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| 1 | Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese显示文摘Alzheimer's disease is the most common neurodegenerative disease,and has a high level of genetic heritability and population heterogeneity.In this study,we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease,followed by independent validation,imaging analysis and function characterization.We identified an exome-wide significant rare missense variant rs3792646(p.K420Q)in the C7 gene in the discovery stage(P=1.09×10^(-6),odds ratio=7.853)and confirmed the association in different cohorts and a combined sample(1615 cases and 2832 controls,P_(combined)=2.99×10^(-7),odds ratio=1.930).The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood,thus resulting in an earlier age of disease onset.Overexpression of the mutant p.K420Q disturbed cell viability,immune activation and β-amyloid processing.Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons.These findings suggested that C7 is a novel risk gene for Alzheimer’s disease in Han Chinese. | Deng-Feng Zhang Yu Fan Min Xu Guihong Wang Dong Wang Jin Li Li-Li Kong Hejiang Zhou Rongcan Luo Rui Bi Yong Wu Guo-Dong Li Ming Li Xiong-Jian Luo Hong-Yan Jiang Liwen Tan Chunjiu Zhong Yiru Fang Chen Zhang Nengyin Sheng Tianzi Jiang Yong-Gang Yao | 2019 | National Science Review2019，6，2： | 6 |
| 2 | MICROSTRUCTURE OF INTERFACE BETWEEN HVOF SPRAYED WC-Co COATING AND SPRING STEEL SUBSTRATE显示文摘MICROSTRUCTUREOFINTERFACEBETWEENHVOFSPRAYEDWC-CoCOATINGANDSPRINGSTEELSUBSTRATE￥ShaoBeiling;LiuAnsheng;WangXiaohua;LiYonghong;... | Shao Beiling Liu Ansheng Wang Xiaohua Li Yonghong Zou Linying Wang Jing Zhang Jianguo Shi Changyong Zhou Yiru(General Research institute For Nonferrous Metals,Beijing 100088) | 1996 | 中国有色金属学会会刊:英文版1996，6，4： | 3 |
| 3 | Hypothalamic-Pituitary-End-Organ Axes:Hormone Function in Female Patients with Major Depressive Disorder显示文摘Classic hypothalamic-pituitary-end-organ feedback loops–the hypothalamic-pituitary-adrenal axis(HPAA),hypothalamic-pituitary-thyroidal axis(HPTA),and hypothalamic-pituitary-gonadal axis(HPGA)–are associated with the neuroendocrine and immune systems in major depressive disorder(MDD).Female patients with MDD present with evident neuroendocrine and immunological changes.Glucocorticoid,thyroid hormone,and reproductive steroid levels fluctuate with menstrual cycles,which might lead to glucocorticoid receptor resistance,impairment of triiodothyronine conversion,and sex hormone secretion disorders.In this review,we summarize the independent and interactive functions of these three axes in female MDD patients.The similar molecular structure of steroids implies an interrelationship between the hypothalamic-pituitary-end-organ axes and the competitive inhibitory effects at the receptor level,especially when considering the HPAA and HPGA. | Yuncheng Zhu Xiaohui Wu Rubai Zhou Oliver Sie Zhiang Niu Fang Wang Yiru Fang | 2021 | Neuroscience Bulletin2021，37，8： | 3 |
| 4 | An Investigation of a Confirmed Imported Case of COVID-19 Infected Abroad—Qingpu District,Shanghai Municipality,China,November 15,2020显示文摘Summary What is already known about this topic?A passenger who was from the United States was taken to the hotel for the required isolation on November 13,2020.During the quarantine she was diagnosed as the COVID-19 patient on November 15,2020.Controlling the importation of COVID-19 remains a major challenge.What is added by this report? | Hongrang Zhou Xiaoling Wang Qiufang Xu Xiaoming Wang Yadong Ma Yiru Shi Zhouli Wu Peifeng Zhu Jinjiang Zhao Ruifang Xu Changpo Lin Ning Xiao | 2021 | China CDC weekly2021，3，10： | 1 |
| 5 | A novel background subtraction method based on color invariants 显示文摘 | Zhou I-Iong Chen Yiru Feng Rong | 2013 | Computer Vision and hnage Understanding2013，117，1： | 1 |
| 6 | Angular Dependence of Critical Current in Ag-Seathed Bi(2223)-Superconductor Tape显示文摘The critical current Ic(B.T.)of Ag-slcatled Bi(223)tape was uuceasured at 4.2 and 77K in magnetic field up to CT as a function of the tield direction.The maximn Ie is observed when the fnx line are along the CuO:planes.This effect is due to an in trinsic pinning between CuO_(2) layers.When H>0.5 T at 4.2K.I_(c) decreascs very slowly with the mlaguetic field.The resnlts nre colusistent with our early-proposed scaling luws for flux pining in Ag-sheathed tape. | GUO Shuquan QIN Xiaonnei ZHANG Jinlong WU Zu'an YE Bin ZENG Roung ZHOU Yiru ZHOU Min | 1993 | Chinese Physics Letters1993，10，9： | 0 |
| 7 | Green Oxidation of Isochromans to Isochromanones with Molecular Oxygen Catalyzed by a Tetranuclear Vanadium Cluster显示文摘Comprehensive Summary Isochromanone is the core structure of many bioactive compounds.Direct oxidation of isochromans is one of leading methods for the construction of isochromanones,while most established processes remain suffering from the use of environmentally unfriendly metal oxidants,harsh reaction conditions,and the difficulty in catalyst recycling and product separation.Herein,we report a convenient,cost-effective,and green method for the synthesis of high-value added isochromanones via isochroman oxidations with O_(2) by a novel heterogeneous vanadium cluster catalyst(Cat.1)under mild conditions.This reaction protocol demonstrates high catalytic activity with good catalyst recyclability and reusability for a wide scope of substrates. | Huixin Huang Baokuan Chen Yiru Fu Jing Sun Yanfeng Bi Ming-Dong Zhou | 2023 | Chinese Journal of Chemistry2023，41，16： | 0 |
| 8 | Optimization of Rolling Process for Bi(2223)/Ag Superconducting Tapes by a Statistical Method显示文摘Ag-sheathed (Bi,Pb)2Sr2Ca2Cu3Ox tapes were prepared by the powder-in-tube method. The influences of rolling parameters on superconducting characteristics of Bi(2223)/Ag tapes were analyzed qualitatively with a statistical method. The results demonstrate that roll diameter and reduction per pass significatly influence the properties of Bi(2223)/Ag superconducting tapes while roll speed does less and working friction the least. An optimized rolling process was therefore achieved according to the above results. | Xuefeng Li, Peiwen Hua, Wenquan Wang, Qijian Jin, Yiru Zhou, Guansen Yuan (General Research Institute for Nonferrous Metals, Beijing 100088, China) | 2001 | Rare Metals2001，20，1： | 0 |
| 9 | PAID study design on the role of PKC activation in immune/inflammation-related depression:a randomised placebo-controlled trial protocol显示文摘Background Inflammation that is mediated by microglia activation plays an important role in the pathogenesis of depression.Microglia activation can lead to an increase in the levels of proinflammatory cytokines,including TNF-α,which leads to neuronal apoptosis in the specific neural circuits of some brain regions,abnormal cognition and treatment-resistant depression(TRD).Protein kinase C(PKC)is a key regulator of the microglia activation process.We assume that the abnormality in PKC might result in abnormal microglia activation,neuronal apoptosis,significant changes in emotional and cognitive neural circuits,and TRD.In the current study,we plan to target at the PKC signal pathway to improve the TRD treatment outcome.Methods and analysis This is a 12-week,ongoing,randomised,placebo-controlled trial.Patients with TRD(N=180)were recruited from Shanghai Mental Health Center,Shanghai Jiao Tong University.Healthy control volunteers(N=60)were recruited by advertisement.Patients with TRD were randomly assigned to‘escitalopram+golimumab(TNF-αinhibitor)’,‘escitalopram+calcium tablet+vitamin D(PKC activator)’or‘escitalopram+placebo’groups.We define the primary outcome as changes in the 17-item Hamilton Depression Rating Scale(HAMD-17).The secondary outcome is defined as changes in anti-inflammatory effects,cognitive function and quality of life.Discussion This study might be the first randomised,placebo-controlled trial to target at the PKC signal pathway in patients with TRD.Our study might help to propose individualised treatment strategies for depression.Trial registration number The trial protocol is registered with ClinicalTrials.gov under protocol ID 81930033 and ClinicalTrials.gov ID NCT04156425. | Xiaoyun Guo Ruizhi Mao Lvchun Cui Fan Wang Rubai Zhou Yun Wang Jia Huang Yuncheng Zhu Yamin Yao Guoqing Zhao Zezhi Li Jun Chen Jinhui Wang Yiru Fang | 2021 | General Psychiatry2021，34，2： | 0 |
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