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| 1 | Effects of soy isoflavone extracts on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized nude mice显示文摘In this study,we explored the effects of soy isoflavone extracts on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice. The ovariectomized athymic mice were implanted with MCF-7 cells. They were fed with low,moderate and high doses of soy isoflavone extracts,at dietary concentrations of 6.25,12.5 and 25 g/kg,respectively. The expression of ki-67 was detected by immunohistochemistry. The pS2 expression in tumors was analyzed by real-time PCR. Estrogen level in the serum was measured by chemiluminescence enzyme immunoassay. Com-pared with the control group,dietary soy isoflavone extracts had a significant stimulatory effect on MCF-7 tumor growth in mice (P < 0.05). The ki-67 and pS2 mRNA expressions in tumors were signifi-cantly increased by 6.25 and 12.5 g/kg dose of soy isoflavone extracts (P < 0.05). And,estrogen level in serum of 6.25 and 12.5 g/kg dose groups was higher than that of control group (P > 0.05). In conclusion,in the tested dietary concentration range soy isoflavone extracts had a stimulatory effect on tumor growth. 6.25 and 12.5 g/kg doses of soy isoflavone extracts can increase the cell proliferation in tumors and induce estrogen-responsive pS2 expression. | WU Qian JIN NianZu YU Jing ZHAO RenChen YU ZePing QIAO ShanLei LU XiaoHe ZHANG ChunWen | 2009 | Chinese Science Bulletin2009，54，1： | 2 |
| 2 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hoq6wxcubufxc6kvk.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 3 | Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters显示文摘Dear Editor,Different from normal differentiated cells,metabolic reprogramming was spotted in cancer cells,due to increased demand for energy and macromolecule synthesis during their rapid proliferation(Hanahan and Weinberg,2011;Pavlova and Thompson,2016).Most cancer cells prefer anaerobic glycolysis even with oxygen in the environment due to its higher speed to produce macromolecular materials required for biosynthesis(Vander Heiden et al.,2009;DeBerardinis and Chandel,2016).But to compensate for the lower efficiency of anaerobic glycolysis in producing ATP,these cancer cells demand much higher glucose supply(Warburg,1956;Vander Heiden et al.,2009).These metabolic characteristics point to the huge demand of cancer cells for carbohydrate substrates,which creates the possibility of treating tumors by exploiting this feature(Patra et al.,2013;DeBerardinis and Chandel,2016). | Meng Gao Jian Huang Xin Jiang Yafei Yuan Huanhuan Pang Shuchen Luo Nan Wang Chengbo Yao Zuwan Lin Debing Pu Shuo Zhang Pengcheng Sun Zhuoyi Liu Yu Xiao Qian Wang Zeping Hu Hang Yin | 2020 | Protein & Cell2020，11，6： | 2 |
| 4 | High-speed photodetectors in optical communication system显示文摘This paper presents a review and discussion for high-speed photodetectors and their applications on optical communications and microwave photonics. A detailed and comprehensive demonstration of high-speed photodetectors from development history, research hotspots to packaging technologies is provided to the best of our knowledge. A few typical applications based on photodetectors are also illustrated, such as free-space optical communications, radio over fiber and millimeter terahertz signal generation systems. | Zeping Zhao Jianguo Liu Yu Liu Ninghua Zhu | 2017 | Journal of Semiconductors2017，38，12： | 1 |
| 5 | Construction technology on pile foundation of No.6 main pier in Dashengguan Yangtze Bridge显示文摘Based on pile foundation construction of No.6 main pier,deep mudstone geological foundation and deep-water construction in Nanjing-Dashengguan Yangtze Bridge,the method of super-large-diameter bored pile in deep water is studied.The spread drill,application of PHP mud,and choice of machine are solved by adopting two machines of KTY4000 and KPG300A.Besides,the airlift reversing circulation is selected in slag discharge.The results show that this method can ensure successfully the construction of pier foundation to satisfy the demands of codes. | Hongbin YU Zeping LIAN | 2009 | Frontiers of Structural and Civil Engineering2009，3，3： | 0 |
| 6 | Colossal structural distortion and interlayer-coupling suppression in a van der Waals crystal induced by atomic vacancies显示文摘The interlayer coupling in van der Waals(vdW)crystals has substantial effects on the performance of materials.However,an indepth understanding of the microscopic mechanism on the defect-modulated interlayer coupling is often elusive,owing partly to the challenge of atomic-scale characterization.Here we report the native Se-vacancies in a charge-density-wave metal 2HNbSe2,as well as their influence on the local atomic configurations and interlayer coupling.Our low-temperature scanning tunneling microscopy(STM)measurements,complemented by density functional theory calculations,indicate that the Sevacancies in few-layer NbSe2 can generate obvious atomic distortions due to the Jahn-Teller effect,thus breaking the rotational symmetry on the nanoscale.Moreover,these vacancies can locally generate an in-gap state in single-layer NbSe2,and more importantly,lead to a colossal suppression of interlayer coupling in the bilayer system.Our results provide clear structural and electronic fingerprints around the vacancies in vdW crystals,paving the way for developing functional vdW devices. | Liangguang Jia Fei Gao Yu Zhang Yaoyao Chen Baofei Hou Zeping Huang Quanzhen Zhang Xu Wu Liwei Liu Shiwu Gao Mads Brandbyge Hong-Jun Gao Yeliang Wang | 2023 | Nano Research2023，16，4： | 0 |
| 7 | Small-molecule agents for cancer immunotherapy显示文摘Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer therapy.They induce long-term tumor regression and overall survival benefit in many types of cancer.With the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for immunotherapy.Small molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively investigated.Monotherapy of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor resistance.Here,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations. | Fang Wang Kai Fu Yujue Wang Can Pan Xueping Wang Zeyu Liu Chuan Yang Ying Zheng Xiaopeng Li Yu Lu Kenneth Kin Wah To Chenglai Xia Jianye Zhang Zhi Shi Zeping Hu Min Huang Liwu Fu | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 8 | Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill显示文摘Cancer still has elevated morbidity and mortality,which undoubtedly impacts the life quality of affected individuals.Remarkable advances have been made in cancer therapy,although the toxicities of traditional therapies remain an obvious challenge.Dahuang Zhechong Pill(DHZCP),developed by Zhongjing Zhang in the Synopsis of the Golden Chamber,represents an effective anticancer traditional Chinese medicine(TCM).In this review,it was found that DHZCP is therapeutically utilized in liver,lung,gastric,pancreatic and other cancers in clinic.Pharmacological evidence showed that its anti-tumor mechanisms mainly involve induced cell cycle arrest,apoptosis and autophagy,as well as suppressed tumor cell proliferation,obstructed angiogenesis and metastasis,enhanced immunity,and reversal of multidrug resistance.The present review provides a solid basis for the clinical application of DHZCP and may promote the wide use of TCM in clinical antitumor application. | Yingying Tian Beibei Ma Shangyue Yu Yilin Li Hailuan Pei Shiqiu Tian Xinyue Zhao Chuang Liu Zeping Zuo Zhibin Wang | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
| 9 | Adjustment of Land Use Structure Based on County-wide Economic Development: A Case Study of Changfeng County显示文摘On the basis of survey of current land use situation in Changfeng County,this paper analyzed land use structure,trend and environment of structural adjustment. Besides,it explored county-wide land use structure mode,namely, ' division + indicator + policy'. Through reasonable distribution,it is expected to build proper land use structure framework,avoid passive situation of relying on policies simply,and bring into play stability keeping function of land use structure,so as to promote county-wide economic development,and bring into play countywide lever function of rural transition areas. | Zeping HE Zhongxiang YU | 2015 | Asian Agricultural Research2015，7，5： | 0 |
| 10 | A fully inkjet-printed disposable gas sensor matrix with molecularly imprinted gas-selective materials显示文摘A method was used to fabricate a fully inkjet-printed gas sensor matrix on photographic paper.An electrode matrix comprising 36 interdigital electrodes in a high-density layout that is easy to integrate has been fabricated using a combination of insulating ink and commercial silver ink.Molecular-imprinted polymer(MIP)inks were then made using a simple solution mixing method,and these inks were printed together with carbon black ink on the electrode matrix to complete production of the sensor.Finally,experimental dynamic sensing of volatile organic compounds verifies that for detection of gases corresponding to the MIP template molecules,the MIP layer offers improvements in both sensitivity and selectivity when compared with non-imprinted polymer layers.The matrix can produce a response of more than 20%to 3 ppm propenoic acid gas through adjustment of the printing times for the carbon black layer and the MIP layer. | Lingpu Ge Xiao Ye Zeping Yu Bin Chen Chuanjun Liu Hao Guo Shiyi Zhang Fumihiro Sassa Kenshi Hayashi | 2022 | npj Flexible Electronics2022，6，1： | 0 |
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