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| 1 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 2 | Web data retrieval and extraction显示文摘 | Zoe L | 2003 | Data and Knowledge Engineering2003，44，3： | 1 |
| 3 | A Literature Review of Low Pressure Steam Turbine Exhaust Hood and Diffuser Studies显示文摘 | Zoe B Grant L I Simon H | 2013 | Journal of Engineering for Gas Turbines and Power2013，135，06： | 1 |
| 4 | The Influence of Inlet A- symmetry on Steam Turbine Exhaust Hood Flows显示文摘 | Zoe B Simon H Grant L I | 2013 | Journal of Engineering for Gas Turbines and Power2013，136，04： | 1 |
| 5 | Changes in human hepatic metabolism in steatosis and cirrhosis显示文摘AIM To understand the underlying metabolic changes in human liver disease we have applied nuclear magnetic resonance(NMR) metabolomics analysis to human liver tissue.METHODS We have carried out pilot study using 1H-NMR to derive metabolomic signatures from human liver from patients with steatosis, nonalcoholic steatohepatitis(NASH) or alcohol-related liver damage(ARLD) to identify species that can predict outcome and discriminate between alcohol and metabolic-induced liver injuries. RESULTS Changes in branched chain amino acid homeostasis, tricarboxylic acid cycle and purine biosynthesis intermediates along with betaine were associated with the development of cirrhosis in both ARLD and nonalcoholic fatty liver disease. Species such as propylene glycol and as yet unidentified moieties that allowed discrimination between NASH and ARLD samples were also detected using our approach.CONCLUSION Our high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance. | Zoe Schofield Michelle AC Reed Philip N Newsome David H Adams Ulrich L Günther Patricia F Lalor | 2017 | World Journal of Gastroenterology2017，23，15： | 1 |
| 6 | Thennostable α- amylase productien by Bacillus subtilis entrapped incalcium alginate gel capsules显示文摘 | Zoe K Maria L K | 2006 | Enzyme and Microbial Technology2006，，39： | 1 |
| 7 | Diabetes mellitus and risk of Alzheimer disease and decline in cognitive func- tion显示文摘 | Zoe Arvanitakis Robert S Wilson Julia L Bienias | 2004 | Arch Neurol2004，61，： | 1 |
| 8 | Cell cycle checkpoints as therapeutic targets显示文摘 | Zoe A Stewart L Jennifer A | 1999 | J Mammary Gland Biol Neoplasia1999，4，4： | 1 |
| 9 | Effect of endogenous antioxidants of sesame seeds and sesame oil to the thermal stability of edible vegetable oils显示文摘 | Zoe K Maria L K | | 0，，09： | 1 |
| 10 | Thermostable a-amylase production by Bacillus subtilis entrapped incalcium alginate gel capsules 显示文摘 | Zoe K Maria L K | 2006 | Enzymeand Microbial Technology2006，，39： | 1 |
| 11 | Thermostable α-amylase productionby Bacillus subtilis entrapped incalcium alginate gel capsules显示文摘 | Zoe K Maria L K | 2006 | Enzymeand Microbial Technology2006，，39： | 1 |
| 12 | Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline显示文摘 | Talbot Konrad Wang Hoau-Yan Kazi Hala Han Li-Ying Bakshi Kalindi P Stucky Andres Fuino Robert L Kawaguchi Krista R Samoyedny Andrew J Wilson Robert S Arvanitakis Zoe Schneider Julie A Wolf Bryan A Bennett David A Trojanowski John Q Arnold | 2012 | EN2012，，4： | 1 |
| 13 | Predicting pro-environmental agriculture practices:the social psychological and contextual influences on land management显示文摘 | JENNIFER C P ZOE L | 2014 | Journal of Rural Studies2014，34，7： | 1 |
| 14 | Web data retrieval and extraction显示文摘 | Zoe L | 2003 | Data and Knowledge Engineering2003，44，3： | 1 |
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