|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 2 | 串联压电微泵特性研究显示文摘介绍了一种压电驱动的串联无阀微泵.基于收缩管/扩展管整流特性的分析,建立了微泵输出特性的表达公式.采用有限元仿真软件ANSYS对微泵内流体的流动过成进行了数值模拟,结果显示,在相同的驱动条件下,串联无阀微泵的工作性能优于单腔无阀微泵的工作性能.泵流量随着驱动电压的增加而增加.当固定的驱动电压下,存在最优的压电层厚度使得泵流量最大.研究结果为串联微泵的优化设计提供了依据. | 崔琦峰 刘成良 Xuan F.(William)Zha | 2006 | 传感技术学报2006，19，05B： | 4 |
| 3 | A New Network Coding Mechanism Balancing Coding Opportunities, Energy and QoS in WSNs显示文摘A new Network Coding mechanism in WSNs(Wireless Sensor Networks), which is named COEQ and aims at balancing coding opportunities, energy and QoS, is proposed and analyzed. Implemented on the basis of traditional AODV protocol, COEQ evaluates several metrics of paths comprehensively with TOPSIS method including minimum remaining energy, coding opportunities, QoS and so on, so as to select the optimal transmitting route. Experiments on NS[2] show that COEQ can improve throughput and save energy when the transmitting rate is low. | ZHENG Kangfeng WANG Xiujuan ZHA Xuan XIAO Huan | 2014 | China Communications2014，11，6： | 3 |
| 4 | Effects of the vegetation restoration years on soil microbial community composition and biomass in degraded lands in Changting County,China显示文摘We evaluated the effects of the number of years of restoration of vegetation on soil microbial community structure and biomass in degraded ecosystems.We investigated the microbial community structure by analyzing their phospholipid fatty acids then examined microbial biomass carbon and nitrogen by chloroform fumigation extraction of restoration soils over several years.The data were compared with those of highly degraded lands and native vegetation sites.The results show that the duration of vegetation on the sites substantially increased microbial biomass and shifted the microbial community structure even after only 4 years.However,microbial communities and biomass did not recover to the status of native vegetation even after 35 years of vegetation cover.A redundancy analysis and Pearson correlation analysis indicated that soil organic carbon,total nitrogen,available potassium,soil water content,silt content and soil hardness explained 98.4%of total variability in the microbial community composition.Soil organic carbon,total nitrogen,available potassium and soil water content were positively correlated with microbial community structure and biomass,whereas,soil hardness and silt content were negatively related to microbial community structure and biomass.This study provides new insights into microbial community structure and biomass that influence organic carbon,nitrogen,phosphorus and potassium accumulation,and clay content in soils at different stages of restoration. | Yonghui Bai Xuan Zha Shifa Chen | 2020 | Journal of Forestry Research2020，31，4： | 3 |
| 5 | Study on creep-fatigue damage evaluation for advanced 9%–12% chromium steels under stress controlled cycling显示文摘Creep-fatigue interaction is one of the main damage mechanisms in high temperature plants and their components. Assessment of creep-fatigue properties is of practical importance for design and operation of high temperature components. However, the standard evaluation techniques, i.e. time fraction rule and ductility exhaustion one have limitations in accounting for the effects of control mode on the cyclic deformations. It was found that conventional linear cumulative damage rule failed in accurately evaluating the creep-fatigue life under stress controlled condition. The calculated creep damages by time fraction rule were excessively high, which led to overly conservative prediction of failure lives. In the present study, it was suggested that such over estimation of creep damage was mainly caused by anelastic strain upon stress loading. For precise assessment under conditions of stress control, a modified creep damage model accounting for the effect of anelastic creep was proposed. The assessments of creep fatigue data under stress controlled condition were performed with the new approach developed in this paper for a rotor material and a boiler material used in ultra supercritical power plants. It was shown that a more moderate amount of creep damage was obtained by the new model, which gave better predictions of failure life. | Peng ZHA O Fuzhen XUAN | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，2： | 2 |
| 6 | Lower levels sex hormone-binding globulin independently associated with metabolic syndrome in pre-elderly and elderly men in China显示文摘Objective To examine the relationship between sex hormone–binding globulin (SHBG) and the metabolic syndrome (MetS) in pre-elderly and elderly men in China. Methods A cross-sectional studywas done among 437men, aged 45 to 94 years old. Early morning fasting sera were assayed for total testosterone (TT), SHBG and other biochemical markers. Free testosterone (FT) was calculated. Results The SHBG level of the MetS group was significantly lower than those without MetS 35.70 (25.18, 47.10) nmol/L vs. 41.90 (31.80, 55.20) nmol/L; P < 0.001). As the number of MetS components increases, SHBG and TT levels became lower. SHBG correlated with age, as did TT and most of metabolic components. Body mass index (BMI), high density lipoprotein-cholesterol (HDL-C), triglyceride (TG), and TT remained independently associated with SHBG by multivariate regression analysis. In a logistic regression taking MetS as the dependent variable, SHBG (95% confidence interval (95% CI): 0.975��0.994, P = 0.018) and homeostasis model assessment for insulin resistance (HOMA-IR) (95%CI: 1.535��2.647, P < 0.001) were included in the final model. Conclusions Lower SHBG is independently associated with MetS among pre-elderly and elderly men. SHBG may be an independent predictor of MetS, but the mechanism of how SHBG is involved in MetS requires further studied. | Xiao-Na Pang Yu Hu Ying Yuan Ji-Ping Shen Xiao-Yun Zha Xuan Sun | 2013 | Journal of Geriatric Cardiology2013，10，1： | 2 |
| 7 | Integration of the Step based Assembly Model and XML Schema with the Fuzzy Analytic Hi erarchy Process (FAHP) for Muti Agent Based As sembly Evaluation显示文摘 | Zha Xuan F | 2006 | Journal of Intelligent Manu- facturing2006，17，52： | 1 |
| 8 | Soft computing in engineering design: a hybrid dual cross-mapping neural network model显示文摘 | Xuan F. Zha | 2005 | Neural Computing and Applications2005，，3： | 1 |
| 9 | maps analysis: A robust Discriminant diffusion manifold /earner for dimensionality reduction and its applications in machine condition monitoring and fault diagnosis 显示文摘 | Huang Yixiang Xuan F Zha | 2013 | Mechanical Systems and Signal Processing (S0888-3270)2013，34，12： | 1 |
| 10 | Knowledge-intensive collaborative design modeling and support Part Ⅱ: System implementation and application 显示文摘 | ZHA XUAN F DU H | 2006 | Computers in Industry2006，，57： | 1 |
| 11 | Platform-based product design and development:A knowledge-intensive support approach显示文摘 | Xuan F Zha Ram D Sriram | 2006 | Knowledge-Based Systems2006，19，： | 1 |
| 12 | Knowledge-intensive collaborative decision support for design processes:A hybrid decision support model and agent显示文摘 | Xuan F Zha Ram D Sriram Marco G Fernandez | 2008 | Computers in Industry2008，59，： | 1 |
| 13 | Hierarchical macro-microporous WPU-ECM scaffolds combined with Microfracture Promote in Situ Articular Cartilage Regeneration in Rabbits显示文摘Tissue engineering provides a promising avenue for treating cartilage defects.However,great challenges remain in the development of structurally and functionally optimized scaffolds for cartilage repair and regeneration.In this study,decellularized cartilage extracellular matrix(ECM)and waterborne polyurethane(WPU)were employed to construct WPU and WPU-ECM scaffolds by water-based 3D printing using low-temperature deposition manufacturing(LDM)system,which combines rapid deposition manufacturing with phase separation techniques.The scaffolds successfully achieved hierarchical macro-microporous structures.After adding ECM,WPU scaffolds were markedly optimized in terms of porosity,hydrophilia and bioactive components.Moreover,the optimized WPU-ECM scaffolds were found to be more suitable for cell distribution,adhesion,and proliferation than the WPU scaffolds.Most importantly,the WPU-ECM scaffold could facilitate the production of glycosaminoglycan(GAG)and collagen and the upregulation of cartilage-specific genes.These results indicated that the WPU-ECM scaffold with hierarchical macro-microporous structures could recreate a favorable microenvironment for cell adhesion,proliferation,differentiation,and ECM production.In vivo studies further revealed that the hierarchical macro-microporous WPU-ECM scaffold combined with the microfracture procedure successfully regenerated hyaline cartilage in a rabbit model.Six months after implantation,the repaired cartilage showed a similar histological structure and mechanical performance to that of normal cartilage.In conclusion,the hierarchical macro-microporous WPU-ECM scaffold may be a promising candidate for cartilage tissue engineering applications in the future. | Mingxue Chen YangYang Li Shuyun Liu Zhaoxuan Feng Hao Wang Dejin Yang Weimin Guo Zhiguo Yuan Shuang Gao Yu Zhang Kangkang Zha Bo Huang Fu Wei Xinyu Sang Qinyu Tian Xuan Yang Xiang sui Yixin Zhou Yufeng Zheng Quanyi Guo | 2021 | Bioactive Materials2021，6，7： | 1 |
| 14 | Knowledge-intensive collaborative design modeling and support, part II : system implementation and application 显示文摘 | Xuan F Zha H Du | 2006 | Computers in Industry2006，57，1： | 1 |
| 15 | A UML-based object-oriented approach for design and simulation of a drug delivery system显示文摘 | Qifeng Cui Xuan F. Zha Chengliang Liu Wen F. Lu | 2008 | Microsystem Technologies2008，，6： | 1 |
| 16 | Manufacturing process and material selection in concurrent collaborative design of MEMS devices显示文摘 | Zha Xuan F Du H | 2003 | J of Micromechanics and Micro Engineering2003，13，5： | 1 |
| 17 | Study on a piezoelectric micropump for the controlled drug delivery system 显示文摘 | Cui Qifeng Liu Chengliang Zha Xuan F | 2007 | Microfluidics and Nanofluidics2007，3，4： | 1 |
| 18 | Simulation and optimization of a piezoelectric micropump for medical applications 显示文摘 | Cui Qifeng Liu Chengliang Zha Xuan F | 2008 | The International Journal of Advanced Manufacturing Technology2008，36，56： | 1 |
| 19 | A Knowledge Intensive Multi Agent System For Cooperative Collaborative Assembly Modeling And Process Planning显示文摘 | XUAN F ZHA S LIM Y E | 2003 | Transactions of the SDPS2003，7，1： | 1 |
| 20 | Discrimi- nant diffusion maps analysis: a robust manifold learner for dimensionality reduction and its applications in machine condition monitoring and fault diagnosis 显示文摘 | HUANG Yi-xiang ZHA Xuan F Lee Jay | 2013 | Mechanical Systems and Signal Processing2013，34，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员