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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Water transfer characteristics during methane hydrate formation and dissociation processes inside saturated sand显示文摘Gas hydrates formation and dissociation processes inside porous media are always accompanied by water transfer behavior, which is similar to the water behavior of ice freezing and thawing processes. These processes have been studied by many researchers, but all the studies are so far on the water transfer characteristics outside porous media and the water transfer characteristics inside porous media have been little known. In this study, in order to study the water transfer characteristics inside porous media during methane hydrate formation and dissociation processes, a novel apparatus with three pF-meter sensors which can detect water content changes inside porous media was applied. It was experimentally observed that methane hydrate formation processes were accompanied by water transfer from bottom to top inside porous media, however, the water behavior during hydrate dissociation processes was abnormal, for which more studies are needed to find out the real reason in our future work. | Peng Zhang, Qingbai Wu, Yibin Pu, Guanli Jiang, Jing Zhan, Yingmei Wang State Key Laboratory, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China | 2010 | Journal of Natural Gas Chemistry2010，19，1： | 3 |
| 3 | Effects of Temperature Gradient and Cooling Rate on the Formation of Methane Hydrates in Coarse Sand显示文摘Temperature gradient and cooling rate have an obvious effect on formation of methane hydrate. The process for formation of methane hydrate in coarse sand is monitored to understand the relationship between temperature gradient and cooling rate and nucleation, growth and distribution of methane hydrate by using the electrical resistivity method. The results show that the change of resistivity can better reflect the nucleation and growth and distribution of methane hydrate. Temperature gradient promotes the nucleation, formation, and formation rate of methane hydrate. At a temperature gradient of 0.11 ℃/cm, the rate of methane hydrate formation and saturation reaches a maximum. Cooling rate has little effect on the methane hydrate formation process. Judging from the outcome of final spatial distribution of methane hydrate, the cooling rate has an obvious but irregular effect in coarse sand. The effect of temperature gradient on distribution of methane hydrate in coarse sand is less than that of cooling rate. At a temperature gradient of 0.07 ℃/cm, methane hydrate is distributed uniformly in the sample. If the temperature gradient is higher or lower than this value, the hydrate is enriched in the upper layer of sample. | Wang Yingmei Wu Qingbai Zhang Peng Jiang Guanli | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，2： | 2 |
| 4 | Water transfer characteristics in the vertical direction during methane hydrate formation and dissociation processes inside non-saturated media显示文摘In order to study water transfer characteristics inside non-saturated media during methane hydrate formation and dissociation processes,water changes on the top,middle and bottom locations of experimental media during the reaction processes were continuously followed with a novel apparatus with three pF-meter sensors.Coarse sand,fine sand and loess were chosen as experimental media.It was experimentally observed that methane hydrate was easier formed inside coarse sand and fine sand than inside loess.Methane hydrate formation configuration and water transfer characteristics during methane hydrate formation processes were very different among the different non-saturated media,which were important for understanding methane hydrate formation and dissociation mechanism inside sediments in nature. | Peng Zhang Qingbai Wu Guanli Jiang Jing Zhan Yingmei Wang | 2010 | Journal of Natural Gas Chemistry2010，19，2： | 2 |
| 5 | Preparation and rheological studies on the solvent based acrylic pressure sensitive ad- hesives with different crosslinking density 显示文摘 | Zhang Xiaowen Ding Yuting Zhang Guanli | 2011 | International Journal of Adhesion and Adhesives2011，31，7： | 1 |
| 6 | Relation between soil matrix potential changes and water conversion ratios during methane hydrate formation processes in loess显示文摘With a new apparatus designed and assembled by ourselves, the matrix potential of non-saturated loess was firstly measured and studied during methane hydrate formation processes. The experimental results showed that during two formation processes, the matrix potential changes of the loess all presented a good linear relationship with water conversion ratios. In addition, although it was well known that the secondary gas hydrate formation was easier than the initial, our experimental results showed that the initial hydrate formation efficiency in non-saturated loess was higher than that of the secondary. | Peng Zhang Qingbai Wu Guanli Jiang Yibin Pu | 2011 | Journal of Natural Gas Chemistry2011，20，2： | 1 |
| 7 | Preparation and rheological studies on the solvent based acrylic pressure sensitive adhesives with different crosslinking density显示文摘 | Xiaowen Zhang Yuting Ding Guanli Zhang | 2011 | International Journal of Adhesion & Adhesives2011，31，7： | 1 |
| 8 | Assessing the permafrost temperature, thickness conditions favorable for the occurrence of gas hydrate in the Qinghaih-Tibet Plateau显示文摘 | Wu Qingbai Jiang Guanli Zhang Peng | 2010 | Energy Conversion and Management2010，1，4： | 1 |
| 9 | Experience inheritance from famous specialists based on real- world clinical research paradigm of traditional Chinese medicine显示文摘从在繁体中文药(TCM ) 的著名专家的经验继承的当前的模式包括主人和门徙,文学评论, clinical-epidemiology-based 临床的研究观察和经由计算机和数据库技术的数据采矿。每个模式有它的优点和劣势。然而,一个科学、有启发性的经验继承模式没被开发。大数据时代以及形成和在真实世界上的 TCM 临床的研究范例的实践累积的来临为从著名 TCM 专家继承经验提供了新观点,技术,和方法。通过连续探索和实践,研究组基于真实世界的 TCM 临床的研究范例建议革新研究模式,它包含存在模式的继承和革新。这个模式与它 TCM 的自己的发展整齐一致被提出并且被期望在临床的领域里成为经验继承的主要模式。 | Guanli Song Yinghui Wang Runshun Zhang Baoyan Liu Xuezhong Zhou Xiaji Zhou Hong Zhang Yufeng Guo Yanxing Xue Lili Xu | 2014 | Frontiers of Medicine2014，8，3： | 1 |
| 10 | Effect of Penetration Rates on the Piezocone Penetration Test in the Yellow River Delta Silt显示文摘Partial drainage often occurs during piezocone penetration testing on Yellow River Delta silt because of its intermediate physical and mechanical properties between those of sand and clay.Yet,there is no accurate understanding for the range of penetra-tion rates to trigger the partial drainage of silt soils.In order to fully investigate cone penetration rate effects under partial drainage condi-tions,indoor 1 g penetration model tests and numerical simulations of cavity expansion at variable penetration rates were carried out on the Yellow River Delta silt.The boundary effect of the model tests and the variation of key parameters at the different cavity ex-pansion rates were analyzed.The 1 g penetration model test results and numerical simulations results consistently indicated that the penetration rate to trigger the partially drainage of typical silt varied at least three orders of magnitude.The numerical simulations also provide the reference values for the penetration resistance corresponding to zero dilation and zero viscosity at any given normalized penetration rate for silt in Yellow River Delta.These geotechnical properties can be used for the design of offshore platforms in Yel-low River Delta,and the understanding of cone penetration rate effects under the partially drained conditions would provide some technical support for geohazard evaluation of offshore platforms. | ZHANG Jiarui MENG Qingsheng ZHANG Yan FENG Xiuli WEI Guanli SU Xiuting LIU Tao | 2022 | Journal of Ocean University of China2022，21，2： | 1 |
| 11 | Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation显示文摘Multiple myeloma(MM)is characterized by excessive aggregation of B-cell-derived malignant plasma cells in the hematopoietic system of bone marrow.Previously,we synthesized an innovative molecule named dihydrocelastrol(DHCE)from celastrol,a triterpene purified from medicinal plant Tripterygium wilfordii.Herein,we explore the therapeutic properties and latent signal transduction mechanism of DHCE action in bortezomib(BTZ)-resistant(BTZ-R)MM cells.In this study,we first report that DHCE shows antitumor activities in vitro and in vivo and exerts stronger inhibitory effects than celastrol on BTZ-R cells.We find that DHCE inhibits BTZ-R cell viability by promoting apoptosis via extrinsic and intrinsic pathways and suppresses BTZ-R MM cell proliferation by inducing G0/G1 phase cell cycle arrest.In addition,inactivation of JAK2/STAT3 and PI3K/Akt pathways are involved in the DHCE-mediated antitumor effect.Simultaneously,DHCE acts synergistically with BTZ on BTZ-R cells.PSMB5,a molecular target of BTZ,is overexpressed in BTZ-R MM cells compared with BTZ-S MM cells and is demonstrated to be a target of STAT3.Moreover,DHCE downregulates PSMB5 overexpression in BTZ-R MM cells,which illustrates that DHCE overcomes BTZ resistance through increasing the sensitivity of BTZ in resistant MM via inhibiting STAT3-dependent PSMB5 regulation.Overall,our findings imply that DHCE may become a potential therapeutic option that warrants clinical evaluation for BTZ-R MM. | Shuhan Jin Bo Li Bibo Zhang Xuejie Gao Xinyan Jia Li Xu Shuaikang Chang Ke Hu Guanli Wang Zhijian Xu Ting Zhang Dongliang Song Guang Yang Xiaosong Wu Huabin Zhu Cheng Huang Yumeng Lu Jumei Shi Weiliang Zhu Gege Chen | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
| 12 | A case study on the soil classification of the Yellow River Delta based on piezocone penetration test显示文摘Piezocone penetration test(CPTu),the preferred in-situ tool for submarine investigation,is significant for soil classification and soil depth profile prediction,which can be used to predict soil types and states.However,the accuracy of these methods needs to be validated for local conditions.To distinguish and evaluate the properties of the shallow surface sediments in Chengdao area of the Yellow River Delta,seabed CPTu tests were carried out at ten stations in this area.Nine soil classification methods based on CPTu data are applied for soil classification.The results of classification are compared with the in-situ sampling to determine whether the method can provide sufficient resolution.The methods presented by Robertson(based on soil behavior type index Ic),Olsen and Mitchell are the more consistent and compatible ones compared with other methods.Considering that silt soils have potential to liquefy under storm tide or other adverse conditions,this paper is able to screen soil classification methods suitable for the Chengdao area and help identify the areas where liquefaction or submarine landslide may occur through CPTu investigation. | Jiarui Zhang Qingsheng Meng Lei Guo Yan Zhang Guanli Wei Tao Liu | 2022 | Acta Oceanologica Sinica2022，41，4： | 0 |
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