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| 1 | Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要)显示文摘 | Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 141 |
| 2 | Novel redox potential-based screening strategy for rapid isolation of Klebsiella pneumoniae mutants with enhanced 1,3-propanediol- producing capability显示文摘 | Du, CY Zhang, YP Li, Y Cao, Z | 2007 | 中国生物学文摘2007，21，10： | 15 |
| 3 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 4 | Journal of Hepatology|肝细胞癌中的抗程序性死亡受体1耐药性的潜在分子机理显示文摘目前,迫切需要探索免疫检查点阻断治疗的耐受机制,并确定一种联合治疗策略以提高其在HCC治疗中的有效性。作为免疫豁免器官,肝脏含有大量巨噬细胞,包括常驻细胞(例如Kupffer细胞)和募集的巨噬细胞。浸润肿瘤组织的巨噬细胞也称为肿瘤相关巨噬细胞(TAM),在功能和表型上与交替激活的(M2样)巨噬细胞相似,在肿瘤进展、免疫逃逸和ICB治疗抵抗中起重要作用。 | 樊嘉 WEI CY ZHU MX ZHANG PF | 2022 | 临床肝胆病杂志2022，38，3： | 9 |
| 5 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 6 | Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention显示文摘AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. | Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 7 | Effect of angiotensin II type I receptor blocker losartan on bone deterioration in orchiectomized male hypertensive and normotensive rats显示文摘 | ZHANG Ya-feng QIN Ling Timothy CY Kwok Benson HY Yeung LI Guo-dong LIU Fan | 2013 | Chinese Medical Journal2013，，14： | 3 |
| 8 | Thymidine kinase gene mutation leads to reduced virulence of pseudorabies virus显示文摘To explore correlation between the tk gene structure of pseudorabies virus (PRV) and its virulence, to study the effect of the gene mutation on PRV biological properties, and to investigate mechinism of reduced virulence, thymidine kinase (TK)-deficient mutant of pseudorabies virus strain Hubei (PRV HB) was isolated by selection for resistance to 5-bromodeoxyuridine. The tk genes of PRV HB and its TK mutant were cloned and sequenced. 1587 base pairs of the tk gene and flanking regions of wild-type (wt) virus were sequenced, which included an open reading frame (ORF) of 1098 bp encoding a protein of 366 amino acids. The ORF contained two 137-bp repeated sequences, which were connected by an adenosine. 1458 bp of the tk and flanking regions of TK- mutant were sequenced. Analysis of the tk gene sequence of TK mutant indicated that one of 137 bp repeated sequence and the connecting adenosine in the tk gene of the wt virus was deleted and a repeated sequence of 8 nucleotides (GCGCGCC) was inserted. All | Pan, ZS Zhang, CY Ding, JH Min, P | 2001 | Chinese Science Bulletin2001，46，23： | 2 |
| 9 | Uncoupling protein 2 negatively regulates insulin secretion and is amajor link between obesity, beta celldys function, and type 2 diabetes 显示文摘 | Zhang CY Baffy G Perret P | 2001 | Cell2001，105，6： | 1 |
| 10 | Evaluation of human immunodeficiency virus type-1 infected Chinese patients treated with highly active antiretroviral therapy for two years 显示文摘 | Zhou HY Zheng YH Zhang CY | 2007 | Viral Immunol2007，20，1： | 1 |
| 11 | Highly pathogenic avian influ- enza A virus H5N1 NS1 protein induces caspase-dependent apop- tosis in human alveolar basal epithelial cells显示文摘 | Zhang CY Yu T Zhou XW | 2010 | Virol J2010，7，51： | 1 |
| 12 | A novel deletion mutation of the EXT2 gene in a large Chinese pedigree with herediary mutiple exostosis显示文摘 | Xiao CY Wang J Zhang SZ | 2001 | Br J Cancer2001，85，2： | 1 |
| 13 | Uncoupling protein 2 knock out mice have enhanced insulin secretory capacity after a high fat diet显示文摘 | Joseph JW Koshkin V Zhang CY | 2002 | Diabetes2002，51，11： | 1 |
| 14 | The A21M polymorphism in CYP7A1 gene affects its promoter activity 显示文摘 | Chen Y J Zhang SZ Xiao CY | 2006 | Chi j Biochem Mol Biol2006，22，： | 1 |
| 15 | The clinical observation of bipolar transurethral plasma kinetic resection of prostate for high risk benign prostate hyperplasia 显示文摘 | Liu DY Gu J Zhang CY | 2009 | Zhonghua Wai Ke Za Zhi2009，47，7： | 1 |
| 16 | A pilot study of serum microRNA signatures as a novel biomarker for occult hepatitis B virus infection 显示文摘 | Chert Y Li L Zhou Z Wang N Zhang CY Zen K | 2012 | Med Microbiol Immunol2012，201，3： | 1 |
| 17 | Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity,beta cell dysfunction,and type 2 diabetes显示文摘 | Baffy G Perret P | 2001 | Cell2001，106，6： | 1 |
| 18 | Comparative proteomics of apoptosis initiation induced by 5-fluorouracil in human gastric cancer显示文摘 | Chen CY Jia JH Zhang MX | 2006 | Chin J Physiol2006，49，1： | 1 |
| 19 | Effects of intensive glucose control on incidence of cardiovascular events in patients with type 2 diabetes: a meta-analysis 显示文摘 | Zhang CY Sun AJ Zhang SN | 2010 | Ann Med2010，42，4： | 1 |
| 20 | Superoxide-mediateda activion of uncoupling protein 2 causes pancreatic b cell dysfunction显示文摘 | Krauss S Zhang CY Scorrano L | 2003 | J Clin Invest2003，112，12： | 1 |
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