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| 1 | A new iridovirus isolated from soft - shelled turtle 显示文摘 | Chen Zaixian Zheng Jianchuan Jiang Yulin | 1999 | Virus research1999，63，1： | 1 |
| 2 | A new iridovirus isolated from soft - shelled turtle 显示文摘 | Chen Zaixian Zheng Jianchuan Jiang Yulin | 1999 | Virus research1999，63，1： | 1 |
| 3 | Equivalent force control method for substructure pseudo-dynamic test of a full-scale masonry structure 显示文摘 | CHEN Zaixian XU Guoshan WU Bin | 2014 | Earthquake Engineering and Structural Dynamics2014，43，7： | 1 |
| 4 | Equivalent force control method for substructure pseudo-dynamic test of a full-scale masonry structure显示文摘 | Chen Zaixian Xu Guoshan Wu Bin | 2014 | Earthquake Engineering and Structural Dynamics2014，43，96： | 1 |
| 5 | A new iridovirus isolated from soft -shelled turtle 显示文摘 | Chen Zaixian Zheng Jianchuan Jiang Yulin | 1999 | Virus research1999，63，1： | 1 |
| 6 | Equivalent force control method for substructure pseudo‐dynamic test of a full‐scale masonry structure显示文摘 | Zaixian Chen Guoshan Xu Bin Wu Yongtao Sun Huanding Wang Fenglai Wang | 2014 | Earthquake Engng Struct Dyn2014，，7： | 1 |
| 7 | Whole-exome sequencing reveals genetic underpinnings of salivary adenoid cystic carcinoma in the Chinese population显示文摘Salivary gland carcinomas(SGCs)are rare malignancies that remain poorly understood owing to their low incidence(Matsuba et al.,1986b;Liu et al.,2012).As per GLOBOCAN 2018.52.800 new cancers arising from salivary glands were estimated to be diag-nosed across the world that year.Because of their high propensity to invade local and perineural structures. | Shuhang Wang Yue Yu Yuan Fang Huiyao Huang Dawei Wu Hong Fang Ying Bai Chao Sun Anqi Yu Qi Fan Zicheng Yu Chao Zhang Changxi Wang Zaixian Tai Yi Huang Ning Li | 2020 | Journal of Genetics and Genomics2020，47，7： | 0 |
| 8 | Research on the Dilemma and Countermeasures of Graduate Student Recruitment Publicity in University Branch Area-Based on Harbin Institute of Technology(Weihai)显示文摘Graduate student recruitment publicity is a very important link in graduate student recruitment,the quality of students directly affects the quality of graduate education.Taking Harbin Institute of Technology(Weihai)as the research object,this paper analyzes the internal and external factors affecting the improvement of graduate student quality in the branch campus,and carries out the corresponding countermeasures,puts forward the propaganda strategy of all-round research and recruitment,and effectively improves the quality of graduate student in the branch campus. | Lianmao Yang Yiqun Liu Zaixian Chen | 2022 | 教育研究前沿(中英文版)2022，12，3： | 0 |
| 9 | Genomic evolution during locoregional recurrence in colorectal cancer determined by whole-exome sequencing: a retrospective observational study显示文摘Objective:The genomic landscapes of metastatic colorectal cancer(mCRC)have been extensively studied;however,the genetic mechanisms underlying the locoregional recurrence(LR)of CRC remain unclear.The objective of our study was to investigate genomic evolution during LR in CRC using high-throughput sequencing.Methods:Twenty-three CRC patients with matched primary and LR tissues were recruited from Nanfang Hospital and Zhejiang Cancer Hospital between January 2011 and December 2018.The last date of follow-up was March 2020.Tissue samples were analyzed by whole-exome sequencing and the genomic profiles were depicted by single nucleotide variation,mutational signature,copy number variation,clonal architecture,and other features.The evolutionary process was speculated with comparison of the genetic variations between primary and LR lesions.The disseminating clusters from primary to LR lesions were identified by variant allele frequency dynamics.Furthermore,the early-recurrent biomarker was explored by comparing the indel signature between early-and late-recurrent patients.The study was approved by the Institutional Review Board of Nanfang Hospital of Southern Medical University(approval No.2020010)on September 11,2020.Results:The results highlighted distinct origins of LR between patients with high microsatellite instability and microsatellite stability.LR lesions evolved independently in patients with high microsatellite instability,while LR lesions were highly clonally related to the primary lesions in patients with microsatellite stability.Late-acquired variations in LR lesions encompassed a wide range of driver genes involved in histone methylation,DNA replication,T cell activation,PDCD1 gain,and LMNA loss.Furthermore,clonal analysis of the disseminating cells identified a dominant polyclonal seeding pattern during LR.The indel signature ID4 was associated with significantly shorter disease-free survival in patients with relapsed CRC according to a public dataset.Conclusion:These findings pose a challenge for the development of new approaches targeting the interactions of multiple clones in the establishment of LR and in terms of optimizing the clinical management of susceptible patients. | Xiaoliang Lan Xiaoxiao Wu Chao Zhang Genxia Wei Bingbing Li Weihao Qiu Danyi Li Huanwen Wu Yanqing Ding Jie Yuan Zaixian Tai Zuoquan Yang Zhiyong Liang Dan Su Li Liang | 2022 | Journal of Bio-X Research2022，5，4： | 0 |
| 10 | Enhanced osteogenic differentiation of human periodontal ligament stem cells by suberoylanilide hydroxamic acid显示文摘Periodontitis is a type of chronic inflammation in the gingival tissue caused by infectious bacteria colonizing the surface of the teeth,leading to the destruction of tooth-supporting tissues and loss of alveolar bone.Suberoylanilide hydroxamic acid(SAHA),a class of histone deacetylase(HDAC)inhibitor,has the potential to stimulate osteoblast differentiation by acetylating histone proteins,and thus suppressing the expression of adipogenic and chondrogenic genes.However,the effect of SAHA on the differentiation of human periodontal ligament stem cells(hPDLSCs)is yet to be elucidated.Herein,we investigated the effects of SAHA on in vitro proliferation and differentiation of hPDLSCs by MTT assay,Alizarin Red-S,and alkaline phosphatase staining,and real-time PCR.Notably,300 ng/mL SAHA treatment enhanced the proliferation and mineralization of hPDLSCs,indicating their osteogenic potential.Moreover,a significant enhancement of osteogenesis gene markers and proteins was observed.We also demonstrated that ERK is a positive regulator of Runx2 transcription factors during osteoblast differentiation.These results indicate that SAHA may be a useful osteogenic induction agent for periodontal bone regeneration. | YUNZE XUAN BIN JIN SAYAN DEB DUTTA MENGMENG LIU ZAIXIAN SHEN XIWEN LIU YANG KANGJUAN LIM KI-TAEK | 2020 | BIOCELL2020，44，3： | 0 |
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