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| 1 | Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study显示文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations. | Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye | 2019 | Cancer Biology & Medicine2019，16，1： | 7 |
| 2 | Clinical characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital显示文摘Objectives:To evaluate the characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital.Methods:Patients with pulmonary nodules 4–25 mm in diameter detected via computed tomography(CT)in 2013 were consecutively included.The analysis was restricted to patients with a histological nodule diagnosis or a 2-year follow-up period without nodule growth confirming benign disease.Patient information was collected from hospital records.Results:Among the 314 nodules examined in 299 patients,212(67.5%)nodules in 206(68.9%)patients were malignant.Compared to benign nodules,malignant nodules were larger(18.0 mm vs.12.5 mm,P<0.001),more often partly solid(16.0%vs.4.7%,P<0.001)and more often spiculated(72.2%vs.41.2%,P<0.001),with higher density in contrast-enhanced CT(67.0 HU vs.57.5 HU,P=0.015).Final diagnosis was based on surgery in 232 out of 314(73.9%)nodules,166 of which were identified as malignant[30(18.1%)stage III or IV]and 66 as benign.In 36 nodules(11.5%),diagnosis was confirmed by biopsy and the remainder verified based on stability of nodule size at follow-up imaging(n=46,14.6%).Among 65 nodules subjected to gene(EGFR)mutation analyses,28(43.1%)cases(EGFR19 n=13;EGFR21 n=15)were identified as EGFR mutant and 37(56.9%)as EGFR wild-type.Prior to surgery,the majority of patients[n=194(83.6%)]received a contrast-enhanced CT scan for staging of both malignant[n=140(84.3%)]and benign[n=54(81.8%)]nodules.Usage of positron emission tomography(PET)-CT was relatively uncommon[n=38(16.4%)].Conclusions:CT-derived nodule assessment assists in diagnosis of small to intermediate-sized malignant pulmonary nodules.Currently,contrast-enhanced CT is commonly used as the sole diagnostic confirmation technique for pre-surgical staging,often resulting in surgery for late-stage disease and unnecessary surgery in cases of benign nodules. | Xiaonan Cui Daiwei Han Marjolein AHeuvelmans Yihui Du Yingru Zhao Lei Zhang Harry JMGroen Geertruida Hde Bock Monique DDorrius Matthijs Oudkerk Rozemarijn Vliegenthart Zhaoxiang Ye | 2020 | Cancer Biology & Medicine2020，17，1： | 5 |
| 3 | Genesis of the Gold Deposit in the Indus-Yarlung Tsangpo Suture Zone,Southern Tibet:Evidence from Geological and Geochemical Data显示文摘The Nianzha gold deposit,located in the central section of the Indus-Yarlung Tsangpo suture(IYS) zone in southern Tibet,is a large gold deposit(Au reserves of 25 tons with average grade of 3.08 g/t) controlled by a E-W striking fault that developed during the main stage of Indo-Asian collision(~65-41 Ma).The main orebody is 1760 m long and 5.15 m thick,and occurs in a fracture zone bordered by Cretaceous diorite in the hanging wall to the north and the Renbu tectonic melange in the footwall to the south.High-grade mineralization occurs in a fracture zone between diorite and ultramafic rock in the Renbu tectonic melange.The wall-rock alteration is characterized by silicification in the fracture zone,serpentinization and the formation of talc and magnesite in the ultramafic unit,and chloritization and the formation of epidote and calcite in diorite.Quartz veins associated with Au mineralization can be divided into three stages.Fluid inclusion data indicate that the deposit formed from H_2O-NaCl-organic gas fluids that homogenize at temperatures of 203℃-347℃ and have salinities of 0.35wt%-17.17wt%NaCl equivalent.The quartz veins yield δ^(18)O_(fluid) values of 0.15‰-10.45‰,low δD_(V-SMOW)values(-173‰ to-96‰),and the δ^(13)C values of-17.6‰ to-4.7‰,indicating the ore-forming fluids were a mix of metamorphic and sedimentary orogenic fluids with the addition of some meteoric and mantle-derived fluids.The pyrite within the diorite has δ^(34)S_(V-CDT) values of-2.9‰-1.9‰(average-1.1‰),^(206)Pb/^(204)Pb values of 18.47-18.64,^(207)Pb/^(204)Pb values of 15.64-15.74,and ^(208)Pb/^(204)Pb values of 38.71-39.27,all of which are indicative of the derivation of S and other ore-forming elements from deep in the mantle.The presence of the Nianzha,Bangbu,and Mayum gold deposits within the IYS zone indicates that this area is highly prospective for large orogenic gold deposits.We identified three types of mineralization within the IYS,namely Bangbu-type accretionary,Mayum-type microcontinent,and Nianzha-type ophiolite-associated orogenic Au deposits.The three types formed at different depths in an accretionary orogenic tectonic setting.The Bangbu type was formed at the deepest level and the Nianzha type at the shallowest. | ZHANG Xiong DENG Xueguo YANG Zhusen HOU Zengqian ZHENG Yuanchuan LIU Yingchao ZHAO Xiaoyan XU Bo PEI Yingru ZHOU Jinsheng ZHAO Miao YUAN Jianfei | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 4 |
| 4 | Fluid Inclusion and Stable Isotope Geochemistry of the Shangxu Gold Deposit, Northern Tibet显示文摘Objective The Shangxu gold deposit is located in the south of the middle Bangong-Nujiang suture zone in northern Tibet.The origin of this deposit as an orogenic gold deposit is debatable.The study of the Shangxu deposit has a profound implication on gold exploration in the BangongNujiang metallogenic belt and can also improve our understanding of gold mineralization in northern Tibet. | PEI Yingru YANG Zhusen ZHAO Xiaoyan ZHANG Xiong MA Wang MAO Jingtao | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 2 |
| 5 | Review and outlook on the international renewable energy development显示文摘Renewable energy has become an important choice to solve the energy crisis and environmental problems.A sustainable development needs policies and strategies policies,which can improve energy efficiency and reduce greenhouse gas emissions.By collecting the research results released by relevant statistical departments and authoritative institutions,this paper summarizes the international energy development situation,systematically combs the energy development situation of the European Union,United States,Australia,India,Brazil.The development trend of wind,solar,biomass,geothermal,ocean,and hydrogen energy have been analyzed.In addition,this paper proposes that China should draw up its own development path of renewable energy from international development experience,and actively explore renewable energy policies and strategies adapted to different stages of development. | Li Li Jian Lin Nianyuan Wu Shan Xie Chao Meng Yanan Zheng Xiaonan Wang Yingru Zhao | 2022 | Energy and Built Environment2022，3，2： | 2 |
| 6 | Performance analysis andparametric optimum criteria of an irreversible Atkinsonheatengine显示文摘 | ZHAO Yingru CHEN Jincan | 2006 | Applied Energy2006，83，8： | 1 |
| 7 | Optimum performance analysis of an irreversible Diesel heat engine affected by variable heat capacities of working fluid显示文摘 | ZHAO Yingru CHEN Jincan | 2007 | Energy Conversion and Management2007，48，： | 1 |
| 8 | Performance anal-ysis and parametric optimum Criteria of anirrevers-ible Atkinson heat-engine 显示文摘 | Yingru Zhao Jinean Chen | 2006 | Applied Energy2006，83，： | 1 |
| 9 | Performance analysis of an irreversible Miller heat engine and its optimum criteria 显示文摘 | Yingru Zhao Jincan Chen | 2007 | Applied Thermal Engineering2007，27，1112： | 1 |
| 10 | Performance analysis and parametrie optimum criteria of an irreversible Atkinson heatengine 显示文摘 | Yingru Zhao Jincan Chen | 2006 | Applied Energy2006，83，： | 1 |
| 11 | Maximum power and corresponding efficiency of an irreversible blue heat engine for harnessing waste heat and salinity gradient energy显示文摘In this study,a novel irreversible cyclic model of a capacitive mixing blue heat engine mainly consisting of super capacitors,charging and discharging circuits,a heat source,as well as two water sources with given salt concentrations is established for harvesting salinity gradient energy and waste heat.Additionally,the effects of the charging voltage and ratio of the minimum to maximum surface electric charge density on the thermodynamic efficiency and power output of the cycle are discussed.The maximum power output of the cycle is calculated.The optimized ranges of efficiency and power output as well as the temperatures of two isothermal processes are determined.It is established that during the isoelectric quantity process,there is not only an increase in thermal voltage owing to the temperature difference,but also an increase in concentration voltage owing to the salinity gradient.Consequently,the blue heat engine can obtain higher energy conversion efficiency than a conventional heat engine.When the temperature ratio of the heat source to the heat sink is 1.233,the maximum efficiency can reach approximately36%.The results obtained can promote the application of capacitive mixing technology in real life,reducing the consumption of fossil fuels. | LIN Jian XIE Shan JIANG ChenXing SUN YiFei CHEN JinCan ZHAO YingRu | 2022 | Science China(Technological Sciences)2022，65，3： | 1 |
| 12 | Optimaum performance analysis of an irreversible Diesel heat engine affected by variable heat capacities of working fluid显示文摘 | Yingru Zhao Jincan Chen | 2007 | Energy Conversion and Management2007，48，： | 1 |
| 13 | Effect of Detail Nursing Intervention on Headache and Negative Emotion in Patients with Subarachnoid Hemorrhage显示文摘objective: to explore the effect of detail nursing intervention on headache and negative emotion in patients with subarachnoid hemorrhage. Methods: the clinical data of 100 cases of subarachnoid hemorrhage from January 2015 to January 2017 of neurosurgery in our hospital were randomly divided into the control group and the experimental group, Detail nursing intervention in experimental group, Comparison of two groups of clinical nursing effects. Results the duration of hospitalization and headache in the experimental group were shorter than those in the control group. Fewer headaches than control group (P<0.05) Less headache than control group (p<0.05). Results: the results of SAS and SDS scores were significantly lower than those in the control group (p<0.05) after nursing in the experimental group. Conclusion: the patients with subarachnoid hemorrhage receive detailed nursing intervention;contribute to the alleviation of their headache symptoms, Relieves the patient of negative emotional problems. | Yangyang Zhao Jingyi Yang Zhenyao Wang Yingru Chen | 2018 | Journal of Advances in Medicine Science2018，1，3： | 0 |
| 14 | Perspective on the R&Ds in energy chemistry systems engineering显示文摘1 Introduction Energy chemistry systems engineering(ECSE),the application of the principles of system engineering in the field of energy chemistry,is a rapidly developing cutting-edge interdiscipline.It is used for various processes and systems in the domain of energy chemistry,dealing with problems of the efficient conversion,comprehensive utilization and complementary integration of material and energy with the theories,methods and techniques of system engineering,in order | Yingru Zhao Xiangyan Zhan Shiqi Zhang Meng Wang | 2017 | Science China Chemistry2017，60，11： | 0 |
| 15 | Advances in component and operation optimization of solid oxide electrolysis cell显示文摘Considering the earth powered by intermittent renewable energy in the coming future,solid oxide electrolysis cell(SOEC)will play an indispensable role in efficient energy conversion and storage on demand.The thermolytic and kinetic merits grant SOEC a bright potential to be directly integrated with electrical grid and downstream chemical synthesis process.Meanwhile,the scientific community are still endeavoring to pursue the SOEC assembled with better materials and operated at a more energy-efficient way.In this review article,at cell level,we focus on the recent development of electrolyte,cathode,anode and buffer layer materials for both steam and CO_(2)electrolysis.On the other hand,we also discuss the next generation SOEC operated with the assistant of other fuels to further reduce the energy consumption and enhance the productivity of the electrolyzer.And stack level,the sealant,interconnect and stack operation strategies are collectively covered.Finally,the challenges and future research direction in SOECs are included. | Xiaoxin Zhang Bo Liu Yanling Yang Jianhui Li Jian Li Yingru Zhao Lichao Jia Yifei Sun | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
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