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| 1 | Neuroprotective action of Ginkgo biloba on the enteric nervous system of diabetic rats显示文摘AIM: To investigate the effect of Ginkgo biloba extract on the enteric neurons in the small intestine of diabetic rats. METHODS: Fifteen Wistar rats were divided into three groups: control group (C), diabetic group (D) and diabetic-treated (DT) daily with EGb 761 extract (50 mg/kg body weight) for 120 d. The enteric neurons were identified by the myosin-V immunohistochemical technique. The neuronal density and the cell body area were also analyzed. RESULTS: There was a significant decrease in the neuronal population (myenteric plexus P = 0.0351; submucous plexus P = 0.0217) in both plexuses of the jejunum in group D when compared to group C. With regard to the ileum, there was a significant decrease (P = 0.0117) only in the myenteric plexus. The DT group showed preservation of the neuronal population in the jejunum submucous plexus and in the myenteric plexus in the ileum. The cell body area in group D increased significantly (P = 0.0001) in the myenteric plexus of both segments studied as well as in the ileum submucosal plexus, when compared to C. The treatment reduced (P = 0.0001) the cell body area of the submucosal neurons of both segments and the jejunum myenteric neurons. CONCLUSION: The purified Ginkgo biloba extract has a neuroprotective effect on the jejunum submucous plexus and the myenteric plexus of the ileum of diabetic rats. | Glasiella Gonzalez Perez da Silva Jacqueline Nelisis Zanoni Nilza Cristina Buttow | 2011 | World Journal of Gastroenterology2011，17，7： | 8 |
| 2 | palliative care and end-stage colorectal cancer management:The surgeon meets the oncologist显示文摘Colorectal cancer(CRC)is a common neoplasia in the Western countries,with considerable morbidity and mortality.Every fifth patient with CRC presents with metastatic disease,which is not curable with radical intent in roughly 80%of cases.Traditionally approached surgically,by resection of the primitive tumor or stoma,the management to incurable stageⅣCRC patients has significantly changed over the last three decades and is nowadays multidisciplinary,with a pivotal role played by chemotherapy(CHT).This latter have allowed for a dramatic increase in survival,whereas the role of colonic and liver surgery is nowadays matter of debate.Although any generalization is difficult,two main situations are considered,asymptomatic(or minimally symptomatic)and severely symptomatic patients needing aggressive management,including emergency cases.In asymptomatic patients,new CHT regimens allow today long survival in selected patients,also exceeding two years.The role of colonic resection in this group has been challenged in recent years,as it is not clear whether the resection of primary CRC may imply a further increase in survival,thus justifying surgeryrelated morbidity/mortality in such a class of shortliving patients.Secondary surgery of liver metastasis is gaining acceptance since,under new generation CHT regimens,an increasing amount of patients with distant metastasis initially considered non resectable become resectable,with a significant increase in long term survival.The management of CRC emergency patients still represents a major issue in Western countries,and is associated to high morbidity/mortality.Obstruction is traditionally approached surgically by colonic resection,stoma or internal by-pass,although nowadays CRC stenting is a feasible option.Nevertheless,CRC stent has peculiar contraindications and complications,and its long-term cost-effectiveness is questionable,especially in the light of recently increased survival.Perforation is associated with the highest mortality and remains mostly matter for surgeons,by abdominal lavage/drainage,colonic resection and/or stoma.Bleeding and other CRC-related symptoms(pain,tenesmus,etc.)may be managed by several mini-invasive approaches,including radiotherapy,laser therapy and other transanal procedures. | Renato Costi Francesco Leonardi Daniele Zanoni Vincenzo Violi Luigi Roncoroni | 2014 | World Journal of Gastroenterology2014，20，24： | 6 |
| 3 | Myenteric neurons and intestinal mucosa of diabetic rats after ascorbic acid supplementation显示文摘AIM: To investigate the effect of ascorbic acid (AA) dietary supplementation on myenteric neurons and epithelial cell proliferation of the jejunum of adult rats with chronic diabetes mellitus. METHODS: Thirty rats at 90 d of age were divided into three groups: Non-diabetic, diabetic and diabetic treated with AA (DA) (1 g/L). After 120 d of treatment with AA the animals were killed. The myenteric neurons were stained for myosin-V and analyzed quantitatively in an area of 11.2 mm2/animal. We further measured the cellular area of 500 neurons per group. We also determined the metaphasic index (MI) of the jejunum mucosa layer of about 2500 cells in the intestinal crypts, as well as the dimensions of 30 villi and 30 crypts/animal. The data area was analyzed using the Olympus BX40 microscope. RESULTS: There was an increase of 14% in the neuronal density (792.6 ± 46.52 vs 680.6 ± 30.27) and 4.4% in the cellular area (303.4 ± 5.19 vs 291.1 ± 6.0) respectively of the diabetic group treated with AA when compared to control diabetic animals. There were no signifi cant differences in MI parameters, villi height or crypt depths among the groups.CONCLUSION: Supplementation with AA in the diabetic animal promoted moderate neuroprotection. There was no observation of alteration of the cellular proliferation of the jejunum mucosa layer of rats with chronic diabetes mellitus with or without supplementation with AA. | Priscila de Freitas Maria Raquel Maral Natali Renata Virginia Fernandes Pereira Marcilio Hubner Miranda Neto Jacqueline Nelisis Zanoni | 2008 | World Journal of Gastroenterology2008，14，42： | 3 |
| 4 | Recombination mechanisms and thermal droop in AlGaN-based UV-B LEDs显示文摘This paper reports a comprehensive analysis of the origin of the electroluminescence(EL)peaks and of the thermal droop in UV-B AlGaN-based LEDs.By carrying out spectral measurements at several temperatures and currents,(i)we extract information on the physical origin of the various spectral bands,and(ii) we develop a novel closed-form model based on the Shockley–Read–Hall theory and on the ABC rate equation that is able to reproduce the experimental data on thermal droop caused by non-radiative recombination through deep levels.In the samples under test,the three EL bands are ascribed to the following processes:band-to-band recombination in the quantum wells(main EL peak),a parasitic intra-bandgap radiative transition in the quantum well barriers,and a second defect-related radiative process in the p-AlGaN superlattice. | CARLO DE SANTI MATTEO MENEGHINI DESIREE MONTI JOHANNES GLAAB MARTIN GUTTMANN JENS RASS SVEN EINFELDT FRANK MEHNKE JOHANNES ENSLIN TIM WERNICKE MICHAEL KNEISSL GAUDENZIO MENEGHESSO ENRICO ZANONI | 2017 | Photonics Research2017，5，2： | 2 |
| 5 | Extension of impact-ionization multiplication coefficient measurements to high electric fields in advanced Si BJT's显示文摘 | Zanoni E Crabbe E F | 1993 | IEEE Elec Dev Lett1993，14，2： | 2 |
| 6 | Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats显示文摘AIM:To investigate the effect of quercetin supplementation on the myenteric neurons and glia in the cecum of diabetic rats.METHODS:Total preparations of the muscular tunic were prepared from the ceca of twenty-four rats divided into the following groups:control(C),control supplemented with quercetin(200 mg/kg quercetin body weight)(CQ),diabetic(D)and diabetic supplemented with quercetin(DQ).Immunohistochemical double staining technique was performed with HuC/D(general population)/nitric oxide synthase(nNOS),HuC-D/S-100and VIP.Density analysis of the general neuronal population HuC/D-IR,the nNOS-IR(nitrergic subpopulation)and the enteric glial cells(S-100)was performed,and the morphometry and the reduction in varicosity population(VIP-IR)in these populations were analyzed.RESULTS:Diabetes promoted a significant reduction(25%)in the neuronal density of the HuC/D-IR(general population)and the nNOS-IR(nitrergic subpopulation)compared with the C group.Diabetes also significantly increased the areas of neurons,glial cells and VIP-IR varicosities.Supplementation with quercetin in the DQ group prevented neuronal loss in the general population and increased its area(P<0.001)and the area of nitrergic subpopulation(P<0.001),when compared to C group.Quercetin induced a VIP-IR and glial cells areas(P<0.001)in DQ group when compared to C,CQ and D groups.CONCLUSION:In diabetes,quercetin exhibited a neuroprotective effect by maintaining the density of the general neuronal population but did not affect the density of the nNOS subpopulation. | Paulo Emilio Botura Ferreira Cláudia Regina Pinheiro Lopes Angela Maria Pereira Alves der Paulo Belato Alves David Robert Linden Jacqueline Nelisis Zanoni Nilza Cristina Buttow | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 7 | Detection of bovine viral diarrhea (VBD) virus using the polymerase chain reaction显示文摘 | Hertig C Pauli U Zanoni R | 1991 | Vet Microbio1991，26，： | 1 |
| 8 | FDG PET/CT predic tire role in follicular lymphoma显示文摘 | Egesta Lopci Lucia Zanoni Arturo Chiti | 2012 | Eur J Nucl Med Mol Ima- ging2012，39，5： | 1 |
| 9 | Modeling the Growth of Enterococcus faecium in Bologna Sausage显示文摘 | Zanoni | 1993 | Appl Environ Microbiol1993，59，： | 1 |
| 10 | Effects of extreme dcageing and electron-beam irradiation in InGaN/A1- GaN/GaN light-emitting diodes 显示文摘 | Pavesi M Rossi F Zanoni E | 2006 | Semicond Sci Technol2006，21，2： | 1 |
| 11 | Reliability of visible GaN LEDs in plastic package显示文摘 | MENEGHESSO G LEVADA S ZANONI E | 2003 | Microelectronics Reliability2003，43，911： | 1 |
| 12 | On how buy- back and remanufaeturing strategies affect the profitability of spare parts supply chains 显示文摘 | Rainer Kleber Simone Zanoni Lucio Zavanella | 2011 | International Journal of Pro- duction Economics2011，133，1： | 1 |
| 13 | Study of the stability of dried tomato halves during shelf-life to minimise oxidative damage 显示文摘 | Zanoni B Pagliarini E Foschino R | 2000 | Journal of the Science of Food and Agriculture2000，80，： | 1 |
| 14 | Photoelectrocatalytic degradation of Remazol Brilliant Orange 3R on titanium dioxide thin-film electrodes 显示文摘 | Maria Valnice B Zanoni Jeosadaque J Sene Marc A Anderson | 2003 | Journal of Photochemistry and Photobiology A : Chemistry2003，157，1： | 1 |
| 15 | Chilled or frozen decision strategies for sustainable food supply chains显示文摘 | Zanoni S Zavanella L | 2012 | Int J of Production Economics2012，140，2： | 1 |
| 16 | Serum Hsp70 as an ealry perdictor of fatal outcome after severe traumatic brain injury in males显示文摘 | da Rocha A B Zanoni C de Freitas G R | 2005 | J Neuortrauma2005，22，9： | 1 |
| 17 | A one-vendor multi-buyer integrated production-inventory model: the 'consigrmaent stock' case 显示文摘 | Zavanella L Zanoni S | 2009 | International Journal of Production Economics2009，118，1： | 1 |
| 18 | Impact of insulin re-ceptor substrate-1 genotypes on platelet reactivity and cardiovascu-lar outcomes in patients with type 2 diabetes mellitus and coronaryartery disease 显示文摘 | Angiolillo DJ Bernardo E Zanoni M | 2011 | J Am Coll Cardiol2011，58，1： | 1 |
| 19 | Prevention and monitoring of adverse events following immunization:the'Green Channel'of the Veneto region in Italy显示文摘 | Nguyen TMD Valseechi M | 2003 | Vaccine2003，22，： | 1 |
| 20 | Regulation of antigen up- take, migration, and lifespan of dendritic cell by Toll-llke receptors 显示文摘 | IVAN ZANONI FRANCESCA GRANUCCI | 2010 | J Mol Med2010，88，： | 1 |
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