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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Research on optimal immunization strategies for hepatitis B in different endemic areas in China显示文摘INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis B.It is important o determine optimal immunization | Li H Wang L Wang SS Gong J Zeng XJ Li RC Nong Y Huang YK Chen XR Huang ZN | 2000 | World Journal of Gastroenterology2000，6，3： | 9 |
| 4 | Subtyping Animal Influenza Virus with General Multiplex RT-PCR and Liquichip High Throughput (GMPLex)显示文摘This study developed a multiplex RT-PCR integrated with luminex technology to rapidly subtype simultaneously multiple influenza viruses. Primers and probes were designed to amplify NS and M genes of influenza A viruses HA gene of H1, H3, H5, H7, H9 subtypes, and NA gene of the N1 and N2 subtypes. Universal super primers were introduced to establish a multiplex RT-PCR (GM RT-PCR). It included three stages of RT-PCR amplification, and then the RT-PCR products were further tested by LiquiChip probe, combined to give an influenza virus (IV) rapid high throughput subtyping test, designated as GMPLex. The IV GMPLex rapid high throughput subtyping test presents the following features: high throughput, able to determine the subtypes of 9 target genes in H1, H3, H5, H7, H9, N1, and N2 subtypes of the influenza A virus at one time; rapid, completing the influenza subtyping within 6 hours; high specificity, ensured the specificity of the different subtypes by using two nested degenerate primers and one probe, no cross reaction occurring between the subtypes, no non-specific reactions with other pathogens and high sensitivity. When used separately to detect the product of single GM RT-PCR for single H5 or N1 gene, the GMPLex test showed a sensitivity of 10-5(= 280ELD50) forboth tests and the Luminex qualitative ratio results were 3.08 and 3.12, respectively. When used to detect the product of GM RT-PCR for H5N1 strain at the same time, both showed a sensitivity of 10-4(=2800 ELD50). The GMPLex rapid high throughput subtyping test can satisfy the needs of influenza rapid testing. | Zhi-feng Qin Jie Sun Ti-kang Lu Shao-ling Zeng Qun-yi Hua Qing-yan Ling Shu-kun Chen Jian-qiang Lv Cai-hong Zhang Bing Cheng Zhou-xi Ruan Ying-zuo Bi Joseph J Giambrone Hong-zhuan Wu | 2012 | Virologica Sinica2012，27，2： | 8 |
| 5 | BNIP3 is essential for mediating 6-thioguanine- and 5-fluorouracil-induced autophagy following DNA mismatch repair processing显示文摘DNA 失配修理(MMR ) 与象 6-thioguanine (6-TG ) 和 5 氟尿嘧啶(5-FU ) 那样的临床上重要的 nucleoside 类似物处理化学上导致的错误对追随者处理。这些药处理的 MMR 为不可弥补的 DNA 损坏为修理和 apoptosis 或 autophagy 的以后的正式就职在延长 G2/M 房间周期拘捕的激活被含有。在这研究,我们在 autophagy,和在 G2/M 房间周期拘捕之间的时间的关系的激活和 6-TG 和 5-FU 处理的调停 BNIP3 的 autophagy 追随者 MMR 的激活调查了 Bcl2 和侵入人体气管粘膜的病菌 E1B Nineteen-kilodalton 交往蛋白质(BNIP3 ) 的角色。我们发现 BNIP3 蛋白质层次是在一个 MLH1 (MMR+) 依赖者的 upregulated 方式追随者 6-TG 和 5-FU 处理。随后的小介入的 RNA (siRNA ) 调停了 BNIP3 击倒废除 6-TG-induced autophagy。我们也发现击倒的 p53 或由 rapamycin cotreatment 的 mTOR 活动的抑制损害 6-TG- 和 BNIP3 蛋白质层次和 autophagy 的 5-FU-induced upregulation。而且,检查点 kinase 的抑制 1 (Chk1 ) 有在由 Chk1 siRNA 的 6-TG-induced G2/M 房间周期拘捕的随后的减小的表示支持 6-TG-induced autophagy 的程度。这些调查结果建议 BNIP3 调停以一种 p53 依赖、 mTOR 依赖的方式的 6-TG- 和 5-FU-induced autophagy。另外,激活 Chk1 的 G2/M 房间周期拘捕的持续时间决定这些 nucleoside 类似物处理的 autophagy 追随者 MMR 的水平。 | Xuehuo Zeng | 2010 | Cell Research2010，20，6： | 4 |
| 6 | JWA regulates melanoma metastasis by integrin alpha(V)beta(3) signaling(摘要)显示文摘 | Bai, J Zhang, J Wu, J Shen, L Zeng, J Ding, J Wu, Y Gong, Z Li, A Xu, S Zhou, J Li, G | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 7 | Living high training low induces physiological cardiac hypertrophy accompanied by down-regulation and redistribution of the renin-angiotensin system显示文摘 | Wei SHI J Gary MESZAROS Shao-ju ZENG Ying-yu SUN Ming-xue ZUO | 2013 | Acta Pharmacologica Sinica2013，34，3： | 4 |
| 8 | Expression of matrix metallo-proteinase-28 in human normal cytotrophoblast cells and a choriocarcinoma cell line,JEG-3显示文摘There are striking similiarities present between the behavior of invasive placentaL cells and that of invasive cancer cells. Matrix metalloproteinases (MMPs) are one of the most important mediators. MMP-28, the new member of MMPs, was sequenced and identified recently. Expression of MMP-28 mRNA and protein in the cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 cell, was conducted by zymography, RT-PCR and Northern blot. There is MMP-28 mRNA expression in both the cytotrophoblast cells and JEG-3 cells by RT-PCR. The activity of MMP-28 in cytotrophoblast cells was significantly weaker than that in JEG-3 (P < 0.01) by zymography. Furthermore, mRNA expression of MMP-28 was significantly stronger (P < 0.001) in JEG-3 than in human cytotrophoblast cells in a time-dependent way by Northern Blot. Our results suggest that MMP-28 may play a role in some of the tissue-remodeling events associated with normal pregnancy and tumor progression. | Zhang, J Cao, YJ Liu, WM Zhao, BS Zeng, GQ Duan, EK | 2002 | Chinese Science Bulletin2002，47，9： | 4 |
| 9 | Periodic output feedback stabilization of neutral systems 显示文摘 | Tarn T J Yang T Zeng X | 1996 | IEEE Tran Automat Contr1996，41，4： | 2 |
| 10 | Expression of heavy-chain variable domain of mAb against Encephalitis Type B virus in transgenic tobacco显示文摘SINCE the first report on immunoglobulin gene expression in plant by Hiatt et al. in 1989,analogous researches have been further developed. Up to now, it has become a new method touse transgenic plants and plant cells to produce antibodies and study disease-resistance breedingof crops, plant metabolism and growth, which is an organic combination of immunologyand plant sciences at molecular level. According to recent reports, both higher and lowerplants, such as tobacco, Arabidopsis, calli of maize and unicellular green alga, can | Wu, YQ Xiong, XM Zeng, JZ Zhang, J Wang, DJ Huang, HL | 1997 | Chinese Science Bulletin1997，42，12： | 2 |
| 11 | 中国女性孕期抑郁孕晚期发生率与影响因素显示文摘采用横截面研究分析了中国人群中孕晚期的抑郁发生率与影响因素。本研究通过一间妇女儿童健康医院登记记录募集研究对象。测量量表包括中文版抑郁自评量表,艾森克人格问卷,社会支持评定量表和简化版应对策略问卷。292名研究对象中,抑郁症状检出率为28.5%。 | Zeng Y Cui Y Li J 张继 | 2017 | 中华预防医学杂志2017，51，2： | 2 |
| 12 | CT Scanning For the Evaluation of Cervical Spine Trauma.显示文摘Thirty-three cases of cervical spine fractures were inenti-fied among 51 cases undergoing GT of the cervical spine fol- | Zeng Youlu et al. Dept Radiology China-Japan Friendship Hospital. Beijing 100029. Chin J Orth | 1995 | Chinese Medical Journal1995，，11： | 2 |
| 13 | Gas-phase transformations of mercury in coal-fired power plants显示文摘 | Constance L Senior Adel F Sarofim Taofang Zeng Joseph J Helble Ruben Mamani-Paco | 2000 | Fuel Processing Technology2000，，2： | 2 |
| 14 | Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation 显示文摘 | Zeng J Yang L X Liang Q Z | 2005 | J Controlled Release2005，105，12： | 1 |
| 15 | Seed coat microsculpturing changes during seed development in diploid and amphidipoid Brassic species显示文摘 | ZENG C L WANG J B LIU A H | 2004 | Annals of Botany2004，93，： | 1 |
| 16 | A proximal method for pseudomonotone type variational-like inequalities显示文摘 | Schaible S Yao J C Zeng L C | 2006 | Taiwanese Journal of Mathematics2006，10，2： | 1 |
| 17 | More active PtRu/C catalyst for methanol electrooxidation by reversal of mixing sequence in catalyst preparation 显示文摘 | ZENG J H LEE J Y | 2007 | Materials Chemistry and Physics2007，104，： | 1 |
| 18 | Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain-potential function of a novel receptor 显示文摘 | Hong Y Dai P Jiang J Zeng X | 2004 | Br J Pharmacol2004，141，： | 1 |
| 19 | Electroless Ni-P coating of cenospheres using silver nitrate activator 显示文摘 | Zeng A X Xiong W H Xu J | 2005 | Surface&Coatings Technology2005，197，23： | 1 |
| 20 | Effects of homocysteine on murine splenic B lymphocyte proliferation and its signal transduction mechanism显示文摘 | Zeng X Guo J | 2001 | Cardiovasc Res2001，52，2： | 1 |
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