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| 1 | 肠道菌群在功能性便秘中的作用显示文摘功能性便秘非常常见,但其发病机制尚不明了。越来越多的证据显示,功能性便秘与肠道微生态失调有关,而肠道微生态与肠道转运之间很可能存在相互影响。本文对功能性便秘发生过程中肠道微生态所发挥作用的证据进行了总结。肠道微生态通过胆酸、短链脂肪酸、5-羟色胺和甲烷等相关微生物代谢活动调控结肠动力、结肠黏膜分泌和吸收,进而促使功能性便秘的发生。作为肠道微生态影响功能性便秘的证据支持,用益生菌、益生元、合生元和中药治疗功能性便秘时,常可观察到患者肠道微生态在菌种组成和功能上的改变。深入研究功能性便秘的病理发生,阐明微生态制剂治疗功能性便秘的药理机制,将为功能性便秘的新型治疗方法提供理论基础。 | Shengsheng Zhang Ruixin Wang Danyan Li Luqing Zhao Lixin Zhu | 2021 | Gastroenterology Report2021，9，5： | 13 |
| 2 | VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis显示文摘尽管 VEGFR-3 缺乏破坏血脉管的开发在早 embryogenesis 期间,内在的机制不是清楚的。在 angiogenesis 和 lymphangiogenesis 描绘它的函数,我们在这研究雇用了二个遗传上修改的鼠标模特儿,与一个 inactivation 点变化(Vegfr3TKmut ) 为 ligand 有约束力的域(Vegfr3 螖 L BD ) 或酷氨酸 kinase 域指向编码区域。我们证明淋巴的生长在 Vegfr3 螖 L BD/螖 L BD 和 Vegfr3TKmut/TKmut 老鼠被破坏,但是血容器在胚胎和蛋黄囊通常发展了。有趣地在 Vegfr3 螖 L BD/螖 L BD 然而并非 Vegfr3TKmut/TKmut 老鼠,淋巴囊是在场的,但是有发芽的 lymphangiogenic 的缺乏。我们进一步证明 VEGFR-3 的野类型、变异的形式能与 VEGFR-2 形成 heterodimers,并且减少在 endothelial 房间的 phospho-VEGFR-2 和下游的 phospho-Erk1/2 的水平当他们与 VEGF 被对待时 -- 一。这些调查结果显示发信号由它的血缘的 ligands (VEGF-C/-D ) 经由 VEGFR-3 激活调停了没为 angiogenesis 被要求,并且那 VEGFR-3 可以由 modulating VEGFR-2-mediated 信号在这个过程起一个作用。 | Luqing Zhang Fei Zhou Wencan Han Bin Shen Jincai LUO Masabumi Shibuya Yulong He | 2010 | Cell Research2010，20，12： | 7 |
| 3 | Effects of Mercuric Chloride on Antioxidant System and DNA Integrity of the Crab Charybdis japonica显示文摘Mercury (Hg) is one of the commonly encountered heavy metals, which is widespread in inshore sediments of China. In order to investigate the toxicity of Hg on marine invertebrates, we studied the effects of the divalent mercuricion (Hg2+) (at two final concentrations of 0.0025 and 0.0050 mg L-1, prepared with HgCl2) on metallothionein (MT) content, DNA integrity (DNA strand breaks) and catalase (CAT) in the gills and hepatopancreas, antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), in the hemolymph, gills and hepatopancreas of the portunid crab Charybdis japonica for an experiment period up to 15 d. The results indicated that MT was significantly induced after 3 d, with a positive correlation with Hg2+ dose and time in the hepatopancreas and a negative correlation with Hg2+ dose and time in the gills. While CAT in the hemolymph was not detected, it increased in the hepatopancreas during the entire experiment; SOD and GPx in the three tissues were stimulated after 12 h, both attained peak value and then reduced during the experimental period. Meanwhile, DNA strand breaks were all induced significantly after 12 h. These results suggested the detoxification strategies against Hg2+ in three tissues of C. japonica. | ZHANG Hongxia PAN Luqing MIAO Jingjing XU Chaoqun | 2009 | Journal of Ocean University of China2009，8，4： | 4 |
| 4 | Effects of Heavy Metal Ions (Cu^(2+), Pb^(2+) and Cd^(2+)) on DNA Damage of the Gills, Hemocytes and Hepatopancreas of Marine Crab, Charybdis japonica显示文摘There are rising concerns about the hazardous effects of heavy metals on the environment. In this study, comet assay and DNA alkaline unwinding assay were conducted on the tissues (gills, hepatopancreas, and hemocytes) of Charybdis japonica in order to illustrate genotoxicity of three heavy metal ions (Cu2+, Pb2+, and Cd2+) on the marine crabs C. japonica. The crabs were exposed to Cu2+ (10, 50, and 100 ?g.L?1), Pb2+ (50, 250, and 500 ?g L?1) and Cd2+ (5, 25, and 50 ?g L?1), and the tissues were sampled at days 0.5, 1, 3, 6, 9, and 15. DNA alkaline unwinding assay was used for testing the DNA single strand break in gills and hepatopancreas and comet assay was employed for testing the DNA damage in hemocytes. The results showed that the DNA damage (F-value) of gills in the crabs exposed to the three heavy metals was decreased gradually during the exposure periods and there was a dose-time response relationship in certain time, suggesting that the levels of DNA single strand break in all the experimental groups increased significantly compared to the controls. Changes of F-value in hepatopancreas of the crabs exposed to the three heavy metals were similar to those in gills except that the peak values were found in the 500 ?g L?1 Pb2+ treatment group at day 3 and the 50 ?g L?1 Cd2+ treatment group at day 9. The ranks of DNA damage in gills and hepatopancreas induced by the three heavy metal ions (50 ?g L?1, day 15) were Cd2+ >Pb2+ >Cu2+ and Pb2+ >Cu2+ >Cd2+. The levels of DNA damage in gills were higher than those in hepatopancreas in the same experimental group. It can be concluded that indices of DNA damage can be used as the potential biomarkers of heavy metal pollution in marine environment. | PAN Luqing LIU Na ZHANG Hongxia WANG Jing MIAO Jingjing | 2011 | Journal of Ocean University of China2011，10，2： | 4 |
| 5 | Effects of Qizhukangxian granules on idiopathic pulmonary fibrosis:a randomized,double blind,placebo-controlled and multicenter clinical pilot trial显示文摘OBJECTIVE:To evaluate the effects of Qizhukangxian granules(QG)on idiopathic pulmonary fibrosis(IPF).METHODS:This is a randomized,double blind,placebo-controlled and multicenter clinical pilot trial.Six medical centers in Tianjin,China,participated in the study.A total of 120 IPF patients were enrolled and randomized into two groups,with 60 patients in each group.The treatment group was treated with QG,while the control group received a Qizhukangxian placebo.The pharmacological treatment lasted for 48 weeks from the enrollment date.The indexes of patients were recorded on the admission day and at the end of the 24th and 48th weeks.Data were analyzed to study the effects of QG;forced vital capacity,change in forced vital capacity and maximal 6-min walk test(6MWT)distance were the primary endpoints.Secondary endpoints were percentage of patients with episodes of acute exacerbation of IPF,pulmonary function,changes in pulse oxygen saturation during the 6MWT,dyspnea score,St.George's respiratory questionnaire score,arterial blood gas analyses and the total Traditional Chinese Medicine symptom pattern score.RESULTS:After 24 weeks of treatment,QG showed greater efficacy than the placebo in certain parameters,including the dyspnea score,Traditional Chinese Medicine symptom pattern score and some indicators in the St.George's respiratory questionnaire score.Analysis of the indexes obtained from all patients at the end of the 48th week showed that the therapeutic effects in the treatment group were significantly better than those in the control group because remarkable differences were observed in most of the primary and secondary endpoints between the two groups,except for the maximal distance of the 6MWT and arterial blood gas analyses.No adverse reaction was observed in either group during the 48-week trial treatment period.CONCLUSION:QG could effectively treat IPF patients by ameliorating pulmonary function,improving the quality of life and lowering the percentage of acute exacerbations. | Guo Sijia Song Yalin Feng Jihong Liu Shuang Li Yuechuan Liu Min Wei Luqing Zhang Xian Xie Hui Sun Zengtao | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 6 | Immunotoxicity Effect of Benzo[α]Pyrene on Scallop Chlamys farreri显示文摘The toxic effects of benzo[α]pyrene (B[α]P) at different concentrations (0.1, 0.5, 1, 2.5 and 7.5 μgL-1) on scallop (Chlamys farreri) immune system were studied. The results showed that B[α]P had significant toxic effects on the haemocyte counts, neutral red uptake, phagocytosis, bacteriolytic and antibacterial activity (P<0.05), while the seawater control and acetone control had no significant differences. The haemocyte counts, neutral red uptake, phagocytosis and bacteriolytic activity in all B[α]P treatment groups as well as antibacterial activity in groups of 0.5, 1, 2.5 and 7.5 μgL-1 B[α]P decreased significantly (P<0.05). Some of these indices tended to be stable on the sixth day and others on the ninth day, and the indices showed clear time-and concentra- tion-response to B[α]P. Bacteriolytic activity in 0.1μgL-1 B[α]P treatment group and antibacterial activity in 0.1 μgL-1 and 0.5 μgL-1 B[α]P treatment groups increased at the beginning of exposure and reached their peaks on day 1 and day 6, respectively. Following that, both activities decreased gradually and became stable after day 9. When all the indices reached stability, they were significantly lower than those in control group (P<0.05), except for antibacterial activity in 0.1 μgL-1 B[α]P treatment group (P>0.05). Thus, B[α]P has evident toxic effects on scallop immune system, which supports the view that a relationship exists between pollution and immunomodulation in aquatic organisms. | ZHANG Lin PAN Luqing LIU Jing | 2009 | Journal of Ocean University of China2009，8，1： | 2 |
| 7 | The effect of oxidation on physicochemical properties and aqueous stabilization of multiwalled carbon nanotubes:comparison of multiple analysis methods显示文摘Surface oxidation can alter physicochemical properties of multiwalled carbon nanotubes(MWCNTs) and influence their aqueous stabilization.Many techniques have been used to characterize the physicochemical properties and aqueous stabilization of MWCNTs.However,the relationship between the change in physicochemical property and the aqueous stabilization of MWCNTs merits more studies,and the multiple characterization techniques have not been well compared.This study systematically and comparatively investigated the effect of oxidation on the physicochemical properties and aqueous stabilization of MWCNTs using multiple analysis methods.Increased surface area,disclosed tube ends,defects on the sidewalls,disruption of the electronic structure,and removal of metal catalysts and amorphous carbon were observed for the oxidized MWCNTs(o-MWCNTs) using the multipoint Brunauer-Emmett-Teller(BET) method,transmission electron microscope observation,Raman spectroscopy,UV-Vis spectroscopy,and thermogravimetric analysis.An oxidation-time-dependent increase in oxygen content of the MWCNTs was verified by the methods of elemental analysis,mass difference calculation,and X-ray photoelectron spectroscopy(XPS).Fourier transform infrared spectroscopy,XPS,and the Boehm titration were employed to study the functionalities on the MWCNT surfaces.Despite the limitations of these techniques,the results indicated that the dramatic increase in carboxyl groups was mainly responsible for the significant increase in oxygen content after the oxidation.The dissociation of the grafted functional groups increased electronegativity of the o-MWCNTs and facilitated the aqueous stabilization of o-MWCNTs through electrostatic repulsions.The oxidation affected the UV-Vis absorbance of MWCNT suspensions.The absorbances at 800 nm of the stabilized MWCNT suspensions had a good correlation with the MWCNT concentrations and could be used to quantify the MWCNT suspensions.The findings of this work are expected to boost the research on carbon nanotubes and their environmental behaviors. | Luqing Zhang Minhao Wang Jing Fang Kun Yang Daohui Lin | 2016 | Science China Chemistry2016，59，11： | 2 |
| 8 | Preparation of slightly crosslinked monodisperse poly(maleic anhydride-cyclohexyl vinyl ether-divinylbenzene)functional microspheres with anhydride groups via precipitation polymerization显示文摘Slightly crosslinked monodisperse poly(maleic anhydride-cyclohexyl vinyl ether-divinylbenzene)(MA-CHVE-DVB) microspheres were prepared via precipitation polymerization while using 2,2-azobisisobutyronitrile as an initiator in a mixture of methyl ethyl ketone and n-heptane without any stabilizer.The number-average diameter of the resultant poly(MA-CHVE-DVB) microspheres ranged from 0.478 to 1.386 μm with a polydispersity index of 1.00 to 1.02 that depended on the feed ratios of the MA/CHVE/DVB monomers.The introduction of one electron donor monomer cyclohexyl vinyl ether strongly affected the yield,size,and morphology of these slightly crosslinked microspheres.Quinolinetype chelating resins were obtained after combining the poly(MA-CHVE-DVB) with 8-hydroxyquinoline;the adsorption properties of these materials were measured through their ability to remove Cu^(2+) ions from water.The poly(MA-CHVE-DVB) microspheres with low degrees of crosslinldng provided more effective functional groups and therefore better ion removal capabilities.These slightly crosslinked microspheres may have applications in water treatment as well as in sensing and drug delivery. | Cen Yin Anhou Xu Li Gong Luqing Zhang Bing Geng Shuxiang Zhang | 2015 | Particuology2015，13，2： | 2 |
| 9 | Reactive oxygen species in paraventricular nucleus involved in cardiac sympathetic afferent reflex in rats显示文摘Objective: The present study was designed to determine if reactive oxygen species (ROS) in the paraventricular nucleus (PVN) were involved in modulating cardiac sympathetic afferent reflex (CSAR) in anesthetized rats. Methods: Malondialdehyde (MDA), the end product of lipid peroxidation, in the PVN, was determined by thiobarbituric acid (TBA) spectrometric method. Renal sympathetic nerve activity (RSNA) and arterial pressure were recorded in sinoaortic-denervated and cervical-vagotomized rats. The CSAR was evaluated by the response of the RSNA evoked by epicardial application of bradykinin (BK, 0.4 μg). Results: The MDA in the PVN was significantly increased after epicardial application of BK compared with control (2.0±0.3 vs 0.8±0.1 nmol/mg protein, P<0.01). Microinjection of a superoxide anion scavenger, tiron (20 nmol) into the PVN significantly inhibited the CSAR evoked by BK (12.3±1.9 vs 4.2±1.2%, P<0.01) and decreased MDA level (1.9±0.3 vs 0.6±0.1 nmol/mg protein, P<0.01) compared with control. Conclusion: The ROS in the PVN is involved in modulating the CSAR in rats. | Feng Zhang Yang Yu Ying Zhang Yingchun Li Luqing Zhang Lingling Fan Yingya Gao Guoqing Zhu | 2005 | Journal of Nanjing Medical University2005，19，6： | 2 |
| 10 | A hypothesis for crack free interior surfaces of Longyou caverns caved in argillaceous siltstone 2000 years ago显示文摘Five complete caverns were discovered in Longyou in 1992.They were manually caved in argillaceous siltstone at shallow depths more than 2000 years ago.When they were un-watered,their integrity was maintained completely,and their interior rock surfaces were free of old cracks.Since then,however,the rock's interior faces have initiated and propagated more and more cracks.This paper attempts to address the question of why the rock interior faces were free of old cracks once they were unearthed.To address this question,this paper proposes a hypothesis that the argillaceous siltstone has the ability of self-healing its cracks over a short period of time under weak acid water environment.Data and evidence are presented herewith to prove the hypothesis.They include observations and measurements in the field and test results in the laboratory.Specifically,a three-point bending test is used to form a tensile crack in a rectangular rock specimen and a deadload test for the specimen immersed in initially weak acid water is used for self-healing its crack.The results have shown that the argillaceous siltstone is in a state of weak alkalinity and the rain water at the site is in a state of weak acidity.Therefore,when it is immersed in weak acid water for some time,the argillaceous siltstone would be able to make chemical reactions to generate new minerals such as calcite.The new minerals would be able to infill the cracks and then heal the crack within a few years.Once the crack is self-healed,the rock can regain its strength and integrity.Consequently,the rock interior surfaces could be free of old cracks when the water was pumped out of the caverns. | Zhong Qi YUE Shaopeng FAN Zhifa YANG Lihui LI Luqing ZHANG Zhongjian ZHANG | 2010 | Frontiers of Structural and Civil Engineering2010，4，2： | 2 |
| 11 | The synchronization of spontaneous BOLD activity predicts extraversion and neuroticism显示文摘 | Luqing Wei Xujun Duan Yang Yang Wei Liao Qing Gao Ju-rong Ding Zhiqiang Zhang Weixi Zeng Yuan Li Guangming Lu Huafu Chen | 2011 | Brain Research2011，，： | 2 |
| 12 | Back-analysis of viscoelastic displacements in a soft rock road tunnel显示文摘 | Yang Zhifa Wang Zhiyin Zhang Luqing Zhou Ruiguang Xing Nianxing | 2001 | International Journal of Rock Mechanics and Mining Sciences2001，，3： | 1 |
| 13 | Back-analysis of viscoelastic displacements in a soft rock road tunnel显示文摘 | Yang Zhifa Wang Zhiyin Zhang Luqing | 2001 | International Journal of Rock Mechanics and Mining Sciences2001，38，3： | 1 |
| 14 | Evidence for contact sex recognition pheromone of the Asian longhorned beetle, Anoplophora glabripennis (Coleoptera: Cerambycidae)显示文摘 | Aijun Zhang James E. Oliver Kamal Chauhan Boguang Zhao Luqing Xia Zhichun Xu | 2003 | Naturwissenschaften2003，，9： | 1 |
| 15 | Two new reinforcement techniques applicable in high steep slopes along the Chengdu-Lhasa Highway, Southwest China显示文摘Anti-slide pile and anchoring hole are two types of reinforcement techniques popularly used in slope reinforcement. However, some defects of these two techniques are found in slope engineering practices. Utilizing higher tensile strength of pre-stressed structures, the authors devise two new types of slope reinforcement techniques, i.e. pre-stressed anchoring beam and pre-stressed anti-slide pile, in an attempt to overcome those defects of the existing techniques. These two new techniques are characterized by gathering multiple functions, e.g. engineering investigation, reinforcement, drainage, monitoring and strength supplement, so as to achieve high reinforcement efficiency, convenient checking, and higher ratio of function to cost. It is hoped that, if applying these two new techniques in remedies of landslide hazards along the Chengdu-Lhasa Highway, better reinforcement effects will be obtained. | YANG ZhifaZHU Jiewang ZHANG Luqing, CUI Peng, LI Xiao & SHANG Yanjun Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Institute of Mountain Hazards and Environment, Chinese Academy of Sciences and Ministry of Water Resources, Chengdu 610041, China | 2003 | Science China(Technological Sciences)2003，46，z1： | 1 |
| 16 | Back-analysis of viscoelastic displacements in a soft rock road tunnel显示文摘 | Yang Zhifa Wang Zhiyin Zhang Luqing | 2001 | Int J Rock Mech Min2001，38，3： | 1 |
| 17 | Alternating method study on stress analysis of surrounding rock for two random geometry tunnel显示文摘 | LU Aizhong ZHANG Luqing | | 0，，02： | 1 |
| 18 | Back-analysis of viscoelastic displacements in a soft rock road tunnel 显示文摘 | Yang Zhifa Wang Zhiyin Zhang Luqing | 2001 | International Journal of Rock Mechanics & Mining Sci ences2001，38，3： | 1 |
| 19 | An ethical solution to the challenges in teaching anatomy with disseetion in the Chinese cuhure显示文摘 | Luqing Zhang Yunfeng Wang Ming Xiao | 2008 | Anat Sci Ed2008，，1： | 1 |
| 20 | Identification of differentially expressed genes in the digestive gland of manila clam Ruditapes philippinarum exposed to BDE-47显示文摘 | Jingjing Miao Luqing Pan Wenhao Zhang Dong Liu Yuefeng Cai Lizhen | 2013 | Comparative Biochemistry and Physiology, Part C2013，，： | 1 |
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