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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Competing endogenous RNA screening based on long noncoding RNA-messenger RNA co-expression profile in Hepatitis B virus-associated hepatocarcinogenesis显示文摘OBJECTIVE: To profile the liver cancer specific long noncoding RNAs(lnc RNAs) and competing endogenous RNA(ce RNA) networks of Hepatitis B virus(HBV)-associated hepatocarcinogensis(HCG) and to examine the effect of compound K on the expression of identified ce RNA networks.METHODS: Based on lnc RNA and messenger RNA(m RNA) microarray data of HBV-associated liver cancer, the current study profiles the cancer specific lnc RNAs and ce RNA networks of HBV-associated HCG through comprehensive application of Reg RNA 2, mi RTar Base and Pearson correlation coefficient analysis. Compound K-treated liver cancer cells were harvested for analysis of transcriptional levels of both enoyl-Co A hydratase and 3-hydroxyacyl Co A dehydrogenase(EHHADH)-AS1 and ENTPD5.RESULTS: The results revealed that 11 Encyclopedia of DNA Elements annotated lnc RNAs were differentially expressed in the process of HBV-associated HCG. Among these lnc RNAs, 95 potential ce RNA networks with highly positively correlated expression profiles between the interacting lnc RNAs and m RNAs(Pearson correlation coefficient ≥ 0.7) were constructed. Of note, two HBV-associated ce RNA networks, EHHADH-AS1-hsa-mi R-4459-ectonucleoside triphosphate diphosphohydrolase 5 and LINC01018-hsa-mi RNA-574-5p-glucose-6-phosphatase catalytic subunit, with Pearson correlation coefficient ≥ 0.9, may play a critical role in hepatocellular carcinoma development, which was supported by experimental evidence. Interestingly, compound K, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin, which has been proven to promote apoptosis of human hepatocellular carcinoma cells, was found to impede the down-regulation of EHHADH-AS1 in several liver cancer cell lines including Hep G3 B, Huh-7 and plc/prf/5 cells.CONCLUSION: Comprehensive application of co-expression network analysis and prediction of RNA interaction may be a feasible strategy to unravel the potential ce RNA networks involved in the process of human diseases. | Wen Quan Yang Yao Chen Xianhua Pan Xiaodong Han Qi Wang Dong Deng Youcai Li Xiaohui Yan Jun Zhou Jihong | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 3 |
| 3 | Reinforcement by crack-tip blunting in porous ceramics显示文摘 | Zhen-Yan Deng Jihong She Yoshiaki Inagaki Jian-Feng Yang Tatsuki Ohji Yoshihisa Tanaka | 2003 | Journal of the European Ceramic Society2003，，7： | 1 |
| 4 | A new pyrolysis technology and equipment for treatment of municipal household garbage and hospital waste显示文摘 | Zhang Yufeng Deng Na Ling Jihong | 2003 | Renew Energy2003，28，15： | 1 |
| 5 | Reinforcement by crack-tip blunting in porous ceramics显示文摘 | Deng Zhenyan She Jihong Yoshiaki Inagaki | 2004 | J Eur Ceram Soc2004，24，7： | 1 |
| 6 | Intergeneric somatic hybridization and its application to crop genetic improvement显示文摘 | Jihong Liu Xiaoyong Xu Xiuxin Deng | 2005 | Plant Cell Tissue and Organ Culture2005，，1： | 1 |
| 7 | Molecular engineering of microporous crystals: (VI) Structure-directing effect in the crystallization process of layered aluminophosphates显示文摘 | Xiaoqiang Tong Jun Xu Liang Xin Pai Huang Huiying Lu Chao Wang Wenfu Yan Jihong Yu Feng Deng Huai Sun Ruren Xu | 2012 | Microporous and Mesoporous Materials2012，，： | 1 |
| 8 | Molecular engineering of microporous crystals: (V) Investigation of the structure-directing ability of piperazine in forming two layered aluminophosphates显示文摘 | Xiaoqiang Tong Jun Xu Chao Wang Huiying Lu Pai Huang Wenfu Yan Jihong Yu Feng Deng Ruren Xu | 2012 | Microporous and Mesoporous Materials2012，，： | 1 |
| 9 | A new pyrolysis technology and equipment for treatment of municipal household garbage and hospital waste 显示文摘 | Zhang Yufeng Deng Na Ling Jihong | 2003 | Renewable Energy2003，28，15： | 1 |
| 10 | Regeneration and analysis of citrus interspecific mixoploid hybrid plants from asymmetric somatic hybridization 显示文摘 | Liu Jihong Deng Xiuxin | 2002 | Euphytica2002，125，： | 1 |
| 11 | A new pyrolysis technology and equipment for treatment of municipal household garbage and hospital waste 显示文摘 | ZHANG Yufeng DENG Na LING Jihong | 2003 | Renew Energy2003，28，15： | 1 |
| 12 | A robust solution for hesitate phenomenon in pick up process of aerospace electromagnetic relay显示文摘As for aerospace electromagnetic relay (AEMR) which is of small batches and having difficulty in automatic production, the uncertainty phenomenon is remarkable due to excessive manual work involved in the assembly and adjustment processes. This kind of uncertainty may increase the coil voltage difference (CVD) caused by hesitate phenomenon in the pick up process of AEMR. Taking a certain type of AEMR for example, the CVD problem in the actual producing process has been studied in this paper. The primary cause of this issue, two-steps of armature motion (namely hesitate phenomenon) in the pick up process, has been found by analyzing the matching characteristics of electromagnetic and mechanical torques of AEMR. Through the optimization of the matching characteristics, the two-steps of armature motion problem is solved by robust design of the return reed which is a key part of AEMR. The validity of this research has been proved by the comparison of characteristics of AMER before and after the optimization. | Ye Xuerong Deng Jie Ma Yue Zhai Guofu Yan Jihong | 2013 | Chinese Journal of Aeronautics2013，26，3： | 1 |
| 13 | 血管内皮生长因子、微血管密度在子宫平滑肌瘤中的表达意义(英文)显示文摘Objective:To investigate vascular endothelial growth factor(VEGF) expression and microvessel density(MVD) on the fibromyoma uteri treated with mifepristone.Methods:VEGF expression and MVD were counted on 60 cases of the fibromyoma uteri by SP method,including 40 cases of mifepristone treated and 20 cases of untreated patients as controlled group.Results:VEGF positive expression rate and MVD in treated group were 37.5% and 9.90 ± 5.95,which were lower than those in controlled group(80% and 16.36 ± 2.07;P < 0.05).Meanwhile,in treated group,those in marked shrink in tumor size sub-group were lower than in not obvious sub-group(12.0% and 7.89 ± 4.36 vs.80% and 11.29 ± 3.10;P < 0.05).Conclusion:VEGF and MVD expression decreases in the fibromyoma uteri after treatment with mifepristone,suggesting that mifepristone could inhibit angiogenesis and blood supply resulting in tumor shrink. | Huaqing Wen Jihong Deng Ping Pu Haitao Wang Wei Yin | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，10： | 0 |
| 14 | Engineering Coordination Environment of Cobalt Center in Molecular Catalysts for Improved Photocatalytic CO_(2) Reduction显示文摘The creation of effective and inexpensive catalysts is essential for photocatalytic CO_(2) reduction.Homogeneous molecular catalysts,possessing definite crystal structures,are desirable to study the relationship between catalytic performance and coordination microenvironment around catalytic center.In this report,we elaborately developed three Co(II)-based molecular catalysts with different coordination microenvironments for CO_(2) reduction,named[CoN_(3)O]ClO_(4),[CoN_(4)]ClO_(4),and[CoN_(3)S]ClO_(4),respectively.The optimal[CoN_(3)O]ClO_(4) photocatalyst has a maximum TON of 5652 in photocatalytic reduced CO_(2) reduction,which is 1.28 and 1.65 times greater than that of[CoN_(4)]ClO_(4) and[CoN_(3)S]ClO_(4),respectively.The high electronegativity of oxygen in L1(N,N-bis(2-pyridylmethyl)-N-(2-hydroxybenzyl)amine)provides the Co(II)catalytic centers with low reduction potentials and a more stable*COOH intermediate,which facilitates the CO_(2)-to-CO conversion and accounts for the high photocatalytic activity of[CoN_(3)O]ClO_(4).This work provides researchers new insights in development of catalysts for photocatalytic CO_(2) reduction. | Yuchen Wang Jihong Zhang Wei Yang Weixue Tao Keying Tao Jihua Deng Wenjie Shi Dichang Zhong Tongbu Lu | 2023 | Chinese Journal of Chemistry2023，41，23： | 0 |
| 15 | Profile of the levonorgestrel-releasing intrauterine system users in China显示文摘The widespread usage of modem contraceptive methods has predominantly been driven by government family planning policies in efforts to mandate reduced total fertility rates.1 In particular,the high prevalence of long-acting contraception usage can be attributed to the mandatory requirement in the early 1980s for women with one child to have a copper intrauterine device (IUD) fitted and for sterilization for those with two or more children,2and more recently through financial incentives for married couples to use long-acting contraceptive methods.1 The levonorgestrel-releasing intrauterine system (LNG-IUS) has been available in China since 2000 for contraception and treatment of heavy menstrual bleeding.Little is known about the profile of the Chinese women opting to use the LNG-IUS and the type of information they received before intrauterine system placement.We undertook this survey to profile the Chinese women choosing to use the LNG-IUS in clinical practice. | Zhang Ying Bi Shiliang Zhao Shuping Wang Yan Qin Wen Deng Jihong Li Jian | 2014 | Chinese Medical Journal2014，，5： | 0 |
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