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| 1 | Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation显示文摘Tissue injury leads to gradients of chemoattractants,which drive multiple processes for tissue repair,including the inflam-matory response as well as endogenous cell recruitment.However,a limited time window for the gradients of chemoattract-ants as well as their poor stability at the injury site may not translate into healthy tissue repair.Consequently,intelligent multifunctional scaffolds with the capability to stabilize injury-induced cytokines and chemokines hold great promise for tissue repair.Vascular endothelial growth factor(VEGF)plays a significant role in wound healing by promoting angiogen-esis.The overarching objective of this research was to develop intelligent multifunctional scaffolds with the capability to endogenously recruit VEGF and promote wound healing via angiogenic and immunomodulatory dual functions.Prominin-1-derived peptide(PR1P)was encapsulated into electrospun poly(L-lactide-coglycolide)/gelatin(P/G)-based bandages.The sustained release of PR1P recruited VEGF in situ,thereby stabilizing the protein concentration peak in vivo and affording a reparative microenvironment with an adequate angiogenic ability at the wound site.Meanwhile,PR1P-recruited VEGF-induced macrophage reprogramming towards M2-like phenotypes further conferred immunomodulatory functions to the bandages.These dual functions of proangiogenesis and immunomodulation formed a cascade amplification,which regulated matrix metalloproteinases(MMP-9)as well as inflammatory factors(nuclear factor(NF)-κb,tumor necrosis factor(TNF)-α)in the wound microenvironment via the VEGF/macrophages/microenvironment axis.Consequently,the bandages realized multifunctional regeneration in splinted excisional wounds in rats,with or without diabetes,affording a higher skin append-age neogenesis,sensory function,and collagen remodeling.Conclusively,our approach encompassing in situ recruitment of VEGF at the injury site with the capability to promote immunomodulation-mediated tissue repair affords a promising avenue for scarless wound regeneration,which may also have implications for other tissue engineering disciplines. | Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen | 2023 | Advanced Fiber Materials2023，5，1： | 1 |
| 2 | Future directions for research on tissue-engineered trachea显示文摘As the only way for air to enter the lungs,the trachea plays an indispensable role in conducting,cleaning,and humidifying air.Tumors,trauma,and congenital disease of the trachea are serious threats to patients[1].Local tracheal disease can be treated with a balloon or stent,but for extensive tracheal disease,tracheal reconstruction after surgical resection is the only treatment[2–4].However,the tension of the anastomotic site also increases with expansion of the resection range,which causes a series of complications,such as poor anastomotic healing,anastomotic fistulae,and tracheal rupture,and even life-threatening complications in severe cases[5]. | Hai Tang Weiyan Sun Yi Chen Yunlang She Chang Chen | 2022 | Bio-Design and Manufacturing2022，5，3： | 0 |
| 3 | Correction to:Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation显示文摘Correction to:Advanced Fiber Materials http://gffzzd3cc09b8251d45dfsovcwuonu6vuo6c0v.ffgz.tsg.suse.edu.cn/10.1007/s42765-022-00226-8 In this article the author name Muhammad Shafiq was incorrectly written as Shafiq Muhammad.The original article has been corrected. | Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
| 4 | Deconstructing the intra-tumor subclonal heterogeneity of lung synchronous ground-glass nodules using whole-genome sequencing显示文摘Dear Editor,The persistent presence of ground-glass opacity nodules(GGN)on thin-section computed tomography(CT)usually suggests the presence of lung adenocarcinoma,1 which include atypical adenomatous hyperplasia(AAH),adenocarcinoma in situ(AIS),minimally invasive adenocarcinoma,and invasive adenocarcinoma(AD).2 Recent data indicate that up to 20%of GGN patients(3%of the screening population)are diagnosed with synchronous multiple ground-glass nodules(SM-GGNs).3 At present,neither auxiliary tests that could assist in differential diagnosis nor recommended strategy for the identification and treatment of GGNs exist in the clinical practice guidelines for lung cancer,although clinical evidence suggests that SM-GGNs are more complicated,making treatment decisions difficult. | Yijiu Ren Minfang Song Yunlang She Huikang Xie Hui Zheng Chang Chen Yiwen Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 0 |
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