|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Integrated positron emission tomography and computed tomography in preoperative lymph node staging of non-small cell lung cancer显示文摘 | Xu N Jiao Y Fang WG Wang MZ Zhu ZH Zhang YQ | 2014 | Chinese Medical Journal2014，，4： | 8 |
| 4 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 5 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 6 | Silicon nanowires prepared by laser ablation at high temperature显示文摘 | Zhang Y F Tang Y H Wang N | 1998 | Appl Phys Lett1998，72，15： | 2 |
| 7 | Modeling and simulation of point-non-point source effluent trading in Taihn Lake area: perspective of non-point sources control in China 显示文摘 | Wang X J Zhang W Huang Y N | 2004 | Science of the Total Environment2004，325，13： | 1 |
| 8 | Improved image filter based on SPCNN显示文摘 | ZHANG Y D WU L N | 2008 | Science in China F edition:Information Science2008，51，12： | 1 |
| 9 | 显示文摘 | ZHANG X J XU Y N SHI H H | 2007 | Chin J Lumin2007，28，4： | 1 |
| 10 | On fuzzy cluster validity indices显示文摘 | Wang W N Zhang Y J | 2007 | Fuzzy Sets and Systems2007，158，： | 1 |
| 11 | Comparison of various lazaroid compounds for protection against ischemic liver injury显示文摘 | Zhu Y Zhang S | 1997 | Transplantation1997，63，： | 1 |
| 12 | Hydrogen Peroxide stimulates extracellular signal-- regulated protein kinases in pulmonary arterial smooth muscle cells显示文摘 | Jin N Liu Y Rhoades RA | 1998 | AmJ RespirCell Mol Biol1998，19，2： | 1 |
| 13 | Properties of crosslinked casein/waterborne polyurethane composites 显示文摘 | Wang N G Zhang L N Lu Y S | 2004 | Journal of Applied Polymer Science2004，91，1： | 1 |
| 14 | RECK, a novel matrix metallop roteinase regulator显示文摘 | Meng N Li Y Zhang H | 2008 | Histol Histopathol2008，23，8： | 1 |
| 15 | Analysis of user equilibrium traffic patterns on bottlenecks with time-varying capacities and their applications 显示文摘 | Zhang X N Zhang H M Li L Y | 2010 | International Journal of Sustainable Transportation2010，3，1： | 1 |
| 16 | Precipitation selectivity of perovskite phase from Ti-bearingblast furnace slag under dynamic oxidation conditions 显示文摘 | Zhang L Zhang L N Wang M Y | 2007 | Journal of Non - CrystaUine Solids2007，353，： | 1 |
| 17 | A recurrent neuralnetwork for solving sylvester equation with time-varyingcoefficients显示文摘 | ZHANG Y N JIANG D C WANG J | 2002 | IEEE Transactions on Neural Networks2002，13，5： | 1 |
| 18 | Rapid clearance of fetal DNA from maternal plasma显示文摘 | Lo Y M Zhang J Leung T N | 1999 | Am J Hum Genet1999，64，： | 1 |
| 19 | Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis 显示文摘 | Zhang Y Fujita N Tsuruo T | 1999 | Oncogene1999，18，5： | 1 |
| 20 | A Pacific interdecadal climate oscillation with impacts on salmon production 显示文摘 | Mantua N J Hare S R Zhang Y | 1997 | Bulletin American Meteorological Society1997，78，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员