|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 2 | Prophylaxis for venous thromboembolism after resection of hepatocellular carcinoma on cirrhosis: Is it necessary?显示文摘AIM: To assess the safety and effectiveness of prophylaxis for venous thromboembolism (VTE) in a large population of patients with hepatocellular carcinoma (HCC) on cirrhosis.METHODS: Two hundred and twenty nine consecutive cirrhotic patients with HCC who underwent hepatic resection were retrospectively evaluated to assess whether there was any difference in the incidence of thrombotic or hemorrhagic complications between those who received and those who did not receive prophylaxis with low-molecular weight heparin.Differences and possible effects of the following parameters were investigated: age,sex,Child-Pugh and model for end-stage liver disease (MELD) score,platelet count,presence of esophageal varices,type of hepatic resection,duration of surgery,intraoperative transfusion of blood and fresh frozen plasma (FFP),body mass index,diabetes and previous cardiovascular disease.RESULTS: One hundred and fifty seven of 229 (68.5%) patients received antithromboembolic prophylaxis (group A) while the remaining 72 (31.5%) patients did not (group B).Patients in group B had higher Child-Pugh and MELD scores,lower platelet counts,a higher prevalence of esophageal varices and higher requirements for intraoperative transfusion of FFP.The incidence of VTE and postoperative hemorrhage was 0.63% and 3.18% in group A and 1.38% and 1.38% in group B,respectively;these differences were not significant.None of the variables analyzed including prophylaxis proved to be risk factors for VTE,and only the presence of esophageal varices was associated with an increased risk of bleeding.CONCLUSION: Prophylaxis is safe in cirrhotic patients without esophageal varices;the real need for prophylaxis should be better assessed. | Marco Vivarelli Matteo Zanello Chiara Zanfi Alessandro Cucchetti Matteo Ravaioli Massimo Del Gaudio Matteo Cescon Augusto Lauro Eva Montanari Gian Luca Grazi Antonio Daniele Pinna | 2010 | World Journal of Gastroenterology2010，16，17： | 6 |
| 3 | The impact of extent of pancreatic and venous resection on survival for patients with pancreatic cancer显示文摘Background:Borderline resectable pancreatic cancer may require extended resections in order to achieve tumor-free margins,especially in the case of up-front resections,but it is important to know the limits of surgical therapy in this disease.This study aimed to investigate the impact of extent of pancreatic and venous resection on short-and long-term outcomes in patients with pancreatic adenocarcinoma(PDAC).Methods:This was a retrospective study from a prospectively maintained database of pancreatic resections for PDAC.Short-and long-term outcomes were analyzed in patients having borderline resectable PDAC submitted to up-front total pancreatectomy(TP)or pancreaticoduodenectomy(PD)with simultaneous portal vein(PV)and/or superior mesenteric vein(SMV)resection.Venous resections were carried out as tangential venous resection(TVR)or segmental venous resection(SVR).Patients were divided into 4 groups:(1)PD+TVR,(2)PD+SVR,(3)TP+TVR,(4)TP+SVR.Uni-and multivariate Cox regression analysis were performed to identify factors associated with survival.Results:Ninety-nine patients were submitted to simultaneous pancreatic and venous resection for PDAC.Among them,25 were submitted to PD+TVR(25.3%),12 to PD+SVR(12.1%),23 to TP+TVR(23.2%),and 39 to TP+SVR(39.4%).Overall,major morbidity(Clavien-Dindo grade≥IIIA)was 26.3%.Thirty-and 90-day mortality were 3%and 11.1%,respectively.There were no significant differences among groups in terms of short-term outcomes.Median overall survival of patients submitted to PD+TVR was significantly higher than those to TP+SVR(29.5 vs 7.9 months,P=0.001).Multivariate analysis identified TP(HR=2.11;95%CI:1.31–3.44;P=0.002)and SVR(HR=2.01;95%CI:1.27–3.15;P=0.003)as the only independent prognostic factors for overall survival.Conclusions:Up-front TP associated to SVR was predictive of worse survival in borderline resectable PDAC.Perioperative treatments in high-risk surgical groups may improve such poor outcomes. | Matteo Serenari Giorgio Ercolani Alessandro Cucchetti Matteo Zanello Enrico Prosperi Guido Fallani Michele Masetti Raffaele Lombardi Matteo Cescon Elio Jovine | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，4： | 2 |
| 4 | Prognostic criteria for postoperative mortality in 170 patients undergoing major right hepatectomy显示文摘BACKGROUND: Postoperative hepatic failure is a dreadful complication after major hepatectomy and carries high morbidity and mortality rates. In this study, we assessed the accuracy of the 50/50 criteria (bilirubin >2.9 mg/dL and international normalized ratio >1.7 on postoperative day 5) and the Mullen criteria (bilirubin peak >7 mg/dL on postoperative days 1-7) in predicting death from hepatic failure in patients undergoing right hepatectomy only. In addition, we identified prognostic factors linked to intra-hospital morbidity and mortality in these patients. METHODS: One hundred seventy consecutive patients underwent major right hepatectomy at a tertiary medical center from 2000 to 2008. Nineteen (11.2%) patients suffered from liver cirrhosis. Univariate and multivariate analyses were performed to identify predictors of intra-hospital mortality, morbidity and death from hepatic failure. RESULTS: The intra-hospital mortality was 6.5% (11/170). Of the six patients who died from hepatic failure, one was positive for the 50/50 criteria, but all six patients were positive for the Mullen criteria. Multivariate analysis showed that male gender, hepatitis C (HCV), hepatocellular carcinoma, postoperative bilirubin >7 mg/dL and ALT<188 U/L on postoperative day 1 were predictive of death from hepatic failure in the postoperative period. Age >65 years, HCV, reoperation, andrenal failure were significant predictors of overall intra-hospital mortality on multivariate analysis. CONCLUSIONS: The Mullen criteria were more accurate than the 50/50 criteria in predicting death from hepatic failure in patients undergoing right hepatectomy. A bilirubin peak >7 mg/dL in the postoperative period, HCV positivity, hepatocellular carcinoma, and an ALT level <188 U/L on postoperative day 1 were associated with death from hepatic failure in our patient population. | Filippo Filicori Xavier M Keutgen Matteo Zanello Giorgio Ercolani Salomone Di Saverio Federico Sacchetti Antonio Daniele Pinna Gian Luca Grazi | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 2 |
| 5 | Assessment of sperm DNA integrity in workers exposed to styrene 显示文摘 | MIGLIORE L NACCARATI A ZANELLO A | 2002 | Hum Reprod2002，17，11： | 1 |
| 6 | Improved diagnostic imaging and interventional therapies prolong survival after resection for hepatocellular carcinoma in cirrhosis:the university of bologna experience over 10 years显示文摘 | Cucchetti A Zanello M Cescon M | 2011 | Ann Surg Oncol2011，18，6： | 1 |
| 7 | Bone cell proliferation on carbon nanotubes显示文摘 | Zanello LP Zhao B Hu H | 2006 | Nano Lett2006，6，3： | 1 |
| 8 | lalpha,25-Dihydroxyvitamin D (3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP- l/p21 (wafl) upregulation in human osteosarcoma显示文摘 | Wu Wei Zhang Xiao-yu Zanello LP | 2007 | Cancer Lett2007，254，1： | 1 |
| 9 | Changes in the surgical approach to hilar cholangiocarcinoma during an 18-year period in a Western single center显示文摘 | Giorgio Ercolani Matteo Zanello Gian Luca Grazi Matteo Cescon Matteo Ravaioli Massimo Gaudio Gaetano Vetrone Alessandro Cucchetti Giovanni Brandi Giovanni Ramacciato Antonio Daniele Pinna | 2010 | Journal of Hepato-Biliary-Pancreatic Sciences2010，，3： | 1 |
| 10 | Influence of attention on an auditory-verbal learning test in schizophrenic patients显示文摘 | Huguelet P Nicastro R Zanello A | 2002 | Encephale2002，28，4： | 1 |
| 11 | Continuity of care in children with special healthcare needs:a qualitative study of family's perspectives显示文摘 | Zanello E Calugi S Rucci P | 2015 | Ital J Pediatr2015，41，1： | 1 |
| 12 | Intrapancreatic accessory spleen mimicking a neuroendocrine tumor: magnetic resonance findings and possible diagnostic role of different nuclear medicine tests显示文摘 | Brasca LE Zanello A De Gaspari A | 2004 | Eur Radiol2004，14，7： | 1 |
| 13 | Effect of Different Immunosuppressive Schedules on Recurrence-Free Survival After Liver Transplantation for Hepatocellular Carcinoma显示文摘 | Marco Vivarelli Alessandro Dazzi Matteo Zanello Alessandro Cucchetti Matteo Cescon Matteo Ravaioli Massimo Del Gaudio Augusto Lauro Gian Luca Grazi Antonio Daniele Pinna | 2010 | Transplantation2010，，2： | 1 |
| 14 | Portal Vein Thrombosis and Liver Transplantation: Evolution During 10 Years of Experience at the University of Bologna显示文摘 | Matteo Ravaioli Matteo Zanello Gian Luca Grazi Giorgio Ercolani Matteo Cescon Massimo Del Gaudio Alessandro Cucchetti Antonio Daniele Pinna | 2011 | Annals of Surgery2011，，2： | 1 |
| 15 | saretin MRCP and endoscopic pancreatic manometry in the evaluation of sphincter of eddi function: a comparative pilot study in patients with idiopathic recurrent pancreafitis 显示文摘 | Mariani A Curiorti S Zanello A | 2003 | Gastrointest Endosc2003，58，6： | 1 |
| 16 | Screening of Dengue virus antiviral activity of marine seaweeds by an in situ enzyme-linked im- munosorbent assay显示文摘 | Koishi AC Zanello PR Bianco eM | 2012 | PLoS One2012，7，51： | 1 |
| 17 | Diffusion-weighted imaging (DWI) of adenomyosis and fibroids of the uterus 显示文摘 | Jha RC Zanello PA Ascher SM | 2014 | Abdom Imaging2014，39，3： | 1 |
| 18 | Menstruation, inflammation andcomorbidities: implications for woman health 显示文摘 | Graziottin A Zanello PP | 2015 | Minerva Ginecol2015，67，1： | 1 |
| 19 | Assessment ofsperm DNA integrity in workers exposed to styrene显示文摘 | Lucia Migliore Alessio Naccarati Alessia Zanello | 2002 | Human Reproduction2002，17，11： | 1 |
| 20 | Saccharomyees boulardii effects on gastrointestinal diseases显示文摘 | Zanello G Meurens F Berri M | 2009 | Curr Issues Mol Biol2009，11，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员