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| 1 | TD-AltBOC:A new COMPASS B2 modulation显示文摘AltBOC(15,10) is the baseline of COMPASS B2 signal modulation.It is a BOC-like signal having different PN codes in the lower and the upper main split lobes,which allow one signal service per lobe.The two lobes can be received and processed separately like two BPSK(10) signals,or coherently processed to achieve better performance.Interoperability among COMPASS B2,Galileo E5 and GPS L5 is also achievable using AltBOC modulation.However,Galileo's 4-code AltBOC has drawbacks such as low efficiency and great receiver complexity.This paper presents a new modulation type named TD-AltBOC (Time Division AltBOC).The signal generation scheme and receiving method are presented,and are compared with AltBOC in the areas of power spectrum,ranging accuracy,anti-multipath performance,anti-interference performance,processing flexibility and complexity.Analysis results show TD-AltBOC has similar spectrum characteristics,interoperability,flexibility and anti-interference performance with AltBOC.When the frontend bandwidth is more than 50 MHz,TD-AltBOC can achieve better ranging accuracy and anti-multipath performance.It also has such advantages as high efficiency and low receiver complexity.TD-AltBOC could be a good solution to COMPASS B2 navigation signal. | TANG ZuPing ZHOU HongWei WEI JiaoLong YAN Tao LIU YuQi RAN YiHang ZHOU YanLing | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 20 |
| 2 | Chinese progress in geomorphometry显示文摘Geomorphometry,the science of digital terrain analysis(DTA),is an important focus of research in both geomorphology and geographical information science(GIS).Given that 70% of China is mountainous,geomorphological research is popular among Chinese scholars,and the development of GIS over the last 30 years has led to significant advances in geomorphometric research.In this paper,we review Chinese progress in geomorphometry based on the published literature.There are three major areas of progress:digital terrain modelling methods,DTA methods,and applications of digital terrain models(DTMs).First,traditional vector-and raster-based terrain modelling methods,including the assessment of uncertainty,have received widespread attention.New terrain modelling methods such as unified raster and vector,high-fidelity,and real-time dynamic geographical scene modelling have also attracted research attention and are now a major focus of digital terrain modelling research.Second,in addition to the popular DTA methods based on topographical derivatives,geomorphological features,and hydrological factors extracted from DTMs,DTA methods have been extended to include analyses of the structure of underlying strata,ocean surface features and even socioeconomic spatial structures.Third,DTMs have been applied to fields including global climate change,analysis of various typical regions,lunar surface and other related fields.Clearly,Chinese scholars have made significant progress in geomorphometry.Chinese scholars have had the greatest international impact in areas including high-fidelity digital terrain modelling and DTM-based regional geomorphological analysis,particularly in the Loess Plateau and the Tibetan Plateau regions. | LV Guonian XIONG Liyang CHEN Min TANG Guoan SHENG Yehua LIU Xuejun SONG Zhiyao LU Yuqi YU Zhaoyuan ZHANG Ka WANG Meizhen | 2017 | Journal of Geographical Sciences2017，27，11： | 14 |
| 3 | Comparative study on skin temperature response to menstruation at acupuncture points in healthy volunteers and primary dysmenorrhea patients显示文摘OBJECTIVE:To assess skin temperature response to menstruation at acupuncture points in primary dysmenorrhea(PD) patients and healthy volunteers so as to explore acupuncture point specificity in reflecting diseases in the light of skin temperature.METHODS:Fifty-two PD patients and 49 healthy volunteers were recruited.Skin temperature measurements were performed with a skin temperature assessment device at 10 points.Absolute difference between skin temperature of the same point on the left and right side is used as main outcome measure.RESULTS:On the first day of menstruation, when menstrual pain attacking in PD patients, a significant increase in skin temperature difference was detected at Taixi(KI 3) compared with the healthy group(P < 0.01).A significant reduction in skin temperature difference was detected at Taixi(KI 3) in the first day of menstruation compared with those values in the third day after menstruation(P < 0.01)in the healthy group.On the third day after menstruation, a significant reduction in skin temperature difference was found at Zhongdu(LR 6) in PD group compared with the healthy group(P < 0.05).No significant differences of skin temperature were detected at other points(P > 0.05).CONCLUSION:The skin temperature difference at menstruation-relevant points in PD patients did not all change significantly more than those in women without PD.Significant difference was only found in Taixi(KI 3), the Yuan-source point of Kidney meridian. | She Yanfen Ma Liangxiao Zhu Jiang Qi Conghui Wang Yanxia Tang Ling Li Chunhua Yuan Hongwen Liu Yuqi Song Jiashan | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 8 |
| 4 | Diamond Raman laser:a promising high-beam-quality and low-thermal-effect laser显示文摘Stimulated Raman-scattering-based lasers provide an effective way to achieve wavelength conversion.However,thermally induced beam degradation is a notorious obstacle to power scaling and it also limits the applicable range where high output beam quality is needed.Considerable research efforts have been devoted to developing Raman materials,with diamond being a promising candidate to acquire wavelength-versatile,high-power,and high-quality output beam owing to its excellent thermal properties,high Raman gain coefficient,and wide transmission range.The diamond Raman resonator is usually designed as an external-cavity pumped structure,which can easily eliminate the negative thermal effects of intracavity laser crystals.Diamond Raman converters also provide an approach to improve the beam quality owing to the Raman cleanup effect.This review outlines the research status of diamond Raman lasers,including beam quality optimization,Raman conversion,thermal effects,and prospects for future development directions. | Yulan Li Jie Ding Zhenxu Bai Xuezong Yang Yuqi Li Jingling Tang Yu Zhang Yaoyao Qi Yulei Wang Zhiwei Lu | 2021 | High Power Laser Science and Engineering2021，9，3： | 7 |
| 5 | Development of an automatic calibration device for high-accuracy low temperature thermometers显示文摘Based on the analysis and investigation of calibration systems for high-accuracy low temperature thermometers,a new facility for automatic calibration of high-accuracy low temperature thermometers was developed.Continuous calibration for multiple points can be made automatically with this device.According to the thermophysical characteristics of the constant-temperature block in this device,segmented Fuzzy-PID (proportional-integral-differential) algorithm was applied.The experimental results showed that the temperature fluctuation was smaller than ±0.005 K in 30 min.Therefore,this new device can fully meet the calibration requirement of high-precision low temperature thermometers. | CHEN GuangMing,GAO Xu,ZHANG ShaoZhi,CHEN Qi,TANG LiMing & LAN YuQi Institute of Refrigeration and Cryogenics,Zhejiang University,Hangzhou 310027,China | 2010 | Science China(Technological Sciences)2010，53，9： | 6 |
| 6 | The cost of obsessive- compulsive disorder (OCD) in China: a multi- center cross- sectional survey based on hospitals显示文摘Background Obsessive-compulsive disorder(OCD)is considered a very debilitating disorder with severe loss of quality of life and income.Aims This study estimates the quality of life and economic consequences of OCD in China.Methods The research team interviewed 639 patients with OCD in 13 hospitals in 12 cities in China.The direct method was used to get the direct cost of OCD.Indirect costs associated with OCD were estimated using the human capital approach.Linear regression analysis was conducted for quality of life and generalised linear model analysis was conducted for total cost.Sensitivity analysis was used to analyse the uncertainty of total cost.Results The mean quality of life score for OCD was 52.78(20.46).The annual total cost of OCD per capita was 24503.78(95%CI:22621.53 to 26386.03)renminbi(RMB)(US$3465.88(95%CI:US$3199.65 to US$3732.11)).The annual cost of OCD in China was estimated to be 37.74 billion(95%CI:34.95 billion to 40.53 billion)RMB(equal to US$5.34 billion(95%CI:US$4.94 billion to US$5.73 billion)).Sensitivity analysis showed that the total annual cost of OCD in China was between 23.15 billion RMB(US$3.27 billion)and 370.00 billion RMB(US$52.33 billion).Worse social function status,more psychiatric symptoms and higher Yale Brown Obsessive-Compulsive Scale(Y-BOCS)score were associated with worse quality of life.The numbers of clinic visits and hospitalisations,socioeconomic status,education,Y-BOCS scores and age were found to be significantly associated with total cost.Conclusions OCD is associated with low quality of life and high costs in China.The findings call for concerted efforts to improve services for patients with OCD.Improvements may include early detection and diagnosis,the provision of evidence-based treatments and relapse prevention strategies. | Weili Yang Zhen Tang Xijin Wang Xiancang Ma Yuqi Cheng Bin Wang Ping Sun Wenxin Tang Jia Luo Changhong Wang Ping Li Guiyun Xu Jun Yan Vlasios Brakoulias Zhen Wang | 2021 | General Psychiatry2021，34，6： | 3 |
| 7 | The solar wind plasma upstream of Mars observed by Tianwen-1:Comparison with Mars Express and MAVEN显示文摘On the great journey to Mars,China’s first planetary exploration mission,the Tianwen-1 came within 26 million kilometers of Mars from 31 October 2020 to 25 January 2021 and was getting closer to its destination,the red planet,in search of answers to the cataclysmic climate change that occurred in Martian history.Both the escape of the Martian atmosphere and the loss of surface water were firmly influenced by solar activities.Tianwen-1 provided a unique chance to depict the solar wind streams between Earth and Mars during the minimum of Solar Cycle 25.During the three-month cruise phase of Tianwen-1,the solar wind flows were successively observed at Earth,Tianwen-1,and Mars.After the field of view correction and noise reduction,the solar wind velocity and density measured by Tianwen-1 show good agreement with those at Earth and Mars.The results indicate that the performance of the ion analyzer onboard the Tianwen-1 orbiter is reliable and stable.It is worth looking forward to the joint observations of ion escape with other Mars probes in the following Martian years. | Kai FAN Limei YAN Yong WEI Aibing ZHANG Linggao KONG Markus FRÄNZ Fei HE Lihui CHAI Chongjing YUAN Yuqi WANG Jun ZHONG Zhaojin RONG Zhonghua YAO Yongxin PAN Jun CUI Jiansen HE Wenya LI Binbin TANG Chi WANG | 2022 | Science China Earth Sciences2022，65，4： | 2 |
| 8 | Carbon-Based Electrode Materials for Supercapacitor: Progress, Challenges and Prospective Solutions显示文摘 | Xian Jian Shiyu Liu Yuqi Gao Wei Tian Zhicheng Jiang Xiangyun Xiao Hui Tang Liangjun Yin | 2016 | Journal of Electrical Engineering2016，4，2： | 2 |
| 9 | Object-oriented change detection based on the Kolmogorov–Smirnov test using high-resolution multispectral imagery显示文摘 | Yuqi Tang Liangpei Zhang Xin Huang | 2011 | International Journal of Remote Sensing2011，，20： | 1 |
| 10 | Review of the Regulations for Clinical Research in Herbal Medicines in USA显示文摘In 2012,USA Food and Drug Administration(FDA) approved 39 new drugs,however,there are only two botanical drugs(one topical and one oral)approved by FDA since the publication of the FDA's industry guidelines for the botanical drug product in June 2004.The approval shows the Western guideline can be used for herbal medicines,authors investigate current regulation on herbal medicine clinical research,identify challenges conducting clinical trials,and seek to produce some guidance for potential investigators and sponsors considering a clinical trial in this area.Key words were formulated for searching on Medline and FDA website to locate relevant regulations for clinical research in herbal medicines to understand current environment for herbal medicine usage and examine the barriers affecting herbal medicine in clinical trials.Authors critically explore case study of the 1st FDA approved botanical drugs,Veregen(sinecatechins),green tea leaves extract,a topical cream for perianal and genital condyloma.In consideration of current regulation environment in USA,based on the findings and analysis through the literature review and Veregen case study,authors produce and propose a Checklist for New Drug Application of Herbal Medicines for potential investigators and sponsors considerina in a herbal medicine clinical trial. | Tony Yuqi Tang 李方舟 Janyne Afseth | 2014 | Chinese Journal of Integrative Medicine2014，20，12： | 1 |
| 11 | Formulation of pH-responsive PEGylated nanoparticles with high drug loading capacity and programmable drug release for enhanced antibacterial activity显示文摘In the current global crisis of antibiotic resistance,delivery systems are emerging to combat resistant bacteria in a more efficient manner.Despite the significant advances of antibiotic nanocarriers,many challenges like poor biocompatibility,premature drug release,suboptimal targeting to infection sites and short blood circulation time are still challenging.To achieve targeted drug delivery and enhance antibacterial activity,here we reported a kind of pH-responsive nanoparticles by simply self-assembly of an amphiphilic poly(ethylene glycol)-Schiff-vancomycin(PEG-Schiff-Van)prodrug and free Van in one drug delivery system.The acid-liable Schiff base furnished the PEG-Schiff-Van@Van with good storage stability in the neutral environment and susceptible disassembly in response to faintly acidic condition.Notably,on account of the combination of physical encapsulation and chemical conjugation of vancomycin,these nanocarriers with favorable biocompatibility and high drug loading capacity displayed a programmed drug release behavior,which was capable of rapidly reaching high drug concentration to effectively kill the bacteria at an early period and continuously exerting an bacteria-sensitive effect whenever needed over a long period.In addition,more Schiff-base moieties within the PEG-Schiff-Van@Van nanocarriers may also make great contributions on promoting the antimicrobial activity.Using this strategy,this system was designed to have programmable structural destabilization and sequential drug release due to changes in pH that were synonymous with bacterial infection sites,thereby presenting prominent antibacterial therapy both in vitro and in vivo.This work represents a synergistic strategy on offering important guidance to rational design of multifunctional antimicrobial vehicles,which would be a promising class of antimicrobial materials for potential clinical translation. | Dawei Li Guoke Tang Hui Yao Yuqi Zhu Changgui Shi Qiang Fu Fei Yang Xing Wang | 2022 | Bioactive Materials2022，7，10： | 1 |
| 12 | DeceFL:a principled fully decentralized federated learning framework显示文摘Traditional machine learning relies on a centralized data pipeline for model training in various applications;however,data are inherently fragmented.Such a decentralized nature of databases presents the serious challenge for collaboration:sending all decentralized datasets to a central server raises serious privacy concerns.Although there has been a joint effort in tackling such a critical issue by proposing privacy-preserving machine learning frameworks,such as federated learning,most state-of-the-art frameworks are built still in a centralized way,in which a central client is needed for collecting and distributing model information(instead of data itself)from every other client,leading to high communication burden and high vulnerability when there exists a failure at or an attack on the central client.Here we propose a principled decentralized federated learning algorithm(DeceFL),which does not require a central client and relies only on local information transmission between clients and their neighbors,representing a fully decentralized learning framework.It has been further proven that every client reaches the global minimum with zero performance gap and achieves the same convergence rate O(1=T)(where T is the number of iterations in gradient descent)as centralized federated learning when the loss function is smooth and strongly convex.Finally,the proposed algorithm has been applied to a number of applications to illustrate its effectiveness for both convex and nonconvex loss functions,time-invariant and time-varying topologies,as well as IID and Non-IID of datasets,demonstrating its applicability to a wide range of real-world medical and industrial applications. | Ye Yuan Jun Liu Dou Jin Zuogong Yue Tao Yang Ruijuan Chen Maolin Wang Chuan Sun Lei Xu Feng Hua Yuqi Guo Xiuchuan Tang Xin He Xinlei Yi Dong Li Guanghui Wen Wenwu Yu Hai-Tao Zhang Tianyou Chai Shaochun Sui Han Ding | 2023 | National Science Open2023，2，1： | 1 |
| 13 | Object-oriented change detection based on the Kolmogorov-Smirnov test using high-resolution multispectral imagery显示文摘 | Tang Yuqi Zhang Liangpei Huang Xin | 2011 | International Journal of Remote Sensing2011，32，20： | 1 |
| 14 | Genome sequence and evolution of Betula platyphylla显示文摘Betula L.(birch)is a pioneer hardwood tree species with ecological,economic,and evolutionary importance in the Northern Hemisphere.We sequenced the Betula platyphylla genome and assembled the sequences into 14 chromosomes.The Betula genome lacks evidence of recent whole-genome duplication and has the same paleoploidy level as Vitis vinifera and Prunus mume.Phylogenetic analysis of lignin pathway genes coupled with tissue-specific expression patterns provided clues for understanding the formation of higher ratios of syringyl to guaiacyl lignin observed in Betula species.Our transcriptome analysis of leaf tissues under a time-series cold stress experiment revealed the presence of the MEKK1–MKK2–MPK4 cascade and six additional mitogen-activated protein kinases that can be linked to a gene regulatory network involving many transcription factors and cold tolerance genes.Our genomic and transcriptome analyses provide insight into the structures,features,and evolution of the B.platyphylla genome.The chromosome-level genome and gene resources of B.platyphylla obtained in this study will facilitate the identification of important and essential genes governing important traits of trees and genetic improvement of B.platyphylla. | Su Chen Yucheng Wang Lili Yu Tao Zheng Sui Wang Zhen Yue Jing Jiang Sapna Kumari Chunfang Zheng Haibao Tang Jun Li Yuqi Li Jiongjiong Chen Wenbo Zhang Hanhui Kuang Jon SRobertson Patrick XZhao Huiyu Li Shengqiang Shu Yordan SYordanov Haijiao Huang David MGoodstein Ying Gai Qi Qi JiuMeng Min ChunYan Xu SongBo Wang Guan-Zheng Qu Andrew HPaterson David Sankoff Hairong Wei Guifeng Liu Chuanping Yang | 2021 | Horticulture Research2021，8，1： | 1 |
| 15 | Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment显示文摘Intramedullary spinal cord tumor(IMSCT)is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy regimen.Currently,there are very limited researches for IMSCT treatment using nanomedicine.To fill this gap,we originally reported a targeted strategy by leveraging nano-engineered mesenchymal stem cells(MSCs)for synergistic antiIMSCT treatment.In this study,two mode drugs paclitaxel(PTX)and metformin(MET)were co-loaded in maleimide-modified poly(lactic-co-glycolicacid)(PLGA-MAL)nanoparticles,which were further conjugated onto MSCs surface via the thioether bond formed between PLGA-MAL and MSCs without affecting the migration ability of MSCs.Owing to the excellent tumor tropism and penetrability of MSCs and good biodegradability of PLGA,the designed drug delivery platform could accurately target IMSCT sites to exert long-term synergistic antitumor efficacy,exhibiting promising research value for alternative IMSCT management beyond surgery. | Lu Tang Mengying Xie Jing Li Yijun Mei Yuqi Cao Qiaqia Xiao Haijuan Dong Yuhui Zhang Wei Wang | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 16 | Massive and parallel 10 Tbit/s physical random bit generation with chaotic microcomb显示文摘Ultrafast physical random bit(PRB)generators and integrated schemes have proven to be valuable in a broad range of scientifc and technological applications.In this study,we experimentally demonstrated a PRB scheme with a chaotic microcomb using a chip-scale integrated resonator.A microcomb contained hundreds of chaotic channels,and each comb tooth functioned as an entropy source for the PRB.First,a 12 Gbits/s PRB signal was obtained for each tooth channel with proper post-processing and passed the NIST Special Publication 800-22 statistical tests.The chaotic microcomb covered a wavelength range from 1430 to 1675 nm with a free spectral range(FSR)of 100 GHz.Consequently,the combined random bit sequence could achieve an ultra-high rate of about 4 Tbits/s(12 Gbits/s×294=3.528 Tbits/s),with 294 teeth in the experimental microcomb.Additionally,denser microcombs were experimentally realized using an integrated resonator with 33.6 GHz FSR.A total of 805 chaotic comb teeth were observed and covered the wavelength range from 1430 to 1670 nm.In each tooth channel,12 Gbits/s random sequences was generated,which passed the NIST test.Consequently,the total rate of the PRB was approximately 10 Tbits/s(12 Gbits/s×805=9.66 Tbits/s).These results could ofer potential chip solutions of Pbits/s PRB with the features of low cost and a high degree of parallelism. | Yuqi Hu Qingsong Bai Xi Tang Wei Xiong Yilu Wu Xin Zhang Yanlan Xiao Runchang Du Leiji Liu Guangqiong Xia Zhengmao Wu Junbo Yang Heng Zhou Jiagui Wu | 2023 | Frontiers of Optoelectronics2023，16，3： | 0 |
| 17 | Evaluation on the applicability of ERA5 reanalysis dataset to tropical cyclones affecting Shanghai显示文摘Based on the 16 historical tropical cyclones(TCs)affecting Shanghai from 2007 to 2019,the suitability of ERA5 for studying TCs affecting Shanghai is systematically evaluated from the perspective of TC track,intensity,10-m and upper-level wind,using TC best-track data of China Meteorological Administration and surface observations and sounding data.Corresponding to tropical storm(TS),strong tropical storm(STS),typhoon(TY),strong typhoon(STY)and super typhoon(SuperTY),the median TC track bias is 68.1,52.9,42.5,25.4,and 18.2 km,respectively,the median maximum 10-m wind speed(VMAX10m)bias is-3.7,-6.5,-11.4,-21.7,and-32.2 m·s-1,respectively,and the median minimum mean sea level pressure(MSLPmin)bias is 2.2,5.6,8.1,28.2,and 48.7 hPa,respectively.With the increase of TC intensity,the median TC track bias decreases,while the median VMAX10m and MSLPmin bias increase.In general,VMAX10m in ERA5 is lower than observed,and MSLPmin is larger than observed.Under influence of TS,STS,TY and STY,the median 10-m wind speed(V10m)bias in the city is 3.2,4.2,4.7,and 5.4 m·s-1,respectively,and is 4.4-5.2 m·s-1 near the east coast,respectively.V10m is mostly biased high,showing an'M'type pattern with the distance between TC and Shanghai.The median 10 m wind direction(WD10m)bias is in a range of-7° to+7°.The median upper-level wind speed(Vupper)bias decreases with height,with a maximum of~5 m·s-1 at 975 hPa.Below 900 hPa Vupperin ERA5 is typically larger than the radiosonde observation,and its mean bias error(MBE)increases with TC intensity.The upper-level wind direction(WDupper)matches the sounding data well,with a maximum bias of a few degrees only.The results provide a reference for the application of ERA5 to coastal cities affected by TCs. | Zhihui HAN Caijun YUE Changhai LIU Wen GU Yuqi TANG Yongyu LI | 2022 | Frontiers of Earth Science2022，16，4： | 0 |
| 18 | High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator显示文摘3D photoacoustic computed tomography(3D-PACT)has made great advances in volumetric imaging of biological tissues,with high spatial-temporal resolutions and large penetration depth.The development of 3D-PACT requires high-performance acoustic sensors with a small size,large detection bandwidth,and high sensitivity.In this work,we present a new high-frequency 3D-PACT system that uses a microring resonator(MRR)as the acoustic sensor.The MRR sensor has a size of 80μm in diameter and was fabricated using the nanoimprint lithography technology.Using the MRR sensor,we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of~23 MHz,an imaging depth of~8 mm,a lateral resolution of 114μm,and an axial resolution of 57μm.We have demonstrated the 3D PACT’s performance on in vitro phantoms,ex vivo mouse brain,and in vivo mouse ear and tadpole.The MRR-based 3D-PACT system can be a promising tool for structural,functional,and molecular imaging of biological tissues at depths. | Qiangzhou Rong Youngseop Lee Yuqi Tang Tri Vu Carlos Taboada Wenhan Zheng Jun Xia David A.Czaplewski Hao F.Zhang Cheng Sun Junjie Yao | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 19 | Multiple rapid-responsive probes for hypochlorite detection based on dioxetane luminophore derivatives显示文摘In recent years,various methods for detecting exogenous and endogenous hypochlorite have been studied,considering its essential role as a biomolecule.However,the existing technologies still pose obstacles such as their invasiveness,high costs,and complicated operation.In the current study,we developed a glow-type chemiluminescent probe,hypochlorite chemiluminescence probe(HCCL)-1,based on the scaffold of Schaap's 1,2-dioxetane luminophores.To better explore the physiological and pathological functions of hypochlorite,we modified the luminophore scaffold of HCCL-1 to develop several probes,including HCCL-2,HCCL-3,and HCCL-4,which amplify the response signal of hypochlorite.By comparing the luminescent intensities of the four probes using the IVIS®system,we determined that HCCL-2 with a limit of detection of 0.166 mM has enhanced sensitivity and selectivity for tracking hypochlorite both in vitro and in vivo. | Yingai Sun Yuqi Gao Chunchao Tang Gaopan Dong Pei Zhao Dunquan Peng Tiantian Wang Lupei Du Minyong Li | 2022 | Journal of Pharmaceutical Analysis2022，12，3： | 0 |
| 20 | Comparative and population genomics of buckwheat species reveal key determinants of flavor and fertility显示文摘Common buckwheat(Fagopyrum esculentum)is an ancient crop with a world-wide distribution.Due to its excellent nutritional quality and high economic and ecological value,common buckwheat is becoming increasingly important throughout the world.The availability of a high-quality reference genome sequence and population genomic data will accelerate the breeding of common buckwheat,but the high heterozygosity due to the outcrossing nature has greatly hindered the genome assembly.Here we report the assembly of a chromosome-scale high-quality reference genome of F.esculentum var.homotropicum,a homozygous self-pollinating variant of common buckwheat.Comparative genomics revealed that two cultivated buckwheat species,common buckwheat(F.esculentum)and Tartary buckwheat(F.tataricum),underwent metabolomic divergence and ecotype differentiation.The expansion of several gene families in common buckwheat,including FhFAR genes,is associated with its wider distribution than Tartary buckwheat.Copy number variation of genes involved in the metabolism of flavonoids is associated with the difference of rutin content between common and Tartary buckwheat.Furthermore,we present a comprehensive atlas of genomic variation based on whole-genome resequencing of 572 accessions of common buckwheat.Population and evolutionary genomics reveal genetic variation associated with environmental adaptability and floral development between Chinese and non-Chinese cultivated groups.Genome-wide association analyses of multi-year agronomic traits with the content of flavonoids revealed that Fh05G014970 is a potential major regulator of flowering period,a key agronomic trait controlling the yield of outcrossing crops,and that Fh06G015130 is a crucial gene underlying flavor-associated flavonoids.Intriguingly,we found that the gene translocation and sequence variation of FhS-ELF3 contribute to the homomorphic self-compatibility of common buckwheat.Collectively,our results elucidate the genetic basis of speciation,ecological adaptation,fertility,and unique flavor of common buckwheat,and provide new resources for future genomics-assisted breeding of this economically important crop. | Kaixuan Zhang Yuqi He Xiang Lu Yaliang Shi Hui Zhao Xiaobo Li Jinlong Li Yang Liu Yinan Ouyang Yu Tang Xue Ren Xuemei Zhang Weifei Yang Zhaoxia Sun Chunhua Zhang Muriel Quinet Zlata Luthar Mateja Germ Ivan Kreft Dagmar Janovska Vladimir Meglic Barbara Pipan Milen I.Georgiev Bruno Studer Mark A.Chapman Meiliang Zhou | 2023 | Molecular Plant2023，16，9： | 0 |
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