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| 1 | Type 2 diabetes mellitus and CA 19-9 levels显示文摘AIM:To prospectively investigate serum CA 19-9 levels in type 2 diabetic patients in comparison with age-and gender-matched control subjects. METHODS:We recorded duration of diabetes and examined fasting glucose levels,HbA1c levels and serum CA 19-9 levels in 76 type 2 diabetic patients and 76 controls.Abdominal CT was performed in order to eliminate abdominal malignancy in the diabetic and control groups. RESULTS:The average CA 19-9 level was 46.0±22.4 U/mL for diabetic patients whereas it was 9.97±7.1 U/mL for the control group(P<0.001).Regression analysis showed a positive correlation between diabetes and CA 19-9 independent from age,gender,glucose level and HbA1c level(t=8.8,P<001).Two of the diabetic patients were excluded from the study because of abdominal malignancy shown by CT at the initial evaluation.For all patients,abdominal CT showed no pancreatic abnormalities. CONCLUSION:CA 19-9 is a tumor-associated antigen, which is elevated in pancreatic,upper gastrointestinal tract,ovarian hepatocellular,and colorectal cancers,as well as in inflammatory conditions of the hepatobiliary system,biliary obstruction and in thyroid diseases. Diabetes has been claimed to be a risk factor for pancreatic cancer,which is increasing its incidence and has one of the lowest survival rates of all cancers.CA 19-9 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes.We propose that a higher cut- off value of CA 19-9 should be used in diabetics to differentiate benign and malignant pancreatic disease, and subtle elevations of CA 19-9 in diabetics should be considered as the indication of exocrine pancreatic dysfunction. | Oya Uygur-Bayramicli Resat Dabak Ekrem Orbay Can Dolapclo■lu Mehmet Sargin Gamze Kilico■lu Yüksel Güleryüzlü Alpaslan Mayada■li | 2007 | World Journal of Gastroenterology2007，13，40： | 63 |
| 2 | Study on the expression of matrix metalloproteinase-2 mRNA in human gastric cancer显示文摘 | Ji F Wang WL Yang ZL Li YM Huang HD Chen WD | 1999 | World Journal of Gastroenterology1999，5，5： | 19 |
| 3 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 4 | The effect of retinoic acid on Ito cell proliferation and content of DNA and RNA显示文摘 | Gao ZL Li DG Lu HM Gu XH | 1999 | World Journal of Gastroenterology1999，5，5： | 13 |
| 5 | ANOMALOUS BEHAVIOR REVISITED:DYNAMIC RESPONSE OF ELASTIC-PLASTIC STRUCTURES显示文摘Based on the minimum principle of acceleration in the elastic-plastic continua under fi-nite deformation,the dynamic response of an elastic-perfectly plastic pin-ended beam subjected to rect-angular impulse loading is studied with the help of a numerical approach.The calculated results once a-gain show the anomalous behavior of the beam during its response process,which was previously foundin[1].By carefully analyzing the instantaneous distribution of the bending moment,the membraneforce,the curvature and displacement during the response process,it is concluded that the interactiveeffect between the geometry and materials nonlinearities of the structure is the key reason for leading tothe anomalous behavior.This will be helpful for clarifying some misunderstandings in explaining theproblem before. | Xi, F Yang, JL Li, ZL | 1998 | Acta Mechanica Solida Sinica1998，11，4： | 7 |
| 6 | The Photochemical Study of HSA and BSA with Resonance Light Scattering and Fluorescence Spectra显示文摘The resonance light-scattering (RLS) of human serum albumin (HSA) and bovine serum albumin (BSA) is reported for the first time, and applied to study photochemical reaction of HSA and BSA. The fact of photocrosslinking self-association effect in HSA and BSA solutions is identified by the enhancement of RLS. The fluorescence quenching at about 350 um and 700 um proves that tryptophan (Trp) residues are one of the photochemical activity sites in HSA and BSA molecules. The Rayleigh scattering (RS) spectra of HSA and BSA that were neglected in fluorescence spectra before are found at about 296 um, 592 um and 888 um for the first time, and are of adventageous to studying the aggregation of HSA or BSA. The possible photochemical reaction mechanism is also proposed. | Liang, H Shen, XC Li, F Jiang, ZL | 2000 | Chinese Chemical Letters2000，11，3： | 4 |
| 7 | Preparation and characterization of highly active nanosized strontium-doped lanthanum cobaltate catalysts with high surface areas显示文摘La1?xSrxCoO3?δ (x=0, 0.4) nanoparticles have been prepared using the citric acid complex-ing-hydrothermal synthesis coupled method and citric acid complexing method. The physico-chemical properties of these materials were characterized by means of X-ray diffraction (XRD), high resolution scanning electron microscopy (HRSEM), element analysis (EDX), X-ray photoelectron spectroscopic (XPS), oxygen temperature-programmed desorption (O2-TPD), hydrogen temperature-programmed re-duction (H2-TPR) as well as surface area measure-ments and oxidation state titration. Their catalytic performance was examined for the total oxidation of ethylacetate (EA). It is found that the La1?xSrxCoO3?δ (x=0, 0.4) catalysts were single-phase and rhombo-hedrally-structured perovskites and their surface ar-eas ranged from 16 to 26 m2/g. The Sr-doped sample derived from the coupled procedure was uniformly distributed nanoparticles with a short rod-shaped morphology. The doping of Sr (i) enhanced the con-centrations of Co3+ and oxygen vacancies, (ii) in-creased the amount of oxygen adsorbed on the sur-face at low temperatures, (iii) promoted the mobility of lattice oxygen, and (iv) improved the properties of redox. The La0.6Sr0.4CoO2.78 catalyst prepared by the citric acid complexing-hydrothermal synthesis cou-pled strategy performed the best in the oxidation of EA, furthermore no partially oxidized products were formed. Based on the above results, we conclude that in addition to the surface area, the catalytic ac-tivity of the perovskite-type oxide nanoparticles was associated with the structural defect (oxygen vacancy) concentration and redox ability. | NIU Jianrong LIU Wei DAI Hongxing HE Hong Zl Xuehong LI Peiheng | 2006 | Chinese Science Bulletin2006，51，14： | 2 |
| 8 | The influence of the thyroid function status toward myocardial cell apoptosis in rats 显示文摘 | Zhou Q Li ZL Wang CH | 2001 | Di - si Junyi Daxue Xuebao2001，22，15： | 1 |
| 9 | Genistein and its synthetic analogs as anticancer agents显示文摘 | Li Qs Li CY Li ZL | 2012 | A nti-cancer agents in medicinal chemistry2012，12，3： | 1 |
| 10 | Trogia venenata (Agricales),a novel poisonous species caused hundreds of deaths in southwestern China显示文摘 | Yang ZL Li YC Tang LP | 2012 | Mycological Progress2012，11，4： | 1 |
| 11 | Chronic supplementation of paeonol com- bined with danshensu for the improvement of vascular reactivity in the cerebral basilar artery of diabetic rats显示文摘 | I-Iu J Li YL Li ZL | 2012 | Int J Mol Sci2012，13，14： | 1 |
| 12 | Biphasic effects of TGF beta1 on BMP9-induced osteogenic differentiation of mesenchymal stem cells显示文摘 | Li RD Deng ZL Hu N | 2012 | BMB Rep2012，45，9： | 1 |
| 13 | An evaluation of a 10-gauge vacu- m-assisted system for ultrasound-guided excision of clinically be- nigu breast lesions显示文摘 | Wang ZL Li JL Su L | 2009 | Breast2009，18，3： | 1 |
| 14 | Inhibition of prohferation and induction of apoptosis by genistein in coloncancer HT-29 cells 显示文摘 | Yu ZL Li WJ Liu FY | 2004 | Cancer Lett2004，2，： | 1 |
| 15 | GRP78 knockdown enhances apoptosis via the down regulation of oxidative stress and akt pathway after epirubicin treatment in colon cancer DLD 1 cells显示文摘 | Chang YJ Huang YP Li ZL | 2012 | PLoS One2012，7，35： | 1 |
| 16 | Novel mutation breed- ing method forStreptomyces avermitilis using an atmospheric pressure glow discharge plasma 显示文摘 | Wang LY Huang ZL Li G | 2010 | J Appl Microbiol2010，108，3： | 1 |
| 17 | Metabonomic study on Kidney-Yang Deficiency syndrome' and intervention effects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry 显示文摘 | Lu XM Xiong ZL Li J J | 2011 | Talanta2011，83，3： | 1 |
| 18 | Safety and immunogenicity of a novel human enterovirus 71 (EV71) vaccine: a ran- domized , placebo -controlled , double -blind , phase | clini- cal tlial显示文摘 | Li YP Liang ZL Gao Q | 2012 | Vaccine2012，30，22： | 1 |
| 19 | Effect of CYP3A4 1Gon the fentanyl consumption for intravenous patient-controlled analge- sia aftcr total abdominal hysterectomy in Chinese Han popula- tion显示文摘 | Dang ZL Li H Chen QX | 2012 | J Clin Pharm Ther2012，37，2： | 1 |
| 20 | Design and synthesis of Novel C14-Hydroxyl substituted triptolide derivatives as po-tential selective antitumor agents显示文摘 | Li Z Zhou ZL Miao ZH | 2009 | J Med Chem2009，52，16： | 1 |
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