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| 1 | Advances in the Pathogenesis of Alzheimer’s Disease:Focusing on Tau-Mediated Neurodegeneration显示文摘In addition to senile plaques and cerebral amyloid angiopathy,the hyperphosphorylation of tau protein and formation of intraneuronal neurofibrillary tangles(NFTs)represents another neuropathological hallmark in AD brain.Tau is a microtubule-associated protein and localizes predominantly in the axons of neurons with the primary function in maintaining microtubules stability.When the balance between tau phosphorylation and dephosphorylation is changed in favor of the former,tau is hyperphosphorylated and the level of the free tau fractions elevated.The hyperphosphorylation of tau protein and formation of NFTs represent a characteristic neuropathological feature in AD brain.We have discussed the role of Aβin AD in our previous review,this review focused on the recent advances in tau-mediated AD pathology,mainly including tau hyperphosphorylation,propagation of tau pathology and the relationship between tau and Aβ. | Yale Duan Suzhen Dong Feng Gu Yinghe Hu Zheng Zhao | 2012 | Translational Neurodegeneration2012，1，1： | 15 |
| 2 | Advances in the pathogenesis of Alzheimer’s disease:a re-evaluation of amyloid cascade hypothesis显示文摘Alzheimer’s disease(AD)is a common neurodegenerative disease characterized clinically by progressive deterioration of memory,and pathologically by histopathological changes including extracellular deposits of amyloid-beta(A-beta)peptides forming senile plaques(SP)and the intracellular neurofibrillary tangles(NFT)of hyperphosphorylated tau in the brain.This review focused on the new developments of amyloid cascade hypothesis with details on the production,metabolism and clearance of A-beta,and the key roles of some important A-beta-related genes in the pathological processes of AD.The most recent research advances in genetics,neuropathology and pathogenesis of the disease were also discussed. | Suzhen Dong Yale Duan Yinghe Hu Zheng Zhao | 2012 | Translational Neurodegeneration2012，1，1： | 13 |
| 3 | Potassium pre-inserted K1.04Mn8O16 as cathode materials for aqueous Li-ion and Na-ion hybrid capacitors显示文摘For the applications of aqueous Li-ion hybrid capacitors and Na-ion hybrid capacitors,potassium ions are pre-inserted into MnO2 tunnel structure,the as-prepared K1.04Mn8 O16 materials consist of nanoparticles and nanorods were prepared by facile high-temperature solid-state reaction.The as-prepared materials were well studied and they show outstanding electrochemical behavior.We assembled hybrid supercapacitors with commercial activated carbon(YEC-8 A)as anode and K1.04Mn8 O16 as cathode.It shows high energy and power densities.Li-ion capacitors reach a high energy density of 127.61 Wh kg-1 at the power density of 99.86 W kg-1 and Na-ion capacitor obtains 170.96 Wh kg-1 at 133.79 W kg-1.In addition,the hybrid supercapacitors demonstrate excellent cycling performance which maintain 97%capacitance retention for Li-ion capacitor and 85%for Na-ion capacitor after 10,000 cycles. | Yamin Zhang Lina Chen Chongyang Hao Xiaowen Zheng Yixuan Guo Long Chen Kangrong Lai Yinghe Zhang Lijie Ci | 2020 | Journal of Energy Chemistry2020，29，7： | 1 |
| 4 | Sedimentary Characteristics and Models of Paleo-salt Lake During Paleocene and Eocene in the Jiangling Depression of Central China显示文摘1 Sedimentary Characteristics of Paleo-salt Lake In early sedimentary stages of Shashi formation,because of drought climate and the concentration of lake,a set of salt strata of hundreds of meters is developed in the | WANG Chunlian LIU Chenglin XU Haiming YU Xiaocan XIE tengxiao ZHENG Yinghe | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 0 |
| 5 | Spatially Resolved Properties of the GW170817 Host Galaxy显示文摘GW170817 is the unique gravitational-wave(GW)event associated with the electromagnetic(EM)counterpart GRB 170817A.NGC 4993 is identified as the host galaxy of GW170817/GRB 170817A.In this paper,we focus on the spatially resolved properties of NGC 4993.We present the photometric results from the comprehensive data analysis of the high spatial-resolution images in the different optical bands.The morphological analysis reveals that NGC 4993 is a typical early-type galaxy without significant remnants of a major galaxy merger.The spatially resolved stellar population properties of NGC 4993 suggest that the galaxy center has passive evolution with the outskirt formed by gas accretion.We derive the merging rate of the compact object per galaxy by a co-evolution scenario of a supermassive black hole and its host galaxy.If the galaxy formation is at redshift 1.0,the merging rate per galaxy is from 3.2×10^(-4)to 7.7×10^(-5)within the merging decay time from 1.0 to 5.0 Gyr.The results provide vital information for ongoing GW EM counterpart detections.The Hubble space telescope data analysis presented in this paper can be also applied to Chinese Space Station Telescope research in the future. | Yubin Li Jirong Mao Jianbo Qin Xianzhong Zheng Fengshan Liu Yinghe Zhao Xiaohong Zhao | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 0 |
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