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| 1 | clusterProfiler 4.0:A universal enrichment tool for interpreting omics data显示文摘Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms. | Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu | 2021 | The Innovation2021，2，3： | 40 |
| 2 | Structure reveals that BAK1 as a co-receptor recognizes the BRIl-bound brassinolide显示文摘 | Yadong Sun Zhlfu Han Jiao Tang Zehan Hu Chengliang Chai Bin Zhou Jijie Chai | 2013 | Cell Research2013，23，11： | 24 |
| 3 | Centimeter-scale growth of two-dimensional layered high-mobility bismuth films by pulsed laser deposition显示文摘Ever since discovery of graphene,two-dimensional(2D)materials become a new tool box for information technology.Among the 2D family,ultrathin bismuth(Bi)has attracted a great deal of attention in recent years due to its unique topological insulating properties and large magnetoresistance.However,the scalable synthesis of layered Bi ultrathin films is rarely been reported,which would greatly restrict further fundamental investigation and practical device development.Here,we demonstrate the direct growth of homogeneous and centimeter-scale layered Bi films by pulsed laser deposition(PLD)technique.The as-grown Bi film exhibits high-purity phase and good crystallinity.In addition,both(111)and(110)-oriented Bi films can be synthesized by precisely controlling the processing temperature.The characterization of optical properties shows a thickness dependent band gaps(0.075-0.2 eV).Moreover,Bi thin-film-based field-effect transistors have been demonstrated,exhibiting a large carrier mobility of 220 cm2 V−1 s−1.Our work suggests that the PLD-grown Bi films would hold the potential to develop spintronic applications,electronic and optoelectronic devices used for information science and technology. | Zhibin Yang Zehan Wu Yongxin Lyu Jianhua Hao | 2019 | InfoMat2019，1，1： | 11 |
| 4 | Small signal stability analysis of a synchronized control-based microgrid under multiple operating conditions显示文摘In this paper,a synchronized control strategy of double fed induction generator that can provide reserve capability and primary frequency support for microgrid is firstly developed.The microgrid based small signal stability performance is investigated under multiple operating conditions.The effect of three categories of key controller parameters on dominant eigenvalues is studied by sensitivity analysis,including:1)active power drooping coefficient;2)reactive power drooping coefficient;3)parameters of outer loop excitation current control.Finally,some constructive suggestions on how to tune controller parameters to improve microgrid’s small signal stability performance are discussed. | Zehan LU Zhen WANG Huanhai XIN Kitpo WONG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，3： | 8 |
| 5 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 6 | Structural basis for specific self-incompatibility response in Brassica显示文摘自我障碍(SI ) 是在阻止自体受精的 flowering 植物的普遍机制并且使近交。在 Brassica,高度多态的 S 地点充满半胱氨酸的蛋白质的识别(SCR;或 S 地点蛋白质 11 ) 由同样多态的 S 地点受体, kinase (SRK ) 支配 SI 特性。这里,我们从 Brassica rapa 与 SCR9 在建筑群报导 SRK9 (eSRK9 ) 的细胞外的领域的水晶结构。SCR9 绑定导致 eSRK9 homodimerization,形成 2:2 eSRK : 有象信 A 一样的形状的 SCR heterotetramer。SCR9 的特定的识别通过三超(hv ) 被调停 eSRK9 的区域。每 SCR9 同时从第二 eSRK9 单体从一 eSRK9 单体和 hvII 的另外的一半与 hvII 的 hvI 和一个一半交往,起在调停的一个主要作用没有包含在二个 SCR9 分子之间的相互作用的 SRK9 homodimerization。为 eSRK9-SCR9 相互作用批评的残余的单个变化在 vitro 破坏他们的绑定。我们的学习文饰由 SRK 的 SCR 的特定的识别上的数据的身体并且为理解在 SRK 和 SCR 之间的合作进化提供一个结构的模板。 | Rui Ma Zhifu Han Zehan Hu Guangzhong Lin Xinqi Gong Heqiao Zhang June B Nasrallah Jijie Chai | 2016 | Cell Research2016，26，12： | 3 |
| 7 | Multi-scale synergic optimization strategy for dielectric energy storage ceramics显示文摘Dielectric capacitors,serving as the indispensable components in advanced high-power energy storage devices,have attracted ever-increasing attention with the rapid development of science and technology.Among various dielectric capacitors,ceramic capacitors with perovskite structures show unique advantages in actual application,e.g.,excellent adaptability in high-temperature environments.And the optimization of their energy storage performance has become a hot research topic recently.This review presents the basic principles of energy storage in dielectric ceramics and introduces multi-scale synergic optimization strategies according to the key factors for superior energy storage performance.By summarizing the common points in numerous works,several universal modification strategies are reviewed,and future research on fatigue fracture of ceramic capacitors under multi-field including but not limited to force,electric,and thermal coupling conditions is also anticipated. | Xuhui Fan Jing Wang Hao Yua Zehan Zheng Ji Zhang Kongjun Zhu | 2023 | Journal of Advanced Ceramics2023，12，4： | 2 |
| 8 | Structural basis for specific flagellin recognition by t ~ILR protein NAIP5显示文摘充满域的核苷酸绑定和包含蛋白质(NLR ) 的充满白氨酸的重复(LRR ) 作为细胞内部的有免疫力的受体工作检测导出病原体或导出主人的信号的存在。NLR 怎么察觉到他们的 ligands 的机制留下逃犯。这里,我们与 cryo 电子显微镜学在 4.28 点决定的 NLR 蛋白质 NAIP5 和 NLRC4 在建筑群报导细菌的 flagellin 衍生物的结构吗?分辨率。结构表明 flagellin 衍生物形成包括 NAIP5 的 BIR1 和 LRR 与多重领域交往的二平行 helices。对在 flagellin 衍生物的将近完全的埋葬的 NAIP5 结果有约束力,因此稳定 NAIP5 的活跃符合构造。flagellin 的极端 C 终端方面被抛锚到 NAIP5 的一个位地抑制的有约束力的衣袋,它多半由 NAIP5 为不同细菌的 flagellins 的辨别充当一个结构的决定因素,一个观点进一步由生物化学的数据支持了。一起拿,我们的结果使位于 NLR ligand 下面的分子的机制清楚些感觉。 | Xinru Yang Fan Yang Weiguang Wang Guangzhong Lin Zehan Hu Zhifu Han Yijun Qi Liman Zhang Jiawei Wang Sen-Fang Sui Jijie Chai | 2018 | Cell Research2018，28，1： | 2 |
| 9 | Significantly influenced photocatalytic performance for H_(2)O_(2)generation over ultrathin g-C_(3)N_(4)through regulating the migration orientation of photogenerated charge carriers显示文摘H_(2)O_(2)has been widely applied in the fields of chemical synthesis,medical sterilization,pollutant removal,etc.,due to its strong oxidizing property and the avoidable secondary pollution.Despite of the enhanced performance for H_(2)O_(2)generation over g-C_(3)N_(4)semiconductors through promoting the separation of photo-generated charge carriers,the effect of migration orientation of charge carriers is still ambiguous.For this emotion,surface modification of g-C_(3)N_(4)was employed to adjust the migration orientation of charge carriers,in order to investigate systematically its effect on the performance of H_(2)O_(2)generation.It was found that ultrathin g-C_(3)N_(4)(UCN)modified by boron nitride(BN),as an effective hole-attract agent,demonstrated a significantly enhanced performance.Particularly,for the optimum UCN/BN-40%catalyst,4.0-fold higher yield of H_(2)O_(2)was obtained in comparison with the pristine UCN.As comparison,UCN modified by carbon dust demonstrated a completely opposite tendency.The remarkably improved performance over UCN/BN was ascribed to the fact that more photo-generated electrons were remained inside of triazine structure of g-C_(3)N_(4),leading to the formation of larger amount of 1,4-endoxide.It is anticipated that our work could provide new insights for the design of photocatalyst with significantly improved performance for H_(2)O_(2)generation. | Xinxia He Hongyan Shang Chuan Wang Le Chen Zehan Gong Jun Wang Shilin Zhao Jun Ma | 2021 | Chinese Chemical Letters2021，32，11： | 2 |
| 10 | Crystal structure of an LRR protein with two solenoids显示文摘 | Peiyuan Liu Zehan Hu Bin Zhou Simiao Liu Jijie Chai | 2013 | Cell Research2013，23，2： | 2 |
| 11 | COVID-19 vaccine development:milestones,lessons and prospects显示文摘With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern(VOC),the implementation of vaccination is critically important.Existing SARS-CoV-2 vaccines mainly include inactivated,live attenuated,viral vector,protein subunit,RNA,DNA,and virus-like particle(VLP)vaccines.Viral vector vaccines,protein subunit vaccines,and mRNA vaccines may induce additional cellular or humoral immune regulations,including Th cell responses and germinal center responses,and form relevant memory cells,greatly improving their efficiency.However,some viral vector or mRNA vaccines may be associated with complications like thrombocytopenia and myocarditis,raising concerns about the safety of these COVID-19 vaccines.Here,we systemically assess the safety and efficacy of COVID-19 vaccines,including the possible complications and different effects on pregnant women,the elderly,people with immune diseases and acquired immunodeficiency syndrome(AIDS),transplant recipients,and cancer patients.Based on the current analysis,governments and relevant agencies are recommended to continue to advance the vaccine immunization process.Simultaneously,special attention should be paid to the health status of the vaccines,timely treatment of complications,vaccine development,and ensuring the lives and health of patients.In addition,available measures such as mix-and-match vaccination,developing new vaccines like nanoparticle vaccines,and optimizing immune adjuvant to improve vaccine safety and efficacy could be considered. | Maochen Li Han Wang Lili Tian Zehan Pang Qingkun Yang Tianqi Huang Junfen Fan Lihua Song Yigang Tong Huahao Fan | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 2 |
| 12 | Chk1 mediates S and G2 arrests through CDC25A degradation in response to DNA-damaging agents显示文摘 | ZHAN X ZEHAN C ANGELO H G | 2003 | J Biol Chem2003，278，21： | 1 |
| 13 | The Phonocardiogram exercise test显示文摘 | Shouzhong X Zehan C | 1999 | IEEE Engineering in Medicine and Biology Magazine1999，18，： | 1 |
| 14 | A study on phonocardiogram exercise test显示文摘 | XIAO YIHUA XIAO SHOUZHONG CAO ZEHAN | 1999 | IEEE Engin Med Biology Magazine1999，18，4： | 1 |
| 15 | The Phytophthora effector Avh241 interacts with host NDR1-like proteins to manipulate plant immunity显示文摘Plant pathogens rely on effector proteins to suppress host innate immune responses and facilitate colonization.Although the Phytophthora sojae RxLR effector Avh241 promotes Phytophthora infection,the molecular basis of Avh241 virulence remains poorly understood.Here we identified non-race specific disease resistance 1(NDR1)-like proteins,the critical components in plant effector-triggered immunity(ETI)responses,as host targets of Avh241.Avh241 interacts with NDR1 in the plasma membrane and suppresses NDR1-participated ETI responses.Silencing of GmNDR1s increases the susceptibility of soybean to P.sojae infection,and overexpression of GmNDR1s reduces infection,which supports its positive role in plant immunity against P.sojae.Furthermore,we demonstrate that GmNDR1 interacts with itself,and Avh241 probably disrupts the self-association of GmNDR1.These data highlight an effective counter-defense mechanism by which a Phytophthora effector suppresses plant immune responses,likely by disturbing the function of NDR1 during infection. | Bo Yang Sen Yang Baodian Guo Yuyin Wang Wenyue Zheng Mengjun Tian Kaixin Dai Zehan Liu Haonan Wang Zhenchuan Ma Yan Wang Wenwu Ye Suomeng Dong Yuanchao Wang | 2021 | Journal of Integrative Plant Biology2021，63，7： | 1 |
| 16 | The phonocardiogram exercise test显示文摘 | Yihua Xiao Shouzhong Xiao Zehan Cao | 1999 | IEEE Engineering in Medicine and Biology Magazine1999，18，4： | 1 |
| 17 | Structural Basis for flg22-Induced Activation of the Arabidopsis FLS2-BAK1 Immune Complex显示文摘 | Yadong Sun Lei Li Alberto P. Macho Zhifu Han Zehan Hu Cyril Zipfel Jian-Min Zhou Jijie Chai | 2013 | Science . 2013 (6158)2013，，6158： | 1 |
| 18 | A study on phonocardiogram exercise test 显示文摘 | Xiao Yihua Xiao Shouzhong Cao Zehan Zhou Shiyong Pei Jianhua | 1999 | IEEE Engineering in Medicine and Biology Magazine1999，18，4： | 1 |
| 19 | A study on phonocardiogram exercise test显示文摘 | XIAOYIHUA XIAO SHOUZHONG CAO ZEHAN | 1999 | IEEE Engineering Medicine Biology Magazine1999，18，4： | 1 |
| 20 | A study on phonocardiogram exercise test显示文摘 | Xiao Yihua Xiao Shouzhong Cao Zehan Zhou Shiyong Pei Jianhua | 1999 | IEEE Engineering in Medicine and Biology Magazine1999，18，4： | 1 |
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