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| 1 | Dendritic Cells Transduced with SOCS1 Gene Exhibit Regulatory DC Properties and Prolong Allograft Survival显示文摘SOCS1 is a key regulator of cytokine signaling and is important for maintaining balance in the immune system. It is thought to participate in negative feedback loops in cytokine signaling and may be an important signal for the regulation of dendritic cell (DC) maturation. However, it remains unclear whether DCs transduced with SOCS1 exhibit characteristics of regulatory DCs and induce allogeneic T-cell hyporesponsiveness. In this study, we constructed adenoviral vector coding SOCS1 (Ad-SOCS1) that can efficiently increase SOCS1 gene expression in bone marrow-derived dendritic cells. DCs transduced with Ad-SOCS1 (DC-SOCS1) expressed low levels of costimulatory and MHC molecules, were resistant to maturation and activation stimulation, induced allogeneic T-cell hyporesponsiveness, and promoted the generation of regulatory-like T cells in vitro. DC-SOCS1 pretreatment significantly prolonged the survival of allografts and led to a substantial increase in the generation of regulatory T cells. Our data suggest that SOCS1 inhibits DC maturation and induces regulatory DC generation, therefore possessing therapeutic potential to prevent rejection in organ transplantation. | Hong Fu Shaohua Song Fang Liu Zhijia Ni Xiaoyun Shen Liang Xiao Guoshan Ding Quanxing Wang | 2009 | Cellular & Molecular Immunology2009，6，2： | 20 |
| 2 | Geobiological processes of the formation of lacustrine source rock in Paleogene显示文摘Gypsum-salt rocks and coccolith calcareous shale are widely deposited in the lower part of the Paleogene Shahejie Formation in the Dongying Sag,Shandong Province.The gypsum-salt rock is believed to be formed during the earlier deposition in salt lake,while the overlying coccolith shale in saline lake with relatively low salinity.By comparing the lake environment and lacustrine microbial communities between ancient and recent lakes,cyanobacteria are regarded as the main representative of productivity during the formation of gypsum-salt strata series,with the annual productivity of 1500-2000 gC m-2 yr-1.Based on the research of ultramicrofossils in the calcareous shale,coccolith is considered as the main contributor to the productivity during the formation of calcareous shale.On the basis of statistic data of sedimentary rates,shale laminations,and coccolith fossils in each lamination,the quantitative value of productivity is calculated,with the annual productivity of 2250-3810gC m-2 yr-1(averagely 3120 gC m-2 yr-1).Statistic data of large amount of pyrite framboids indicate that the lower water column was persistently in sulfidic or anoxic conditions during the deposition of gypsum-salt strata series,but it changed to be dysoxic when the coccolith calcareous shale was deposited.Both of these water conditions are favorable for the preservation of organic matter.It is estimated that the organic carbon burial efficiency of the Lower Paleogene salt lakes and saline lakes of Dongying Depression is about 10%-15%,which is calculated and analyzed using the multi-parameter geobiological model. | LI GuoShan WANG YongBiao LU ZongSheng LIAO Wei SONG GuoQi WANG XueJun XU XingYou | 2014 | Science China Earth Sciences2014，57，5： | 10 |
| 3 | Superhydrophobic modification of ceramic membranes for vacuum membrane distillation显示文摘The hydrophobically modi fied ceramic membranes have great potential for energy-ef ficient membrane distillation.In this work,flat-sheet ceramic membranes with a superhydrophobic surface were fabricated by grafting 1H,1H,2H,2H-per fluorooctyltrichlorosilane or 1H,1H,2H,2H-per fluorodecyltriethoxysilane and followed by ultraviolet irradiation.The surface water contact angle was improved from 46° of original ceramic membrane to 159°,which exhibited a stable and excellent superhydrophobic effect.The modi fied membranes showed a high flux of 27.28 kg·m^(-2)·h^(-1) and simultaneously maintained an excellent retention rate of 99.99%,when used in vacuum membrane distillation process for treatment of a 1 wt% NaCl(75 °C) aqueous solution.These results suggested that superhydrophobic modi fication of ceramic surface is a facile and cost-effective way to achieve higher membrane distillation performance.The superhydrophobically-modi fied ceramic membrane with an excellent desalination capacity would show considerable potential in practical membrane distillation utilizations. | Yanhui Yang Qianqian Liu Haizhi Wang Fusheng Ding Guoshan Jin Chunxi Li Hong Meng | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 9 |
| 4 | State and Output Feedback Finite-time Guaranteed Cost Control of Linear It Stochastic Systems显示文摘The problem of guaranteed cost control based on finite-time stability for stochastic system is first investigated in this paper.The motivation of solving this problem arises from an observation that finite/infinite-horizon guaranteed cost control does not consider the transient performance of the closed-loop system,but guaranteed cost control based on finite-time stability involves this practical requirement.In order to explain this problem explicitly,a concept of the stochastic finite-time guaranteed cost control is introduced,and then some new sufficient conditions for the existence of state and output feedback finite-time guaranteed cost controllers are derived,which guarantee finite-time stochastic stability of closed-loop systems and an upper bound of a quadratic cost function.Furthermore,this problem is reduced to a convex optimization problem with matrix inequality constraints and a new solving algorithm is given.Finally,an example is given to illustrate the effectiveness of the proposed method. | YAN Zhiguo ZHANG Guoshan WANG Jiankui ZHANG Weihai | 2015 | Journal of Systems Science & Complexity2015，28，4： | 4 |
| 5 | A trust region algorithm for bilevel programing problems显示文摘A trust region algorithm is proposed for solving bilevel programming problems where the lower level programming problem is a strongly convex programming problem with linear constraints. This algorithm is based on a trust region algorithm for nonsmooth unconstrained optimization problems, and its global convergence is also proved. | LIU Guoshan 1, HAN Jiye 2 and WANG Shouyang 3 1. Department of Mathematics, Beijing Normal University, Beijing 100875, China 2. Institute of Applied Mathematics, Chinese Academy of Sciences, Beijing 100080, China 3. Institute of Systems Science, Chi | 1998 | Chinese Science Bulletin1998，43，10： | 3 |
| 6 | Dense Mapping From an Accurate Tracking SLAM显示文摘In recent years, reconstructing a sparse map from a simultaneous localization and mapping(SLAM) system on a conventional CPU has undergone remarkable progress. However,obtaining a dense map from the system often requires a highperformance GPU to accelerate computation. This paper proposes a dense mapping approach which can remove outliers and obtain a clean 3D model using a CPU in real-time. The dense mapping approach processes keyframes and establishes data association by using multi-threading technology. The outliers are removed by changing detections of associated vertices between keyframes. The implicit surface data of inliers is represented by a truncated signed distance function and fused with an adaptive weight. A global hash table and a local hash table are used to store and retrieve surface data for data-reuse. Experiment results show that the proposed approach can precisely remove the outliers in scene and obtain a dense 3D map with a better visual effect in real-time. | Weijie Huang Guoshan Zhang Xiaowei Han | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，6： | 3 |
| 7 | Species-specific detection and quantification of scyphomedusae in Jiaozhou Bay,China,using a quantitative real-time PCR assay显示文摘Over the past decades,jellyfish occurred increasingly and abundantly in coastal areas worldwide.Usually,biomass of jellyfish,especially when they bloom,can be determined by visual counting.However,tiny individuals of jellyfish(e.g.,planulae,polyps,and ephyrae)are difficult to detect in the field.In this study,species-specific quantitative real-time PCR assays(qPCR)(SYBR Green I)targeting the mitochondrial 16S rDNA(mt-16S rDNA)of jellyfish were developed and were used to estimate the distribution and seasonal fluctuations of four jellyfish species(Nemopilema nomurai,Cyanea nozakii,Rhopilema esculentum,and Aurelia coerulea)in Jiaozhou Bay(JZB),China in 2013.The mt-16S rDNA of A.coerulea and N.nomurai was detected in most of the survey months and it peaked in July(1.03×10^(4) copies/L)and September(1.08×10^(6) copies/L),respectively.The mt-16S rDNA of C.nozakii occurred from August to October only with monthly mean values of 7.18-46.17 copies/L and was mainly located from the middle part to the outer part of the bay.The mt-16S rDNA of R.esculentum was the least abundant among the four species and was detected in only one sample(B2 station in March),with a value of 88.49 copies/L.The Spearman correlation test revealed that phytoplankton biomass was significantly and positively correlated with the mt-16S rDNA abundance of A.coerulea(R=0.37,P<0.01)and negatively with the mt-16S rDNA of N.nomurai(R=-0.36,P<0.01).The qPCR assay will enable the identification and quantification of jellyfish species in their whole life history and can be used as an approach in combination of the traditional jellyfish survey. | Jianyan WANG Tiezhu MI Zhigang YU Guoshan WANG Qinsheng WEI Jing YANG Yu ZHEN | 2021 | Journal of Oceanology and Limnology2021，39，4： | 3 |
| 8 | A combined dynamic inhalation device designed for moxa-smoking toxicity testing显示文摘OBJECTIVE: To design a combined dynamic inhalation device for testing the toxicity induced by moxa smoking.METHODS: The new apparatus(Patent No.201120101911.5) includes air renewal and recycling systems, a gas generating device, a gas control unit, and a device to measure and control temperature and humidity. Sprague-dawley rats were tested for acute and sub-chronic toxicity after exposure to moxa-burning smoke.RESULTS: We found an LC50 of 1.2 × 104mg/m3 in the acute toxicity assays. In sub-chronic toxicity tests the organ coefficients studied showed no sig-nificant differences within rats groups of the same gender after treatment with moxa smoke or a month of recovery. However, mean gray degree of lung 70 heat shock protein(HSP70) was significantly elevated in the high dose group in comparison with the low dose group(P < 0.05); mean gray degree, mean optical density, gross area of HSP70 in other organs and caspase-9 parameters showed no significant differences between groups.CONCLUSION: These results suggest that moxa smoke had no overt toxicity in rats. This work provides evidence and reference for the design of dynamic inhalation exposure systems. | Lan Lei Chang Xiaorong Zhang Guoshan Shi Jia | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 3 |
| 9 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 3 |
| 10 | Finite Time Consensus Problem for Multiple Non-Holonomic Agents with Communication Delay显示文摘In this paper, finite time consensus problem is discussed for multiple non-holonomic mobile agents with constant communication delay. The objective is to design non-smooth distributed control laws such that multiple non-holonomic mobile agents can be all in agreement within any given finite time larger than communication delay. The authors propose a novel switching control strategy with the help of Lyapunov-based method and graph theory. | WANG Jiankui FU Jiankuan ZHANG Guoshan | 2015 | Journal of Systems Science & Complexity2015，28，3： | 2 |
| 11 | OPTIMALITY CONDITIONS FOR NONCONVEX BILEVEL PROGRAMMING PROBLEMS显示文摘In this paper, we derive an exact penalty function for nonconvex bilevel programming problem based on its KS form. Based on this exact penalty function a sufficient condition for KS to be partially calm is presented and a necessary optimality condition for nonconvex bilevel programming problems is given. Some existing results about the differentiability of the value function of the lower level programming problem are extended and a sufficient condition for CRCQ to hold for VS form of BLPP with linear lower level programming problem is also given. | LIU Guoshan HAN Jiye (Institute of Aoolied Mathematics, Academia Sinica, Beijing 100080, China) | 1997 | Systems Science and Mathematical Sciences1997，10，2： | 2 |
| 12 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 1 |
| 13 | Calibration ruler for CW-EPR distance measurement using diradical molecule of rigid structure显示文摘许多试验性的因素和控制不了的因素可以由连续波浪电子在距离测量介绍错误顺磁的回声。处理这个问题,几 C 60 nitroxide diradical 与僵硬结构和明确的分子的尺寸使内收被用作距离刻度统治者。经由增加试验性的系列和偶极的拓宽功能的模拟节目基于距离计算节目的改进分别地,距离刻度方法在象不同溶剂,答案集中,测量温度,和微波力量那样的不同条件下面被开发。作为结果,稳定的距离刻度统治者在 813 的范围以内被建立 ? 。距离刻度效果被评估导致 0.84 的相应距离测量精确 ? 。结果建议非偶极的光谱的拓宽因素的影响能被克服,并且建立试验性并且计算方法对大量状况合适。发达方法将在 biomacromolecular 分析保证更精确、客观的距离测量。 | Guofu Dong Hongyao Wang Jianbo Cong Changzhen Wang Junwang Guo Tong Zhang Jingkui Yang Guoshan Yang Ke Wu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 1 |
| 14 | Equivalent force control method for substructure pseudo-dynamic test of a full-scale masonry structure 显示文摘 | CHEN Zaixian XU Guoshan WU Bin | 2014 | Earthquake Engineering and Structural Dynamics2014，43，7： | 1 |
| 15 | Exact penalty function for convex bilevel programming problems 显示文摘 | Liu Guoshan Han Jiye Zhang Jianzhong | 2001 | Journal of Optimization Theory and Applications2001，110，3： | 1 |
| 16 | Equivalent force control method for substructure pseudo-dynamic test of a full-scale masonry structure显示文摘 | Chen Zaixian Xu Guoshan Wu Bin | 2014 | Earthquake Engineering and Structural Dynamics2014，43，96： | 1 |
| 17 | Infinite horizon H-two/H-infinity control for descriptor systems:Nash game approach显示文摘This paper studies the infinite time horizon mixed H-two/H-infinity control problem for descriptor systems using Nash game approach. A necessary/sufficient condition for the existence of infinite horizon H-two/H-infinity control is presented in the form of two coupled algebraic Riccati equations, respectively. Finally, a suboptimal H-two/H-infinity controller design is given based on an iterative linear matrix inequality algorithm. | Zhiguo Yan Guoshan Zhang Jiankui Wang | 2012 | 控制理论与应用(英文版)2012，10，2： | 1 |
| 18 | Matching supply with demand: A power control and real time pricing approach显示文摘 | Jie Yang Guoshan Zhang Kai Ma | 2014 | International Journal of Electrical Power and Energy Systems2014，，： | 1 |
| 19 | Hepatic RIG-I Predicts Survival and Interferon-α Therapeutic Response in Hepatocellular Carcinoma显示文摘 | Jin Hou Ye Zhou Yuanyuan Zheng Jia Fan Weiping Zhou Irene O.L. Ng Huichuan Sun Lunxiu Qin Shuangjian Qiu Joyce M.F. Lee Chung-Mau Lo Kwan Man Yuan Yang Yun Yang Yingyun Yang Qian Zhang Xuhui Zhu Nan Li Zhengxin Wang Guoshan Ding Shi-Mei Zhuang Limin Zheng | 2013 | Cancer Cell2013，，： | 1 |
| 20 | A New Descent Algorithm for Sovling Quadratic Bilevel Programming Problems显示文摘 | HAN Jiye LIU Guoshan WANG Shouyang | | 0，，： | 1 |
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