|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Correlation between the Amplitude of Glucose Excursion and the Oxidative/Antioxidative System in Subjects with Different Types of Glucose Regulation显示文摘Objective To investigate effects of glucose excursion on the oxidative/antioxidative system in subjects with different types of glucose regulation. Methods A total of 30 individuals with normal glucose regulation (NGR), 27 subjects with impaired glucose regulation (IGR) and 27 subjects with newly diagnosed type 2 diabetes mellitus (T2DM) were selected and recruited for 3 days' continuous glucose monitor system (CGMS) assessment. The data from CGMS was used to calculate the mean amplitude of glycemic excursion (MAGE), mean blood glucose (MBG) and its standard deviation (SDBG), area under the ROC curve when the blood glucose >5.6 mmol/L within 24 h (AUC 5.6), mean of daily differences (MODD), and mean postprandial glucose excursion (MPPGE). In all groups, the content or activity of malondialdehyde (MDA), total antioxidation capacity (TAOC) and glutathione peroxidase (GSH‐Px) were detected. Results Glucose excursion parameters of subjects with T2DM or IGR were higher than those of NGR subjects (P<0.05 or 0.01). Moreover, Glucose excursion parameters of T2DM subjects were higher than those of IGR subjects (P<0.05 or 0.01). Subjects with T2DM or IGR had significant higher MDA levels and lower GSH‐Px/MDA and TAOC/MDA levels compared to NGR subjects (P<0.01). T2DM subjects had even higher MDA levels and lower GSH‐Px/MDA levels than IGR (P<0.05 or 0.01). According to the median of normal population for MAGE, T2DM and IGR subjects were divided into MAGE>2.6mmol/L Group and MAGE≤2.6mmol/L Group. MAGE>2.6mmol/L Group had higher levels of MDA and lower levels of GSH‐Px/MDA than MAGE≤2.6mmol/L Group (P<0.05). There was no significant difference between the two groups (P>0.05) in terms of the levels of TAOC/MDA. Pearson correlation analysis showed that MDA was positively correlated with FPG, 2hPG, MAGE, and SBP. GSH‐Px/MDA was negatively correlated with MAGE and TC. TAOC/MDA was negatively correlated with FPG. Partial correlation analysis showed that the relationship between MDA and MAGE, GSH‐Px/MDA, and MAGE remained significant after adjustments for the other differences among groups. Conclusion Glucose excursion contributed significantly to promoting lipid peroxidation and decreasing antioxidation capacity than chronic sustained hyperglycemia did in the subjects with different types of glucose regulation. | WANG Zhou LI Lin ZHENG FenPing JIA ChengFang RUAN Yu LI Hong | 2011 | Biomedical and Environmental Sciences2011，24，1： | 6 |
| 2 | Effects of eggshell addition on calcium-deficient acid soils contaminated with heavy metals显示文摘在这研究,水条件完成(泛滥,湿,或干燥)并且蛋壳剂量( 0 , 0.1 , 1.0 ,和 10.0 g/kg 土壤,分别地)在 pH 变化上,内容无法获得重金属的状态,重金属的形式,并且在与重金属污染的酸土壤的可得到的滋养的元素钙( Ca )分别地被调查。土壤样品连续地在室内被栽培并且由毒性分析了特征的沥滤参考(BCR ) 的过程和社区局顺序的抽取过程。结果证明蛋壳的增加能有效地改进酸土壤的 pH 并且增加它到中立水平。而且,内容无法获得重金属 Cu, Zn,和 Cd 的状态显著地增加了。而且,当土壤与 1.0 g/kg 蛋壳在充满的条件下面被栽培时,无法获得 Cu, Zn,和 Cd 的状态增加了大多数,并且这些重金属被转变成剩余状态。在另一方面, Ca 的可得到的状态的数量与 1.0 g/kg 蛋壳的增加从 73.34 mg/kg 增加了到 432.19,它显示蛋壳的增加戏剧性地改进了 Ca 的可得到的状态。因此,蛋壳能改善它有效地导致了授精的可得到的重金属和改进的减少的土壤环境。简言之,这研究显示蛋壳的增加将是为与重金属污染的酸地土壤的补习的一个新潜在的方法。 | Weiqi Luo Yanping Ji Lu Qu Zhi Dang Yingying Xie Chengfang Yang Xueqin Tao Jianmin Zhou Guining Lu | 2018 | Frontiers of Environmental Science & Engineering2018，12，3： | 1 |
| 3 | A heterometallic microporous MOF exhibiting high hydrogen uptake显示文摘 | Wei Wei Zhengqiang Xia Qing Wei Gang Xie a Sanping Chen Chengfang Qiao Guochun Zhang Chunsheng Zhou | | 0，，： | 1 |
| 4 | Immunotoxicity of Hydrocortisone on Th1/Th2-Related Cytokine Production Is Associated with Yang-Deficient State in Traditional Chinese Medicine显示文摘Steroid hormone serving as an immunosuppressor often induces immunotoxicity when administered in highest dosage or accumulated in long-term usage. The stage of high concentration of steroid hormone leading to a wide range of symptoms is associated to the yang-deficient state,which is the part of yin-yang imbalance involved in processes of many diseases in traditional Chinese medicine. Here we intend to investigate the profile of Th1/Th2-related cytokine transcriptions under yang-deficient conditions in a yang-deficient animal model by intramuscular injection of hydrocortisone (a kind of steroid hormone). The yang-deficient symptoms were estimated by detecting activity,appetite,body weight and so on. T cell proliferation and cytokine transcriptions were analyzed. The results showed that yang-deficient mice were established successfully since typical yang-deficient symptoms were observed in this model with decreased activities,appetite,body weight and temperature. More interestingly,the transcriptions of IFN-γ,IL-2,IL-4 and IL-10 in this model were markedly suppressed and the proliferation of lymphocytes significantly decreased as well. The results suggested that yang-deficient symptoms were related to the steroid-induced reduction of cytokine transcription and impairment of lymphocyte proliferation. Therefore,novel strategies through regulating cytokine production might be considered as potent approach to patients with yang-deficiency symptoms. | Chengfang Yao Li Wang Jian Zhang Xianbin Zhou Cai Zhang | 2007 | Cellular & Molecular Immunology2007，4，5： | 1 |
| 5 | Stopping Power of Au and Ag for He Ions显示文摘Energy loss of 0.45-5.0 MeV 4He ions in Au and Ag films were measured with the Rutherford backscattering method,and the stopping powers at lower energy range were extracted by comparing with that determined by Anderson et al.at higher energy range.Significant deviation between the experimental data and the semiempirical calculations by TRIM-90 appears around the stopping maximum.The accuracy of our results was expected to be±l%. | HUANG Xiaojing LU Xiting JIN Changwen ZHOU Chengfang YE Yanlin XIA Zonghuang LIU Hongtao JIANG Dongxing | 1993 | Chinese Physics Letters1993，10，4： | 0 |
| 6 | The role of FZR1 in tumorigenesis: Focus on cell-cycle control显示文摘Fizzy-related protein homolog 1 (FZR1) mainly functions as a specific activator of the anaphase-promotingcomplex/cyclosome (APC/C) in the cell cycle and controls the G0 and G1 phases of the cell cycle. We highlightrecent work that has studied the role of FZR1 in tumorigenesis, growth, differentiation, and genome stability throughcell-cycle control. We summarize the current state of knowledge regarding FZR1 structure, function, and the distinctways of APC/C dysregulation in solid tumors and hematologic malignancies. We also discuss novel approaches fortargeting the FZR1 as a cancer therapy and research area for future work. | HUI LI CHENGFANG ZHOU MEI KUANG YUN LIU JIEPING CHEN | 2023 | BIOCELL2023，47，10： | 0 |
| 7 | BnlR:A multi-omics database with various tools for Brassica napus research and breeding显示文摘In the post-genome-wide association study era,multi-omics techniques have shown great power and poten-tial for candidate gene mining and functional genomics research.However,due to the lack of effective data integration and multi-omics analysis platforms,such techniques have not still been applied widely in rape-seed,an important oil crop worldwide.Here,we report a rapeseed multi-omics database(BnlR;http:/l yanglab.hzau.edu.cn/BnlR),which provides datasets of six omics including genomics,transcriptomics,variomics,epigenetics,phenomics,and metabolomics,as well as numerous'variation-gene expression-phenotype'associations by using multiple statistical methods.In addition,a series of multi-omics search and analysis tools are integrated to facilitate the browsing and application of these datasets.BnlR is the most comprehensive multi-omics database for rapeseed so far,and two case studies demonstrated its power to mine candidate genes associated with specific traits and analyze their potential regulatory mechanisms. | Zhiquan Yang Shengbo Wang Lulu Wei Yiming Huang Dongxu Liu Yupeng Jia Chengfang Luo Yuchen Lin Congyuan Liang Yue Hu Cheng Dai Liang Guo Yongming Zhou Qing-Yong Yang | 2023 | Molecular Plant2023，16，4： | 0 |
| 8 | A Peridynamic Model for Dynamic Fracture of Layered Engineered Cementitious Composites显示文摘In this paper,a peridynamic model for simulating the dynamic fracture in layered engineered cementitious composites(LECC)is applied.The model takes into account the location information of the fibers as well as the distribution form.In addition,numerical simulations of LECC beams under four-point bending are carried out.The effects of notch size and fiber volume fraction are investigated.The numerical results show that the notch size and gradient distribution of fiber volume fraction affect the crack propagation pattern,which can help to understand the dynamic fracture behavior of engineered cementitious composites. | You Wu Jiajia Zhou Jiyu Tang Chengfang Yuan Zhanqi Cheng | 2022 | Acta Mechanica Solida Sinica2022，35，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员