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| 1 | Screening for gastric cancer in China:Advances,challenges and visions显示文摘Gastric cancer(GC)is one of the major cancers in China and all over the world.Most GCs are diagnosed at an advanced stage with unfavorable prognosis.Along with some other countries,China has developed the government-funded national screening programs for GC and other major cancers.GC screening has been shown to effectively decrease the incidence of and mortality from GC in countries adopting nationwide screening programs(Japan and Korea)and in studies based on selected Chinese populations.The screening of GC relies mostly on gastroendoscopy,the accuracy,reliability and safety of which have been indicated by previous studies.However,considering its invasive screening approach,requirements on skilled endoscopists and pathologists,and a high cost,developing noninvasive methods to amend endoscopic screening would be highly needed.Numerous studies have examined biomarkers for GC screening and the combination of biomarkers involving pepsinogen,gastrin,and Helicobacter pylori antibodies has been proposed for risk stratification,seeking to narrow down the high-risk populations for further endoscopy.Despite all the achievements of endoscopic screening,evidence on appropriate screening age,intervals for repeated screening,novel biomarkers promoting precision prevention,and health economics need to be accumulated to inform policymakers on endoscopic screening in China.With the guide of Health China 2030 Planning Outline,we have golden opportunities to promote prevention and control of GC.In this review,we summarize the characteristics of screening programs in China and other East Asian countries and introduce the past and current approaches and strategies for GC screening,aiming for featuring the latest advances and key challenges,and illustrating future visions of GC screening. | Xiaohan Fan Xiangxiang Qin Yang Zhang Zhexuan Li Tong Zhou Jingying Zhang Weicheng You Wenqing Li Kaifeng Pan | 2021 | Chinese Journal of Cancer Research2021，33，2： | 21 |
| 2 | A cellular automata evacuation model considering friction and repulsion显示文摘There exist interactions among pedestrians and between pedestrian and environment in evacuation. These interactions include attraction, repulsion and friction that play key roles in human evacuation behaviors, speed and efficiency. Most former evacuation models focus on the attraction force, while repulsion and friction are not well modeled. As a kind of multi-particle self-driven model, the social force model introduced in recent years can represent those three forces but with low simulation efficiency because it is a continuous model with complex rules. Discrete models such as the cellular automata model and the lattice gas model have simple rules and high simulation efficiency, but are not quite suitable for interactions’ simulation. In this paper, a new cellular automata model based on traditional models is introduced in which repulsion and friction are modeled quantitatively. It is indicated that the model can simulate some basic behaviors, e.g. arching and the “faster-is-slower” phenomenon, in evacuation as multi-particle self-driven models, but with high efficiency as the normal cellular automata model and the lattice gas model. | SONG Weiguo YU Yanfei FAN Weicheng Zhang Heping | 2005 | Science China(Technological Sciences)2005，48，4： | 19 |
| 3 | S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance显示文摘最近的研究证明 UHRF1 被指向 DNMT1 到 DNA 复制 foci 为 DNA methylation 维护要求,大概通过它的唯一的半甲醇化物有 DNMT1 的 DNA 有约束力的活动和相互作用。UHRF2, UHRF 家庭蛋白质的另一个成员,高度类似于在顺序和结构的 UHRF1,关于它在 DNA methylation 的角色的涨的问题。在这研究,我们证明 UHRF2 象 UHRF1 一样,也优先地绑在 methylated histone H3 离氨酸 9 (H3K9 ) 通过它的保存 tudor,通过 SET 和戒指的领域和半甲醇化物 DNA 联系了领域。象 UHRF1 一样, UHRF2 在 pericentric heterochromatin 被充实。heterochromatin 本地化取决于到大程度它的 methylated H3K9 有约束力的活动并且到它的 methylated 上的更少的程度 DNA 有约束力的活动。Coimmunoprecipitation 实验证明 UHRF1 和 UHRF2 与 DNMT1, DNMT3a, DNMT3b 和 G9a 交往。尽管有所有这些保存功能,我们发现 UHRF2 不能在 Uhrf1 空老鼠救 DNA methylation 缺点胚胎的干细胞。这个罐头在房间周期的 S 阶段期间为 UHRF2 被归因于无能到成员 DNMT1 到复制 foci。确实,我们发现当 UHRF1 在房间以一种 S 阶段依赖者方式与 DNMT1 交往时, UHRF2 不做。因此,我们的学习证明 UHRF2 和 UHRF1 不在 DNA methylation 维护是机能上地冗余的并且作为为 DNA methylation 指向 DNMT1 的关键规章的机制揭示在 UHRF1 和 DNMT1 之间的 cell-cycle-dependent 相互作用。 | Jiqin Zhang Qinqin Gao Pishun Li Xiaoli Liu Yuanhui Jia Weicheng Wu Jiwen Li Shuo Dong Haruhiko Koseki Jiemin Wong | 2011 | Cell Research2011，21，12： | 12 |
| 4 | Precipitation seesaw phenomenon and its formation mechanism in the eastern and western parts of Northwest China during the flood season显示文摘Extending across three major plateaus,namely the Qinghai-Tibetan Plateau,the Inner Mongolia-Xinjiang Plateau and the Loess Plateau,Northwest China has the complex terrain and spatio-temporal climate variations,and is affected by the interactions among different circulation systems,such as the summer monsoon,the westerlies and the plateau monsoon.The understanding of the climate variability,as well as its characteristics and evolution mechanisms in this area has been limited so far.In this paper,the precipitation characteristics and mechanisms in the eastern and western parts of Northwest China during the flood season are compared and analyzed based on the data from 192 national meteorological observational sites in Northwest China in 1961-2016.The results show that,divided by the northern boundary of the East Asian summer monsoon,there are huge differences in the precipitation variation characteristics between the eastern and western parts.The inter-annual variations,interdecadal variations and total trends in the two parts all show a significant seesaw phenomenon.Moreover,it is found that the seesaw phenomenon of precipitation variation is closely related to the opposite variation between the East Asian summer monsoon index(MI)and the westerly circulation index(WI).In addition,the inverse variations on different time scales are only related to the contributions of precipitation at specific grades.Besides,in the two matching patterns of precipitation in the seesaw phenomenon,the middle and high latitudes are occupied by the'high-low-high'wave trains in the precipitation increases in the east of Northwest China(ENWC)and decreases in the west of Northwest China(WNWC)pattern,meaning precipitation increases in ENWC and decreases in WNWC.Whereas the opposite'low-high-low'wave trains at 500 hPa height are observed in the middle and high latitudes in the WH-EA pattern at 500 hPa height,meaning precipitation increases in WNWC and decreases in ENWC.Thus,the atmosphere circulation situation with two wave train types can support both the precipitation seesaw phenomenon and the opposite variation between MI and WI.Moreover,the seesaw phenomenon is shown to be related to the separate or joint effects of the South Asian High,ENSO and the plateau heating on the common but opposite effect on the summer monsoon and the westerlies,in which the South Asian High probably plays a more critical role.This study could deepen the scientific understanding of precipitation mechanisms and improve the weather forecast technology in Northwest China during the flood season. | Qiang ZHANG Jingjing LIN Weicheng LIU Lanying HAN | 2019 | Science China Earth Sciences2019，62，12： | 11 |
| 5 | A systematic review of metabolomic profiling of gastric cancer and esophageal cancer显示文摘Objective:Upper gastrointestinal(UGI)cancers,predominantly gastric cancer(GC)and esophageal cancer(EC),are malignant tumor types with high morbidity and mortality rates.Accumulating studies have focused on metabolomic profiling of UGI cancers in recent years.In this systematic review,we have provided a collective summary of previous findings on metabolites and metabolomic profiling associated with GC and EC.Methods:A systematic search of three databases(Embase,PubMed,and Web of Science)for molecular epidemiologic studies on the metabolomic profiles of GC and EC was conducted.The Newcastle–Ottawa Scale(NOS)was used to assess the quality of the included articles.Results:A total of 52 original studies were included for review.A number of metabolites were differentially distributed between GC and EC cases and non-cases,including those involved in glycolysis,anaerobic respiration,tricarboxylic acid cycle,and protein and lipid metabolism.Lactic acid,glucose,citrate,and fumaric acid were among the most frequently reported metabolites of cellular respiration while glutamine,glutamate,and valine were among the most commonly reported amino acids.The lipid metabolites identified previously included saturated and unsaturated free fatty acids,aldehydes,and ketones.However,the key findings across studies to date have been inconsistent,potentially due to limited sample sizes and the majority being hospital-based case-control analyses lacking an independent replication group.Conclusions:Studies on metabolomics have thus far provided insights into etiological factors and biomarkers for UGI cancers,supporting the potential of applying metabolomic profiling in cancer prevention and management efforts. | Sha Huang Yang Guo Zhexuan Li Yang Zhang Tong Zhou Weicheng You Kaifeng Pan Wenqing Li | 2020 | Cancer Biology & Medicine2020，17，1： | 11 |
| 6 | Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines显示文摘单性生殖的胚胎的茎(足) 细胞为学习位于印的 genomic 下面的分子的机制提供一个珍贵试管内模型系统。然而,足房间的 thepluripotency 和父亲一般地表示的印的基因的表示侧面一直不是充分探索了。在这研究,三根老鼠足房间线被建立,在扩大文化的这些房间的区别潜力被评估。无差别的房间有正常核型和同型结合的染色体,并且表示了 ES-cell-specific 分子的标记。房间在超过 50 个段落以后仍然保持无差别并且展出了 pluripotentdifferentiation 能力。确定的 ES 房间的所有三根线生产了 teratomas;ES 房间的二根线生产了怪物和细菌线传播。而且,在这些房间的父亲一般地表示的印的基因 Snrpn, U2af1-rs1, Peg3,影响, Zfp127, Dlk1 和 Mest 的激活被检测。父亲一般地表示的印的基因被发现在单性生殖的联盟者的胚囊阶段被表示的一些激活胚胎试管内,他们的表示水平与扩大的足细胞培养增加了。而且,我们在足房间的这些父亲一般地表示的印的基因的激活在 ther 的甲基化与一个变化被联系的数据表演鼓舞了差别 methylated 区域。这些调查结果为足房间的 thepluripotency 提供直接证据并且在足房间表明在脱氧核糖核酸甲基化模式和父亲一般地表示的印的基因的激活之间的协会。因此,确定的 ES 房间线为在哺乳动物的开发学习 epigenetic 规定提供一个珍贵模型。 | Hua Jiang Bowen Sun Weicheng Wang Zhihong Zhang Furong Gao Guilai Shi Bing Cui XiangyinKong Zhao He Xiaoyan Ding Ying Kuang Jian Fei Yi Juan Sun Yun Feng Ying Jin | 2007 | Cell Research2007，17，9： | 10 |
| 7 | ROS signaling cascades:dual regulations for osteoclast and osteoblast显示文摘Accumulating evidence indicates that intracellular reactive oxygen species(ROS)production is highly involved in bone homeostasis by intervening osteoclast or osteoblast differentiation.Interestingly,ROS that are known as oxidizing agents exert dose-dependent biphasic properties in bone remodeling,including preventing osteoblast activity but accelerating osteoclast resorption.ROS mainly composed of superoxide anion radical,hydroxyl radical,nitric oxide,and two-electron reduction product hydrogen peroxide,which are important components to regulate bone cell metabolism and function in mammal skeleton.These free radicals can be partly produced in bone and boosted in an inflammation state.Although numerous researches have emphasized the impacts of ROS on bone cell biology and verified the mechanism of ROS signaling cascades,the recapitulatory commentary is necessary.In this review article,we particularly focus on the regulation of the intracellular ROS and its potential mechanism impacting on cell-signaling transduction in osteoclast and osteoblast differentiation for preferable understanding the pathogenesis and searching for novel therapeutic protocols for human bone diseases. | Huaqiang Tao Gaoran Ge Xiaolong Liang Weicheng Zhang Houyi Sun Meng Li Dechun Geng | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 8 |
| 8 | Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway显示文摘Periprosthetic osteolysis(PPO)remains the key factor in implant failure and subsequent revision surgery and is mainly triggered by wear particles.Previous studies have shown that inhibition of osteoblastic differentiation is the most widespread incident affecting the interface of trabecular and loosening prostheses.Additionally,the NLRP3 inflammasome is activated by prosthetic particles.Sirtuin3,an NAD+-dependent deacetylase of mitochondria,regulates the function of mitochondria in diverse activities.However,whether SIRT3 can mitigate wear debris-induced osteolysis by inhibiting the NLRP3 inflammasome and enhancing osteogenesis has not been previously reported.Therefore,we investigated the role of SIRT3 during the process of titanium(Ti)particle-induced osteolysis.We revealed that upregulated SIRT3 dramatically attenuated Ti particle-induced osteogenic inhibition through suppression of the NLRP3 inflammasome and improvement of osteogenesis in vivo and in vitro.Moreover,we found that SIRT3 interference in the process of Ti particle-induced osteolysis relied on the GSK-3β/β-catenin signalling pathway.Collectively,these findings indicated that SIRT3 may serve as a rational new treatment against debris-induced PPO by deacetylase-dependent inflammasome attenuation. | Kai Zheng Jiaxiang Bai Ning Li Meng Li Houyi Sun Weicheng Zhang Gaoran Ge Xiaolong Liang Huaqiang Tao Yi Xue Yuefeng Hao Chen Zhu Yaozeng Xu Dechun Geng | 2021 | Bioactive Materials2021，6，10： | 5 |
| 9 | Recovery of photosynthesis,sucrose metabolism,and proteolytic enzymes in Kandelia obovata from rare cold events in the northernmost mangrove,China显示文摘Introduction:Understanding how mangroves respond to rare cold events has implications for both restoration and conservation under climate change scenarios.This study investigated the responses of photosynthesis and activities of key enzymes involving carbon and nitrogen metabolism at different ages of Kandelia obovata to a rare cold event in the winter of 2010.Methods:This study took place on Ximen Island,Zhejiang Province,China.We measured the physiological recovery of 2-3-,5-6-,9-10-and 54-55-year-old K.obovata trees after freezing injury in February and March in 2011 and 2012,respectively.Results:Chilling injury index and electrolyte leakage of K.obovata increased with increasing tree age in the winter of 2010,and electrolyte leakage in K.obovata at different ages in the winter of 2010 was far higher than that in the winter of 2011.The rare cold events significantly changed the recoveries of the leaf net photosynthetic rate(Pn)and stomatal conductance(Gs);ratios of chlorophyll a/chlorophyll b(Chl a/Chl b);contents of total soluble sugar(TSS),sucrose,free amino acid(FAA),and soluble protein;and activities of sucrose phosphate synthase(SPS),endopeptidase,and carboxypeptidase in K.obovata at different ages.These effects were mainly due to changes in the physiological mechanism in the 2-year-old trees.A clear decrease in Pn of the 2-year-old trees was observed in February 2011,as exemplified by reductions in ratios of Chl a/Chl b and chlorophyll/carotenoid(Chl/Car),as well as inhibition of the levels of TSS and FAA(osmotic substances).During recovery in 2011 and 2012,the activities of SPS and sucrose synthase(SS)were responsible for sucrose synthesis after the rare cold events in 2011,but only SPS activity was one of the main factors contributing to the metabolism of stachyose to sucrose without cold damage in 2012.Carboxypeptidase played a more important role than endopeptidase during protein hydrolysis after the rare cold events.Conclusions:The results suggest that the recovery of photosynthetic capacity in K.obovata was changed after a rare cold event,which is associated with pigment components and activities of SS,SPS,and carboxypeptidase,especially the seedlings. | Chunfang Zheng Yong Ye Weicheng Liu Jianwu Tang Chengnian Zhang Jianbiao Qiu Jinong Chen | 2016 | Ecological Processes2016，5，1： | 4 |
| 10 | A Stiffness Variable Passive Compliance Device with Reconfigurable Elastic Inner Skeleton and Origami Shell显示文摘Devices with variable stiffness are drawing more and more attention with the growing interests of human-robot interaction,wearable robotics,rehabilitation robotics,etc.In this paper,the authors report on the design,analysis and experiments of a stiffness variable passive compliant device whose structure is a combination of a reconfigurable elastic inner skeleton and an origami shell.The main concept of the reconfigurable skeleton is to have two elastic trapezoid four-bar linkages arranged in orthogonal.The stiffness variation generates from the passive deflection of the elastic limbs and is realized by actively switching the arrangement of the leaf springs and the passive joints in a fast,simple and straightforward manner.The kinetostatics and the compliance of the device are analyzed based on an efficient approach to the large deflection problem of the elastic links.A prototype is fabricated to conduct experiments for the assessment of the proposed concept.The results show that the prototype possesses relatively low stiffness under the compliant status and high stiffness under the stiff status with a status switching speed around 80 ms. | Zhuang Zhang Genliang Chen Weicheng Fan Wei Yan Lingyu Kong Hao Wang | 2020 | Chinese Journal of Mechanical Engineering2020，33，5： | 4 |
| 11 | Improving the performance of solid oxide electrolysis cell with gold nanoparticles-modified LSM-YSZ anode显示文摘Gold, as the common current collector in solid oxide electrolysis cell(SOEC), is traditionally considered to be inert for oxygen evolution reaction at the anode of SOEC. Herein, gold nanoparticles were loaded onto conventional strontium doped lanthanum manganite-yttria stabilized zirconia(LSM-YSZ) anode, which evidently improved the performance of oxygen evolution reaction at 800 °C. The current densities at 1.2 V and 1.4 V increased by 60.0% and 46.9%, respectively, after loading gold nanoparticles onto the LSM-YSZ anode. Physicochemical characterizations and electrochemical measurements suggested that the improved SOEC performance was attributed to the accelerated electron transfer of elementary process in anodic polarization reaction and the newly generated triple phase boundaries in gold nanoparticles-loaded LSMYSZ anode. | Yuefeng Song Xiaomin Zhang Yingjie Zhou Houfu Lv Qingxue Liu Weicheng Feng Guoxiong Wang Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 12 | Effect of ultrasonic micro-forging treatment on microstructure and mechanical properties of GH3039 superalloy processed by directed energy deposition显示文摘In this work,ultrasonic micro-forging treatment(UMFT)was introduced to achieve homogeneous microstructure,reduce defects and improve mechanical properties of GH3039 superalloy cladding layer processed by directed energy deposition(DED).The microstructure,defects and mechanical properties of the cladding layers treated by UMFT with different ultrasonic powers(UIPs)were investigated.Results revealed a gradient structure as equiaxed grains distributed at the top,a columnar-to-equiaxed transition(CET)region that mixed of columnar dendrites and equiaxed grains distributed at the middle and columnar dendrites at the bottom of the cladding layer was formed.After UMFT,the proportion of equiaxed grains was increased,the average size of equiaxed grains was refined to 10μm from 16μm,the orientation of grains was more uniform and the phases enriched of Al,Ti,C,Nb and Mo were precipitated.The grain refinement can be attributed to the fracture of columnar dendrites induced by the ultrasonic vibration during solidification.Besides,the porosity of the cladding layer was reduced after UMFT.The microhardness of the cladding layers exhibited a depth-dependent gradient at the top region.The microhardness of the top surface was the highest and showed an increasing trend with the increase of UIP.The microhardness of different grain morphologies exhibited no substantial difference.However,due to grain refinement and precipitation of strengthening phase induced by UMFT,the microhadness of some local locations were improved.These results indicated UMFT has a significant effect on improving the microstructure,defects and mechanical properties of the deposited cladding layer. | Qingqing Li Yong Zhang Jie Chen Bugao Guo Weicheng Wang Yuhai Jing Yong Liu | 2021 | Journal of Materials Science & Technology2021，，11： | 4 |
| 13 | Fusaricidins in Paenibacillus polymyxa A21 and their antagonistic activity against Botrytis cinerea on tomato显示文摘Four kinds of antifungal compounds from an extract of Paenibacillus polymyxa A21 with molecular masses of 883.56, 897.59, 947.55, and 961.58 Da were characterized as the members of fusaricidin-type of antibiotics according to LC-MS analysis. Fusaricidins isolated from culture filtrate displayed high antagonistic activity against several plant fungal pathogens, especially Botrytis cinerea, the causal agent of gray mold. The fusaricidins biosynthetic gene cluster(BGC) from A21 was cloned by PCR and comparative cluster analysis revealed that gene fus TE, the 3′ boundary of the fusaricidin BGC in strain PKB1, was not present in fusaricidin BGC of A21, indicating that fus TE is not necessary for fusaricidin synthesis. Fusaricidin extract from A21 significantly reduced gray mold disease incidence and severity on tomato. The m RNA levels for three pathogenesis-related proteins(PRs) revealed that treatment of tomato leaves with fusaricidin extract induced the expression of PR genes to different levels, suggesting that one reason for the reduction of gray mold infection by fusaricidin is induction of PR proteins, which lead to increased resistance to pathogens. This is the first report of the application of fusaricidins to control tomato gray mold and the comparative cluster analysis provides important molecular basis for research on fusaricidin biosynthesis. | Weicheng LIU Xiaoli WU Xuelian BAI Hong ZHANG Dan DONG Taotao ZHANG Huiling WU | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 4 |
| 14 | Helicobacter pylori antibody responses in association with eradication outcome and recurrence: a population-based intervention trial with 7.3-year follow-up in China显示文摘Objective:To identify serum biomarkers that may predict the short or long term outcomes of anti-Helicobacter pylori(H.pylori)treatment,a follow-up study was performed based on an intervention trial in Linqu County,China.Methods:A total of 529 subjects were selected randomly from 1,803 participants to evaluate total anti-H.pylori immunoglobulin G(Ig G)and 10 specific antibody levels before and after treatment at 1-,2-and 7.3-year.The outcomes of anti-H.pylori treatment were also parallelly assessed by 13C-urea breath test at 45-d after treatment and 7.3-year at the end of follow-up.Results:We found the medians of anti-H.pylori Ig G titers were consistently below cut-off value through 7.3years in eradicated group,however,the medians declined in recurrence group to 1.2 at 1-year after treatment and slightly increased to 2.0 at 7.3-year.While the medians were significantly higher(>3.0 at 2-and 7.3-year)among subjects who failed the eradication or received placebo.For specific antibody responses,baseline seropositivities of Fli D and Hpa A were reversely associated with eradication failure[for Fli D,odds ratio(OR)=0.44,95%confidence interval(95%CI):0.27–0.73;for Hpa A,OR=0.32,95%CI:0.17–0.60].The subjects with multiple positive specific antibodies at baseline were more likely to be successfully eradicated in a linear fashion(Ptrend=0.006).Conclusions:Our study suggested that total anti-H.pylori Ig G level may serve as a potential monitor of longterm impact on anti-H.pylori treatment,and priority for H.pylori treatment may be endowed to the subjects with multiple seropositive antibodies at baseline,especially for Fli D and Hap A. | Tianyi Wang Yang Zhang Huijuan Su Zhexuan Li Lian Zhang Junling Ma Weidong Liu Tong Zhou Weicheng You Kaifeng Pan | 2017 | Chinese Journal of Cancer Research2017，29，2： | 3 |
| 15 | Synthesis and Secondary Conformations of Homochiral β-Oligopeptides Containing Aryl Side Chains显示文摘 | ZHANG Yonghong LI Liangchun YUAN Weicheng ZHANG Xiaomei | 2015 | Chemical Research in Chinese Universities2015，31，3： | 2 |
| 16 | Organic–inorganic hybrid perovskite scintillators for mixed field radiation detection显示文摘Sensitive and fast detection of neutrons and gamma rays is vital for homeland security,high-energy physics,and proton therapy.Fast-neutron detectors rely on light organic scintillators,andγ-ray detectors use heavy inorganic scintillators and semiconductors.Efficient mixed-field detection using a single material is highly challenging due to their contradictory requirements.Here we report hybrid perovskites(C_(8)H_(12)N)_(2)Pb(Br_(0.95)Cl_(0.05))_(4)that combine light organic cations and heavy inorganic skeletons at a molecular level to achieve unprecedented performance for mixed-field radiation detection.High neutron absorption due to a high density of hydrogen,strong radiative recombination within the highly confined[PbX_(6)]^(4-)layer,and sub-nanometer distance between absorption sites and radiative centers,enable a light yield of 41000 photons/MeV,detection pulse width of 2.97 ns and extraordinary linearity response toward both fast neutrons andγ-rays,outperforming commonly used fast-neutron scintillators.Neutron energy spectrum,time-of-flight based fast-neutron/γ-ray discrimination and neutron yield monitoring were all successfully achieved using(C_(8)H_(12)N)_(2)Pb(Br_(0.95)Cl_(0.05))_(4)detectors.We further demonstrate the monitoring of reaction kinetics and total power of a nuclear fusion reaction.We envision that molecular hybridized scintillators open a new avenue for mixed-field radiation detection and imaging. | Mengling Xia Guangda Niu Linyue Liu Runlong Gao Tong Jin Pengying Wan Weicheng Pan Xianpeng Zhang Zuoxiang Xie Sam Teale Zenghua Cai Jiajun Luo Shan Zhao Haodi Wu Shiyou Chen Zhiping Zheng Qingguo Xie Xiaoping Ouyang Edward HSargent Jiang Tang | 2022 | InfoMat2022，4，9： | 2 |
| 17 | Lewis Base Organocatalyzed Enantioselective Hydrosilylation of α-Keto Ketimines显示文摘 | LIU Lixin ZHENG Yongsheng HU Xiaoyan LIAN Chunxia YUAN Weicheng ZHANG Xiaomei | 2014 | Chemical Research in Chinese Universities2014，30，2： | 2 |
| 18 | KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma显示文摘Feedback regulation plays a pivotal role in determining the intensity and duration of TGF-p signaling and subsequently affecting the pathophysiological roles of TGF-p,including those in liver malignancy.KLF2,a member of the Kruppel-like factor(KLF)fam ily transcription factors,has been implicated in impeding hepatocellular carcinoma(HCC)development.However,the underlying molecular mechanisms are not fully understood.In the present study,we found that TGF-p stimulates the expression of KLF2 gene in several HCC cell lines.KLF2 protein is able to inhibit TGF-p/Smad signaling in HCC cells as assessed by luciferase reporter assay.Further studies indicated that KLF2 inhibits the transcriptional activity of Smad2/3 and Smad4 and ameliorates TGF-p-induced target gene expression,therefore creating a novel negative feedback loop in TGFp signaling.Functionally,stably expression of KLF2 in HCCLM3 cells attenuated TGF-卜induced cancer cell motility in wound-healing and transwell assays by interfering with TGF-p-mediated upregulation of MMP2.Together,our results revealed that KLF2 protein has a tumor-suppressive function in HCC through a negative feedback loop over TGF-p signaling. | Yining Li Shuo Tu Yi Zeng Cheng Zhang Tian Deng Weicheng Luo Lingyan Lian Ling Chen Xiangyang Xiong Xiaohua Yan | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 19 | Spatial-temporal Analysis of Emotions in Society in News显示文摘Spatial-temporal analysis of emotions in society has become popular in many studies integrating geography with the humanities,and has shown its influence on social sensing and geo-computation for social sciences.Emotions in society are often volatile,irrational,and vulnerable to the social environment.A critical challenge is to analyze changes in long-term and large-scale emotions in society.In this paper,we propose exploiting this challenge by using spatial-temporal analysis.After extracting emotional,temporal,and spatial information,a spatial standardization approach based on adataset of administrative district changes addresses the problem of Chinese toponym changes.Finally,over 1.7 million news data from the People’s Daily from 1956 to 2014 were collected to explore the changes,spatial distribution,and driving factors of emotions in society using spatial-temporal analysis.The experimental results found that the spatial-temporal analysis of emotions in society in the news is consistent with the results of related sociological research. | An HUAI Xueying ZHANG Weicheng AI Tianyang CAO | 2022 | Journal of Geodesy and Geoinformation Science2022，5，2： | 2 |
| 20 | Effect of ziprasidone and clozapine on the quality of life in patients with schizophrenia显示文摘 | Weicheng Han Zhang Xiaoming Huang | 2009 | Chinese Jottrnal of Behavioral M~dical and Brain Sciences2009，23，5： | 1 |
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