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| 1 | Journal of Hepatology|肝细胞癌中的抗程序性死亡受体1耐药性的潜在分子机理显示文摘目前,迫切需要探索免疫检查点阻断治疗的耐受机制,并确定一种联合治疗策略以提高其在HCC治疗中的有效性。作为免疫豁免器官,肝脏含有大量巨噬细胞,包括常驻细胞(例如Kupffer细胞)和募集的巨噬细胞。浸润肿瘤组织的巨噬细胞也称为肿瘤相关巨噬细胞(TAM),在功能和表型上与交替激活的(M2样)巨噬细胞相似,在肿瘤进展、免疫逃逸和ICB治疗抵抗中起重要作用。 | 樊嘉 WEI CY ZHU MX ZHANG PF | 2022 | 临床肝胆病杂志2022，38，3： | 9 |
| 2 | Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene显示文摘拼接 Trans,包含劈开并且二个分开的抄本加入的一个过程,能在优核质扩展 transcriptome 和 proteome。拼接 trans 产生的妄想的 RNA 逐渐地在文学被描述。在自然环境和人的肠的抗菌素抵抗基因的普遍存在为公共健康正在成为重要挑战。某些抗菌素抵抗基因,例如氨比西林抵抗基因(安培 r ), 经常在 recombinant plasmids 被使用。直到现在,拼接 trans 包含 recombinant 导出 plasmid 的外长的抄本和内长的细胞的 RNA 没被报导。Acyl-CoA:cholesterol acyltransferase (ACAT1 ) 1 是涉及细胞的胆固醇动态平衡的关键酶。4.3-kb 人 ACAT1 妄想的 mRNA 能与不同酶的活动生产 50-kDa 和 56-kDa isoforms。这里,我们证明人的 ACAT1 56-kDa isoform 从通过安培 r ( asAmp )现在在普通安培 r -plasmids 和 4.3-kb 内长的 ACAT1 妄想的 mRNA ,它大概通过 interchromosomal 拼接trans 的一个优先的事件被处理。惊人地,与一个在上游的重新结合的神秘倡导者一起包含 asAmp 的 DNA 碎片和相应外长的 asAmp 抄本在人的房间被检测了。我们的调查结果使人的 ACAT1 56-kDa isoform 生产的机制清楚些,揭示一个外长内长的拼接 trans 系统,在 recombinant,导出 plasmid 的外长的抄本在人的房间与内长的细胞的 RNA 被连接,并且建议外长的 DNA 可能影响在 DNA 和 RNA 层次的人的基因表示。 | Guang-Jing Hu Jia Chen Xiao-Nan Zhao Jia-JiaXu Dong-Qing Guo Ming Lu Ming Zhu Ying Xiong Qin Li Catherine CY Chang Bao-Liang Song Ta-Yuan Chang Bo-Liang Li | 2013 | Cell Research2013，23，8： | 4 |
| 3 | Hepatitis B virus infection and related factors in hemodialysis patients in China-systematic review and meta-analysis 显示文摘 | Wang CY Sun JH Zhu B | 2010 | Ren Fail2010，32，10： | 1 |
| 4 | Glyceroglycolipids from Serratula strangulata显示文摘 | Zhu QX Zhao CY | 2000 | Phtochem2000，58，： | 1 |
| 5 | Testin is tightly associated with testicular cell membrane upon its secretion by sertoli cells whose steady-state mRNA level in the testis correlates with the turnover and integrity of inter-testicular cell junctions显示文摘 | Grima J Zhu L Cheng CY | 1997 | Biol Chem1997，272，10： | 1 |
| 6 | MiR-223 suppresses cell proliferation by targeting IGF-IR 显示文摘 | Ia CY Li HH Zhu XC | 2011 | PLoS One2011，6，27： | 1 |
| 7 | Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP- 9 expression 显示文摘 | Wagsaeter D Zhu CY Bjoerck HM | 2009 | Atherosclerosis2009，202，2： | 1 |
| 8 | Laboratory Assessment of Lubricants for Wheel/Rail Lubrication显示文摘The antiwear properties of two wheel/rail lubricating oils were tested and compared on an Amsler machine. Under same testing conditions, oil A (developed by authors) showed much better wear resistance and higher load-carrying capacity than oil B (imported from abroad). The X-ray diffraction (XRD) analyses of the worn surfaces showed that different extreme pressure (EP) lubricating films were formed on the surfaces when the rollers were lubricated with different oils under boundary Iubrication condition. The EP film of oil A was a composite film containing three compounds, FeO, FeSx and FeP, while oil B formed only a simple EP film of FePO4. The composite EP film showed lower shear strength and better antiwear property than the simple EP film,which brought about different wear resistance of the two wheel/rail lubricating oils. | Zhao, XZ Liu, JJ Zhu, BL Wang, CY | 1997 | Journal of Materials Science & Technology1997，13，1： | 1 |
| 9 | Cytotoxicity of titanium dioxide nanoparticles in mouse fibroblast cells 显示文摘 | Jin CY Zhu BS Wang XF | 2008 | Chem Res Toxicol2008，21，9： | 1 |
| 10 | Cornea-specific expression of K12 keratin during mouse development 显示文摘 | Liu CY Zhu G Westerhausen LA Converse R Kao CW Sun TT | 1993 | Curr Eye Res1993，12，11： | 1 |
| 11 | Immunosuppressive property of dried human amniotic membrane显示文摘 | Park CY Kohanim S Zhu L | 2009 | Ophthalm Res2009，41，2： | 1 |
| 12 | A study of the internal friction and modulus of epoxy resin dispersed nanometer-sized alumina particles显示文摘 | Zhang LD Xie CY Zhu XF | 1994 | J Alloys Compounds1994，，： | 1 |
| 13 | Genistein and its synthetic analogs as antican- cer agents显示文摘 | Li QS Li CY Li ZL Zhu HL | 2012 | Anticancer Agents Med Chem2012，12，3： | 1 |
| 14 | Isolation and identification ofbio- surfactant producing and crude oil degrading Pseudomonas aeruginosa strains显示文摘 | ZHANG XS XU DJ ZHU CY | 2012 | Chem Eng J2012，209，： | 1 |
| 15 | Fabrication of biomimetie apatite coating on porous titanium and their osteointegration in femurs of dogs 显示文摘 | Zhao CY Zhu X D Yuan T | 2010 | Materials Science & Engineering C2010，30，1： | 1 |
| 16 | Hepatitis B virus infection and related factors in hemodialysis patients in China-systematic review and meta-analysis显示文摘 | Wang CY Sun JH Zhu B | 2010 | Renal Failure2010，32，10： | 1 |
| 17 | Cutaneous ehromoblastomycosis caused by Veronaea botryosa in a patient with pemphigus vulgaris and review of published reports 显示文摘 | Zhu CY Yang YP Sheng P | 2015 | Mycopathologia2015，180，12： | 1 |
| 18 | Effect of sodium dimercapto propanesulfonate on antagonism tetramethy lenedisul photetramine to GABA receptor显示文摘 | Zhang CY Zhu TJ Hu GX | 2001 | Acta Pharmacol sin2001，22，5： | 1 |
| 19 | Effect of sodium dimercaptopropane sulfonate on antagonism of tetramethylenedi Sulphotetramine to GABA receptor显示文摘 | Zhang CY Zhu T J Hu GX | 2001 | Acta Pharmacol Sin2001，22，5： | 1 |
| 20 | Fingerprint analysis of Radix Aconiti using ultra-performance liquid chromatography-electros pray ioni- zation/tandem mass spectrometry (UPLC-ESI/MSn) combined with stoichiometry 显示文摘 | Zhu HB Wang CY Qi Y | 2012 | Talanta2012，103，12： | 1 |
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