| 5 | Non-coding RNAs and stem cells:the dream team for neural regeneration in Parkinson’s disease?显示文摘Parkinson’s disease(PD)is a widely spread neurodegenerative movement disorder,affecting approximately 10 million people worldwide.It is primarily caused by the loss of dopaminergic neurons in the substantia nigra,which causes decreased secretion of dopamine leading to tremors,bradykinesia and rigid muscle movement.The development of PD is complex and needs to be better understood.Current treatment strategies primarily involve targeting disease symptoms,however,since there is a continuous loss of dopaminergic neurons in the brain,PD appears to be incurable.Moreover,treatment strategies often carry severe side effects related to dopamine production,where too little or too much can cause debilitating issues such as dyskinesia.The pool of neural stem/progenitor cells(NSCs)located in sub-ventricular zone and hippocampal dentate gyrus,proliferate and are responsible to give rise to neurons and glia in response to any cellular damage.Though this activation of NSCs is highly regulated,it is insufficient to overcome the loss of dopaminergic neurons in PD.In this line,non-coding RNAs(ncRNAs)are involved in the underlying mechanisms of PD and are known to have important functional roles in neural regeneration(Acharya et al.,2020).Thus,the study of ncRNAs in NSC activation and adult neurogenesis post PD development is an extremely attractive area of research with significant clinical application potential. | Shubhra Acharya Andrew I.Lumley Yvan Devaux | 2021 | Neural Regeneration Research2021，16，10： | 0 |
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