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| 1 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 2 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 3 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 4 | Reversible oriented surface immobilization of functional proteins on oxide surfaces显示文摘 | Evelyne L Thomas A K Zoltan D | 1997 | Analytical Chemistry1997，69，11： | 1 |
| 5 | Inten- sity modulated diode laser radar using frequency-modula- tion/continuous-wave ranging techniques 显示文摘 | Barry L Stann William C Ruff Zoltan G Sztankay | 1996 | Society of Photo-Optical Instrumentation Engineers1996，35，： | 1 |
| 6 | Biocatalytic asymmetric hydroxylation of hydrocarbons with the topsoil-microorganism Bacillus megaterium显示文摘 | WALDEMAR A ZOLTAN L DAG H | 2000 | J Org Chem2000，65，： | 1 |
| 7 | Column extraction of residues of several pesticides from fruits and vegetables:A simple multiresidue analysis method显示文摘 | Kadenczki L Zoltan A Gardi L Pesticide and industrial chemical residues | 1992 | Aasoc Off Anal Chem Int1992，75，1： | 1 |
| 8 | Free-boundary conditions of arbitrary polygonal topography in a two- dimensional explicit elastic finite-difference scheme 显示文摘 | Jih R S McLaughlin K L Zoltan A | 1988 | Geophysics1988，53，8： | 1 |
| 9 | A practical low-cost high-range-resolution ladar显示文摘 | Barry L Stann William C Ruff Zoltan G Sztankay | 1995 | SPIE1995，2472，： | 1 |
| 10 | Intensity modulated diode laser radar using frequency-modulation/continuous-wave ranging techniques显示文摘 | Barry L Stann William C Ruff Zoltan G Sztankay | 1996 | Society of Photo-Optical Instrumentation Engineers1996，35，： | 1 |
| 11 | Partial Conway and iteration semirings显示文摘 | BLOOM S L ZOLTAN Esik WERNER Kuich | 2008 | Fundara Inforra2008，86，： | 1 |
| 12 | Geographical origin identification of pure Sri Lanka tea infusions with electronic nose,electronic tongue and sensory profile analysis显示文摘 | ZOLTAN K ISTVAN D LARINA L | | 0，，： | 1 |
| 13 | Knowledge spill-overs, innovation and regional development 显示文摘 | HENRI L F DE GROOT PETER NIJKAMP ZOLTAN ACE | 2001 | Regional Science2001，，80： | 1 |
| 14 | Effect of crop rotation and fertilisation on maize and wheat yields and yield stability in a long-term experiment 显示文摘 | ZOLTAN BERZSENYI BELA RFFY DANG Q L | 2000 | Eur J Agr2000，13，2： | 1 |
| 15 | Immunocytochemical localization of acyl-lipid desaturases in cyanobacterlal cells: Evidence that both thylakoid membranes and cytoplasmic membranes are sites of lipid desaturation显示文摘 | Laszlo M Dmitry A L Zoltan G | 1996 | Plant Biology1996，93，10： | 1 |
| 16 | Geographical origin identification of pure Sri Lanka tea infusions with electronic nose,electronic tongue and sensory profile analysis显示文摘 | ZOLTAN K ISTVAN D LARINA L | | 0，，24： | 1 |
| 17 | The so- cial value of productive entrepreneurship显示文摘 | Zoltan J A Boardman M C Mcneely C L | 2013 | Small Business Economics2013，40，3： | 1 |
| 18 | A Ccmparison of the ECMWF,MSC,and NCEP global ensemble prediction systems显示文摘 | Buizza R P L Houtekamer Zoltan Toth | 2005 | Mon Wea Rev2005，133，5： | 1 |
| 19 | Patents and Innovation Counts as measures of regional production of new knowledge显示文摘 | Zoltan J Acs Anselln L Varga | 2002 | Research Policy2002，31，： | 1 |
| 20 | ADMA Impairs Nitric Oxide_Mediated Arteriolar Function Due to Increased Superoxide Production by Angi- otensinII-NAD (P)H Oxidase Pathway 显示文摘 | Zoltan V Anita R Gabor L | 2008 | Hypertension2008，52，5： | 1 |
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