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| 1 | Tunable optical frequency comb from a compact and robust Er:fiber laser显示文摘We report on a compact and robust self-referenced optical frequency comb with a tunable repetition rate,generated by an all-polarization-maintaining(PM)mode-locked Er-doped fiber laser.The spacing between comb teeth can be tuned above 300 kHz at a repetition rate of 101 MHz.The repetition rate and the carrier-envelope offset of the laser are stabilized separately,and the relative residual phase noises are determined to be 336µrad and 713 mrad(1 Hz-1 MHz).The accurate frequency characteristics and the stable structure show great potential for the use of such a comb in applications of precision measurements. | Zhiwei Zhu Yang Liu Daping Luo Chenglin Gu Lian Zhou Gehui Xie Zejiang Deng Wenxue Li | 2020 | High Power Laser Science and Engineering2020，8，2： | 2 |
| 2 | Integrated strategies for chemotherapy cycles in nasopharyngeal carcinoma patients: Real-world data from two epidemic centers guiding decision-making显示文摘objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not evidence-confirmed.This study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and cost-effectiveness.Methods:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)analyses.The enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the groups.We developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk stratifications.Results:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,respectively.Five-year survivals were similar among the three groups after PSM and confirmed by IPTW.Grade 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other groups.Further exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by LRRFS.Conclusions:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC+3CCRT probably shortened LRRFS in high-and low-risk populations,respectively. | Zejiang Zhan Yingying Huang Jiayu Zhou Zhuochen Cai Haoyang Huang Ying Deng Wenze Qiu Xun Cao Xi Chen Chixiong Liang Lulu Zhang Xiang Guo Taize Yuan Xing Lyu | 2023 | Chinese Journal of Cancer Research2023，35，2： | 1 |
| 3 | Optimizing noise characteristics of mode-locked Yb-doped fiber laser using gain-induced RIN-transfer dynamics显示文摘Gain-parameter-dependent transfer functions and phase-noise performances in a mode-locked Yb-doped fiber laser are measured in this study.It is discovered that the corner frequency in the amplitude and phase domains is determined by the absorption coefficient of the gain fiber,when the total absorption and other cavity parameters are fixed.This shows that an oscillator using gain fiber with higher dopant concentration accumulates more phase noise.Furthermore,we present net cavity dispersion-dependent transfer functions to verify the effect of dispersion management on the frequency response.We derive a guideline for optimizing mode-locked fiber laser design to achieve low phase noise and timing jitter. | Jiangshuoxue Han Yang Liu Zejiang Deng Gehui Xie Daping Luo Chenglin Gu Lian Zhou Wenxue Li | 2021 | High Power Laser Science and Engineering2021，9，3： | 1 |
| 4 | Mid-infrared optical frequency comb in the 2.7-4.0μm range via difference frequency generation from a compact laser system显示文摘We report on the generation of a mid-infrared(mid-IR)frequency comb with a maximum average output power of250 mW and tunability in the 2.7-4.0μm region.The approach is based on a single-stage difference frequency generation(DFG)starting from a compact Yb-doped fiber laser system.The repetition rate of the near-infrared(NIR)comb is locked at 75 MHz.The phase noise of the repetition rate in the offset-free mid-IR comb system is measured and analyzed.Except for the intrinsic of NIR comb,environmental noise at low frequency and quantum noise at high frequency from the amplifier chain and nonlinear spectral broadening are the main noise sources of broadening the linewidth of comb teeth,which limits the precision of mid-IR dual-comb spectroscopy. | Lian Zhou Yang Liu Gehui Xie Chenglin Gu Zejiang Deng Zhiwei Zhu Cheng Ouyang Zhong Zuo Daping Luo Bin Wu Kunfeng Chen Wenxue Li | 2020 | High Power Laser Science and Engineering2020，8，4： | 1 |
| 5 | Multi-channel laser interferometer based on automatic frequency stabilization system for improving coordinate measurement accuracy显示文摘A multi-channel laser interferometer(MCLI)is proposed to improve the coordinate measurement accuracy.A 780 nm external cavity laser is locked on the D2 line of ^(87)Rb atom by polarization spectroscopy,and a high frequency stabilized laser source is obtained with a linewidth of 385.8 k Hz at root mean square(RMS).The interferometers share the stabilized source and individually install on 4 axes of a coordinate measuring system.As a result,the measurement uncertainty is reduced from 1.2μm to 0.2μm within the dynamic measurement range of 1.0 m.The MCLI is adept at integrate and flexible installation,which caters to various applications on precision measurement. | PANG Chengkai ZHANG Qiongqiong ZHANG Hongqiao HUANG Haiyan DENG Zejiang WU Guang | 2022 | Optoelectronics Letters2022，18，10： | 0 |
| 6 | Tunable compact asynchronous optical sampling system using Er-doped fiber laser显示文摘We report a compact,tunable,self-starting,all-fiber laser-based asynchronous optical sampling(ASOPS)system.Two Er-doped fiber oscillators were used as the pulsed-laser source,whose repetition rate could be set at 100 MHz with a tuning range of 1.25 MHz through a fiber delay line.By employing phase-locked and temperature control loops,the repetition rate offset of the two lasers was stabilized with 7.13×10^(−11)fractional instability at an average time of 1 s.Its capabilities in the terahertz regime were demonstrated by terahertz time-domain spectroscopy,achieving a spectral bandwidth of 3 THz with a dynamic range of 30 dB.The large range of repetition rate adjustment in our ASOPS system has the potential to be a powerful tool in the terahertz regime. | Zilin Zhao Daping Luo Yang Liu Zejiang Deng Lian Zhou Gehui Xie Chenglin Gu Yanzhao Yang BinWu Wenxue Li | 2023 | High Power Laser Science and Engineering2023，11，2： | 0 |
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