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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 4 | ^(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice显示文摘99m Tc-Methylene diphosphonate(99m Tc-MDP) is widely used in clinical settings to detect bone abnormalities.However, the mechanism of99 m Tc-MDP uptake in bone is not well elucidated. In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography(gamma scintigraphy or SPECT),ex vivo micro-computed tomography, and histology to monitor99 m Tc-MDP uptake in injury sites during skeletal healing. In an ex vivo culture system, calvarial cells were differentiated into osteoblasts with osteogenic medium, pulsed with99 m Tc-MDP at different time points, and quantitated for99 m Tc-MDP uptake with a gamma counter. We demonstrated that99 m Tc-MDP uptake in the injury sites corresponded to osteoblast generation in those sites throughout the healing process. The99 m Tc-MDP uptake within the injury sites peaked on day 7 post-injury, while the injury sites were occupied by mature osteoblasts also starting from day 7.99 m Tc-MDP uptake started to decrease 14 days post-surgery, when we observed the highest level of bony tissue in the injury sites. We also found that99 m Tc-MDP uptake was associated with osteoblast maturation and mineralization in vitro. This study provides direct and biological evidence for99 m Tc-MDP uptake in osteoblasts during bone healing in vivo and in vitro. | Zhendong A Zhong Anderson Peck Shihong Li Jeff Van Oss John Snider Casey J Droscha Tingtung A Chang Bart O Williams | 2015 | Bone Research2015，3，2： | 2 |
| 5 | On fuzzy random linear programming显示文摘 | Zhong O Yue Z Guangyuan W | 1994 | Fuzzy Sets and Systems1994，65，： | 1 |
| 6 | Soluble vascular endothelial growth factor receptor-1 mediates downregulation of Flt-I and prevents activated neutrophils from women with preeclampsia from additional migration by VEGF 显示文摘 | KRYSIA K O BRETSCHNEIDER A ZHONG E | 2005 | Circ Res2005，97，12： | 1 |
| 7 | Application of time-stress superposition to nonlinear creep of polyamide 66 filled with nanoparticles of various sizes 显示文摘 | STARKOVA O YANG Jinglei ZHANG Zhong | 2007 | Compos Sci Technol2007，67，： | 1 |
| 8 | First trimester assessment of placenta function and the prediction of pre-eclampsia and intrauterine growth restriction显示文摘 | Zhong Y Tuuli M Odibo A O | 2010 | Prenat Diagn2010，30，4： | 1 |
| 9 | Increase of island density via formation of secondary ordered islands on pit-patterned Si(001) substrates显示文摘 | Zhong Z Schmid O G Bauer G | 2005 | Appl Phys Lett2005，87，13： | 1 |
| 10 | Gene transduction into aortic wall using plasmid-loaded cationized gelatin hydrogel-coated polyester stent graft显示文摘 | Zhong H Matsui O Xu K | 2009 | J Vasc Surg2009，50，6： | 1 |
| 11 | Computers Play the Beer Game:Can Artificial Agents Manage Supply Chains显示文摘 | WU D J ZHONG F | 2002 | Decision Support Systems2002，33，3： | 1 |
| 12 | ASPP Proteins Specifically Stimulate the Apoptotic Function of p53显示文摘 | Yardena Samuels-Lev Daniel J. O’Connor Daniele Bergamaschi Giuseppe Trigiante Jung-Kuang Hsieh Shan Zhong Isabelle Campargue Louie Naumovski Tim Crook Xin Lu | 2001 | Molecular Cell2001，，4： | 1 |
| 13 | Multiple positive solutions for the one-dimensional singular p-Laplaeian显示文摘 | H Sh Lv D O'Regan Ch K Zhong | 2002 | Appl Math Comput2002，133，23： | 1 |
| 14 | Computers play the beer game: can artificial Agents manage supply chains? 显示文摘 | KIMBROUGH S O WU D J ZHONG F | 2002 | Decision Support Systems2002，33，3： | 1 |
| 15 | Triterpeniod saponins from Ardisia crenata 显示文摘 | Zhong H J Ka Z K Tai C O | 1994 | Phytochemistry1994，37，5： | 1 |
| 16 | Abrupt onset of the Little Ice Age triggered by volcanism and sustained by sea-ice/ocean feedbacks显示文摘 | Miller G.H Geirsdóttir (A) Zhong Y Larsen D.J Otto-Bliesner B.L Holland M.M Bailey D.A Refsnider K.A Lehman S.J Southon J.R Anderson C Bj(o)rnsson H Thordarson T | | 0，，： | 1 |
| 17 | Diffraction enhanced imaging contrast mechanisms in breast cancer specimens显示文摘 | Zhong Z Oltulu O | 2002 | Med Phys2002，29，10： | 1 |
| 18 | Multiple positive solutions for the one-dimensional singular p-Laplacian显示文摘 | LV H S Donal O' Regan Zhong C K | 2002 | Applied Mathematics and Computation2002，133，： | 1 |
| 19 | Existence of strong global attractors for hyperbolic equation with linear memory 显示文摘 | Ma O Z Zhong C K | 2004 | Applied Mathematics and Computation2004，157，： | 1 |
| 20 | Nanoscale alloying,phase-segregation,and core-shell evolution of gold-platinum nanoparticles and their electrocatalytic effect on oxygen reduction reaction显示文摘 | WANJALA B N LUOJ LOUKRAKPAM R FANG B MOTT D NJOKI PN ENGELHARD M NASLUND H R WUJK WANGL MALIS O ZHONG C J | 2010 | Chem Mater2010，22，14： | 1 |
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