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| 1 | A novel miR167a-OsARF6-OsAUX3 module regulates grain length and weight in rice显示文摘Grain size is one of the most important factors that control rice yield,as it is associated with grain weight(GW).To date,dozens of rice genes that regulate grain size have been isolated;however,the regulatory mechanism underlying GW control is not fully understood.Here,the quantitative trait locus qGL5 for grain length(GL)and GW was identified in recombinant inbred lines of 9311 and Nipponbare(NPB)and fine mapped to a candidate gene,OsAUX3.Sequence variations between 9311 and NPB in the OsAUX3 promoter and loss of function of OsAUX3 led to higher GL and GW.RNA sequencing,gene expression quantification,dual-luciferase reporter assays,chromatin immunoprecipitation-quantitative PCR,and yeast one-hybrid assays demonstrated that OsARF6 is an upstream transcription factor regulating the expression of OsAUX3.OsARF6 binds directly to the auxin response elements of the OsAUX3 promoter,covering a single-nucleotide polymorphism site between 9311 and NPB/Dongjin/Hwayoung,and thereby controls GL by altering longitudinal expansion and auxin distribution/content in glume cells.Furthermore,we showed that miR167a positively regulate GL and GW by directing OsARF6 mRNA silencing.Taken together,our study reveals that a novel miR167a-OsARF6-OsAUX3 module regulates GL and GW in rice,providing a potential target for the improvement of rice yield. | Jiyue Qiao Hongzhen Jiang Yuqing Lin Lianguang Shang Mei Wang Dongming Li Xiangdong Fu Markus Geisler Yanhua Qi Zhenyu Gao Qian Qian | 2021 | Molecular Plant2021，14，10： | 8 |
| 2 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 3 | Inducing Flow Velocities to Manage Fish Reproduction in Regulated Rivers显示文摘Conservation of endangered or economic fish and control of invasive fish is a great challenge of hydraulic engineering worldwide.Flow velocity has been recognized to affect the spawning of fishes delivering drifting eggs in rivers.However,solid scientific supports and associated mechanisms to establish quantitative relations between flow velocity and fish reproduction,taking into account spawning,fertilizing,hatching,as well as surviving,are lacking.In this paper,we quantified the relationship between flow velocity and reproduction of Chinese carps through both lab and field experiments.The results showed that a minimum velocity was required to trigger Hypophthalmichthys molitrix(H.molitrix)releasing eggs,and a velocity range was preferred to sustain spawning activity.However,the embryo incubation and larvae development of H.molitrix were found to be inhibited with the increase in flow velocity.Considering the requirements of spawning and hatching,as well as larvae surviving,an optimized flow velocity processes was identified for the reproduction of H.molitrix in rivers.These findings were of great significance to the adaptive operation of reservoirs to create reasonable and precise ecological flows for managing fish reproduction,as shown by the promising results in the engineering application to the Three Gorges Reservoir. | Qiuwen Chen Jianyun Zhang Yuchen Chen Kangle Mo Jun Wang Lei Tang Yuqing Lin Lei Chen Yong Gao Wei Jiang Yuxin Zhang | 2021 | Engineering2021，7，2： | 4 |
| 4 | Benthic Habitat Quality Assessment Based on Biological Indices in Xiaoqing River Estuary and Its Adjacent Sea of Laizhou Bay,China显示文摘Based on the macrofauna data(2008-2011) in Xiaoqing River estuary and its adjacent sea, Laizhou Bay of Bohai Sea, China, the AZTI Marine Biotic Index(AMBI) and Multivariate AMBI(M-AMBI) were used for benthic habitat quality(BHQ) assessment. Results showed that BHQ presented an obvious trend of improvement along the direction of stream channel and river mouth, and in the coastal areas. AMBI and M-AMBI were significantly related to environmental pressure gradient data. Therefore, the two indices can well indicate BHQ in the studied area. However, there were significant differences between results of the two indices. In the cases of low taxa number and high abundance of single species, AMBI might overestimate BHQ. We thus adjusted its thresholds to solve this problem. And M-AMBI might overestimate BHQ when benthic assemblage was dominated by the opportunistic species. Then we could raise the weight of AMBI in the calculation of M-AMBI to handle the problem. | LUO Xianxiang LIN Song YANG Jianqiang SHEN Jiayu FAN Yuqing ZHANG Longjun | 2017 | Journal of Ocean University of China2017，16，3： | 3 |
| 5 | MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation显示文摘 | Yunhui Cheng Xiaojun Liu Jian Yang Ying Lin Da-Zhong Xu Qi Lu Edwin A. Deitch Yuqing Huo Ellise S. Delphin Chunxiang Zhang | 2009 | Circulation Research2009，，2： | 2 |
| 6 | National guidelines for diagnosis and treatment of thyroid cancer 2022 in China(English version)显示文摘Contents 1. Overview 2. Diagnosis and management 2.1 Screening for high-risk group 2.2 Clinical manifestations 2.2.1 Symptoms 2.2.2 Signs 2.2.3 Invasion and metastasis 2.3 Laboratory examination 2.3.1 Routine examination 2.3.2 Special examination 2.4 Imaging 2.4.1 Ultrasonography 2.4.2 Computed tomography (CT)2.4.3 Magnetic resonance imaging (MRI)2.4.4 Positron emission tomography (PET)-CT。 | 无 Shaoyan Liu Yansong Lin Yiming Zhu Lin Gui Xiaorong Hou Ziren Kong Yuanlin Piao Yuqing Sun Hao Wang Jian Wang Bo Zhang Ye Zhang Kun Zheng | 2022 | Chinese Journal of Cancer Research2022，34，3： | 2 |
| 7 | Comments on National guidelines for diagnosis and treatment of thyroid cancer 2022 in China (English version)显示文摘Thyroid cancer (TC) is the most common endocrine system cancer, of note, the overall survival of TC in China is suboptimal when comparing with the developed countries such as US (84.3%vs.98.3%), posing a great challenge among professionals involved in this field.Standardization of its diagnosis and treatment not only provides the basis for all the care givers to promote the entire level of TC management, but also is helpful in shortening the distance between China and other developed countries. A multidisciplinary team (MDT)should be involved in the comprehensive clinical management of TC, particularly for those advanced or refractory TC, which needs cooperation among members from ultrasonography, radiology, pathology, surgery. | Hao Wang Jian Wang Xiang Wang Yiming Zhu Yuqing Sun Xin Zhang Xiaorong Hou Kun Zheng Shaoyan Liu Yansong Lin | 2022 | Chinese Journal of Cancer Research2022，34，5： | 2 |
| 8 | 奥曲肽持续皮下泵入治疗恶性肠梗阻的临床观察(英文)显示文摘Objective: The aim of the study was to observe the effectiveness of continuously subcutaneous-pumped octreotide infusion in palliative treatment of malignant bowel obstruction (MBO).Methods: Clinical data were retrospectively analyzed in 26 carcinoma patients complicated with MBO,in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,China,from March 2007 to April 2009.All 26 carcinoma patients with MBO were divided into two groups: the controlling group (CG,routine therapy,15 patients) and the octreotide group (OG,11 patients).The octreotide group received routine therapy combined with octreotide (0.3 mg/d) by 24 hours continuously subcutaneous octreotide infusion.The changes of curative effectiveness related to symptoms,the times of recovering exsufflation and defecation,the average drain of gastrointestinal drainage tube,the duration of gastrointestinal drainage tube and the rate of extubation,were observed and compared between the two groups.Results: After treatment,remarkable changing rates of MBO related symptoms were 81.8% (9/11) in OG,and 46.7% (7/15) in CG (P < 0.05).The 78% of SG and 30% of CG recovered the exsufflation and defecation,and the mean times they needed were 3.2 d and 5.8 d,respectively (P < 0.05).The durations of gastrointestinal drainage tube of OG and CG were (5 ± 1.2) d and (10 ± 2.3) d,respectively,and the rates of extubation were 54.5% and 20%,respectively.The improvement rate in the octreotide group was better than that in the controlling group and the difference was significant (72.7% and 26.7%,P < 0.05).Conclusion: The administration of octreotide in combination with routine treatment can be very effective in the treatment of MBO.It can relieve the symptoms of MBO effectively and improve the quality of life of the end-stage patients.It has provided one kind of new treating thought and method for treatment of malignant bowel obstruction. | Dongfeng Yin Yin Zhu Yuqing Xing Hong Gao Yuzhen Pan Lin Pan Guangyi Tang Xiangrong Xing Lijiang Zhou | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，1： | 2 |
| 9 | Aquaporin-1 Expressed in Cultured Human Trabecular Meshwork Cells显示文摘Objective:To determine if aquaporin-1 could be detected in cultures of human trabecularshwork cells. Methods: Using primers specific for aquaporin-1, reverse transcription combined withpolymerase chain reaction (RT-PCR) yielded a product and its size with total RNAprepared from the human trabecular meshwork cells. SDS-PAGE and immunoblottingwere also used in this study to detect the specific water channel.Results: The presence of this product and its size (298 base pairs) are consistent withthat of an aquaporin-1 message in these cells. A band of 28 kD in agreement with themolecular size of aquaporin-1 was showed in a film by immunoblotting.Conclusion: The presence of aquaporin-1 in human trabecular meshwork cells, thepredominant cell-type of the primary outflow region of the human eye, suggests that waterchannels may be involved in the movement of aqueous fluid out of the eye. In addition,the existence of aquaporin-1 on cultures of human trabecular meshwork cells provides anin vitro model to study the endogenous expression of aquaporin-1 and its possible role inthe regulation of aqueous outflow. | Mingkai Lin, Jian Ge, Yehong Zhuo, Yuqing Lan, Keming Yu, Jianliang ZhengZhongshan Ophthalmic center, Sun Yat-sen University, Guangzhou 510060, China | 2002 | Eye Science2002，18，1X： | 2 |
| 10 | Profiling of 95 MicroRNAs in Pancreatic Cancer Cell Lines and Surgical Specimens by Real-Time PCR Analysis显示文摘 | Yuqing Zhang Min Li Hao Wang William E. Fisher Peter H. Lin Qizhi Yao Changyi Chen | 2009 | World Journal of Surgery2009，，4： | 1 |
| 11 | Phacoemulsification in Patients with Secondary Glaucoma Caused by Uveitis显示文摘Purposes: To evaluate the effect of phacoemulsification in the patients with uveitis,secondary glaucoma and complicated cataract.
Methods: Phacoemulsification and implantation of a foldable intraocular len was performed in 12 patients(13 eyes) with uveitis, secondary glaucoma and complicated cataract. The complications, intraocular pressures (IOP), and visual acuity were observed postoperatively.
Results: No severe complication was found in the patients postoperatively or within the operation procedure. The visual acuity was improved after the operation ( P < 0.05) .The intraocular pressures and/or the number of antiglaucoma medications reduced in 3months of the follow-up time.
Conclusion: phacoemulsification is the best way to treat the patients with secondary glaucoma and complicated cataract caused by uveitis. Eye Science 2001; 17: 8 ~ 10. | Mingkai Lin, Jian Ge, Yizhi Liu, Yuqing Lan, Yehong ZhouZhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences. Guangzhou, 510060, China | 2001 | Eye Science2001，17，1： | 1 |
| 12 | A facile electrochemical method for simuhaneous and on-line measurements of glucose and lactate in brain microdialysate with prussian blue as the electrocatalyst for reduction of hydrogen peroxide 显示文摘 | LIN Yuqing LIU Kun MAO Lanqun | 2007 | Anal Chem2007，79，24： | 1 |
| 13 | The C161T polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPARγ) is associated with risk of coronary artery disease: a meta-analysis显示文摘 | Zhijun Wu Yuqing Lou Wei Jin Yan Liu Lin Lu Guoping Lu | 2013 | Molecular Biology Reports2013，，： | 1 |
| 14 | The Preliminary Study of Interferon-γ Gene Transfection to Human Tenon's Capsule Fibroblasts in Vitro显示文摘 | Yuqing Lan, Jian Ge, Mingkai Lin, Jianliang Zheng, Huiyi Chen, Haiquan Liu, Jing Wei , Yanyan LiZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China Sun Yat-Sen Memorial Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510120, China | 2000 | 眼科学报2000，16，3： | 1 |
| 15 | Abundance and distribution of meiofauna in the Chukchi Sea显示文摘The metazoan meiofauna in the Chukchi Sea were collected from seven shallow water stations(depths ranging 46 to 52 m) and five deep sea stations(depths ranging between 393 and 2 300 m) during the 4th Chinese National Arctic Research Expedition in 2010. The results showed that abundance of meiofauna was higher in shallow water sediments(average of 2 445 ind./(10 cm2)) than in deep sea sediments(407.06 ind./(10 cm2)). A UNIANOVA test for difference between the two different regions was highly significant(F=101.15, p<0.01). Nematodes were numerically dominant, representing(96.6±4.6)% of the total meiofaunal abundance at the shallow water stations and(98.90±1.42)% at deep sea stations. The number of higher taxonomic groups and abundance of meiofauna were higher at Stas CC1, CC4, and R06 near the Bering Strait and the continent, than at the rest of the shallow water and deep sea stations. The primary factors causing the differences were concentrations of nutrients P and Si of bottom seawater(R=0.831, p<0.003), followed by depth(R=-0.655, p<0.05) and sand fractions of sediments(R=0.632, p <0.05). The numbers of meiofauna on the 65 μm and 32 μm sieves were significantly higher than those on the rest of the screens. Differences in numbers of meiofauna retained on screens with different mesh openings were highly significant among all sampling stations(F=31.60, p<0.01). The highest numbers of individuals on screens with 32 μm mesh openings were found at deep sea stations. The number of meiofauna in the top 0–1, 1–2, and 2–4 cm segments constituted 84.4% of the total and was significantly higher than those in the bottom 4–6 and 6–10 cm segments(F=15, p<0.01). | LIN Rongcheng HUANG Dingyong GUO Yuqing CHANG Yu CAO Yinkun WANG Jianjia | 2014 | Acta Oceanologica Sinica2014，33，6： | 1 |
| 16 | A non- oxidative electrochemical approach to online measurements of dopamine release through laccase- catalyzed oxidation and intramolecular cyclization of dopamine 显示文摘 | Yuqing Lin Zipin Zhang Lingzhi Zhao | 2010 | Biosensors and Bioelectronics2010，25，： | 1 |
| 17 | Superoxide-like Cu/GO single-atom catalysts nanozyme with high specificity and activity for removing superoxide free radicals显示文摘Although nanozyme has become an emerging area of research attracting extensive attention recently,the activity and specificity of currently reported nanozymes are generally lower than those of natural enzymes.Developing highly active and specific nanozymes is therefore extremely necessary and also remains a great challenge.Superoxide dismutase(SOD)catalyzes the disproportionation of cytotoxic O_(2)·^(−)into hydrogen peroxide and oxygen,and plays an important role in reducing human oxidative stress.In this work,we prepare Cu single-atom catalysts(Cu/GO SACs,GO=graphene oxide)through a simple and low-cost strategy at room temperature using Cu foam and graphene oxide.Cu/GO SACs can maintain excellent catalytic activity under harsh environment.Compared with the natural enzyme,SOD-like Cu/GO SAC nanozyme has higher catalytic activity and meanwhile,it does not possess the common properties of other mimic enzymes often existing in nanomaterials.Based on the excellent SOD-like enzyme activity of Cu/GO SACs,it successfully eliminates the active oxygen in cigarette smoke.This work not only provides a new idea for the design and synthesis of nanozymes with excellent SOD mimetic properties,but also is promising in the treatment of lung injury and inflammatory diseases related to free radical production. | Mingju Lu Jialu Wang Guoyuan Ren Fengjuan Qin Zhiqiang Zhao Kai Li Wenxing Chen Yuqing Lin | 2022 | Nano Research2022，15，10： | 1 |
| 18 | Unprecedented Heatwave in Western North America during Late June of 2021: Roles of Atmospheric Circulation and Global Warming显示文摘An extraordinary and unprecedented heatwave swept across western North America(i.e.,the Pacific Northwest)in late June of 2021,resulting in hundreds of deaths,a massive die-off of sea creatures off the coast,and horrific wildfires.Here,we use observational data to find the atmospheric circulation variabilities of the North Pacific and Arctic-Pacific-Canada patterns that co-occurred with the development and mature phases of the heatwave,as well as the North America pattern,which coincided with the decaying and eastward movement of the heatwave.Climate models from the Coupled Model Intercomparison Project(Phase 6)are not designed to simulate a particular heatwave event like this one.Still,models show that greenhouse gases are the main reason for the long-term increase of average daily maximum temperature in western North America in the past and future. | Chunzai WANG Jiayu ZHENG Wei LIN Yuqing WANG | 2023 | Advances in Atmospheric Sciences2023，40，1： | 1 |
| 19 | Label-free and sequence-specific DNA detection down to a picomolar level with carbon nanotubes as support for probe DNA显示文摘 | Ningning Zhu Yuqing Lin Ping Yu | 2009 | Analytica Chimica Acta2009，650，： | 1 |
| 20 | On-line electrochemical measurements of cerebral hypoxanthine of freely moving rats显示文摘This study demonstrates an on-line method for continuous measurements of cerebral hypoxanthine in the freely moving rats with integration of selective electrochemical biosensing with in vivo microdialysis sampling. The selective electrochemical biosensing is achieved by using xanthine oxidase (XOD) as the specific sensing element and Prussian blue (PB) as the electrocatalyst for the reduction of H2O2 generated from the oxidase-catalyzed reaction. The method is virtually interference-free from the co-existing electroactive species in the brain and exhibits a good stability and reproducibility. Upon integrated with in vivo microdialysis, the on-line method is well suitable for continuous measurements of cerebral hypoxanthine of freely moving rats, which is illustrated by the measurements of the microdi-alysates after the hypoxanthine standard was externally infused into the rat brain. This study essentially offers a facile on-line electrochemical approach to continuous measurements of cerebral hypoxanthine and could find some interesting applications in physiological and pathological investigations associated with hypoxanthine. | ZHANG ZiPin LIN YuQing MAO LanQun | 2009 | Science China Chemistry2009，52，10： | 1 |
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