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| 1 | Pam3CSK4 enhances adaptive immune responses to recombinant Mycobacterium bovis bacille Calmette-Guérin expressing Plasmodium falciparum C-terminus merozoite surface protein-1显示文摘Objective: To determine the effects of toll-like receptor 2(TLR-2) agonist, Pam3 CSK4, on cellular and humoral immune response against recombinant Mycobacterium bovis bacille Calmette-Guérin(rBCG) expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum.Methods: Six groups of mice(n=6 per group) received intraperitoneal phosphate buffered saline T80(PBS-T80), BCG or rBCG in the presence or absence of Pam3 CSK4. Enzymelinked immunosorbent assay was carried out to measure serum total IgG, IgG1, IgG2 a, and Ig G2 b production. Spleens were also harvested and splenocytes were co-cultured with rBCG antigen for in vitro determination of IL-4 and IFN-γ via enzyme-linked immunosorbent assay.Results: The production of total IgG and the isotype IgG1, IgG2 a and IgG2 b was significantly higher in rBCG-immunised mice than in the BCG and PBS-T80-immunised mice, and Pam3 CSK4 further enhanced their productions. A similar pattern was also observed in IFN-γ production. Moreover, there was no significant difference in IL-4 production in all groups either in the presence or absence of Pam3 CSK4.Conclusions: We present evidence of the adjuvant effects of TLR-2 agonist in enhancing the production of total IgG, IgG1, IgG2 a, IgG2 b, as well as IFN-γ in response to rBCG. However, the presence or absence of Pam3 CSK4 had no effect on IL-4 production. | Mohamed H Abdikarim Muhammad A Abbas Munirah N Zakaria Robaiza Zakaria Rapeah Suppian | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，7： | 3 |
| 2 | Recurrent laryngeal nerve injury in thyroid surgery显示文摘 | ZAKARIA H M AL AWAD N A AL KREEDES A S | 2011 | Oman Med J2011，26，1： | 1 |
| 3 | 显示文摘 | HUTCHINSON J P ZAKARIA P BOWLE A MACKA M AVDALOVIC N HADDAD P R | 2005 | Anal Chem2005，77，2： | 1 |
| 4 | Water balance :case study of a constructed wetland as part of the bio-ecologicaldrainage system ( BIOECODS ) 显示文摘 | Ayub K R Zakaria N A Abdullah R | 2010 | Water Science andTechnology2010，62，8： | 1 |
| 5 | Genetic Programming to Predict Bridge Pier Scour 显示文摘 | Azamathuila H M Ghani A A Zakaria N A | 2010 | Journal of Hydraulic Engineering2010，136，3： | 1 |
| 6 | Application of geoaccumulation index and enrichment factors on the assessment of heavy metal pollu- tion in the sediments显示文摘 | Shafie N A Aris A Z Zakaria M P | 2013 | Journal of Environmental Science and Health Part A Toxic Hazardous Substances & Environmental Engineering2013，48，2： | 1 |
| 7 | Synthesis and characterization of molecularly imprinted polymer membrane for the removal of 2,4-dinitrophenol 显示文摘 | YUSOF N A ZAKARIA N D MAAMOR N A | 2013 | International Journal of Molecular Sciences2013，14，： | 1 |
| 8 | Working together apart?Building a knowledge-sharing culture for global virtual teams显示文摘 | Zakaria N Amelinckx A Wilemon D | 2004 | Creativity and Innovation Management2004，13，1： | 1 |
| 9 | In vivo Antinociceptive and Anti-inflammatory Activities of Dried and Fermented Processed Virgin Coconut Oil 显示文摘 | Zakaria Z A Somchit M N | 2011 | Medi- cal Principles and Practice2011，20，3： | 1 |
| 10 | Effect of Mn doping on structural and optical properties of SnO2 nanoparticles prepared by mechanochemical processing 显示文摘 | SABRI N S DENI M S M ZAKARIA A | 2012 | Phys Proceda2012，25，： | 1 |
| 11 | Application of geoaccumulation index and enrichment factors on the assessment of heavy metal pollution in the sediments 显示文摘 | Shafie N A Afis A Z Zakaria M P | 2013 | Journal of Environmental Science and Health Part A: Toxic/Hazardous Substances and Environmental Engineering2013，48，2： | 1 |
| 12 | Recurrent laryngeal nerve injury in thyroid surgery显示文摘 | ZAKARIA H M AL AWAD N A AL KREEDES A S | 2011 | Oman Med J2011，26，： | 1 |
| 13 | As- sessment of antioxidant activity, total phenolic content and in - vitro toxicity of Malaysian red seaweed, Acanthophora spicifera显示文摘 | ZAKARIA N A IBRAHIM D SULAIMAN S F | 2011 | Journal of Chemical and Pharmaceutical Re- search2011，3，3： | 1 |
| 14 | Recurrent laryngeal nerve injury in thyroid surgery显示文摘 | Zakaria H M M Awad N A A1 Kreedes A S | 2011 | Oman Med J2011，26，1： | 1 |
| 15 | Arterial stiff: ness, inflammatory and pro-atherogenic markers in ges- tational diabetes mellitus 显示文摘 | Salmi A A Zaki N M Zakaria R | 2012 | Vasa2012，41，2： | 1 |
| 16 | Synthesis and Evaluation of a Molecularly Imprinted Polymer for 2,4-Dinitrophenol显示文摘 | Zakaria N D Yusof N A HaronJ | 2009 | J Mol Sci2009，10，1： | 1 |
| 17 | Recurrent laryngeal nerve injury in thyroid surgfeery显示文摘 | ZAKARIA H M AL AWAD N A AL KREEDES A S | 2011 | Oman Med J2011，26，： | 1 |
| 18 | Communication security using chaotic generator,Circuits and Systems显示文摘 | A A Elkouny N S Zakaria M I Sobhy | 2002 | IEEE 20022002，1，： | 1 |
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