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| 1 | Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo显示文摘The sustained-release properties of the biodegradable nano-drug delivery systems were used to improve the residence time of the chemotherapeutic agent in the body. These drug delivery systems were widely used to deliver chemotherapeutic drugs. The 5-fluorouracil loaded chitosan nanoparticles prepared in this paper have the above advantage. Here, we found that when the mass ratio of 5-fluorouracil and chitosan was 1:1, the maximum drug loading of nanoparticles was 20.13 ± 0.007%, the encapsulation efficiency was 44.28 ± 1.69%, the particle size was 283.9 ± 5.25 nm and the zeta potential was 45.3 ± 3.23 mV. The prepared nanoparticles had both burst-release and sustained-release phases in vitro release studies.In addition, the inhibitory effect of the prepared nanoparticles on gastric cancer SGC-7901 cells was similar to that of 5-fluorouracil injection, and the blank vector had no obvious inhibitory effect on SGC-7901 cells. In the pharmacokinetic study of rats in vivo, we found that AUC(0-t), MRT(0-t) and t1/2 z of nanoparticles were significantly increased in vivo compared with 5-fluorouracil solution, indicating that the prepared nanoparticles can play a role in sustained-release. | Li Sun Yunna Chen Yali Zhou Dongdong Guo Yufan Fan Fangyan Guo Yufeng Zheng Weidong Chen | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 4 |
| 2 | Stochastic stability of networked control systems with network-induced delay and data dropout显示文摘This paper deals with the stochastic stability of networked control systems with the presence of network-induced delay and transmitted data dropout. Based on the Lyapunov approach, sufficient conditions for the mean-square stability of the networked control system are derived subject that the sequence of transmission interval is driven by an identically independently distributed sequence and by a finite state Markov chain, respectively. Stabilization controllers are constructed in terms of linear matrix inequalities correspondingly. An example is provided to illustrate our results. | Xiaomei ZHANG Yufan ZHENG Guoping LU | 2008 | 控制理论与应用(英文版)2008，6，4： | 3 |
| 3 | A model of calcium signaling and degranulation dynamics induced by laser irradiation in mast cells显示文摘Recent experiments show that calcium signaling and degranulation dynamics induced by low power laser irradiation in mast cells must rely on extracellular Ca2+ influx. An analytical expression of Ca2+ flux through TRPV4 cation channel in response to interaction of laser photon energy and extracellular Ca2+ is deduced, and a model characterizing dynamics of calcium signaling and degranulation activated by laser irradiation in mast cells is established. The model indicates that the characteristics of calcium signaling and degranulation dynamics are determined by interaction between laser photon energy and Ca2+ influx. Extracellular Ca2+ concentration is so high that even small photon energy can activate mast cells, thus avoiding the possible injury caused by laser irradiation with shorter wavelengths. The model predicts that there exists a narrow parameter domain of photon energy and extracellular Ca2+ concen-tration of which results in cytosolic Ca2+ limit cycle oscillations, and shows that PKC activity is in direct proportion to the frequency of Ca2+ oscillations. With the model it is found that sustained and stable maximum plateau of cytosolic Ca2+ concentration can get optimal degranulation rate. Furthermore, the idea of introducing the realistic physical energy into model is applicable to modeling other physical signal transduction systems. | SHI XiaoMin ZHENG YuFan LIU ZengRong YANG WenZhong | 2008 | Chinese Science Bulletin2008，53，15： | 3 |
| 4 | Grain Boundary Distribution Evolution of 00Cr12Ti FSS during Annealing显示文摘The texture and grain boundary of 00Cr12 Ti FSS have a close correlation with properties and should be controlled to optimize the performance of steel sheets. In this paper, the macrotexture evolution during recrystallization annealing was investigated by XRD, the microtexture and grain boundary distribution evolution during recrystallization annealing were investigated by EBSD. The results showed that the γ fiber texture were mainly generated by replacing α fiber texture in recrystallization process. But with the holding time extending,γ fiber texture transferred to other texture after the holding time got to a certain degree. The major CSLs in 00Cr12 Ti FSS after recrystallization are Σ3 and the frequency of Σ3 climb up and then decline with the holding time extending.Σ11 plays an important role in the process of recrystallized γ fiber texture formation. | 殷安民 WANG Yufan SHU Xuedao ZHU Zhenge PENG Hao | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，4： | 2 |
| 5 | Fish Lateral Line Inspired Flow Sensors and Flow-aided Control: A Review显示文摘Any phenomenon in nature is potential to be an inspiration for us to propose new ideas.Lateral line is a typical example which has attracted more interest in recent years.With the aid of lateral line,fish is capable of acquiring fluid information around,which is of great significance for them to survive,communicate and hunt underwater.In this paper,we briefly introduce the morphology and mechanism of the lateral line first.Then we focus on the development of artificial lateral line which typically consists of an array of sensors and can be installed on underwater robots.A series of sensors inspired by the lateral line with different sensing principles have been summarized.And then the applications of artificial lateral line systems in hydrodynamic environment sensing and vortices detection,dipole oscillation source detection,and autonomous control of underwater robots have been reviewed.In addition,the existing problems and future foci in this field have been further discussed in detail.The current works and future foci have demonstrated that artificial lateral line has great potentials of applications and contributes to the development of underwater robots. | Yufan Zhai Xingwen Zheng Guangming Xie | 2021 | Journal of Bionic Engineering2021，18，2： | 2 |
| 6 | A system inversion approach to chaos-based secure speech communication 显示文摘 | ZHENG Yufan CHEN Guangrong ZHU Canyan | 2005 | International Journal of Bifurcation and Chaos2005，15，8： | 1 |
| 7 | Effects of Cryptococcus laurentii on biocontrol of postharvest decay in Chinese altutus fruits 显示文摘 | ZHENG Xiaodong ZHANG Hongyin XI Yufan | 2004 | Botanical Bulletin of Academia Sinica2004，45，： | 1 |
| 8 | Industrial sector-based volatile organic compound (VOC) source profiles measured in manufacturing facilities in the Pearl River Delta, China显示文摘 | Junyu Zheng Yufan Yu Ziwei Mo Zhou Zhang Xinming Wang Shasha Yin Kang Peng Yang Yang Xiaoqiong Feng Huihua Cai | 2013 | Science of the Total Environment2013，，： | 1 |
| 9 | Industrial sector- based volatile organic compound (VOC) source profiles meas- ured in manufacturing facilities in the Pearl River Delta, China 显示文摘 | ZHENG Junyu YU Yufan MO Ziwei | 2013 | Science of the Total Environment2013，，1： | 1 |
| 10 | Global behavior of dynamical agents in directed network显示文摘This paper investigates the global behavior of controlled dynamical agents in directed networks. The agents are Lyapunov stable, are distributed in a line, and communicate through a directed network. The communication topology of the network is characterized by a directed graph and the control protocol is designed in simple linear decentralized feedback law. We study the different conditions under which agents will achieve aggregation, and critical and divergent trajectories, respectively. Our investigation on the dynamical agent system under network is extended to the time-delay network case. Furthermore, we study the case with two pre-specified virtual leaders in the system. Numerical simulations are given and demonstrate that our theoretical results are effective. | Hongwang YU Yufan ZHENG | 2009 | 控制理论与应用(英文版)2009，7，3： | 1 |
| 11 | Observer design for descriptor Markovian jumping systems with nonlinear perturbations 显示文摘 | Zhang Xiaomei Lu Guoping Zheng Yufan | 2008 | Circuits Syst Signal Process2008，27，： | 1 |
| 12 | Synthesis and application of single-atom catalysts in sulfur cathode for high-performance lithium–sulfur batteries显示文摘Lithium–sulfur(Li-S)batteries are regarded as one of the most promising energy storage devices because of their low cost,high energy density,and environmental friendliness.However,Li-S batteries suffer from sluggish reaction kinetics and serious“shuttle effect”of lithium polysulfides(LiPSs),which causes rapid decay of battery capacity and prevent their practical application.To address these problems,introducing single-atom catalysts(SACs)is an effective method to improve the electrochemical performance of Li-S batteries,due to their high catalytic efficiency and definite active sites for LiPSs.In this paper,we summarized the latest developments in enhancing the electrochemical performance of cathode for Li-S batteries through introducing different SACs.Furthermore,we briefly introduced the catalytic mechanism of SACs and discussed the strategies of synthesizing SACs,including the spatial confinement strategy and the coordination design strategy.Finally,the challenges and prospects in this field are proposed.We believe that this review would help to design and fabricate high-performance Li-S batteries via introducing SACs and boost their practical application. | Yingjie Miao Yufan Zheng Feng Tao Zhijun Chen Yi Xiong Fengzhang Ren Yong Liu | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 13 | On the model-based networked control for singularly perturbed systems显示文摘In this paper, the control of a two-time-scale plant, where the sensor is connected to a linear controller/ actuator via a network is addressed. The slow and fast systems of singularly perturbed systems are used to produce an estimate of the plant state behavior between transmission times, by which one can reduce the usage of the network. The approximate solutions of the whole systems are derived and it is shown that the whole systems via the network control are generally asymptotically stable as long as their slow and fast systems are both stable. These results are also extended to the case of network delay. | Hongwang YU Zhiming WANG Yufan ZHENG | 2008 | 控制理论与应用(英文版)2008，6，2： | 1 |
| 14 | Nonlinear H_∞ filtering for interconnected Markovian jump systems显示文摘The problem of nonlinear H_∞ filtering for interconnected Markovian jump systems is discussed. The aim of this note is the design of a nonlinear Markovian jump filter such that the resulting error system is exponentially mean-square stable and ensures a prescribed H_∞ performance. A sufficient condition for the solvability of this problem is given in terms of linear matrix inequalities(LMIs). A simulation example is presented to demonstrate the effectiveness of the proposed design approach. | Zhang Xiaomei Zheng Yufan | 2006 | Journal of Systems Engineering and Electronics2006，17，1： | 0 |
| 15 | Therapeutic application of chick early amniotic fluid: effective rescue of acute myocardial ischemic injury by intravenous administration显示文摘Myocardial regeneration has been considered a promising option for the treatment of adult myocardial injuries.Previously,a chick early amniotic fluid(ceAF)preparation was shown to contain growth-related factors that pro-moted embryonic growth and cellular proliferation,though the nature of the components within ceAF were not fully defined.Here we tested whether this ceAF preparation is similarly effective in the promotion of myocardial regen-eration,which could provide an alternative therapeutic for intervening myocardial injury.In this study,a myocardial ischemic injury model was established in adult mice and pigs by multiple research entities,and we were able to show that ceAF can efficiently rescue damaged cardiac tissues and markedly improve cardiac function in both experimental models through intravenous administration.ceAF administration increased cell proliferation and improved angio-genesis,likely via down-regulation of Hippo-YAP signaling.Our data suggest that ceAF administration can effectively rescue ischemic heart injury,providing the key functional information for the further development of ceAF for use in attenuating myocardial injury. | Baiping Cui Yufan Zheng Xiang Gao Lihong Zhang Borui Li Jia Chen Xinyan Zhou Mengyuan Cai Wenrui Sun Yuting Zhang Keejong Chang Jiayi Xu Fuyin Zhu Yan Luo Tao Sun Jin Qian Ning Sun | 2022 | Cell Regeneration2022，11，1： | 0 |
| 16 | Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osginl-Mediated Restoration of Efficient Autophagy显示文摘Pancreatitis is the leading cause of hospitalization in gastroenterology,and no medications are available for treating this disease in current clinical practice.FxR plays an anti-inflammatory role in diverse inflammatory diseases,while its function in pancreatitis remains unknown.In this study,we initially observed a marked increase of nuclear FXR in pancreatic tissues of human patients ithpancratis eleting theFXRinpancreati acinar cels FXRicnara/a)ledto moreseverepancreatitis in mousemodels of caerulein-induced acute and chronic pancreatitis,while the FXR agonist GW4064 significantly attenuated pancreatitis in caerulein or arginine-induced acute pancreatitis and caerulein-induced chronic pancreatitis.FXR deletion impaired the viability and stress responses of pancreatic exocrine organoids(PEOs)in vitro.Utilizing RNA-seq and ChIP-seq of PEOs,we identified Osginl as a direct target of FxR in the exocrine pancreas,which was also increasingly expressed in human pancreatitis tissues compared to normal pancreatic tissues.Pancreatic knockdown of Osgin1 by AAV-pan abolished the therapeutic effects of FXR activation on pancreatitis,whereas pancreatic overexpression of Osginl effectively alleviated caerulein-induced pancreatitis.Mechanistically,we found that the FXR-OSGINl axis stimulated autophagic flux in the pancreatic tissues and cell lines,which was considered as the intrinsic mechanisms through which FXR-OSGINI protecting against pancreatitis.Our results highlight the protective role of the FXR-OSGIN1 axis in pancreatitis and provided a new target for the treatment of this disease. | Yufan Zheng Wenrui Sun Zhengyang Wang Jiaying Liu Cong Shan Chenxi He Borui Li Xiao Hu Wenjia Zhu Liyan Liu Fei Lan Changtao Jiang Chao Zhao Xiaobo Li Ning Sun | 2023 | Research2023，，1： | 0 |
| 17 | Study on the application of ultrasonic wave in the removal of microbiofouling on PMMA surface显示文摘Ultrasound has been used for antifouling on the surface of medical devices or food utensils,but it is rarely applied in marine anti-biofouling on underwater instruments.To understand whether ultrasonic antifouling is suitable for underwater optical windows,the effect of ultrasonic conditions including frequency,power and duration on the removal of microbiofouling on the surface of polymethyl methacrylate(PMMA),a type of common optical material,was investigated in this study by three-factor and three-level orthogonal experiments.Before and after the ultrasonic treatment,both surface morphology and fouling degree of PMMA samples immersed in Escherichia coli suspension and seawater were characterized and quantified using laser scanning microscope.The results showed that ultrasonic treatment can effectively remove microfouling from the PMMA surface under suitable conditions.Ultrasonic technology has a great potential for the control of microfouling on the marine optical instruments.When compared with power and duration,ultrasonic frequency has a more significant effect on antifouling efficacy of ultrasound.It is useful for PMMA samples exposed to seawater within 2 days to conduct an antifouling treatment under the condition of an ultrasonic frequency of 20 kHz,ultrasonic power of 40 W,and ultrasonic duration of 7 min. | Liang Zheng Yufan Zeng Yuefan Li Jing Zheng | 2021 | Biosurface and Biotribology2021，7，3： | 0 |
| 18 | VOC emission caps constrained by air quality targets based on response surface model:A case study in the Pearl River Delta Region,China显示文摘Because of the recent growth in ground-level ozone and increased emission of volatile organic compounds(VOCs),VOC emission control has become a major concern in China.In response,emission caps to control VOC have been stipulated in recent policies,but few of them were constrained by the co-control target of PM_(2.5)and ozone,and discussed the factor that influence the emission cap formulation.Herein,we proposed a framework for quantification of VOC emission caps constrained by targets for PM_(2.5)and ozone via a new response surface modeling(RSM)technique,achieving 50%computational cost savings of the quantification.In the Pearl River Delta(PRD)region,the VOC emission caps constrained by air quality targets varied greatly with the NOxemission reduction level.If control measures in the surrounding areas of the PRD region were not considered,there could be two feasible strategies for VOC emission caps to meet air quality targets(160μg/m^(3)for the maximum 8-hr-average 90th-percentile(MDA8-90%)ozone and 25μg/m^(3)for the annual average of PM_(2.5)):a moderate VOC emission cap with<20%NOxemission reductions or a notable VOC emission cap with>60%NOxemission reductions.If the ozone concentration target were reduced to 155μg/m^(3),deep NOxemission reductions is the only feasible ozone control measure in PRD.Optimization of seasonal VOC emission caps based on the Monte Carlo simulation could allow us to gain higher ozone benefits or greater VOC emission reductions.If VOC emissions were further reduced in autumn,MDA8-90%ozone could be lowered by 0.3-1.5μg/m^(3),equaling the ozone benefits of 10%VOC emission reduction measures.The method for VOC emission cap quantification and optimization proposed in this study could provide scientific guidance for coordinated control of regional PM_(2.5)and O_(3)pollution in China. | Ya’nan Hu Bowen Shi Xin Yuan Chuanzeng Zheng Qing’e Sha Yufan Yu Zhijiong Huang Junyu Zheng | 2023 | Journal of Environmental Sciences2023，，1： | 0 |
| 19 | DESIGN OF NONLINEAR OBSERVERS显示文摘DESIGNOFNONLINEAROBSERVERS￥ZHENGYufan;CHENShuzhong(AppliedMathematicsResearchLaborutory,EastChinaNormalUniversity,Shanghai200... | ZHENG Yufan CHEN Shuzhong(Applied Mathematics Research Laborutory, East China Normal University,Shanghai 200062, China) | 1996 | Systems Science and Mathematical Sciences1996，9，4： | 0 |
| 20 | MINIMAL INVERSION AND ITS ALGORITHMS OF DISCRETE-TIME NONLINEAR SYSTEMS显示文摘The left-inverse system with minimal order and its algorithms of discrete-time nonlinear systems are studied in a linear algebraic framework. The general structure of left-inverse system is described and computed in symbolic algorithm. Two algorithms are given for constructing left-inverse systems with minimal order. | ZHENG Yufan Department of Electrical and Electronic Engineering, The University of Melbourne, Parkville, Vic. 3010, Australia Institute of Systems Science, East China Normal University, Shanghai 200062, China. | 2005 | Journal of Systems Science & Complexity2005，18，3： | 0 |
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