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| 1 | Analgesic effect of parecoxib and flurbiprofen axetil for patients undergoing laparoscopic cholecystectomy and their influences on platelet aggregation显示文摘当它能也引起时, opioids 生产手术后的痛觉缺失,这被知道当它能也引起时,副作用喜欢恶心,呕吐,便秘,中略,发痒的皮肤,尿保留和因素都有的甚至呼吸的 inhibition.These 极大地为治疗手术后的疼痛限制了它的临床的使用。同时, non-steroidal 反煽动性拖(NSAID ) 在手术后的痛觉缺失起一个日益重要的作用。一些研究建议 NSAIDS 可能是神经的在服的 ischemic conditions.1 Flurbiprofen 保护 axetil,它利用类脂化合物 microsphere 拖交货系统,可以由煽动性的房间支持在煽动性的损害地点和吸收小粒的 flurbiprofen 的累积,有效地帮助到的 2 个两因素指向治疗。 Parecoxib 是为静脉内的注射可得到的第一个选择 cyclooxygenase-2 ( COX-2 )禁止者,它对产生 NSAIDs3 的病人有益,对胃肠的骚乱敏感的那些喜欢穿孔,溃疡,并且 bleeding.4 这调查为经历血小板聚集上的 laparoscopic 胆囊炎和他们的影响以便为诊所实践提供某指导的病人估计 parecoxib 和 flurbiprofen axetil 的止痛效果。 | JI Fu-hai JIN Xin YANG Jian-ping ZAN Li-li | 2010 | Chinese Medical Journal2010，，12： | 29 |
| 2 | Bufalin suppresses the migration and invasion of prostate cancer cells through HOTAIR, the sponge of miR-520b显示文摘Bufalin, the major active component of the traditional Chinese medicine ChanSu obtained from the skin and parotid venom glands of toads, has long been known as an anticancer agent. Recent studies show that microRNAs (miRs) are involved in the anticancer activities of bufalin, while long non-coding RNAs (lncRNAs) are known to interact with miRNAs to regulate various biological functions. In this paper, we investigated the possible network related to the antimetastatic effect of bufalin in prostate cancer (PCa) cells. We demonstrated that bufalin (0.05?10 μM) dose-dependently suppressed the proliferation of prostate cancer DU145 and PC3 cells with IC50 values of 0.89 and 1.28 μM, respectively. Furthermore, bufalin treatment significantly suppressed the cell migration and invasion. To explore the role of lncRNAs in the antimetastatic activity of bufalin, we used an lncRNA microarray and found that HOX transcript antisense RNA (HOTAIR) was the most markedly downregulated lncRNA in bufalin-treated PCa cells. Overexpression of HOTAIR counteracted the suppressing effects of bufalin on DU145 and PC3 cells. We then predicted and verified that HOTAIR upregulated FGFR1 expression by sponging miR-520b in PCa cells. In 40 patients with PCa bone metastasis, we used in situ hybridization or immunohistochemical assay to assess the HOTAIR and FGFR1 expression, which revealed that both HOTAIR and FGFR1 expression were significantly higher in bone metastasis tissues than in the primary PCa tissues. In addition, the level of serum HOTAIR was positively associated with the levels of serum bone metabolic markers (CTx, OST, B-ALP and PINP) and may serve as a reasonable biomarker for PCa bone metastasis. Taken together, this is the first study revealing that HOTAIR promotes PCa bone metastasis, and bufalin may be a promising candidate for the treatment of this disease. | Jian-jun Zhang Xiao-hui Zhou Yan Zhou Yong-gang Wang Bin-zhi Qian Ai-na He Zan Shen Hai-yan Hu Yang Yao | 2019 | Acta Pharmacologica Sinica2019，40，9： | 13 |
| 3 | Key genes expressed in different stages of spinal cord ischemia/reperfusion injury ischemia/reperfusion injury显示文摘The temporal expression of microRNA after spinal cord ischemia/reperfusion injury is not yet fully understood.In the present study,we established a model of spinal cord ischemia in Sprague-Dawley rats by clamping the abdominal aorta for 90 minutes,before allowing reperfusion for 24 or 48 hours.A sham-operated group underwent surgery but the aorta was not clamped.The damaged spinal cord was removed for hematoxylin-eosin staining and RNA extraction.Neuronal degeneration and tissue edema were the most severe in the 24-hour reperfusion group,and milder in the 48-hour reperfusion group.RNA amplification,labeling,and hybridization were used to obtain the microRNA expression profiles of each group.Bioinformatics analysis confirmed four differentially expressed microRNAs(miR-22-3p,miR-743b-3p,miR-201-5p and miR-144-5p) and their common target genes(Tmem69 and CxcllO).Compared with the sham group,miR-22-3p was continuously upregulated in all three ischemia groups but was highest in the group with no reperfusion,whereas miR-743b-3p,miR-201-5p and miR-144-5p were downregulated in the three ischemia groups.We have successfully identified the key genes expressed at different stages of spinal cord ischemia/reperfusion injury,which provide a reference for future investigations into the mechanism of spinal cord injury. | lian-an Li Chun-fang Zan Peng Xia Chang-jun Zheng Zhi-ping Qi Chun-xu Li Zhi-gang Liu Ting-ting Hou Xiao-yu Yang | 2016 | Neural Regeneration Research2016，11，11： | 9 |
| 4 | Pirarubicin inhibits multidrug-resistant osteosarcoma cell proliferation through induction of G~/M phase cell cycle arrest显示文摘 | Shui-er ZHENG Sang XIONG Feng LIN Guang-lei QIAO Tao FENG Zan SHEN Da-liu MIN Chun-ling ZHANG Yang YAO | 2012 | Acta Pharmacologica Sinica2012，33，6： | 9 |
| 5 | Two selenium tolerant Lysinibacillus sp. strains are capable of reducing selenite to elemental Se efficiently under aerobic conditions显示文摘Microbes play important roles in the transport and transformation of selenium(Se) in the environment, thereby influencing plant resistance to Se and Se accumulation in plant. The objectives are to characterize the bacteria with high Se tolerance and reduction capacity and explore the significance of microbial origins on their Se tolerance, reduction rate and efficiency. Two bacterial strains were isolated from a naturally occurred Se-rich soil at tea orchard in southern Anhui Province, China. The reduction kinetics of selenite was investigated and the reducing product was characterized using scanning electron microscopy and transmission electron microscopy-energy dispersive spectroscopy. The bacteria were identified as Lysinibacillus xylanilyticus and Lysinibacillus macrolides,respectively, using morphological, physiological and molecular methods. The results showed that the minimal inhibitory concentrations(MICs) of selenite for L. xylanilyticus and L. macrolides were 120 and 220 mmol/L, respectively, while MICs of selenate for L.xylanilyticus and L. macrolides were 800 and 700 mmol/L, respectively. Both strains aerobically reduced selenite with an initial concentration of 1.0 mmol/L to elemental Se nanoparticles(SeNPs) completely within 36 hr. Biogenic SeNPs were observed both inside and outside the cells suggesting either an intra-or extracellular reduction process. Our study implied that the microbes from Se-rich environments were more tolerant to Se and generally quicker and more efficient than those from Se-free habitats in the reduction of Se oxyanions. The bacterial strains with high Se reduction capacity and the biological synthesized Se NPs would have potential applications in agriculture, food, environment and medicine. | Ju Zhang Yue Wang Zongyuan Shao Jing Li Shuting Zan Shoubiao Zhou Ruyi Yang | 2019 | Journal of Environmental Sciences2019，31，3： | 7 |
| 6 | Gene admixture in ethnic populations in upper part of Silk Road revealed by mtDNA polymorphism显示文摘To evaluate the gene admixture on the current genetic landscape in Gansu Corridor (GC) in China, the upper part of the ancient Silk Road which connects the Eastern and Central Asia, we examined mitochondrial DNA (mtDNA) polymorphisms of five ethnic populations in this study. Using PCR-RFLP and sequencing, we analyzed mtDNA haplotypes in 242 unrelated samples in three ethnic populations from the GC region and two ethnic populations from the adjacent Xinjiang Uygur Autonomous Region of China. We analyzed the data in comparison with the previously reported data from Eastern, Central and Western Asia and Europe. We found that both European-specific haplogroups and Eastern Asian-specific haplogroups exist in the Gansu Corridor populations, while a modest matrilineal gene flow from Europeans to this region was revealed. The Gansu Corridor populations are genetically located between Eastern Asians and Central Asians, both of who contributed significantly to the maternal lineages of the GC populations. This study made the landscape of the gene flow and admixture along the Silk Road from Europe, through Central Asia, to the upper part of the Silk Road more complete. | YANG LiuQi, TAN SiJie, YU HaiJing, ZHENG BingRong, QIAO EnFa, DONG YongLi, ZAN RuiGuang & XIAO ChunJie Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center, Yunnan University, Kunming 650091, China | 2008 | Science China(Life Sciences)2008，51，5： | 7 |
| 7 | Magnetic properties of surface soils across the southern Tarim Basin and their relationship with climate and source materials显示文摘The magnetic susceptibility (χ) of surface soils on the Chinese Loess Plateau (CLP) has strong positive correlation with mean annual precipitation.It is widely accepted that ultrafine magnetite/maghemite grains produced during pedogenesis are responsible for the enhancement of χ,and loess χ on the CLP has been widely used as a proxy for the intensity of the East Asian summer monsoon.However,few works have investigated mechanisms for the enhancement of χ in the case of surface aeolian sediments in westerly-dominated inland China,north of the Tibetan Plateau.Here detailed rock magnetism and grain size studies of 49 surface samples taken across the southern Tarim Basin for different rainfall/temperature/altitude conditions are presented.The results show that samples taken from desert have the lowest χ values and that χ of loessic sand and loess samples decreases with increasing altitude.In addition,the rock magnetism studies suggest that the magnetic properties of surface soils across the southern Tarim Basin are mainly controlled by the concentration of coarse aeolian ferrimagnetic minerals.The contribution of ultrafine pedogenically produced magnetic grains to χ is very limited. | ZAN JinBo FANG XiaoMin NIE JunSheng YANG ShengLi SONG ChunHui DAI Shuang | 2011 | Chinese Science Bulletin2011，56，3： | 5 |
| 8 | Method of neural network modulation recognition based on clustering and Polak-Ribiere algorithm显示文摘To improve the recognition rate of signal modulation recognition methods based on the clustering algorithm under the low SNR, a modulation recognition method is proposed. The characteristic parameter of the signal is extracted by using a clustering algorithm, the neural network is trained by using the algorithm of variable gradient correction(Polak-Ribiere) so as to enhance the rate of convergence, improve the performance of recognition under the low SNR and realize modulation recognition of the signal based on the modulation system of the constellation diagram.Simulation results show that the recognition rate based on this algorithm is enhanced over 30% compared with the methods that adopt clustering algorithm or neural network based on the back propagation algorithm alone under the low SNR. The recognition rate can reach 90% when the SNR is 4 d B, and the method is easy to be achieved so that it has a broad application prospect in the modulating recognition. | Faquan Yang Zan Li Hongyan Li Haiyan Huang Zhongxian Pan | 2014 | Journal of Systems Engineering and Electronics2014，25，5： | 4 |
| 9 | On the development mechanism of the lacustrine high-grade hydrocarbon source rocks of Chang 91 member in Ordos Basin显示文摘As revealed from recent drilling and organic geochemical testing and research, a series of lacustrine high-grade hydrocarbon source rocks was discovered in the upper section of the Chang 9 oil reservoir member of upper Triassic in Ordos Basin. The hydrocarbon source rocks show average TOC content as high as 5.03%, average bitumen 'A' content as high as 0.8603%, and good quality organic precursors, which are of the sapropelic type mainly derived from lower aquatic plants and have reached the thermal evolution stage featured by oil-producing climax. Generally the lacustrine high-grade hydrocarbon source rocks were developed in local depressions of a lake basin, and the Chang 91 member was particularly formed in a depositional environment characterized by fresh water to weakly saline water, weakly oxidizing to weakly reducing setting and semi-deep lake facies, as was demonstrated by a variety of organic to inorganic geochemical parameters. As a result, high productivity constitutes the principal controlling force for generation of this series of high-grade hydrocarbon source rocks. Deposition of thinly-bedded and laminated tuffs as well as positive Eu anomaly corroborate the possible occurrence of anoxic geological event closely related to contemporaneous volcanic eruption, which would play a key part in development of the Chang 91 member of high-grade hydrocarbon source rocks. | ZHANG WenZheng YANG Hua FU SuoTang ZAN ChuanLi | 2007 | Science China Earth Sciences2007，50，z2： | 4 |
| 10 | LyP-1 peptide-functionalized gold nanoprisms for SERRS imaging and tumor growth suppressing by PTT induced-hyperthermia显示文摘Gold-based nanomaterials with plasmonic properties exhibit various potentials for biomedical applications. In this work, gold nanoprisms (GNPs) was synthesized and then modified with LyP-1, a tumor-homing peptide, to improve the affinity of the GNPs to tumor cells, thus, to improve the efficacy of tumor-targeted photothermal therapy. The introduction of NIR dye IR780 not only enabled the GNPs-based nanosystem with the surface-enhanced resonant Raman scattering (SERRS) property, but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation. The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo, which resulted in enhanced tumor-targeting photothermal therapeutic efficacy after laser irradiation. Hence, the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment. | Xi Huang Yanlong Yin Min Wu Wang Zan Qian Yang | 2019 | Chinese Chemical Letters2019，30，6： | 3 |
| 11 | Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis显示文摘Hydrogen has been used to suppress tumor growth with considerable efficacy.Inhalation of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic routes of hydrogen administration.We have developed a topical delivery method of hydrogen at targeted sites through the degradation of magnesium-based biomaterials.However,the underlying mechanism of hydrogen’s role in cancer treatment remains ambiguous.Here,we investigate the mechanism of tumor cell apoptosis triggered by the hydrogen released from magnesium-based biomaterials.We find that the localized release of hydrogen increases the expression level of P53 tumor suppressor proteins,as demonstrated by the in vitro RNA sequencing and protein expression analysis.Then,the P53 proteins disrupt the membrane potential of mitochondria,activate autophagy,suppress the reactive oxygen species in cancer cells,and finally result in tumor suppression.The anti-tumor efficacy of magnesium-based biomaterials is further validated in vivo by inserting magnesium wire into the subcutaneous tumor in a mouse.We also discovered that the minimal hydrogen concentration from magnesium wires to trigger substantial tumor apoptosis is 91.2μL/mm^(3)per day,which is much lower than that required for hydrogen inhalation.Taken together,these findings reveal the release of H2 from magnesium-based biomaterial exerts its anti-tumoral activity by activating the P53-mediated lysosome-mitochondria apoptosis signaling pathway,which strengthens the therapeutic potential of this biomaterial as localized anti-tumor treatment. | Rui Zan Hao Wang Weijie Cai Jiahua Ni Berengere J.C.Luthringer-Feyerabend Wenhui Wang Hongzhou Peng Weiping Ji Jun Yan Jiazeng Xia Yang Song Xiaonong Zhang | 2022 | Bioactive Materials2022，7，3： | 3 |
| 12 | 骨转换标志物在非小细胞肺癌骨转移临床应用价值的研究(英文)显示文摘Objective:The purpose of this study was to assess the clinical application value of bone turnover markers in non-small-cell lung cancer(NSCLC) patients with bone metastases.Including diagnosing bone metastases,detecting bone metastatic spread.Methods:Alkaline phosphatase(AKP),β-C-terminal telopeptide of type I collagen(β-CTx),osteocalcin(OST) and bone alkaline phosphatase(BALP) were measured in 76 patients with bone metastases from NSCLC and 44 normal people.Results:The level of AKP,β-CTx and BALP in patients with bone metastasis was significantly higher than in the normal people.Significant correlation was observed among bone turnover markers.The levels of BALP and OST were significantly correlated with the extent of bone metastasis.The patients with high-level CTx and low-level BALP had higher risk of pathologic fracture.Conclusion:In NSCLC patients with bone metastases,bone turnover markers can help to make diagnosis and evaluate the severity.It will have a wide range of use in clinical practice. | Zhiyu Wang Chen Yang Yumei Yang Zan Shen Hui Zhao Yang Yao | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，2： | 3 |
| 13 | Plant species coexistence alleviates the impacts of lead on Zea mays L.显示文摘Whether plant coexistence can reduce the impacts of lead (Pb) on crops in agroecosystems has not been well understood. We conducted a factorial experiment to investigate the effects of weeds coexisting with maize (Zea mays L.) on Pb accumulation in maize and soil microbes at two Pb levels (ambient and 300 mg/kg). Elevated Pb tended to increase the Pb concentration in maize and decreased soil microbial activity (indicated by the average well color development, AWCD), functional group diversity, as well as arbuscular mycorrhizal (AM) colonization and vesicle number of maize. Compared to the monoculture, weeds coexisting with maize reduced the Pb concentrations in the root, leaf, sheath and stem of maize at both seedling and mature stages. In maize-weed mixtures, soil microbial activity and functional group diversity tended to increase for both Pb treatments relative to the monoculture. Furthermore, principal component analysis revealed that the soil microbial community structure changed with the introduction of weeds. The highest Pb accumulation in weeds occurred for the elevated Pb treatment in a three species mixture. The results suggest that multiple plant species coexistence could reduce lead accumulation in crop plants and alleviate the negative impacts on soil microbes in polluted land, thereby highlighting the significance of plant diversity in agroecosystems. | Ruyi Yang Ling Liu Shuting Zan Jianjun Tang Xin Chen | 2012 | Journal of Environmental Sciences2012，24，3： | 2 |
| 14 | Synthesis,characterization and experimental investigation of Cu-BTC as CO_2 adsorbent from flue gas显示文摘Porous Cu-BTC material was synthesized by the solvothermal method.Powder X-ray diffraction(PXRD) was used to test the phase purity of the synthesized material and investigate its structural stability under the influence of flue gas components.The thermal stability of the material was determined through thermal gravimetric(TG) analysis.Scanning electron microscopy(SEM) was employed to study the microstructure of the material.Cu-BTC was demonstrated not only to have high CO 2 adsorption capacity but also good selectivity of CO 2 over N 2 by means of packed bed tests.The adsorption capacity of Cu-BTC for CO 2 was about 69 mL/g at 22°C.The influence of the main flue gas components on the CO 2 capacity of the material were discussed as well. | Jiangkun Xie Naiqiang Yan Zan Qu Shijian Yang | 2012 | Journal of Environmental Sciences2012，24，4： | 2 |
| 15 | Retinol-binding protein 4 as a risk factor for cholesterol gallstone formation显示文摘 | Tao Han Diancai Zhang Zan Fu Yueming Sun Wei Yang Cuimei Yuan | 2013 | Molecular and Cellular Biochemistry2013，，1： | 2 |
| 16 | Compound Gaoziban tablet(复方高滋斑片) alleviates depression via toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B pathway显示文摘OBJECTIVE: To evaluate the effect of compound Gaoziban tablet(复方高滋斑片, CGZBT) on depression, and to investigate the underlying mechanism. METHODS: The components of CGZBT were analysed by high-performance liquid chromatography. Then, we assessed the effects of varying doses of CGZBT on an established chronic unpredictable mild stress(CUMS) model in rats. Whether animals were depressed was evaluated by sucrose preference test, open field test and forced swimming test. Neurotransmitters of hippocampus were detected by liquid chromatography-mass spectrometry. Serum levels of tumor necrosis factor-alpha(TNF-α), interleukin(IL)-1β, IL-6, IL-4, and IL-10 were measured by enzyme-linked immunosorbent assay. Expressions of toll-like receptor 4(TLR4), myeloid differentiation factor 88(My D88), phospho-nuclear factorkappa B(p-NF-κB), cyclooxygenase-2(COX-2), ionized calcium binding adapter molecule-1(IBA-1) were assessed by immunohistochemical staining and western blotting. RESULTS: Eight compounds were identified from CGZBT, moreover, our results showed that CGZBT effectively reversed the CUMS-induced decrease in sucrose preference, shortened the movement distance and prolonged immobility time. CGZBT significantly increased levels of 5-hydroxytryptamine, dopamine, norepinephrine, 5-hydroxyindoleacetic acid levels, and reduced the expression of TNF-α, IL-1β, IL-6, yet increased IL-4 and IL-10. Furthermore, the expressions of TLR4, My D88, COX-2, p-NF-κB and IBA-1 in hippocampus were effectively reversed after treatment with CGZBT. CONCLUSIONS: These results indicated that CGZBT could, at least in part, alleviate depression induced by CUMS via the TLR4/My D88/NF-κB pathway, suggesting its potential as an antidepressant drug. | ZOU Xinshuang SHI Lei YIN Hailong LI Haiping WANG Mengheng SONG Wanci LUO Laichun WU Hezhen YANG Yanfang ZAN Junfeng LIU Yanwen DAN Hanxiong YIN Qiang YOU Pengtao | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
| 17 | Fabrication of Poly(1-Vinylimidazole)/Mordenite Grafting Membrane with High Pervaporation Performance for The Dehydration of Acetic Acid显示文摘 | Chen Zan Yang Jianhua Wang Jinqu | 2010 | JMembrSci2010，349，12： | 1 |
| 18 | Circulating copeptin level and the clinical prognosis of patients with chronic liver disease显示文摘BACKGROUND The relationship between copeptin and the severity of circulatory dysfunction and systemic stress response in patients with chronic liver disease(CLD)has been established.Nevertheless,the potential of serum copeptin levels to predict the prognosis of CLD patients remains unclear.AIM To conduct a systematic review and meta-analysis to investigate the correlation between serum copeptin and transplant-free survival(TFS)in this population.METHODS To achieve the objective of the meta-analysis,PubMed,Embase,the Cochrane Library,and the Web of Science were searched to identify observational studies with longitudinal follow-up.The Cochrane Q test was utilized to assess betweenstudy heterogeneity,and the I2 statistic was estimated.Random-effects models were employed to combine the outcomes,taking into account the potential influence of heterogeneity.RESULTS Ten datasets including 3133 patients were involved.The follow-up durations were 1 to 48 mo(mean:12.5 mo).Overall,it was shown that a high level of serum copeptin was associated with a poor TFS[risk ratio(RR):1.82,95%confidence interval:1.52-2.19,P<0.001;I2=0%].In addition,sensitivity analysis by omitting one dataset at a time showed consistent results(RR:1.73-2.00,P<0.05).Finally,subgroup analyses according to study country,study design,patient diagnosis,cutoff of copeptin,follow-up duration,and study quality score also showed similar results(P for subgroup difference all>0.05).CONCLUSION Patients with CLD who have high serum copeptin concentrations may be associated with a poor clinical prognosis. | Hao-Qian Tan Ming Zhao Zan Huang Yang Liu Han Li Long-Hui Ma Jun-Ying Liu | 2023 | World Journal of Gastroenterology2023，29，31： | 1 |
| 19 | Astatine-211 la- beling of insulin= Synthesis and preliminary evalu- ation in vivo and in vitro 显示文摘 | Liu N Yang YY Zan LB | 2007 | J Radioanal Nucl Chem2007，272，1： | 1 |
| 20 | Variation in community structure of arbuscular mycorrhizal fungi associated with a Cu tolerant plant— Elsholtzia splendens显示文摘 | Ruyi Yang Shuting Zan Jianjun Tang Xin Chen Qian Zhang | 2009 | Applied Soil Ecology2009，，3： | 1 |
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