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| 1 | Enhanced digestion inhibition and mucus penetration of F127-modified self-nanoemulsions for improved oral delivery显示文摘Self-nanoemulsifying systems(SNEs) have excellent ability to improve the solubility ofpoorly water-soluble drugs(PWSD). However, SNEs are likely to be degraded in gastroin-testinal(GIT) when their surface is recognized by lipase/co-lipase enzyme complex, result-ing in rapid release and precipitation of encapsulated drugs. The precipitates are then cap-tured and removed by intestinal mucus, reducing the delivery efficacy of SNEs. Herein, theamphiphilic polymer Pluronic? F127 was incorporated into long and short-chain triglyc-erides(LCT, SCT) based SNEs to diminish the recognition and therefore minimized theirdegradation by enzymes and clearance by mucus. The SNEs were characterized in termsof particle size, zeta potential and stability. Ex vivo multiple particles tracking studies wereperformed by adding particle solution into fresh rat mucus. Cellular uptake of SNEs wereconducted by using E12 cells, the absorption and distribution in small intestine were alsostudied after oral administration in male Sprague-Dawley(SD) rats. The in vitro digestionrate of SNEs were found to be in following order SCT-SNE > SCT-F127-SNE > LCT-SNE > LCT-F127-SNE. Moreover, the LCT-F127-SNE was found to be most effective in enhancing cellularuptake, resulting in 3.5-fold, 2.1-fold and 1.7-fold higher than that of SCT-SNE, LCT-SNE andSCT-F127-SNE, respectively. After incubating the SNE with E12 cells, the LCT-F127-SNE ex-hibited the highest amount regarding both mucus penetration and cellular uptake, with anuptake amount number(via bicinchoninic acid(BCA) analysis) of 3.5-fold, 2.1-fold and 1.7-fold higher than that of SCT-SNE, LCT-SNE and SCT-F127-SNE, respectively. The in vivo results revealed that orally administered LCT-F127-SNE could significantly increase the bioavailability of Cyclosporine A(CsA), which was approximately 2.43-fold, 1.33-fold and 1.80-fold higher than that of SCT-SNE, SCT-F127-SNE and LCT-SNE, respectively. We address in this work that F127-modified SNEs have potentials to improve oral drug absorption by significantly reducing gastrointestinal enzymatic degradation and simultaneously enhancing mucus penetration. | Wenyi Song Yuting Yang Miaorong Yu Quanlei Zhu Mohammadali Soleimani Damaneh Haijun Zhong Yong Gan | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，4： | 3 |
| 2 | Differences in the Rainfall Characteristics between Mount Tai and Its Surrounding Areas显示文摘As a typical small-scale, isolated topography, Mount Tai exhibits great differences in precipitation characteristics from the surrounding areas. It was found that the amount of rainfall occurring over Mount Tai is significantly larger than what is observed in the surrounding areas. Based on hourly rain gauge records for the warm season(May to September) of 1996–2015, differences between Mount Tai and its surrounding areas were further revealed in terms of rainfall diurnal variation, spatial scale, and evolution process. The diurnal variation of the enhancement on rainfall amount exhibit 'dual peaks' occurring in the early morning and afternoon, and the dual peaks are mainly attributable to rainfall frequency. The diurnal phase of the rainfall amount in the surrounding areas lags 1 h behind that over Mount Tai. Regarding differences in rainfall spatial scale, compared to those of surrounding areas, precipitation over Mount Tai is characterized by a smaller coverage, especially in the early morning. Mount Tai also tends to have a kind of unique, small-scale rainfall in the afternoon and at night. Based on statistical analysis of precipitation events,differences in rainfall evolution process were identified as well. Rainfall over Mount Tai often starts earlier in the afternoon and ends later at night than it does in the surrounding areas. Furthermore, nocturnal rainfall events over Mount Tai are prone to peaking over a shorter period and enduring for a longer period after reaching their maximum intensity, compared with nocturnal rainfall events occurring in the surrounding areas. Rainfall events over Mount Tai always last longer, especially those occurring in the early morning. In general, Mount Tai has a large enhancement effect on rainfall. | Yuting GAN Nina LI Jian LI | 2019 | Journal of Meteorological Research2019，33，5： | 3 |
| 3 | Enhancement of MoTe2 near-infrared absorption with gold hollow nanorods for photodetection显示文摘Infrared(IR)light photodetection based on two dimensional(2D)materials of proper bandgap has attracted increasing attention.However,the weak IR absorption in 2D materials,due to their ultrathin attribute and indirect bandgap in multilayer structures,degrades their performance when used as IR photodetectors.In this work,we utilize the fact that few-layer MoTe2 flake has a near-IR(NIR)bandgap and demonstrate a^60-fold enhancement of NIR response by introducing a gold hollow nanorods on the surface.Such gold hollow nanorods have distinct absorption peak located also at the NIR regime,therefore induces strong resonance,benefitting NIR absorption in MoTe2,resulting in strong near-field enhancement.With the evidence from steady and transient state optical spectra,we confirm that the enhancement of NIR response originates only photon absorption,rather than electron transport at interfaces as observed in other heterostructures,therefore,precluding the requirement of high-quality interfaces for commercial applications. | Jiawen You Ye Yu Kai Cai Dongming Zhou Haiming Zhu Renyan Wang Qingfu Zhang Hongwei Liu Yuting Cai Dong Lu Jang-Kyo Kim Lin Gan Tianyou Zhai Zhengtang Luo | 2020 | Nano Research2020，13，6： | 1 |
| 4 | A nonenzymatic electrochemical sensor for the detection of hydrogen peroxide in vitro and in vivo fibrosis models显示文摘Fibrosis occurs due to the excessive deposition of extracellular matrix caused by cell injury.After various types of tissue injury,the dysregulation of the internal response can eventually lead to the destruction of organ structure and dysfunction.There is increasing evidence that oxidative stress,which is characterized by excessive production of hydrogen peroxide(H_(2)O_(2)),is an important cause of fibrosis.Therefore,we synthesized a biosensitive and efficient electrochemical H_(2)O_(2)sensor based on PtNi nanoparticle-doped N-reduced graphene oxide(PtNi-N-rGO)to detect H_(2)O_(2)released from transforming growth factorβ1(TGFβ1)-induced myofibroblast.In addition,the sensor could easily detect changes in H_(2)O_(2)in the lung and bronchoalveolar lavage fluid(BALF)of mice with pulmonary fibrosis.Furthermore,the sensor could also detect H_(2)O_(2)in activated hepatic stellate cells and the liver of carbon tetrachloride(CCl_(4))-induced liver fibrosis.Moreover,the alterations in H_(2)O_(2)detected by the sensor were consistent with nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)protein expression and the staining results of pathological sections.Taken together,these results highlight the use of H_(2)O_(2)sensors for the rapid detection of fibrosis and facilitate the rapid evaluation of antifibrotic drug candidates. | Hongyao Liu Yan Yu Taixiong Xue Cailing Gan Yuting Xie Doudou Wang Peilin Li Zhiyong Qian Tinghong Ye | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 5 | A Secure Supply of Antiretroviral Medicines for People Living with HIV During the COVID-19 Pandemic—China’s Experience显示文摘The occurrence of acute infectious diseases or severe natural disasters has a negative impact on the medical system(1).A survey of 105 countries by the World Health Organization(WHO)from March to June 2020 found that health services were disrupted in 90%of countries due to the coronavirus disease 2019(COVID-19)pandemic,with low-and middle-income countries being the most affected.Human immunodeficiency virus(HIV)treatment continuity and healthcare service delivery were also affected by the COVID-19 pandemic(2–3). | Yan Zhao Mengjie Han Yuting Lian Qiang Wang Xiumin Gan Lan Yu Chuntao Ma | 2022 | China CDC weekly2022，4，38： | 0 |
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