| 2 | Classification of invariant Einstein metrics on certain compact homogeneous spaces显示文摘In this paper,we study invariant Einstein metrics on certain compact homogeneous spaces with three isotropy summands.We show that,if G/K is a compact isotropy irreducible space with G and K simple,then except for some very special cases,the coset space G×G/△(K)carries at least two invariant Einstein metrics.Furthermore,in the case that G1,G2 and K are simple Lie groups,with K■G1,K■G2,and G_1≠G2,such that G_1/K and G2/K are compact isotropy irreducible spaces,we give a complete classification of invariant Einstein metrics on the coset space G1×G2/△(K). | Zaili Yan Huibin Chen Shaoqiang Deng | 2020 | Science China Mathematics2020，63，4： | 1 |
| 3 | Eph receptor A4 regulates motor neuron ferroptosis in spinal cord ischemia/reperfusion injury in rats显示文摘Previous studies have shown that the receptor tyrosine kinase Eph receptor A4(EphA4) is abundantly expressed in the nervous system. The EphA4 signaling pathway plays an important role in regulating motor neuron ferroptosis in motor neuron disease. To investigate whether EphA4 signaling is involved in ferroptosis in spinal cord ischemia/reperfusion injury, in this study we established a rat model of spinal cord ischemia/reperfusion injury by clamping the left carotid artery and the left subclavian artery. We found that spinal cord ischemia/reperfusion injury increased EphA4 expression in the neurons of anterior horn, markedly worsened ferroptosis-related indicators, substantially increased the number of mitochondria exhibiting features consistent with ferroptosis, promoted deterioration of motor nerve function, increased the permeability of the blood-spinal cord barrier, and increased the rate of motor neuron death. Inhibition of EphA4 largely rescued these effects. However, intrathecal administration of the ferroptosis inducer Erastin counteracted the beneficial effects conferred by treatment with the EphA4 inhibitor. Mass spectrometry and a PubMed search were performed to identify proteins that interact with EphA4, with the most notable being Beclin1 and Erk1/2. Our results showed that inhibition of EphA4 expression reduced binding to Beclin1, markedly reduced p-Beclin1, and reduced Beclin1-XCT complex formation. Inhibition of EphA4 also reduced binding to p-Erk1/2 and markedly decreased the expression of c-Myc, transferrin receptor 1, and p-Erk1/2. Additionally, we observed co-localization of EphA4 and p-Beclin1 and of EphA4 and p-ERK1/2 in neurons in the anterior horn. In conclusion, EphA4 participates in regulating ferroptosis of spinal motor neurons in the anterior horn in spinal cord ischemia/reperfusion injury by promoting formation of the Beclin1-XCT complex and activating the Erk1/2/c-Myc/transferrin receptor 1 axis. | Yan Dong Chunyu Ai Ying Chen Zaili Zhang Dong Zhang Sidan Liu Xiangyi Tong Hong Ma | 2023 | Neural Regeneration Research2023，18，10： | 0 |
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