|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Distribution of plant species and species-soil relationship in the east central Gurbantunggut Desert, China显示文摘在在东方的种类和土壤因素之间的植物种类和关系的分发 Gurbantunggut 沙漠的中央部分被学习提供更多的卓见进植物群并且越过沙漠的各种各样的部分在植被决定差别。双向簇分析证明在区域的植被能被划分成三个组,第一个组被灌木种类, Ephedra przewalskii 和草种类统治,主要在扁平的根据和轻轻的斜坡的区域的 Carex physodes;第二个组被 C 统治。physodes, Artemisia songorica 和 A。主要沙沙丘和第三个组的斜坡上的 xerophytica 被灌木种类统治,主要沙沙丘的顶上的 Haloxylon persicum。在植物密度在之间没有差别组织 1 和 2,但是在组 3 有重要减少。不到植被组 3 的土壤水比在其它,二个组根本玷污深度的低得多。EC,有机物,全部的 P 和可溶的 Na, Ca 和 Mg 与土壤水很同样变化了。正规通讯分析(CCA ) 令人满意地在区域估计了种类土壤关系。植物种类的分发强烈与水内容,有机物, EC 和营养素的土壤因素被相关。在三把 CCA 斧子解释的种类出现的变化是大约 70% ,显示一些解释地点变量可以在我们的学习参数外面存在。土壤质地被建议在未来研究被包括改进 CCA 的解释。 | AN Ping LI Xiangjun ZHENG Yuanrun ENEJI A. Egrinya QIMAN Yunus ZHENG Mingqing INANAGA Shinobu | 2015 | Journal of Geographical Sciences2015，25，1： | 11 |
| 2 | 胎儿期恰逢1959~1961年饥荒的中国成人精神分裂症的发病率显示文摘背景:精神分裂症是一种常见的中度精神障碍。子宫内营养缺乏可增大患精神分裂症的危险。其主要依据来自1944~1945年荷兰饥饿冬天(Dutch Hunger Winter)研究,当时食品摄入在短期内极剧下降。这项有关饥荒期间受孕人群的大型队列研究显示,发生精神分裂症的危险增大两倍。
目的:确定经受1959~1961年大饥荒的中国人是否有相似的结果。
设计、地点及参试者:发生精神分裂症危险的调查于安徽省芜湖地区进行,这是当初受灾最重的地区之一。对饥荒之前、饥荒期间和饥荒以后出生的人群发病率进行比较。芜湖及其周围6个县是由一所精神病院负责的。对1971~2001年所有的精神病病历记录均进行检查。精神分裂症患者的临床和社会人口学资料由对自然灾害暴露情况不知情的研究者摘录。有关饥荒年出生人数和死亡人数的数据是有效可用的,累积死亡率根据以后的人口学调查进行估计。
主要观测指标:饥荒的证据已经核实,计算未校正的以及对死亡率进行校正后的发生精神分裂症的相对危险度。
结果:安徽省的出生率(每1000人)在饥荒期问降低了约80%,从1958年的28.28降至1959年的20.97、1960年的8.61和1961年的11.06。在饥荒期间出生的人,晚年发生精神分裂症的校正后危险明显增高,从1959年的0.84%增至1960年的2.15%和1961年的1.81%。死亡率校正相对危险在1960年出生者为2.30(95%可信区间,1.99~2.05),1961年出生者为1.93(95%可信区间,1.68~2.23)。
结论:我们的调查重复了荷兰不同种族人群的数据,结果显示,出生前遭受饥荒可增高晚年患精神分裂症的危险。 | David St Clair Mingqing Xu Peng Wang Yaqin Yu Yourong Fang Feng Zhang Xiaoying Zheng Niufan Gu Guoyin Feng Pak Sham Lin He 张继志(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 3 |
| 3 | Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis显示文摘The adenoma-carcinoma sequence is a well-accepted roadmap for the development of sporadic colorectal cancer.However,cellular heterogeneity in aberrant epithelial cells limits our understanding of carcinogenesis in colorectal tissues.Here,we performed a single-cell RNA sequencing survey of 54,788 cells from patient-matched tissue samples,including blood,normal tissue,para-cancer,polyp,and colorectal cancer. | Xiaobo Zheng Jinen Song Chune Yu Zongguang Zhou Xiaowei Liu Jing Yu Guangchao Xu Jiqiao Yang Xiujing He Xin Bai Ya Luo Yu Bao Huifang Li Lie Yang Mingqing Xu Nan Song Xiaodong Su Jie Xu Xuelei Ma Hubing Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 4 | Flowerlike PtCl4/Bi2WO6composite photocatalyst with enhanced visible-light-induced photocatalytic activity显示文摘 | Fang Duan Yan Zheng MingQing Chen | 2011 | Applied Surface Science2011，2，： | 1 |
| 5 | Synthetic Bi2 02 CO3 nanostrnctures : Novel photocatalyst with controlled special surface exposed显示文摘 | Zheng Yan Duan Fang Chen MingQing | 2010 | Journal of Molecular Catalysis A: Chemical2010，317，12： | 1 |
| 6 | Enhanced photocatalytic activity of bismuth molybdates with the preferentially exposed {0<ce:hsp sp='0.25'/>1<ce:hsp sp='0.25'/>0} surface under visible light irradiation显示文摘 | Yan Zheng Fang Duan Ju Wu Liang Liu Mingqing Chen Yi Xie | 2009 | Journal of Molecular Catalysis A Chemical2009，，1： | 1 |
| 7 | Synthetic Bi 2 O 2 CO 3 nanostructures: Novel photocatalyst with controlled special surface exposed显示文摘 | Yan Zheng Fang Duan Mingqing Chen Yi Xie | 2009 | Journal of Molecular Catalysis. A, Chemical2009，，1： | 1 |
| 8 | Flowerlike PtCl4/Bi2WO6 composite photocatalyst with enhanced visible-light-induced photocatalytic activity显示文摘 | Duan Fang Zheng Yan Chen Mingqing | | 0，，： | 1 |
| 9 | Outlook for Oil and Gas Engineering Technology in China显示文摘In the field of global oil and gas engineering science and technology, innovative progress has been made in deep sea exploration, unconventional oil and gas exploration, deep exploration in mature areas, and improvements in recovery efficiency and supporting technologies. The oil and gas industry in China has entered the stage of 'simultaneous development of both shallow and deep sea areas, conventional and unconventional oil and gas, and onshore and offshore exploration', withonshore deep areas,deep sea areas,and unconventional oil and gas as important exploration priorities. Oil and gas engineering science and technology in China has seen 14 breakthroughs made in key areas and 6 key tasks to be completed in the fields of 'onshore deep exploration, deep sea exploration, unconventional oil and gas exploration, recovery efficiency improvement and supporting engineering technologies'. These developments will effectively promote the orderly succession of oil and gas exploration and the efficient use of oil and gas resources to achieve a sustained and healthy development of the oil and gas industry in China and boost the development and utilization of overseas resources. | Liang Kun Zhang Guosheng Su Jian Zheng Jing Meng Hao Zhou Mingqing | 2018 | China Oil & Gas2018，25，1： | 0 |
| 10 | Identification of Bulbocodin D and C as novel STAT3 inhibitors and their anticancer activities in lung cancer cells显示文摘Cancer stands as one of the predominant causes of mortality globally, necessitating ongoing efforts to develop innovative therapeutics. Historically, natural products have been foundational in the quest for anticancer agents. Bulbocodin D (BD) and Bulbocodin C (BC), two bibenzyls derived from Pleione bulbocodioides (Franch.) Rolfe, have demonstrated notable in vitro anticancer activity. In human lung cancer A549 cells, the IC50s for BD and BC were 11.63 and 11.71 μmol·L^(−1), respectively. BD triggered apoptosis, as evidenced by an upsurge in Annexin V-positive cells and elevated protein expression of cleaved-PARP in cancer cells. Furthermore, BD and BC markedly inhibited the migratory and invasive potentials of A549 cells. The altered genes identified through RNA-sequencing analysis were integrated into the CMap dataset, suggesting BD’s role as a potential signal transducer and activator of transcription 3 (STAT3) inhibitor. SwissDock and MOE analyses further revealed that both BD and BC exhibited a commendable binding affinity with STAT3. Additionally, a surface plasmon resonance assay confirmed the direct binding affinity between these compounds and STAT3. Notably, treatment with either BD or BC led to a significant reduction in p-STAT3 (Tyr 705) protein levels, regardless of interleukin-6 stimulation in A549 cells. In addition, the extracellular signal-regulated kinase (ERK) was activated after BD or BC treatment. An enhancement in cancer cell mortality was observed upon combined treatment of BD and U0126, the MEK1/2 inhibitor. In conclusion, BD and BC emerge as promising novel STAT3 inhibitors with potential implications in cancer therapy. | HE Xinyu FU Jiarui LYU Wenyu HUANG Muyang MO Jianshan CHENG Yaxin XU Yulian ZHENG Lijun ZHANG Xiaolei QI Lu ZHANG Lele ZHENG Ying HUANG Mingqing NI Lin LU Jinjian | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员