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| 1 | Unequivocal enantiomeric identi- fication and analysis of 10 ehiral pesticides in fruit and vegetables by QuEChERS method combined with liquid chromatography-quadruple/ linear ion trap mass speetrometry determination显示文摘 | He Zeying Peng Yi Wang Lu | 2015 | Chirality2015，27，12： | 1 |
| 2 | Bridging the structure gap between pellets in artificial dissolution media and in gastro-intestinal tract in rats显示文摘Changes in structure of oral solid dosage forms(OSDF) elementally determine the drug release and its therapeutic effects.In this research,synchrotron radiation X-ray micro-computed tomography was utilized to visualize the 3 D structure of enteric coated pellets recovered from the gastrointestinal tract of rats.The structures of pellets in solid state and in vitro compendium media were measured.Pellets in vivo underwent morphological and structural changes which differed significantly from those in vitro compendium media.Thus,optimizations of the dissolution media were performed to mimic the appropriate in vivo conditions by introducing pepsin and glass microspheres in media.The sphericity,pellet volume,pore volume and porosity of the in vivo esomeprazole magnesium pellets in stomach for2 h were recorded 0.47,1.55 × 10^(8)μm^(3),0.44 × 10^(8)μm^(3)and 27.6%,respectively.After adding pepsin and glass microspheres,the above parameters in vitro reached to 0.44,1.64 × 10^(8)μm^(3)0.38 × 10^(8)μm^(3)and 23.0%,respectively.Omeprazole magnesium pellets behaved similarly.The structural features of pellets between in vitro media and in vivo condition were bridged successfully in terms of 3 D structures to ensure better design,characterization and quality control of advanced OSDF. | Hongyu Sun Siyu He Li Wu Zeying Cao Xian Sun Mingwei Xu Shan Lu Mingdi Xu Baoming Ning Huimin Sun Tiqiao Xiao Peter York Xu Xu Xianzhen Yin Jiwen Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 1 |
| 3 | Multiresidue analysis of over200 pesticides in cereals using a Qu ECh ERS and gas chromatography-tandem mass spectrometry-based method显示文摘 | Zeying He Lu Wang Yi Peng | 2015 | Food Chemistry2015，169，15： | 1 |
| 4 | Multiresidue analysis of 213 pesticides in leek and garlic using QuEChERS-based method and gas chromatography-triple quadrupole mass spectrometry显示文摘 | He Zeying Chen Shanshan Wang Lu | 2015 | Andyti- col and Bioanolyticol Chemistry2015，407，9： | 1 |
| 5 | Mnhiresidue analysis of over 200 pesticides in cereals using a QuEChERS and gas chromatography tan- dem mass spectrometry-based method显示文摘 | He Zeying Wang Lu Peng Yi | 2015 | Food Chemistry2015，169，： | 1 |
| 6 | Effect Mechanism of Low-level PFOS Isomers to A.thaliana Leaves Using High-throughput Untargeted Metabolomics显示文摘The ecotoxicity of perfluorooctane sulfonate(PFOS)to plants has been reported,but the lack of study on the effect of PFOS isomers is of concern.In this paper,the effect mechanism of Arabidopsis thaliana(A.thaliana)against two different concentrations of L-PFOS or perfluoro-3-methylheptanesulfonate(P3MHpS)was investigated via metabolomics.The metabolism of Arabidopsis thaliana leaves was investigated via the metabolomics strategy and statistical analysis.And 41 biomarkers for L-PFOS and 32 biomarkers for P3MHpS were found and identified.There was no significant difference of saccharides between L-PFOS and P3MHpS.More amino acids were affected by P3MHpS than by L-PFOS in high-level exposure group,while the opposite phenomenon was observed in low-level exposure group.More phytohormones were affected by L-PFOS than by P3MHpS in the high-level exposure group,however,the elevated level of indole phytohormones was significantly higher by P3MHpS than by L-PFOS.The level of up-regulation of(poly)phenols in L-PFOS group was significantly higher than that in P3MHpS group.The affected aliphatic glucosinolate metabolism was firstly observed with higher up-regulation induced by L-PFOS than by P3MHpS.New insight of phytotoxicity of PFOS isomers to plants was provided. | WANG Hao ZHANG Yue ZHAO Liuqing HE Zeying ZHANG Jingran LIU Bingjie LIU Xiaowei ZHANG Yanwei | 2023 | Chemical Research in Chinese Universities2023，39，3： | 0 |
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