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| 1 | Mechanism of Ascorbic Acid-induced Reversion Against Malignant Phenotype in Human Gastric Cancer Cells显示文摘Objective To find out the mechanisms of redifferentiation and reversion of malignant human gastric cancer cells induced by ascorbic acid. Methods Human gastric cancer cells grown in the laboratory were used. The Trypan blue dye exclusion method was used to determine the cell doubling time. The electrophoresis rate and colonogenic potential were the indices used to measure the rate of redifferentiation. The content of malondialdehyde (MDA) was measured using the thiobarbituric acid (TBA) method. The activities of superoxide dismutase (SOD), catalase (CAT) and the content of H2O2 were evaluated by spectrophotography. Results Six mmol/L ascorbic acid was used as a positive control. Human gastric cancer cells were treated with 75 μm hydrogen peroxide, which alleviated many of the malignant characteristics. For example, the cell surface charge obviously decreased and the electrophoresis rate dropped from 2.21 to 1.10 μm·s-1·V-1·cm-1. The colonogenic potential, a measure of cell differentiation, decreased 90.2%. After treatment with ascorbic acid, there was a concentration- and time-dependent increase in hydrogen peroxide (H2O2) and the activity of superoxide dismutase (SOD). However, the activity of catalase (CAT) resulted in a concentration- and time-dependent decrease. SOD and 3-amino-1,2,4-triazole (AT) exhibited some effects, but there were statistically significant differences between the SOD and AT group and the H2O2 group. Conclusions Ascorbic acid induces growth inhibition and redifferentiation of human gastric cancer cells through the production of hydrogen peroxide. | YA-XUAN SUN QIU-SHENG ZHENC GANG LI DE-AN GUO ZI-REN WANG | 2006 | Biomedical and Environmental Sciences2006，19，5： | 5 |
| 2 | Tolerance evaluation of rice varieties to the brown planthopper,Nilaparvata lugens feeding显示文摘The brown planthopper, Nilaparvata lugens (Stal) (BPH) is one of the most important insect pests of rice in China and other east-southern Asian countries. | CHEN Jianming YU Xiaoping LU Zhongxian ZHENC Xusong Xu Hongxing,Inst of Plant Protection,Zhejiang Acad of Agri Sci,Hangzhou 310021 CHENG Jia ’an,Dept of Plant Protection,Zhejiang Univ,Hangzhou 310029,China | 2002 | Chinese Rice Research Newsletter2002，10，3： | 2 |
| 3 | Application of BP NN and RBF NN in Modeling Activated Aludge System显示文摘 | WANG W B ZHENC P LI J Y | | 0，，03： | 1 |
| 4 | Study on conductivity property and microstructure of TritonX-100/alkanol/n-heptane/ water microemulsion 显示文摘 | LI X C HE G H ZHENC W J | 2010 | Colloids Surf A : Physicochem Eng Aspects2010，360，13： | 1 |
| 5 | Locally linear dis- criminant embedding: an efficient method for face recognition 显示文摘 | LI Bo ZHENC Chun-hou HUANG De-shuang | 2008 | Pattorn Roeognition2008，41，12： | 1 |
| 6 | Development and Performance of CaO/La2O3 Sorbents During Calcium Looping Cycles for CO2 Capture 显示文摘 | LUO Cong ZHENC Ying Ding Ning | 2010 | Industrial & Engineering Chemistry Research2010，49，11： | 1 |
| 7 | A study on a single-unit Markov repairable system with repair time omission 显示文摘 | ZHENC Z H Cur L R HAWKES A G | 2006 | IEEE Transactions on Reliability2006，55，2： | 1 |
| 8 | Manipulating nanoparticles in solution with electrically contacted nanotubes using dielectrophoresis显示文摘 | ZHENC L F LI S D BRODY J P | 2004 | Langmuir2004，20，20： | 1 |
| 9 | Molecularly imprinted polymer micro-spheres for solid-phase extraction of chloramphenicol residues in foods显示文摘 | SHI Xizhi WU Aibo ZHENC Sulian | 2007 | J Chromatogr: B2007，850，12： | 1 |
| 10 | An expression for fa tigue life ariel probability distribution of fatigue strength under repeated torsion显示文摘 | ZHENG Qing xiong ZHENC Xiu-lin | 1993 | Engineering Fraeture Mechanics1993，44，4： | 1 |
| 11 | Cear fault diagnosis bused on continuous wavelet transform显示文摘 | ZHENC H LI Z CHEN X | | 0，，2： | 1 |
| 12 | Globally optimal lin- ear precoders for finite alphabet signals over complex vector Gaussian channels 显示文摘 | XIAO C ZHENC Y R DING Z | 2011 | IEEE Transactions on Signal Processing2011，59，7： | 1 |
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