|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Laparoscopic Partial Nephrectomy With Segmental Renal Artery Clamping:Technique and Clinical Outcomes显示文摘Background:Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy(PN).The technique of segmental renal artery clamping emerges as an alternative to conventional renal artery clamping for renal hilar control.Objective:To evaluate the feasibility and efficiency of laparoscopic PN(LPN) with segmental renal artery clamping in comparison with the conventional technique.Design,setting,and participants:A total of 75 patients underwent LPN from June 2007 to November 2009.All patients had T1a or T1b tumor in one kidney and a normal contralateral kidney.Thirty-seven patients underwent surgeries with main renal artery clamping,and 38 underwent surgeries with segmental artery clamping.Intervention:All procedures were performed by the same laparoscopic surgeon.Measurements:Blood loss,operation time,warm ischemia(WI) time,and complications affected renal function before and after operation were recorded.Results and limitations:All LPNs were completed without conversion to open surgery or nephrectomy.The novel technique slightly increased WI time(p < 0.001) and intraoperative blood loss(p = 0.006),while it provided better postoperative affected renal function(p < 0.001) compared with the conventional technique.The total complication rate was 12%.Among the 38 cases where segmental renal artery clamping was performed,7 had to convert to the conventional method.Tumor size and location influenced the number of clamped segmental arteries.Long-term postoperative renal function is still awaited.Conclusions:LPN with segmental artery clamping is safe and feasible in clinical practice.It minimizes the intraoperative WI injury and improves early postoperative affected renal function compared with main renal artery clamping.(C) 2010 European Association of Urology.Published by Elsevier B.V.All rights reserved. | Shao,P.F. Qin,C. Yin,C.J. Meng,X.X. Ju,X.B. Li,J. Lü,Q.A. Zhang,W. Xu,Z.Q.Shao,Pengfei Qin,Chao Yin,Changjun Meng,Xiaoxin Ju,Xiaobing Li,Jie Lü,Qiang Zhang,Wei Xu,Zhengquan] Nanjing Med Univ,Affiliated Hosp 1,Dept Urol,Nanjing,Peoples R China.Guangzhou Rd 300,Nanjing 210029,Peoples R China. | 2011 | 南京医科大学学报(自然科学版)2011，31，7： | 123 |
| 2 | Backfilling technology and strata behaviors in fully mechanized coal mining working face显示文摘Based on the principle of fully mechanized backfilling and coal mining technology and combined with the Xingtai Coal Mine conditions,we mainly optimized the coal mining equipment and adjusted the coal mining method in the Xingtai Coal Mine 7606 working face for implementation this technology.Firstly,we define the practical backfilling process as the ''(from backfilling scraper conveyor's) head to tail backfilling,step by step swinging up of the tamping arm,gradual compacting,moving formed backfilling scraper conveyor when the second tamping arm cannot pass and connecting the immediate roof by back material push front material movement''.Meanwhile,the stress changes of backfill body in coal mined out area was monitored by stress sensors,and the roof caving law was analyzed by monitoring the dynamic subsidence of à210 west roadway of this face.The site tests results show that using this new backfilling and coal mining integrated technology,the production capacity in the 7606 working face can reach to 283,000 ton a year,and 282,000 ton of solid materials(waste and fly ash) is backfilled,which meets the needs of high production and efficiency.The goaf was compactly backfilled with solid material and the strata behavior was quite desirable,with an actual maximum vertical stress of the backfill body of 5.5 MPa.Backfill body control the movement of overburden within a certain range,and there is no collapses of major areas in the overlying strata upon backfilled gob.The maximum subsidence and speed were 231 mm and 15.75 mm/d respectively,which proved the practical significance of this integrated technology. | Zhang Qiang Zhang Jixiong Huang Yanli Ju Feng | 2012 | International Journal of Mining Science and Technology2012，22，2： | 55 |
| 3 | Get effective polyclonal antisera in one month显示文摘According to the traditional immunization procedure, after the first injection of the sample A (emulsion of aimed antigen and Freund's complete adjuvant) to immunize rabbit, successive injections of the sample B (emulsion of aimed antigen and Freund's incomplete adjuvant) were followed every 2-4 weeks. In general,high titer of the corresponding polyclonal antisera will be observed after 4-5 injections of sample B in 3-4months. This report presents a simply modified procedure that was able to stimulate the antisera formation in one month and achieve enough avidity to satisfy either Western blot or immunohistochemistry analysis.It just applied an additional injection of the sample A to the rabbit at the 3rd day after the primary immunization injection. You could gain the high titer of the antisera right after the first sample B injection in one month. This method has produced the desired results in three different recombinant antigens with different molecular weight (5.9 KD-55 KD) expressed from prokaryotic or eukaryotic cells. | YUAN XIN HU, Ju YUAN QUO, Lu SHEN, YAN CHEN, Zu CHUAN ZHANG, YONG LIAN ZHANGState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, | 2002 | Cell Research2002，12，2： | 45 |
| 4 | Fate of ^(15)N-Labeled Urea Under a Winter Wheat-Summer Maize Rotation on the North China Plain显示文摘一个地实验被进行在冬小麦(Triticum aestivum L.) 和夏天玉米(Zea mays L.) 下面调查 15N 标签脲和它的剩余效果的命运诺思中国平原上的旋转系统。比作 360 kg N 的常规申请率哈 ? 1 (N360 ) , 120 kg N 的减少的率哈 ?(N120 ) 1 导致了重要增加(P <
0.05 ) 在小麦,产量和没有重要差别被作出对有利的裁决玉米。在在收获的 0 100 厘米土剖面,与 N360 相比, N120 不管多么导致了重要减少(P <
0.05 ) 百分比剩余 N 和百分比未予说明的 N,它可能从管理系统反映了损失。在土剖面的剩余化肥 N 25.6%44.7%和20.7%分别地,,38.2%为 N120 和 N360 在器官的 N 水池0.3%3.0%和11.2%相应地,24.4%在硝酸盐水池,显示一个更高的潜力因为沥滤的损失以常规率与申请联系了。在由接替庄稼的土剖面的剩余 N 的恢复是不到 7.5% 应用 N。为 N120,全部的土壤 N 平衡是否定的;然而,仍然有可观的矿物质 N (NH+4-N 并且没有 ? 3-N ) 在在收获以后的土剖面。因此, N120 能在短期内被认为农学的联盟者可接受,要不是长期的可持续性, N 率应该基于土壤矿物 N 测试和植物组织硝酸盐测试被推荐维持土壤肥力。 | JU Xiao-Tang LIU Xue-Jun PAN Jia-Rong ZHANG Fu-Suo | 2007 | Pedosphere2007，17，1： | 43 |
| 5 | Yield and Nicotine Content of Flue-Cured Tobacco as Affected by Soil Nitrogen Mineralization显示文摘Nitrogen(N)supply is the most important factor affecting yield and quality of flue-cured tobacco(FCT).A field experiment and an in situ incubation method were used to study the effects of soil N mineralization in the later stages of growth on yield and nicotine content of FCT in Fenggang and Jinsha,Guizhou Province.The yield and market value of FCT at Fenggang were much lower than those at Jinsha.However,the nicotine content of middle and upper leaves was much higher at Fenggang than at Jinsha when the same rate of fertilizer N was applied,which might be due to a higher N supply capacity at the Fenggang site.At later stages of growth(7-16 weeks after transplanting),the soil net N mineralization at Fenggang(56 kg N ha^(-1))was almost double that at Jinsha(30 kg N ha^(-1)).While soil NH_4-N and NO_3-N were almost exhausted by the plants or leached 5 weeks after transplanting,the N taken up at the later growth stages at Fenggang were mainly derived from soil N mineralization,which contributed to a high nicotine content in the upper leaves.The order of soil N contribution to N buildup in different leaves was:upper leaves>middle leaves>lower leaves.Thus,soil N mineralization at late growth stages was an important factor affecting N accumulation and therefore the nicotine content in the upper leaves. | JU Xiao-Tang CHAO Feng-Chun LI Chun-Jian JIANG Rong-Feng P. CHRISTIE ZHANG Fu-Suo | 2008 | Pedosphere2008，18，2： | 39 |
| 6 | Effect of in-hospital medical complications on case fatality post-acute ischemic stroke: data from the China National Stroke Registry显示文摘 | WANG Peng-lian ZHAO Xing-quan YANG Zhong-hua WANG An-xin WANG Chun-xue LIU Li-ping WANGYi-long WANG Xin-gao JU Yi CHEN Sheng-yun CHEN Qi-dong QU Hui LU Jing-jing ZHANG Jing MA Rui-hua ZHANG Yu-mei WANG Yong-jun | 2012 | Chinese Medical Journal2012，，14： | 37 |
| 7 | Nitrogen cycling and environmental impacts in upland agricultural soils in North China: A review显示文摘The upland agricultural soils in North China are distributed north of a line between the Kunlun Mountains, the Qinling Mountains and the Huaihe River. They occur in arid, semi-arid and semi-humid regions and crop production often depends on rain-fed or irrigation to supplement rainfall. This paper summarizes the characteristics of gross nitrogen(N) transformation, the fate of N fertilizer and soil N as well as the N loss pathway, and makes suggestions for proper N management in the region. The soils of the region are characterized by strong N mineralization and nitrification, and weak immobilization and denitrification ability, which lead to the production and accumulation of nitrate in the soil profile. Large amounts of accumulated nitrate have been observed in the vadose-zone in soils due to excess N fertilization in the past three decades, and this nitrate is subject to occasional leaching which leads to groundwater nitrate contamination. Under farmer's conventional high N fertilization practice in the winter wheat-summer maize rotation system(N application rate was approximately 600 kg ha–1 yr–1), crop N uptake, soil residual N, NH_3 volatilization, NO_3~– leaching, and denitrification loss accounted for around 27, 30, 23, 18 and 2% of the applied fertilizer N, respectively. NH_3 volatilization and NO_3~– leaching were the most important N loss pathways while soil residual N was an important fate of N fertilizer for replenishing soil N depletion from crop production. The upland agricultural soils in North China are a large source of N_2O and total emissions in this region make up a large proportion(approximately 54%) of Chinese cropland N_2O emissions. The 'non-coupled strong ammonia oxidation' process is an important mechanism of N_2O production. Slowing down ammonia oxidation after ammonium-N fertilizer or urea application and avoiding transient high soil NH4+ concentrations are key measures for reducing N_2O emissions in this region. Further N management should aim to minimize N losses from crop and livestock production, and increase the recycling of manure and straw back to cropland. We also recommend adoption of the 4 R(Right soure, Right rate, Right time, Right place) fertilization techniques to realize proper N fertilizer management, and improving application methods or modifying fertilizer types to reduce NH_3 volatilization, improving water management to reduce NO_3~– leaching, and controlling the strong ammonia oxidation process to abate N_2O emission. Future research should focus on the study of the trade-off effects among different N loss pathways under different N application methods or fertilizer products. | JU Xiao-tang ZHANG Chong | 2017 | Journal of Integrative Agriculture2017，16，12： | 37 |
| 8 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 9 | Changes of net primary productivity in China during recent 11 years detected using an ecological model driven by MODIS data显示文摘网主要生产率(NPP ) 是陆上的碳周期的一个重要部件。精确地在中国印射 NPP 的空间时间的变化为全球碳骑车是关键的学习。在这研究,基于过程的北方的生态系统生产率模拟器(BEPS ) 被采用从 2000 ~ 2010 为时期在中国的生态系统学习 NPP 的变化。BEPS 模型首先用在在不同区域测量的典型流动地点和森林 NPP 测量的粗野主要生产率(GPP ) 被验证。然后,它与叶区域索引( LAI )被驾驶从中等分辨率成像分光辐射函数( MODIS )反射和陆地盖子产品和气象学的数据的 inversed 在 753 个国家基本气象学的车站从观察插入内推从1月1日在每日的时间步和 500 m 的空间分辨率模仿 NPP , 2000 到2010年12月31日。确认证明 BEPS 能在中国的不同区域捕获基于塔的 GPP 的季节的变化和森林 NPP 的空间可变性。年度 NPP 的估计的国家总数从 2.63 变化了到 2.84Pg C 獥吗? | Yibo LIU Weimin JU Honglin HE Shaoqiang WANG Rui SUN Yuandong ZHANG | 2013 | Frontiers of Earth Science2013，7，1： | 30 |
| 10 | An experimental investigation on the mechanism of fluid flow through single rough fracture of rock显示文摘The structure of fractures in nature rock appears irregular and induces complicated seepage flow behavior.The mechanism and quantitative description of fluid flow through rock fractures is a difficult subject that has been greatly concerned in the fields of geotechnical,mining,geological,and petroleum engineering.In order to probe the mechanism of fluid flow and the effects of rough structures,we conducted a few laboratory tests of fluid flow through single rough fractures,in which the Weierstrass-Mandelbrot fractal function and PMMA material were employed to produce the fracture models with various fractal roughnesses.A high-speed video camera was employed to record the fluid flow through the entire single rough fracture with a constant hydraulic pressure.The properties of fluid flow varying with the fracture roughness and the influences of the rough structure were analyzed.The components of flow resistance of a single rough fracture were discussed.A fractal model was proposed to relate the fluid resistance to the fracture roughness.A fractal equivalent permeability coefficient of a single rough fracture was formulated.This study aims to provide an experimental basis and reference for better understanding and quantitatively relating the fluid flow properties to the structures of rock fractures. | JU Yang ZHANG QinGang YANG YongMing XIE HePing GAO Feng WANG HuiJie | 2013 | Science China(Technological Sciences)2013，56，8： | 28 |
| 11 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 12 | Ambient air quality trends and driving factor analysis in Beijing, 1983–2007显示文摘The rapid development in Beijing, the capital of China, has resulted in serious air pollution problems. Meanwhile great efforts have been made to improve the air quality, especially since 1998. The variation in air quality under the interaction of pollution and control in this mega city has attracted much attention. We analyzed the changes in ambient air quality in Beijing since the 1980's using the Daniel trend test based on data from long-term monitoring stations. The results showed that different pollutants displayed three trends: a decreasing trend, an increasing trend and a flat trend. SO2, dustfall, B[a]P, NO2 and PM10 fit decreasing trend pattern, while NOx showed an increasing trend, and CO, ozone pollution, total suspended particulate (TSP), as well as Pb fit the flat trend. The cause of the general air pollution in Beijing has changed from being predominantly related to coal burning to mixed traffic exhaust and coal burning related pollution. Seasonally, the pollution level is typically higher during the heating season from November to the following March. The interaction between pollution sources change and implementation of air pollution control measures was the main driving factor that caused the variation in air quality. Changes of industrial structure and improved energy effciency, the use of clean energy and preferred use of clean coal, reduction in pollution sources, and implementation of advanced environmental standards have all contributed to the reduction in air pollution, particularly since 1998. | Ju Zhang Zhiyun Ouyang Hong Miao Xiaoke Wang | 2011 | Journal of Environmental Sciences2011，23，12： | 22 |
| 13 | Grain yield and water use efficiency of super rice under soil water deficit and alternate wetting and drying irrigation显示文摘This study investigated if super rice could better cope with soil water deficit and if it could have better yield performance and water use efficiency(WUE) under alternate wetting and drying(AWD) irrigation than check rice. Two super rice cultivars and two elite check rice cultivars were grown in pots with three soil moisture levels, well watered(WW), moderate water deficit(MWD) and severe water deficit(SWD). Two cultivars, each for super rice and check rice, were grown in field with three irrigation regimes, alternate wetting and moderate drying(AWMD), alternate wetting and severe drying(AWSD) and conventional irrigation(CI). Compared with that under WW, grain yield was significantly decreased under MWD and SWD treatments, with less reduction for super rice than for check rice. Super rice had higher percentage of productive tillers, deeper root distribution, higher root oxidation activity, and greater aboveground biomass production at mid and late growth stages than check rice, especially under WMD and WSD. Compared with CI, AWMD increased, whereas AWSD decreased grain yield, with more increase or less decrease for super rice than for check rice. Both MWD and SWD treatments and either AWMD or AWSD regime significantly increased WUE compared with WW treatment or CI regime, with more increase for super rice than for check rice. The results suggest that super rice has a stronger ability to cope with soil water deficit and holds greater promising to increase both grain yield and WUE by adoption of moderate AWD irrigation. | ZHOU Qun JU Cheng-xin WANG Zhi-qin ZHANG Hao LIU Li-jun YANG Jian-chang ZHANG Jian-hua | 2017 | Journal of Integrative Agriculture2017，16，5： | 22 |
| 14 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 15 | Responses and stability of power system under small Gauss type random excitation显示文摘With the integration of renewable power and electric vehicle,the power system stability is of increasing concern because the active power generated by the renewable energy and absorbed by the electric vehicle vary randomly.Based on the deterministic differential equation model,the nonlinear and linear stochastic differential equation models of power system under Gauss type random excitation are proposed in this paper.The angle curves under different random excitations were simulated using Euler-Maruyama(EM) numerical method.The numerical stability of EM method was proved.The mean stability and mean square stability of the power system under Gauss type of random small excitation were verified theoretically and illustrated with simulation sample. | ZHANG JianYong JU Ping YU YiPing WU Feng | 2012 | Science China(Technological Sciences)2012，55，7： | 20 |
| 16 | Gastric Lgr5+ stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice显示文摘 | Xiu-Bin Li Guan Yang Liang Zhu Yu-Ling Tang Chong Zhang Zhenyu Ju Xiao Yang Yan Teng | 2016 | Cell Research2016，26，7： | 20 |
| 17 | Arpin contributes to bacterial translocation and development of severe acute pancreatitis显示文摘AIM: To assess the impact of Arpin protein and tight junction(TJ) proteins in the intestinal mucosa onbacterial translocation in patients with severe acute pancreatitis(SAP).METHODS: Fifty SAP patients were identified as study objects and then classified into two groups according to the presence of bacterial translocation(BT) in the blood [i.e., BT(+) and BT(-)].Twenty healthy individuals were included in the control group.BT was analyzed by polymerase chain reaction, colonic mucosal tissue was obtained by endoscopy and the expression of TJ proteins and Arpin protein was determined using immunofluorescence and western blotting.RESULTS: Bacterial DNA was detected in the peripheral blood of 62.0% of patients(31/50) with SAP.The expression of TJ proteins in SAP patients was lower than that in healthy controls.In contrast, Arpin protein expression in SAP patients was higher than in healthy controls(0.38 ± 0.19 vs 0.28 ± 0.16, P < 0.05).Among SAP patients, those positive for BT showed a higher level of claudin-2 expression(0.64 ± 0.27 vs 0.32 ± 0.21, P < 0.05) and a lower level of occludin(OC)(0.61 ± 0.28 vs 0.73 ± 0.32, P < 0.05) and zonula occludens-1(0.42 ± 0.26 vs 0.58 ± 0.17, P = 0.038) expression in comparison with BT(-) patients.Moreover, the level of Arpin expression in BT(+) patients was higher than in BT(-) patients(0.61 ± 0.28 vs 0.31 ± 0.24, P < 0.05).CONCLUSION: Arpin protein affects the expression of tight junction proteins and may have an impact on BT.These results contribute to a better understanding of the factors involved in bacterial translocation during acute pancreatitis. | Wen-Sheng Deng Jian Zhang Hui Ju Hong-Mei Zheng Jiang Wang Su Wang Dian-Liang Zhang | 2015 | World Journal of Gastroenterology2015，21，14： | 20 |
| 18 | Transplantation of magnetically labeled mesenchymal stem cells improves cardiac function in a swine myocardial infarction model显示文摘背景:间充质的干细胞(MSC ) 移植为心肌的修理提供一条新途径。然而,关于 MSC 移植的许多重要基本问题仍然保持未答复。有迫切需要从跳动的心识别 MSC 并且分析这条新途径的功效。试图本地化有磁力地标记的 MSC (MR-MSCs ) 并且监视补药的这研究与磁性的回声(先生) MR-MSCs 完成成像。方法:尖锐心肌的梗塞(AMI ) 被左前面的下降冠的动脉的汽球吸藏在猪创造。房间在心肌的梗塞以后经由 intracoronary 注入被交付。梗塞尺寸变化和心脏的功能与 3.0T 先生扫描仪被估计。结果然后被组织学、西方的污点分析证实。所有统计过程与 Systat (社会科学统计套装软体版本 12.01 ) 被执行。结果:26 猪的一个总数被划分成四个组(假冒操作组, n=6;有 PBS 移植的 AMI 组, n=6;标记的 MSC 组, n=7;未标记的 MSC 组, n=7 ) 。MSC, MR-MSCs (10 (7 ) 房间) 或在 MI 和连续心脏的先生成像研究在移植以后在 0, 4 和 8 个星期被执行以后, PBS 被 intracoronary 注射交付。先生成像证明 MI 尺寸在 MSC 移植以后减少了在标记并且未标记的组然而,增加在 MI 以后在 8 个星期在 AMI 组被看见。左室的喷射部分( LVEF )稍微在 AMI 组被增加(( 41.87+/-2.45 )%对( 39.04+/-2.80 )%, P>0.05 ),但是显著地在 MR-MSCs 组改善了(( 56.85+/-1.29 )%对( 40.67+/-2.00 )%, P<0.05 )并且未标记的组(( 55.38+/-1.07 )%对( 41.78+/-2.08 )%, P<0.05 )在 8 星期术后疗法。MR-MSCs 被普鲁士的蓝色和免疫进一步证实荧光灯的染色。西方的污点分析证明在 MSC 处理组和矩阵 metalloproteinase 的比率有象肌浆球蛋白重链和 troponin T 那样的 cardiomyocyte 标记的增加的表情 2 到 metalloproteinase 的织物禁止者, 1 与 AMI 组和假冒操作组相比在标记的组和未标记的组减少了。结论:移植 MR-MSCs 能改革新心肌层并且在 2 月的后续在一个 MI 模型阻止 remolding 并且代表一个比较喜欢的方法更好在未来理解干细胞治疗的机制临床的研究。 | QI Chun-mei MA Gen-shan LIU Nai-feng SHEN Cheng-xing CHEN Zhong LIU Xiao-jun HU Yao-peng ZHANG Xiao-li TENG Gao-jun JU Sheng-hong MA Ming TANG Yao-liang | 2008 | Chinese Medical Journal2008，，6： | 19 |
| 19 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 20 | Clinical diagnostic performance of the simultaneous amplification and testing methods for detection of the Mycobacterium tuberculosis complex for smear-negative or sputum-scarce pulmonary tuberculosis in China显示文摘 | Fan Lin Zhang Qing Cheng Liping Liu Zhibing Ji Xiaobing Cui Zhenling Ju Jingliang Xiao Heping | 2014 | Chinese Medical Journal2014，，10： | 19 |
您所在的机构暂未开通此部分的功能，请联系管理员