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| 1 | Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese显示文摘Single-nucleotide polymorphisms (SNPs) of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus (T2DM), but there are many conflicting results especially in Chinese populations. To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects. rs16861194 (-11426 A>G) in the putative promoter of ADIPOQ was associated with T2DM (P = 0.007; OR = 1.29, 95% CI 1.08-1.55). None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. There was also no significant difference found from the ADIPOQ haplotype analysis, which contains rs16861194. In addition, we also assessed potential gene-gene interactions in three genes and no interactions were found. In conclusion, our results supported the ADIPOQ gene as a possible risk factor for type 2 diabetes in Han Chinese population. | Yabing Wang Di Zhang Yun Liu Yifeng Yang Teng Zhao Jie Xu Sheng Li Zuofeng Zhang Guoyin Feng Lin He He Xu | 2009 | Journal of Genetics and Genomics2009，36，7： | 7 |
| 2 | Rough set extensions in incomplete information systems显示文摘All eight possible extended rough set models in incomplete information systems are proposed.By analyzing existing extended models and technical meth-ods of rough set theory,the strategy of model extension is found to be suitable for processing incomplete information systems instead of filling possible values for missing attributes.After analyzing the definitions of existing extended models,a new general extended model is proposed.The new model is a generalization of indiscernibility relations,tolerance relations and non-symmetric similarity relations.Finally,suggestions for further study of rough set theory in incomplete informa-tion systems are put forward. | Guoyin WANG Lihe GUAN Feng HU | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，4： | 7 |
| 3 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 4 | 胎儿期恰逢1959~1961年饥荒的中国成人精神分裂症的发病率显示文摘背景:精神分裂症是一种常见的中度精神障碍。子宫内营养缺乏可增大患精神分裂症的危险。其主要依据来自1944~1945年荷兰饥饿冬天(Dutch Hunger Winter)研究,当时食品摄入在短期内极剧下降。这项有关饥荒期间受孕人群的大型队列研究显示,发生精神分裂症的危险增大两倍。
目的:确定经受1959~1961年大饥荒的中国人是否有相似的结果。
设计、地点及参试者:发生精神分裂症危险的调查于安徽省芜湖地区进行,这是当初受灾最重的地区之一。对饥荒之前、饥荒期间和饥荒以后出生的人群发病率进行比较。芜湖及其周围6个县是由一所精神病院负责的。对1971~2001年所有的精神病病历记录均进行检查。精神分裂症患者的临床和社会人口学资料由对自然灾害暴露情况不知情的研究者摘录。有关饥荒年出生人数和死亡人数的数据是有效可用的,累积死亡率根据以后的人口学调查进行估计。
主要观测指标:饥荒的证据已经核实,计算未校正的以及对死亡率进行校正后的发生精神分裂症的相对危险度。
结果:安徽省的出生率(每1000人)在饥荒期问降低了约80%,从1958年的28.28降至1959年的20.97、1960年的8.61和1961年的11.06。在饥荒期间出生的人,晚年发生精神分裂症的校正后危险明显增高,从1959年的0.84%增至1960年的2.15%和1961年的1.81%。死亡率校正相对危险在1960年出生者为2.30(95%可信区间,1.99~2.05),1961年出生者为1.93(95%可信区间,1.68~2.23)。
结论:我们的调查重复了荷兰不同种族人群的数据,结果显示,出生前遭受饥荒可增高晚年患精神分裂症的危险。 | David St Clair Mingqing Xu Peng Wang Yaqin Yu Yourong Fang Feng Zhang Xiaoying Zheng Niufan Gu Guoyin Feng Pak Sham Lin He 张继志(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 3 |
| 5 | Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population显示文摘 | Jixia Liu Yongyong Shi Wei Tang Tingwei Guo Dawei Li Yifeng Yang Xinzhi Zhao Hongsheng Wang Xingwang Li Guoyin Feng Niufan Gu Shaomin Zhu Huijun Liu Yangling Guo Jianguo Shi Hong Sang Lijuan Yan Lin He | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 1 |
| 6 | Differences in CYP3A4 ? 1G genotype distribution and haplotypes of CYP3A4 , CYP3A5 and CYP3A7 in 3 Chinese populations显示文摘 | Jing Du Lan Yu Lei Wang Aiping Zhang Anli Shu Lingyun Xu Mingsheng Xu Yongyong Shi Xingwang Li Guoyin Feng Qinghe Xing Lin He | 2007 | Clinica Chimica Acta2007，，1： | 1 |
| 7 | Systematic screening for polymorphisms in the CYP3A4 gene in the Chinese population显示文摘 | Jing Du Qinghe Xing Lingyun Xu Mingsheng Xu Anli Shu Yongyong Shi Lan Yu Aiping Zhang Lei Wang Hongsheng Wang Xingwang Li Guoyin Feng Lin He | 2006 | Pharmacogenomics2006，，6： | 1 |
| 8 | A novel method for elimination of inconsistencies in ordinal classification with monotonicity constraints显示文摘 | Deng Weibin Wang Guoyin Hu Feng | 2013 | Fundamenta Informaticae2013，126，4： | 1 |
| 9 | An overview of the Semi-arid Climate and Environment Research Observatory over the Loess Plateau显示文摘 | Jianping Huang Wu Zhang Jinqing Zuo Jianrong Bi Jinsen Shi Xin Wang Zhoulin Chang Zhongwei Huang Su Yang Beidou Zhang Guoyin Wang Guanghong Feng Jiuyi Yuan Lei Zhang Hongchao Zuo Shigong Wang Congbin Fu Chou Jifan | | 0，2008，： | 1 |
| 10 | A novel locus of coralliform cataract mapped to chromosome 2p24-pter显示文摘 | Linghan Gao Wei Qin Hao Cui Guoyin Feng Ping Liu Weiqi Gao Lin Ma Pu Li Lin He Songbin Fu | 2005 | Journal of Human Genetics2005，，6： | 1 |
| 11 | Knowledge reduction based on di- vide and conquer method in rough set theory 显示文摘 | Hu Feng Wang Guoyin | 2012 | Mathemati- cal Problems in Engineering2012，，： | 1 |
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