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| 1 | drug-induced autoimmune liver disease:a diagnostic dilemma of an increasingly reported disease显示文摘The aetiology of autoimmune hepatitis(AIH) is uncer-tain but the disease can be triggered in susceptible patients by external factors such as viruses or drugs.AIH usually develops in individuals with a genetic back-ground mainly consisting of some risk alleles of the major histocompatibility complex(HLA).Many drugs have been linked to AIH phenotypes,which sometimes persist after drug discontinuation,suggesting that they awaken latent autoimmunity.At least three clini-cal scenarios have been proposed that refers to drug- induced autoimmune liver disease(DIAILD):AIH with drug-induced liver injury(DILI); drug induced-AIH(DI-AIH); and immune mediated DILI(IM-DILI).In addi-tion,there are instances showing mixed features of DI-AIH and IM-DILI,as well as DILI cases with positive autoantibodies.Histologically distinguishing DILI from AIH remains a challenge.Even more challenging is the differentiation of AIH from DI-AIH mainly relying in histological features; however,a detailed standard-ised histologic evaluation of large cohorts of AIH and DI-AIH patients would probably render more subtle features that could be of help in the differential diag-nosis between both entities.Growing information on the relationship of drugs and AIH is being available,being drugs like statins and biologic agents more fre-quently involved in cases of DIAILD.In addition,there is some evidence on the fact that patients diagnosed with DIAILD may have had a previous episode of hepa-totoxicity.Further collaborative studies in DIAILD will strengthen the knowledge and understanding of this intriguing and complex disorder which might represent different phenotypes across the spectrum of | Agustin Castiella Eva Zapata M Isabel Lucena Raúl J Andrade | 2014 | World Journal of Hepatology2014，6，4： | 13 |
| 2 | Mid-domain models of spe- cies richness gradients: assumptions, methods and evidence 显示文摘 | Zapata F A Gaston K J Chown S L | 2003 | Journal of Animal Ecology2003，72，： | 1 |
| 3 | Polyamines induced by hot water treatments reduce chilling injury and decay in pepper fruit显示文摘 | GONZALEZ-AGUILAR G A GAYOSSO L CRUZ R GUILLEN F VALVERDE J M ZAPATA P J SERRANO M VALERO D | 2000 | Postharvest Biology and Technology2000，18，： | 1 |
| 4 | Detection of Arbitrary Planar Shapes with 3D Pose显示文摘 | Cozar J R Guil N Zapata E L | 2001 | Image and Vision Computing2001，19，14： | 1 |
| 5 | Dy- namics of glyphosate and aminomethylphosphonic acid in a forest soil in Galicia, north - west Spain 显示文摘 | Veiga F Zapata J M Fernandez Mareos M L | 2001 | Sei Total Environ2001，27，： | 1 |
| 6 | Topical use of ra-pamycin in herpetic stromal keratitis显示文摘 | ZAPATA G RACCA L TAU J BERRA A | 2012 | Ocul Immunol In-JZamm2012，20，5： | 1 |
| 7 | Oil absorption of talc minerals and dispersant demand of talc mineral non-aqueous dispersions as a function of talc content: A surface chemistry approach 显示文摘 | HERLEY C JOSEE A O ZAPATA J L | 2007 | Colloids and Surfaces A : Physicochem Eng Aspects2007，299，123： | 1 |
| 8 | Dynamics of glyphosate and aminomethylphosphonic acid in a forest soil in Galicia, north-west Spain显示文摘 | Veiga F Zapata J M Fernandez M L | 2001 | Sci Total Environ2001，27，： | 1 |
| 9 | Tumor markers in lung cancer:does the method of obtaining the cut-off point and reference population influence diagnostic yield?显示文摘 | Pin T C Zapata I T Lpez J B | 1999 | Clin Biochem1999，32，6： | 1 |
| 10 | Activation of subthalamic alpha 2 noradrenergic receptors induces motor deficits as a consequence of neuronal burst firing 显示文摘 | Delaville C Zapata J Cardoit L | 2012 | Neurobiol Dis2012，47，3： | 1 |
| 11 | Early T cell development can be traced in rat fetal liver显示文摘 | Alonso-C L M M J Zapata A G | 2000 | EurJ Immunol2000，30，12： | 1 |
| 12 | Detection of Arbitrary Planar Shapes with 3D Pose显示文摘 | Cozar J R Guil N Zapata E L | 2001 | Image and Vision Computing2001，19，14： | 1 |
| 13 | A fast Hough transform for segment detection 显示文摘 | Guil N Villaba J Zapata E L | 1995 | IEEE Transactions on image processing1995，4，11： | 1 |
| 14 | Separation of chlorophylls and carotenoids from marine phytoplankton:A new HPLC method using a reversed phase C8 column and pyridinecontaining mobile phases显示文摘 | ZAPATA M RODR(I)GUEZ F GARRIDO J L | 2000 | Marine Ecology Progress Series2000，195，： | 1 |
| 15 | A low- latency pipelined 2D and 3D CORDIC processors显示文摘 | Antelo E Villalba J Zapata E L | 2008 | IEEE Transactions on Computers2008，57，3： | 1 |
| 16 | A low-latency pipelined 2D and 3D CORDIC processors 显示文摘 | Antelo E Villalba J Zapata E L | 2008 | IEEE Transactions on Computers2008，57，3： | 1 |
| 17 | Separation of chlorophylls and carotenoids from marine phytoplankton: a new HPLC method using a reversed phase C-8 column and pyridine-containing mobile phases 显示文摘 | Zapata M Rodriguez F Garrido J L | 2000 | Marine Ecology Progress Series2000，195，： | 1 |
| 18 | Separation of chlorophylls and carotenoids from marine phytopl- ankton: a new HPLC method using a reversed phase C-8 column and pyridine-containing mobile phases显示文摘 | Zapata M Rodriguez F Garrido J L | 2000 | Marine Ecology Progress Series2000，195，： | 1 |
| 19 | A fast hough transform for segment detection显示文摘 | GUIL NVILLALBA JZAPATA E L | 1995 | IEEE Transaction on1995，4，11： | 1 |
| 20 | Separation of chlorophylls and carotenoids from marine mobile phases显示文摘 | Zapata M Rodriguez F Garrido J L | | 0，，： | 1 |
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