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| 1 | Advances in COVID-19 mRNA vaccine development显示文摘To date,the coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has determined 399,600,607 cases and 5,757,562 deaths worldwide.COVID-19 is a serious threat to human health globally.The World Health Organization(WHO)has declared COVID-19 pandemic a major public health emergency.Vaccination is the most effective and economical intervention for controlling the spread of epidemics,and consequently saving lives and protecting the health of the population.Various techniques have been employed in the development of COVID-19 vaccines.Among these,the COVID-19 messenger RNA(mRNA)vaccine has been drawing increasing attention owing to its great application prospects and advantages,which include short development cycle,easy industrialization,simple production process,flexibility to respond to new variants,and the capacity to induce better immune response.This review summarizes current knowledge on the structural characteristics,antigen design strategies,delivery systems,industrialization potential,quality control,latest clinical trials and real-world data of COVID-19 mRNA vaccines as well as mRNA technology.Current challenges and future directions in the development of preventive mRNA vaccines for major infectious diseases are also discussed. | Enyue Fang Xiaohui Liu Miao Li Zelun Zhang Lifang Song Baiyu Zhu Xiaohong Wu Jingjing Liu Danhua Zhao Yuhua Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 5 |
| 2 | A review of self-cleaning method for solar cell array显示文摘 | HE Gaofa ZHOU Chuande LI Zelun | 2011 | Procedia Engineering2011，16，： | 1 |
| 3 | Effects of hydrothermal carbonization temperature on carbon retention,stability,and properties of animal manure-derived hydrochar显示文摘Hydrothermal carbonization of animal manure is being increasingly recognized as a green process for hydrochar production.Temperature obviously affects the properties of hydrochar especially with respect to carbon retention and stability.These properties determine the carbon sequestration potential of hydrochar but related researches are limited.In this study,chicken,dairy,and swine manures were collected and hydrothermal carbonized under different temperature conditions,aiming to study the fuel characteristics,carbon retention,and stability of hydrochar influenced by temperature.Results show that high temperature led to low yield and declined H/C,O/C,and volatile matter of hydrochar.While high temperature caused high fixed carbon,fuel ratio,and heating value of hydrochar,indicating that animal manure hydrochar can be adopted as an alternative of fuel.After hydrothermal carbonization,less than half of carbon from animal manure was retained in hydrochar:22.70%-46.71%for chicken manure,39.36%-49.72%for dairy manure,and 36.24%-64.21%for swine manure.The carbon retention decreased with the increase of temperature.Conversely,high temperature improved the aromatic and strengthened the resistance to thermal oxidation of hydrochar,which was evidenced by FTIR and TGA analysis.Moreover,the carbon sequestration capacity of animal manure hydrochar was less than a third of total carbon(originated from animal manure)and relatively low temperature(no more than 250℃)was beneficial to produce hydrochar for carbon sequestration. | Feiyue Li Zelun Jiang Wenchao Ji Yihan Chen Jiran Ma Xiangyang Gui Jianrong Zhao Chunhuo Zhou | 2022 | International Journal of Agricultural and Biological Engineering2022，15，1： | 0 |
| 4 | Hierarchically porous polymers with ultra-high affinity for bisphenol A enables high efficient water purification显示文摘The widespread use of bisphenol A(BPA)poses a serious threat to the environment and human health.However,efficient removal of BPA in water is incredibly challenging,owing to the inert chemical nature and electrical neutrality of BPA.In order to solve this problem,for the first time,we propose that a strategy of designing conjugated porous polymers with the pore size matching the size of BPA can greatly enhance the binding force of BPA.On this basis,we developed a novel conjugated poly 1,3,5-tri[4-(diphenylamino)phenyl]benzene(MPDPB)with intrinsic pore matching the size of BPA and multi-stage porous structure by editing polymerization with nitrobenzene.The binding energy of MPDPB to BPA is the highest at present(37.84 kcal/mol),which is 2.3 times that of the most powerful adsorbent previously reported and five times that of the conventional adsorbent.These advantages make MPDPB have super-high adsorption performance towards BPA and high absorbing stability under extreme environments.Impressively,MPDPB could be easily loaded on a non-woven fabric to generate point-of-use devices,which could eliminate more than 99.8%of BPA,making it the best BPA candidate adsorbent material.We believe that the proposed material design derived from the specific structure of the contaminant molecule can be extended to exploring further innovative adsorbents. | Zelun Li Juan Wang Qian Chen Kelong Ai Lehui Lu | 2021 | Science China Chemistry2021，64，8： | 0 |
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