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| 1 | Recurrence or metastasis of HCC:predictors,early detection and experimental antiangiogenic therapy显示文摘AIM To investigate the predictors forrecurrence or metastasis of HCC,and toevaluate the effect of antiangiogenic therapy onthe growth of transplantable human HCC in nudemice.METHODS RT-PCR was used to measure theexpression of matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)in 56 pairs of nontumorous liver andtumor samples.Sixty blood samples from humanHCC were examined by nested RT-PCR to find outAFP mRNA.Recombinant human endostatin andpolyclonal antibody against VEGF wereadministered to treat human HCC transplanted innude mice.RESULTS Thirty of 56 HCC samples showedstronger expression of MMP-9 in tumoroustissues than in nontumorous tissues.Fifteen ofthe 26 patients with relative expression level ofMMP-9 more than 0.34 developed tumorrecurrence or metastasis,whereas only 7 of 30patients with relative expression level less than0.34 developed tumor recurrence(P<0.05).There was no significant difference in therelative expression level of VEGF betweenpatients with postoperative recurrence ormetastasis and those without recurrence.AFPmRNA was detectable in 53.3% of patients withHCC.The sensitivity and specificity of AFPmRNA as a marker to detect hematogenousdissemination of HCC cells was 81.8% and84.4%,respectively.Recombinant human endostatin and polyclonal antibody against VEGFinhibited the growth of transplantable HCC innude mice by 52.2% and 45.7%,respectively.CONCLUSION MMP-9 expression in HCCcorrelates with the postoperative recurrence ormetastasis of HCC.Patients with high level ofMMP-9 expression in HCC are susceptible tometastasis.AFP mRNA could serve as anindicator of hematogenous spreading of HCCcells in circulation and a predictor of recurrenceor metastasis of HCC.Antiangiogenesis may bean adjuvant therapy for HCC. | Jiang YF Yang ZH Hu JQ | 2000 | World Journal of Gastroenterology2000，6，1： | 57 |
| 2 | Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma显示文摘A previous report has confirmed the existence and clinical significance of vasculogenic mimicry(VM)in glioma.However,its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and,thus,might be unconvincing.The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma.Patients were classified as VM-positive or | Wang SY Ke YQ Lu GH Song ZH Yu L Xiao S Sun XL Jiang XD Yang ZL Hu CC | 2013 | 中国神经肿瘤杂志2013，11，3： | 22 |
| 3 | Inhibitory activity of polysaccharide extracts from three kinds of edible fungi on proliferation of human hepatoma SMMC-7721 cell and mouse implanted S180 tumor显示文摘AIM To determine the activities ofpolysaccharide extracts from Flammulina velutipes (Curt. ex Fr. ) Sing (FV), Lentinusedodes (LE) and Agaricus bisporus Sing (AB)on the proliferation of human hepatoma SMMC-7721 cells in vitro and on mouse implanted S-180tumors in vivo.METHODS The polysaccharide extracts were isolated from the fruit bodies of FV, LE and AB by the methods of hot-water extraction, Sevag’sremoval of proteins, ethanol precipitation,trypsin digestion and ethanol fractionalprecipitation. Human hepatoma SMMC-7721 cells were treated with 50 mg/L Polysaccharide extracts, and the mitosis index, mitochondria activity and cell proliferation were detected at different times in both control and experimental groups. The mice with S-180 implanted tumors were injected with the polysaccharide extracts at 24 mg/ kg body weight for 9 d and the tumorweight was measured on the 15th day.RESULTS The mitosis index of hepatoma cells in vitro could be significantly decreased by treatment with the polysaccharide extracts fromthe three kinds of edible fungi (P < 0 .005 ). Thecell numbers and mitochondria activity of SMMC7721 cells treated with polysaccharide extracts were lower than those in control groups (P <0.005). The inhibition rates of polysaccharide extracts against implanted S-180 tumors in mice were 52.8%, 56.6% and 51 .9% respectivelycompared with that in c0ntrol gr0ups.CONCLUSI0N The POIysaccharide extractsfrom the three kinds of edible fungi could inhibitnot only the Cultured malignant cells in vitfO butalso impIanted Sl80 tum0r i0 vivo. | Jiang SM Xiao ZM Xu ZH | 1999 | World Journal of Gastroenterology1999，5，5： | 5 |
| 4 | Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres显示文摘 | Zhong ZH Jiang WQ Cesare M | | 0，，40： | 1 |
| 5 | The impact of puerarin on SOD activity and MDA level in exhausted exercise mice 显示文摘 | Huang YP Jiang LX Huang ZH | 2006 | Acta Phannacol Sin2006，27，： | 1 |
| 6 | Mechanisms Responsible for Poor Oral Bioavailability of Paeoniflorin:Role of Intestinal Disposition and Interactions with Sinomenine显示文摘 | ZQ Liu ZH Jiang L Liu | 2006 | Pharmaceutical Research2006，23，： | 1 |
| 7 | Identication of inhibitors of the HIV-1 gp41 six helix bundle fornation from extracts of Chinese medicinal herbs Prunella Vulgaris and Rhizoma Cibtte显示文摘 | Liu SW Jiang SB Wu ZH | 2002 | Life Sciences2002，71，15： | 1 |
| 8 | High-performance liquid chromatography coupled with tandem mass spectrometry applied for metabolic study of ginsenoside Rb1 on rat显示文摘 | Qian T Jiang ZH Cai Z | 2006 | Anal Biochem2006，352，1： | 1 |
| 9 | Distinguishing the medicinal herb Oldenlandia diffusa form similar species of the same genus using fluorescene microscopy显示文摘 | Liang ZT Jiang ZH Leung KSY | 2006 | Microsc Res Tech2006，69，4： | 1 |
| 10 | Phase Ⅱ study of carboplatin combined with weekly docetaxel in patients with advanced non-small cell lung cancer显示文摘 | Jiang L Wang DY Zhu ZH | | 0，，3： | 1 |
| 11 | Corabinatlve method using HPLC quantitative and qualitative analyses for quality consistency assessment of a herbal modieinal preparation显示文摘 | Xie Y Jiang ZH Zhou H | 2007 | Journal of Pharmaceutical and Biomedical AnalysisPharm Biomed Anal2007，43，1： | 1 |
| 12 | Protective effects of demethylbellidifolin on myocardial ischemia-reperfusion injury in rats显示文摘 | Tan GS Zhou ZH | 2002 | Planta Med2002，68，8： | 1 |
| 13 | High-performance liquid chromatogra-phy coupled with tandem mass spectrometry applied for metabolic study of ginsenoside Rb1 on rat显示文摘 | Qian TX Jiang ZH Cai ZW | 2006 | Analytical Biochemistry2006，352，： | 1 |
| 14 | Oxidation and sulfonation of cellulosics显示文摘 | Zhang J G Jiang N Dang Zh | 2008 | Cellulose2008，15，3： | 1 |
| 15 | Effect of thymosin-a (1) on T-helper 1 cell and T-helper 2 cell cytokine synthesis in patients with hepatitis virus e antigen-positive chronic hepatitis B 显示文摘 | Jiang YF Ma ZH Zhao PW | 2010 | J Int Med Res2010，38，： | 1 |
| 16 | DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine,chelerythrine,and nitidine显示文摘 | Bai LP Zhao ZZ Cai Z Jiang ZH | 2006 | Bioorg Med Chem2006，14，16： | 1 |
| 17 | Cullin 4B is a novel prognostic marker that correlates with colon cancer progression and pathogene- sis显示文摘 | Jiang T Tang HM Wu ZH | 2013 | Med Oncol2013，30，2： | 1 |
| 18 | A novel approach for harvesting lymphatic endothelial cells from human foreskin dermis显示文摘 | Hu XQ Jiang ZH Liu NF | 2006 | Lymphatic Research & Biology2006，4，： | 1 |
| 19 | Effect of mifepristone on estrogen and progesterone receptors in human endometrial and endometriotic cells in vitro显示文摘 | Jiang J Wu RF Wang ZH | 2002 | Fertil Steril2002，77，5： | 1 |
| 20 | Anatomic and functional evaluation of the lymphatics and lymph nodes in diagnosis of lymphatic circulation disorders with contrast magnetic resonance lymphangiography显示文摘 | Liu NF Lu Q Jiang ZH | 2009 | J Vasc Surg2009，49，4： | 1 |
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