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| 1 | A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL显示文摘Bone regeneration originates from proliferation and differentiation of osteoprogenitors via either endochondral or intramembranous ossifcation;and the regeneration capacities decline with age and estrogen loss.Maillary sinus floor lifting(MSFL)is a commonly used surgical procedure for guiding bone regeneration in mailla.Radiographic analysis of 1210 clinical cases of maxilla bone regeneration after MSFL revealed that the intrasinus osteogenic eficacy was independent of age and gender,however;and this might be related to the Schneiderian membrane that lines the sinus cavity.In view of the particularity of this biological process,our present study aimed to elucidate the underlying mechanism of MSFL-induced bone regeneration.We frst established a murine model to simulate the clinical MSFL.By single cell RNA-sequencing and flow cytometry-based bulk RNA-sequencing,we identifed a novel Krt14^(+)Ctsk^(+)subset of cells that display both epithelial and mesenchymal properties and the transcriptomic feature of osteoprogenitors.Dual recombinases-mediated lineage tracing and oss-offunction analyses showed that these Krt14^(+)Ctsk^(+)progenitors contribute to both MSFL-induced osteogenesis and physiological bone homeostasis by differentiating into Krt14 Ctsk^(+)descendants which show robust osteogenic capacity.In addition,we detected a similar population of Kt14^(+)Ctsk^(+)cells in human samples of Schneiderian membrane,which show a highly similar osteogenic potential and transcriptomic feature to the corresponding cells in mice.The identifcation of this Krt14^(+)Ctsk^(+)population,featured by osteoprogenitor charateristics and dual epithelial-mesenchymal properties,provides new insight into the understanding of bone regeneration and may open more possibilities for clinical applications. | Yuteng Weng Haicheng Wang Di Wu Shuyu Xu Xiaofan Chen Jie Huang Yanhuizhi Feng Lin Li Zuolin Wang | 2022 | Cell Research2022，32，9： | 5 |
| 2 | Dispersion and support dictated properties and activities of Pt/metal oxide catalysts in heterogeneous CO oxidation显示文摘The source of activity of metal/metal oxides has always been an interesting,important but highly challenging research topic in heterogeneous catalysis.In CO oxidation reaction,this work clarifies dispersion and support dictated activities of Pt including single-atom(Pt1),2.8 nm(PtNP-S)and 36 nm(PtNP-L)Pt supported on both reducible TiO_(2) and“inert”Al_(2)O_(3) supports.The X-ray absorption fine structure(XAFS)shows that chemical state of Pt is affected by both dispersion and support:Pt1 presents fully oxidized state in both Pt1/TiO_(2) and Pt1/Al_(2)O_(3);PtNP-S in PtNP-S/TiO_(2) appear nearly oxidized state while about half of Pt is metallic state in PtNP-S/Al_(2)O_(3);PtNP-L in both PtNP-L/TiO_(2) and PtNP-L/Al_(2)O_(3) exhibit metallic state.All the Pt species supported on TiO_(2) present much lower apparent activation barriers(Eapp)than that on Al_(2)O_(3).Moreover,Pt1/TiO_(2) possesses dozen times of efficiency than PtNP-S/TiO_(2) although they have similar Eapp values.A truth is finally made clear that a reducible metal oxide with low oxygen vacancy formation energy is critical to endow Pt/metal oxide a high activity and the single-atom dispersion of Pt is the way to maximize the active sites of Pt/metal oxide. | Jiaojiao Song Yixuan Yang Shoujie Liu Lei Li Nan Yu Yuteng Fan Zhiming Chen Long Kuai Baoyou Geng | 2021 | Nano Research2021，14，12： | 1 |
| 3 | Electron-deficient Cu site catalyzed acetylene hydrochlorination显示文摘Rational design of catalytic sites to activate the C≡C bond is of paramount importance to advance acetylene hydrochlorination. Herein, Cu sites with electron-rich and electron-deficient states were constructed by controlling the impregnation solutions. The π electrons flowing from acetylene to Cu site are facilitated over the electron-deficient Cu sites, achieving high activation of C≡C bond. The contradiction between the increased activation of acetylene required for enhanced catalytic activity and the resistance of Cu site to reduction by acetylene required for maintaining catalytic stability can be balanced by establishing strong interactions of Cu site with pyrrolic-N species. The catalytic activity displays a volcano shape scaling relationship as a function of Cu particle size. Tribasic copper chloride is concomitantly generated with the construction of electron-deficient Cu sites. The H–Cl bond of HCl can be activated over the tribasic copper chloride, accelerating the surface reaction of vinyl chloride production. This strategy of inducing electron deficiency provides new insight into the rational design of catalysts for the synthesis of vinyl chloride with a high catalytic performance. | Bolin Wang Chunxiao Jin Shujuan Shao Yuxue Yue Yuteng Zhang Saisai Wang Renqin Chang Haifeng Zhang Jia Zhao Xiaonian Li | 2023 | Green Energy & Environment2023，8，4： | 0 |
| 4 | Bandgaps and vibration isolation of local resonance sandwich-like plate with simply supported overhanging beam显示文摘The concept of local resonance phononic crystals proposed in recent years provides a new chance for theoretical and technical breakthroughs in the structural vibration reduction.In this paper,a novel sandwich-like plate model with local resonator to acquire specific low-frequency bandgaps is proposed.The core layer of the present local resonator is composed by the simply supported overhanging beam,linear spring and mass block,and well connected with the upper and lower surface panels.The simply supported overhanging beam is free at right end,and an additional linear spring is added at the left end.The wave equation is established based on the Hamilton principle,and the bending wave bandgap is further obtained.The theoretical results are verified by the COMSOL finite element software.The bandgaps and vibration characteristics of the local resonance sandwich-like plate are studied in detail.The factors which could have effects on the bandgap characteristics,such as the structural damping,mass of vibrator,position of vibrator,bending stiffness of the beam,and the boundary conditions of the sandwich-like plates,are analyzed.The result shows that the stopband is determined by the natural frequency of the resonator,the mass ratio of the resonator,and the surface panel.It shows that the width of bandgap is greatly affected by the damping ratio of the resonator.Finally,it can also be found that the boundary conditions can affect the isolation efficiency. | Chenxu QIANG Yuxin HAO Wei ZHANG Jinqiang LI Shaowu YANG Yuteng CAO | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，11： | 0 |
| 5 | HSCA-Net: A Hybrid Spatial-Channel Attention Network in Multiscale Feature Pyramid for Document Layout Analysis显示文摘Document images often contain various page components and complex logical structures,which make document layout analysis task challenging.For most deep learning-based document layout analysis methods,convolutional neural networks(CNNs)are adopted as the feature extraction networks.In this paper,a hybrid spatial-channel attention network(HSCA-Net)is proposed to improve feature extraction capability by introducing attention mechanism to explore more salient properties within document pages.The HSCA-Net consists of spatial attention module(SAM),channel attention module(CAM),and designed lateral attention connection.CAM adaptively adjusts channel feature responses by emphasizing selective information,which depends on the contribution of the features of each channel.SAM guides CNNs to focus on the informative contents and capture global context information among page objects.The lateral attention connection incorporates SAM and CAM into multiscale feature pyramid network,and thus retains original feature information.The effectiveness and adaptability of HSCA-Net are evaluated through multiple experiments on publicly available datasets such as PubLayNet,ICDAR-POD,and Article Regions.Experimental results demonstrate that HSCA-Net achieves state-of-the-art performance on document layout analysis task. | Honghong Zhang Canhui Xu Cao Shi Henyue Bi Yuteng Li Sami Mian | 2023 | Journal of Artificial Intelligence and Technology2023，3，1： | 0 |
| 6 | Genome-wide identification and expression profiling reveal the diverse role of Methyl-CpG-binding domain proteins in tea plant Camellia sinensis显示文摘Methyl-CpG-binding domain(MBD)proteins are important DNA methylation readers that recognise methylated CpG sites and recruit histone deacetylase(HDAC)complexes and chromatin remodelling factors,leading to chromatin compaction,gene transcription,and genome integrity.Currently,MBD genes have only been identified in a few plant species and their structure and function in tea plants(Camellia sinensis)are unknown.In this study,16 C.sinensis MBD genes(CsMBD)were identified on a genome-wide level and classified into eight classes.The CsMBD genes were mapped on nine chromosomes in tea plants,and nine pairs of CsMBD genes existed.Based on conserved domain analysis,all of the identified CsMBD proteins contained at least one MBD domain.Expression analyses showed that CsMBD genes were expressed in tissue-and organ-specific patterns.We investigated the expression patterns of CsMBD genes in response to abiotic and biotic stresses and during different plant growth and development stages.Multiple pthytohormone and stress-related cis-acting was evaluated in their promoter region,such as GGTCA,TGACG,ABRE and LTR.Specific CsMBD genes were associated with environmental stresses and developmental stages,with little overlap.Overall,our findings reveal the diverse roles of CsMBD genes under different stress and developmental conditions,highlighting candidate genes for further functional studies on tea plants. | Yao Chen Yuteng Li Hengze Ren Jianrong Zhou Lu Wang Yajun Yang Xinyuan Hao Xinchao Wang | 2021 | Beverage Plant Research2021，1，1： | 0 |
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