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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 3 | A log-normal distribution model for the molecular weight of aquatic fulvic acids 显示文摘 | Cabaniss S E Zhou Q Maurice P A | 2000 | Environ Sci Technol2000，34，6： | 2 |
| 4 | A study of the electrochemical formation of Cu (Ⅰ)-BTA films on coppor electrodes and the mechanism of copper corrosion inhibition in aqueous chloride/benzotriazole solutions显示文摘 | MODESTOV A D ZHOU G D WU Y P | 1994 | Corrosion Science1994，36，11： | 2 |
| 5 | Size effect on flexural,splitting tensile,and torsional strengths of high-strength concrete显示文摘 | Zhou F P Balendran R V Jeary A P | 1998 | Cement and Concrete Research1998，28，12： | 2 |
| 6 | Influence of steel fibers on strength and ductility of normal and lightweight high strength concrete显示文摘 | BALENDRAN R V ZHOU F P NADEEM A | 2002 | Building and Environment2002，37，12： | 1 |
| 7 | Factors affecting outcome for young women with early stage breast cancer treated with breastconserving therapy显示文摘 | Zhou P Gautam S Recht A | 2007 | Breast Cancer Res Treat2007，101，： | 1 |
| 8 | Selective hepatic vascular exclusion and Pringle maneuver:a comparative study in liver resection显示文摘 | ZHOU W P LI A J PAN Z Y | 2008 | Eur J Surg Oncol2008，34，1： | 1 |
| 9 | Investigation of candidate VRM topologies for future microprocessors显示文摘 | Zhou X Wong P Xu P Lee F C Huang A Q | 2000 | IEEE Transactions on Power Electronics2000，15，6： | 1 |
| 10 | Formation and reduction of nitric oxide in fixed-bed combustion of straw显示文摘 | Zhou H Jensen A D Glarborg P | 2006 | Fuel2006，85，56： | 1 |
| 11 | Influence of the distance between target and substrate on the properties of transparent conducting A1-Zr doped zinc oxide thin films 显示文摘 | Zhang H F Liu H F Zhou A P | 2009 | Journal of Semiconductors2009，30，11： | 1 |
| 12 | A temporal link between the Emeishan large igneous province (SW China) and the end-Guagalupian mass extinction 显示文摘 | Zhou M F Malpas J Song X Y Robinson P T Sun M Kennedy A K Lesher C M Keays R R | 2002 | Earth arut Planetary Science Letters2002，196，： | 1 |
| 13 | Pattern synthesis for arbitrary array using an adaptive array method显示文摘 | ZHOU P Y INGRAM M A | 1999 | IEEE Transactions on Antennas and Propagation1999，47，5： | 1 |
| 14 | Antidiabetic effects of panax ginseng berry extract and the indentification of an ef- fective component 显示文摘 | ATTELE A S ZHOU Y P XIE J T | 2002 | Diabetes2002，5，1： | 1 |
| 15 | SHRIMP U - Pb zircon geochronological and geochemical evidence for Neoproterozoic arc-magmatism along the western margin of the Yangtze Block, South China 显示文摘 | Zhou M F Yan D P Kennedy A K | 2002 | Earth and Planetary Science Letters2002，196，1： | 1 |
| 16 | Supercritical fluid extraction-oxi- dation technology to remediate PCB-contaminated soils/sediments: An economic analysis显示文摘 | Zhou W Aniteseu G Rice P A | 2004 | Environmental Progress2004，23，3： | 1 |
| 17 | Mining and characterizing microsatellites from Citrus ESTs显示文摘 | CHEN C X ZHOU P CHOI Y A | 2006 | Theor Appl Genet2006，112，7： | 1 |
| 18 | NFkappaB and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells显示文摘 | ZHOU L Z H JOHNSON A P RANDO T A | 2001 | Free Radical Biology and Medicine2001，31，11： | 1 |
| 19 | Common knowledge and almost common knowledge of' credible assignments in a coordination game显示文摘 | Bangun L Chaudhuri A Prak P Zhou C | 2006 | Economics Bulletin2006，，1： | 1 |
| 20 | Endogenous nerve growth factor and neurotrophin-3 act simultaneously to ensure the survival of postnatal sympathetic neurons in vivo 显示文摘 | Tafreshi A P Zhou X F Rush R A | 1998 | Neuroscience1998，83，2： | 1 |
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