of Ocean University of China2014，13，2： | 6 |
| 2 | Quantitative response of oil sunflower yield to evapotranspiration and soil salinity with saline water irrigation显示文摘Appropriate application of water-salt-crop function model can optimize agricultural water management in regions with declining water supply,such as the Hetao district.Appropriate use of saline water is also based on the effects of irrigation water demand and water quality on crop growth quantitatively.Therefore,oil sunflower growth testing under both water and salt stress was completed from 2013 to 2014.Water salinity levels at 1.7 ds/m,4 ds/m,6 ds/m and 8 ds/m were used in the experiments.Two water deficit levels were reported,60%and 80%of the irrigation quota,which were considered moderate and mild deficit levels,respectively.All treatments were applied in planting the oil sunflower in critical growing periods,namely,floral initiation,anthesis and maturity.Linear,Cobb-Douglas,quadratic and transcendental function models were used to simulate the relative yield,evapotranspiration(ET)and electrical conductivity(EC).The predictive ability and sensitivity of each model were then evaluated.Compared with salt stress,water stress exerted a more significant effect on the oil sunflower yield;the water parameters(a1 and a3)were most sensitive in the water-salt-crop function model.Oil sunflower was most sensitive to water and salt stress during anthesis.The transcendental function generally showed a relatively high sensitivity coefficient and a relatively small statistical error.Therefore,the transcendental function is the most appropriate model for simulating and predicting the yield of oil sunflower irrigated with saline water.Applying the water-salt-crop function model in planting of oil sunflower can help in the development and utilization of saline water in the Hetao district. | He Xin Yang Peiling Ren Shumei Li Yunkai Jiang Guangyu Li Lianhao | 2016 | International Journal of Agricultural and Biological Engineering2016，9，2： | 4 |
| 3 | Gladius growth pattern and increment of jumbo squid(Dosidicus gigas)in the tropical Pacific Ocean显示文摘Gladius is an accepted hard tissue for determining the age,size-specific growth,and trophic dynamics of pelagic squid.However,little is known about the inter-and intra-stock variability of gladius growth pattern and increment deposition.In this study,the gladius growth patterns with somatic growth and gonad development were evaluated for two geographic stocks of the jumbo squid(Dosidicus gigas)in the tropical Pacific Ocean.The microstructure and periodicity of the gladius growth increments were also investigated.Results showed varied correlations between four gladius morphometric characteristics with dorsal mantle length,while growth in body weight almost followed a power model.Sexual gladius growth patterns occurred with gonad development,possibly due to different biological functions of these gladius parts and sex-specific energetic allocations.Gladius increments were observed formation in the stem and lateral plate and could be consistently enumerated.The daily periodicity of increment deposition,at least over 144 days old,was validated by comparing gladius increments with the ages obtained from the statoliths.The different oceanographic conditions between two areas likely influence the gladius growth and increment deposition and promote higher increment counts in squid from equatorial waters.Above all,these results provided new information on gladius microstructures and growth increment in different stocks of D.gigas and confirmed the use of this tissue for size-specific growth and age determination. | Yi Gong Yunkai Li Xinjun Chen Xiaodi Gao Ling Chen | 2018 | Aquaculture and Fisheries2018，3，4： | 4 |
| 4 | Involvement of long non-coding RNAs in the progression of esophageal cancer显示文摘Esophageal cancer(EC)is one of the most common malignant tumors of the digestive system with high incidence and mortality rate worldwide.Therefore,exploring the pathogenesis of ECand searching for new targeted therapies are the current research hotspot for EC treatment.Long non-coding RNAs(lncRNAs)are endogenous RNAs with more than 200 nucleotides,but without proteincoding function.In recent years,lncRNAs have gradually become the focuses in the field of non-coding RNA.Some lncRNAs have been proved to be closely related to the pathogenesis of EC.Many lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation,apoptosis,and metastasis by inhibiting or promoting target gene expression.LncRNAs can also regulate the progression of EC through epithelial-mesenchymal transformation(EMT),which is closely related to the occurrence,development,and prognosis of EC.In this article,we review and discuss the involvement of lncRNAs in the progression of EC. | Wenhua Xue Yuanyuan Zheng Zhibo Shen Lifeng Li Zhirui Fan Wenbin Wang Zijia Zhu Yunkai Zhai Jie Zhao Quancheng Kan | 2021 | Cancer Communications2021，41，5： | 4 |
| 5 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 6 | Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-β production by mediating H3K79me2/3 methylation in macrophages显示文摘Epigenetic modification,including histone modification,precisely controls target gene expression.The posttranscriptional regulation of the innate signaling-triggered production of inflammatory cytokines and type I interferons has been fully elucidated,whereas the roles of histone modification alteration and epigenetic modifiers in regulating inflammatory responses need to be further explored.Di/tri-methylation modifications of histone 3 lysine 79(H3K79me2/3)have been shown to be associated with gene transcriptional activation.Disruptor of telomeric silencing-1-like(Dot1l)is the only known exclusive H3K79 methyltransferase and regulates the proliferation and differentiation of tumor cells.However,the roles of Dot1l and Dot1l-mediated H3K79 methylation in innate immunity and inflammatory responses remain unclear.Here,we found that H3K79me2/3 modification levels at the Il6 and Ifnb1 promoters,as well as H3K79me2 modification at the Tnfαpromoter,were increased in macrophages activated by Toll-like receptor(TLR)ligands or virus infection.The innate signals upregulated Dot1l expression in macrophages and THP1 cells.Dot1l silencing or a Dot1l inhibitor preferentially suppressed the production of IL-6 and interferon(IFN)-βbut not of TNFαin macrophages and THP1 cells triggered by TLR ligands or virus infection.Dot1l was recruited to the proximal promoter of the Il6 and Ifnb1 but not Tnfαgene and then mediated H3K79me2/3 modification at the Il6 and Ifnb1 promoters,consequently facilitating the transcription and expression of Il6 and Ifnb1.Thus,Dot1l-mediated selective H3K79me2/3 modifications at the Il6 and Ifnb1 promoters are required for the full activation of innate immune responses.This finding adds new insights into the epigenetic regulation of inflammatory responses and pathogenesis of autoimmune diseases. | Xiang Chen Xingguang Liu Yunkai Zhang Wanwan Huai Qingqing Zhou Sheng Xu Xi Chen Nan Li Xuetao Cao | 2020 | Cellular & Molecular Immunology2020，17，1： | 3 |
| 7 | Regulation of the order-disorder phase transition in a Cs_(2)NaFeCl_(6) double perovskite towards reversible thermochromic application显示文摘Multifunctional lead-free double perovskites demonstrate remarkable potential towards applications in various fields.Herein,an environmentally-friendly,low-cost,high-throughput Cs_(2)NaFeCl_(6) single crystal with exceedingly high thermal stability is designed and grown.It obtains a cubic lattice system in the temperature range of 80-500 K,accompanied by a completely reversible chromatic variation ranging from yellow to black.Importantly,the intriguing thermochromism is proved to own extremely high reproducibility(over 1000 cycles)without a hysteretic effect,originating from its structural flexibility that including(i)the noteworthy distortion/deformation of[NaCl_(6)]5−and[FeCl_(6)]3−octahedra;(ii)order-disorder arrangement transition of[NaCl_(6)]5−and[FeCl6]3−octahedra as the function of temperature.This study paves the way towards a new class of smart windows and camouflage coatings with an unprecedented colour range based on a Cs_(2)NaFeCl_(6) perovskite. | Wenzhe Li Naveed Ur Rahman Yeming Xian Hang Yin Yunkai Bao Yi Long Songyang Yuan Yangyi Zhang Yaxuan Yuan Jiandong Fan | 2021 | Journal of Semiconductors2021，42，7： | 2 |
| 8 | CFD and digital particle tracking to assess flow characteristics in the labyrinth flow path of a drip irrigation emitter显示文摘 | Yunkai Li Peiling Yang Tingwu Xu Shumei Ren Xiongcai Lin Runjie Wei Hongbing Xu | 2008 | Irrigation Science2008，，5： | 2 |
| 9 | Preliminary surface topographical characteristics of biofilms attached on drip irrigation emitters using reclaimed water显示文摘 | Li Yunkai Zhou Bo Liu Yaoze | 2013 | Irrigation Science2013，31，4： | 1 |
| 10 | Quantitative relationship between biofilms components and emitter clogging under reclaimed water drip irrigation显示文摘 | Zhou Bo Li Yunkai Pei Yiting | 2013 | Irrigation Science2013，31，6： | 1 |
| 11 | Eight emitters clogging characteristics and its suitability evaluation under on-site reclaimed water drip irrigation显示文摘 | Pei Yiting Li Yunkai Liu Yaoze | 2014 | Irrigation Science2014，32，2： | 1 |
| 12 | Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling显示文摘The cross-talk between cellular lipid metabolism and the innate immune responses remains obscure. In addition to presenting lipid antigens to Natural Killer T-cells (NKT cells), the Cluster of Differentiation 1D Glycoprotein (CD1d) might mediate reverse signaling in antigen-presenting cells (APCs). Here we found CD1d deficiency attenuated Toll-like receptor (TLR)-triggered inflammatory innate responses in macrophages and dendritic cells, protecting mice from endotoxin shock. TLR activation in macrophages induced metabolic changes of glycosphingolipids (GSLs), among which glycolipid isoglobotrihexosylceramide (iGb3) was rapidly produced. The endogenously generated iGb3 bound CD1d in endosomal compartments and then synergized with the initially activated TLR signal to induce Tyr332 phosphorylation of CD1d intracellular domain. This led to the recruitment and activation of proline-rich tyrosine kinase 2 (Pyk2). Pyk2 interacted with IκB kinase β (IKKβ) and TANK-binding kinase 1 (TBK1), and enhanced tyrosine phosphorylation of Tyr188/199 of IKKβ and Tyr179 of TBK1 and thus, their activation to promote full activation of TLR signaling. Thus, intracellular CD1d reverse signaling, triggered by endogenous iGb3, amplifies inflammatory innate responses in APCs. Our findings identify a non-canonical function of CD1d reverse signaling activated by lipid metabolite in the innate immune response. | Xingguang Liu Peng Zhang Yunkai Zhang Zheng Wang Sheng Xu Yingke Li Wanwan Huai Qingqing Zhou Xiang Chen Xi Chen Nan Li Peng Wang Yunsen Li Xuetao Cao | 2019 | Cell Research2019，29，1： | 1 |
| 13 | Effects of average velocity on the growth and surface topography of biofilmsattached on the reclaimed wastewater drip irrigation system laterals显示文摘 | Li Guibing Li Yunkai Xu Tingwu | 2012 | Irrigation Science2012，30，2： | 1 |
| 14 | Structural and fractal characteristics of biofilm attached on the surfaces of aquatic plants and gravels in the rivers and lakes reusing reclaimed wastewater显示文摘 | Liang Mingchao Wang Tianzhi Li Yunkai Yang Peiling Liu Chengcheng Li Pengxiang Zhao Wei | 2013 | Environmental Earth Sciences2013，，5： | 1 |
| 15 | Ana- lysis of tracing ability of different sized particles in drip in'igation emitters with computational fluid dynamics 显示文摘 | LI Yunkai LIU Haisheng YANG Peiling | 2013 | Irrigation and drainage2013，62，3： | 1 |
| 16 | Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis显示文摘Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer metastasis, accompanied with vast epigenetic changes.AMP-activated protein kinase (AMPK), a cellular energy sensor, plays regulatory roles in multiple biological processes. Although afew studies have shed light on AMPK regulating cancer metastasis, the inside epigenetic mechanisms remain unknown. Herein weshow that AMPK activation by metformin relieves the repressive H3K9me2-mediated silencing of epithelial genes (e.g., CDH1)during EMT processes and inhibits lung cancer metastasis. PHF2, a H3K9me2 demethylase, was identified to interact with AMPKα2.Genetic deletion of PHF2 aggravates lung cancer metastasis and abolishes the H3K9me2 downregulation and anti-metastasis effectof metformin. Mechanistically, AMPK phosphorylates PHF2 at S655 site, enhancing PHF2 demethylation activity and triggering thetranscription of CDH1. Furthermore, the PHF2-S655E mutant that mimics AMPK-mediated phosphorylation status further reducesH3K9me2 and suppresses lung cancer metastasis, while PHF2-S655A mutant presents opposite phenotype and reverses the antimetastasiseffect of metformin. PHF2-S655 phosphorylation strikingly reduces in lung cancer patients and the higherphosphorylation level predicts better survival. Altogether, we reveal the mechanism of AMPK inhibiting lung cancer metastasis viaPHF2 mediated H3K9me2 demethylation, thereby promoting the clinical application of metformin and highlighting PHF2 as thepotential epigenetic target in cancer metastasis. | Ying Dong Hao Hu Xuan Zhang Yunkai Zhang Xin Sun Hanlin Wang Weijuan Kan Min-jia Tan Hong Shi Yi Zang Jia Li | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 17 | Simulation of the flow characteristics of a drip irrigation emitter with large eddy methods显示文摘 | Wu Dan Li Yunkai Liu Haisheng | 2011 | Mathematical and Computer Modelling2011，，： | 1 |
| 18 | Micromorphology of macromolecular superabsorbent polymer and its fractal characteristics 显示文摘 | Li Yunkai Xu Tingwu Ouyang Zhiyun | 2009 | Journal of Applied Polymer Science2009，113，6： | 1 |
| 19 | Hydraulic property and flow characteristics of three labyrinth flow paths of drip irrigation emitters under micro-pressure显示文摘 | LI Yunkai YANG Peiling XU Tingwu | 2009 | Transactions o the ASABE2009，52，4： | 1 |
| 20 | Surface topographic characteristics of suspended particulates in reclaimed wastewater and effects on clogging in labyrinth drip irrigation emitters显示文摘 | Li Yunkai Liu Yaoze Li Guibing | 2012 | Irrigation Science2012，30，1： | 1 |
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