|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants显示文摘Abscisic 酸(骆驼毛的织物) 是最重要的荷尔蒙让植物抵抗干旱和另外的不能生活的压力。骆驼毛的织物直接绑在骆驼毛的织物受体的 PYR/PYL 家庭,导致类型 2C 磷酸酶(PP2C ) 和下游的骆驼毛的织物发信号的激活的抑制。骆驼毛的织物由小分子发信号的干预能帮助植物克服象干旱,寒冷和土壤咸度那样的不能生活的压力,这被想象。然而,由植物酶的化学不稳定性和快速的分解代谢限制骆驼毛的织物本身的实际申请。这里,我们报导一件小分子骆驼毛的织物的鉴定模仿(AM1 ) 那充当骆驼毛的织物受体的家庭的多重成员的有势力使活跃之物。在 Arabidopsis, AM1 激活高度类似于由骆驼毛的织物导致了那的一个基因网络。有 AM1 的处理禁止种子萌芽,阻止叶水损失,并且支持干旱抵抗。我们与 PYL2 骆驼毛的织物受体和 HAB1 PP2C 在建筑群解决了 AM1 的水晶结构,它表明 AM1 调停交往的 gate-latch-lock 网络,在骆驼毛的织物界限 receptor/PP2C 建筑群被保存的一个结构的特征。一起,这些结果证明一件单个小分子骆驼毛的织物模仿能激活多重骆驼毛的织物受体并且保护植物免受水损失和干旱应力的伤害。而且, AM1 复杂水晶结构为设计 ABA-mimicking 小分子的下一代提供一个结构的基础。 | Minjie Cao Xue Liu Yan Zhang Xiaoqian Xue X EdwardZhou Karsten Melcher Pan Gao Fuxing Wang Liang Zeng Yang Zhao Pan Deng Dafang Zhong Jian-Kang Zhu H Eric Xu Yong Xu | 2013 | Cell Research2013，23，8： | 17 |
| 2 | 低剂量利福昔明可预防肝硬化失代偿期患者的并发症并提高生存率显示文摘利福昔明已被推荐作为肝性脑病(HE)和自发性细菌性腹膜炎(SBP)的预防药物。该研究旨在探讨低剂量利福昔明是否能预防肝硬化患者的整体并发症和延长生存期。在这项多中心随机开放标签的前瞻性研究中,200例失代偿期肝硬化患者按1∶1的比例随机分配。利福昔明组患者给予利福昔明400 mg,每日2次,疗程6个月,其余治疗策略在两组患者中尽量保持不变。主要疗效终点是总并发症发生率和无肝移植生存率。次要终点是各种主要肝硬化相关并发症的发生率,以及Child-Pugh评分和分级。 | ZENG X SHENG X WANG PQ 朱玉凡 牛俊奇 | 2021 | 临床肝胆病杂志2021，37，3： | 15 |
| 3 | Stereoselective propranolol metabolism in two drug induced rat hepatic microsomes显示文摘AIM To study the influence of inducers BNFand PB on the stereoselective metabolism ofpropranolol in rat hepatic microsomes.METHODS Phase Ⅰ metabolism of propranololwas studied by using the microsomes induced byBNF and PB and the non-induced microsome asthe control.The enzymatic kinetic parameters ofpropranolol enantiomers were calculated byregression analysis of Lineweaver-Burk plots.Propranolol concentrations were assayed byHPLC.RESULTS A RP-HPLC method was developed todetermine propranolol concentration in rathepatic microsomes.The linearity equations forR(+)-propranolol and S(-)-propranolol wereA=705.7C+311.2C(R = 0.9987)and A= 697.2C+311.4C(R = 0.9970)respectively.Recoveriesof each enantiomer were 98.9%,99.5%,101.0%at 60 μmol/L,120 μmol/L,240 μmol/Lrespectively.At the concentration level of120 μmol/L,propranolol enantiomers weremetabolized at different rates in differentmicrosomes.The concentration ratio R(+)/S(-)of control and PB induced microsomesincreased with time,whereas that of microsomeinduced by BNF decreased.The assayed enzymeparameters were:1.Km.Control group:R(+)30+8,S(-)18+5;BNFgroup:R(+)34+3,S(-)39±7;PB group:R(+)38±17,S(-)36±10.2.Vmax.Control group:R(+)1.5+0.2,S(-)2.9±0.3;BNF group:R(+)3.8±0.3,S(-)3.3±0.5;PB group:R(+)0.07±0.03,S(-)1.94±0.07.3.Clint.Control group:R(+)60±3,S(-)170±30;BNF group:R(+)111.0±1,S(-)84± 5;PBgroup:R(+)2.0±2,S(-)56.0±1.Theenzyme.parameters compared with unpaired ttests showed that no stereoselectivity wasobserved in enzymatic affinity of threemicrosomes to enantiomers and their catalyticabilities were quite different and hadstereoselectivities.Compared with the control,microsome induced by BNF enhanced enzymeactivity to propranolol R(+)-enantiomer,andmicrosome induced by PB showed less enzymeactivity to propranolol S(-)-enantiomer whichremains the same stereoselectivities as that ofthe control.CONCLUSION Enzyme activity centers of themicrosome were changed in composition andregioselectivity after the induction of BNF andPB,and the stereoselectivities of propranololcytochrome P450 metabolism in rat hepaticmicrosomes were likely due to thestereoselectivities of the catalyzing function inenzyme.CYP1A subfamily induced by BNFexhibited pronounced contribution to propranololmetabolism with stereoselectivity to R(+)-enantiomer.CYP2B subfamily induced by PBexhibited moderate contribution to propranololmetabolism,but still had the stereoselectivity ofS(-)-enantiomer. | Li X Zeng S | 2000 | World Journal of Gastroenterology2000，6，1： | 4 |
| 4 | Role and pitfalls of hepatic helical multi-phase CT scanning in differential diagnosis of small hemangioma and small hepatocellular carcinoma显示文摘RoleandpitfalsofhepatichelicalmultiphaseCTscanningindiferentialdiagnosisofsmalhemangiomaandsmalhepatocelularcarcinomaYANFuH... | YAN FuHua1, ZENG MengSu1 and ZHOU KangRong1Keywords liver neoplasms/radiography carcinoma, hepatocellular/radiography hemangioma/radiography diagnosis, differential tomography, Xray computed | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 5 | ALIZEXOL A.A NOVEL PROTOSTANE TYPE OF TRITERPENE FROM ALISMA ORIENTALIS(SAM).JUZEP显示文摘ALIZEXOLA.ANOVELPROTOSTANETYPEOFTRITERPENEFROMALISMAORIENTALIS(SAM).JUZEP￥LUZENG;XIANPENANDRUYIZHANG(DepartmentofPhytochemist... | Zeng, L Pen, X Zhang, RY | 1995 | Chinese Chemical Letters1995，6，8： | 4 |
| 6 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 7 | Alkane-assisted adsorption and assembly of phthalocyanines and porphyrins显示文摘 | Qiu X H Wang C Zeng Q D | | 0，，： | 2 |
| 8 | Periodic output feedback stabilization of neutral systems 显示文摘 | Tarn T J Yang T Zeng X | 1996 | IEEE Tran Automat Contr1996，41，4： | 2 |
| 9 | Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation 显示文摘 | Zeng J Yang L X Liang Q Z | 2005 | J Controlled Release2005，105，12： | 1 |
| 10 | Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain-potential function of a novel receptor 显示文摘 | Hong Y Dai P Jiang J Zeng X | 2004 | Br J Pharmacol2004，141，： | 1 |
| 11 | Electroless Ni-P coating of cenospheres using silver nitrate activator 显示文摘 | Zeng A X Xiong W H Xu J | 2005 | Surface&Coatings Technology2005，197，23： | 1 |
| 12 | Comparison of the changes of membrane protective system in rice seedlings during enhancement of chilling resistance by different stress pretreatment显示文摘 | Zeng S X Wang Y R Li M R | 1997 | Acta Botanica Sinica1997，39，： | 1 |
| 13 | Effects of homocysteine on murine splenic B lymphocyte proliferation and its signal transduction mechanism显示文摘 | Zeng X Guo J | 2001 | Cardiovasc Res2001，52，2： | 1 |
| 14 | Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis显示文摘 | Chen J Miller YI | 2005 | J Lipid Res2005，46，： | 1 |
| 15 | , The Concentrations and Distribution of Polycyclic Musks in a Typical Cosmetic Plant 显示文摘 | Chen D H Zeng X Y Sheng Y Q | 2007 | Chemosphere2007，66，2： | 1 |
| 16 | An ANN-based multilevel classification approach using decomposed input space for transient stability assessment显示文摘 | Tso S K Gu X P Zeng Q Y | 1998 | Electric Power Systems Research1998，46，3： | 1 |
| 17 | The role of the basal ganglia and cerebellum in cognitive impairment : a study using event-related potentials 显示文摘 | Hirata K Tanaka H Zeng X H | 2006 | Clin Neurophysiol2006，59，1： | 1 |
| 18 | Inverse Molecular WeightDependence of Cloud Points for Aqueous Poly (Nisopropylacrylamide) Solutions显示文摘 | TONG Z ZENG F ZHENG X | 1999 | Macromolecules1999，32，13： | 1 |
| 19 | Seroprevalenee of neospora caninum Infection in Dairy Cattle of Southern China 显示文摘 | Xia H Y Zhou D H Jia K Zeng X B | 2010 | J Parasitol2010，9，1： | 1 |
| 20 | Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients显示文摘 | Liang Z Zeng X Gao J | 2008 | Bmc Cancer2008，8，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员